WO1999026932A8 - Derives heterocycliques substitues par un groupe amidino et leur utilisation en tant qu'anticoagulants - Google Patents

Derives heterocycliques substitues par un groupe amidino et leur utilisation en tant qu'anticoagulants

Info

Publication number
WO1999026932A8
WO1999026932A8 PCT/US1998/025216 US9825216W WO9926932A8 WO 1999026932 A8 WO1999026932 A8 WO 1999026932A8 US 9825216 W US9825216 W US 9825216W WO 9926932 A8 WO9926932 A8 WO 9926932A8
Authority
WO
WIPO (PCT)
Prior art keywords
anticoagulants
group substituted
substituted heterocyclic
amidino group
heterocyclic derivatives
Prior art date
Application number
PCT/US1998/025216
Other languages
English (en)
Other versions
WO1999026932A1 (fr
Inventor
Paul R Fatheree
Thomas E Jenkins
Yong Li
Martin S Linsell
Roopa Rai
William D Shrader
Sean G Trapp
Wendy B Young
Original Assignee
Axys Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axys Pharm Inc filed Critical Axys Pharm Inc
Priority to AU16071/99A priority Critical patent/AU1607199A/en
Publication of WO1999026932A1 publication Critical patent/WO1999026932A1/fr
Publication of WO1999026932A8 publication Critical patent/WO1999026932A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux dérivés bihétérocycliques inhibiteurs du facteur Xa, leurs oxydes de N et leurs sels pharmaceutiquement acceptables, leurs utilisations en tant qu'agents thérapeutiques et leurs méthodes de production.
PCT/US1998/025216 1997-11-26 1998-11-25 Derives heterocycliques substitues par un groupe amidino et leur utilisation en tant qu'anticoagulants WO1999026932A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16071/99A AU1607199A (en) 1997-11-26 1998-11-25 By amidino group substituted heterocyclic derivatives and their use as anticoagulants

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7265497P 1997-11-26 1997-11-26
US60/072,654 1997-11-26
US19370498A 1998-11-17 1998-11-17
US09/193,704 1998-11-17

Publications (2)

Publication Number Publication Date
WO1999026932A1 WO1999026932A1 (fr) 1999-06-03
WO1999026932A8 true WO1999026932A8 (fr) 1999-09-10

Family

ID=26753594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/025216 WO1999026932A1 (fr) 1997-11-26 1998-11-25 Derives heterocycliques substitues par un groupe amidino et leur utilisation en tant qu'anticoagulants

Country Status (1)

Country Link
WO (1) WO1999026932A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040010004A1 (en) 2000-01-17 2004-01-15 Naoki Tsuchiya Benzimidazole derivatives
KR100903531B1 (ko) 1998-07-15 2009-06-23 데이진 가부시키가이샤 티오벤즈이미다졸 유도체
CA2340100A1 (fr) * 1998-08-11 2000-02-24 Daiichi Pharmaceutical Co., Ltd. Nouveaux derives sulfonyle
GT199900167A (es) * 1998-10-01 2001-03-21 Nuevos bis-benzimidazoles.
WO2000075117A1 (fr) * 1999-06-04 2000-12-14 Elan Pharma International Ltd. Compositions et methodes permettant d'inhiber la mort cellulaire
SI1249450T1 (sl) * 2000-01-17 2008-04-30 Teijin Pharma Ltd Derivati benzimidola kot inhibitorji humane kimaze
JP2001354671A (ja) * 2000-04-14 2001-12-25 Nippon Chemiphar Co Ltd ペルオキシソーム増殖剤応答性受容体δの活性化剤
WO2004010996A1 (fr) * 2002-07-29 2004-02-05 Shizuoka Coffein Co., Ltd. Derive 1,3 azole et composition medicale contenant ce derive pour le traitement de thrombose
WO2004035740A2 (fr) * 2002-10-15 2004-04-29 Synta Pharmaceuticals Corp. Nouveaux composes
HUE025683T2 (hu) 2002-12-03 2016-04-28 Pharmacyclics Llc VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
EP2536285B1 (fr) 2010-02-18 2018-04-25 vTv Therapeutics LLC Dérivés d'imidazole fusionnés et substitués, compositions pharmaceutiques et procédés d'utilisation associés
US9399616B2 (en) 2012-10-22 2016-07-26 Boehringer Ingelheim International Gmbh Process for the manufacture of 4-aminobenzoamidine dihydrochloride
WO2016089648A1 (fr) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Inhibiteurs de bach1 en combinaison avec des activateurs de nrf2 et compositions pharmaceutiques les contenant
WO2019109132A1 (fr) * 2017-12-05 2019-06-13 Bionomics Limited Composés d'isoxazolyle utilisés en tant que composés modulateurs du récepteur, procédés et utilisations de ceux-ci
EP4146639A1 (fr) 2020-05-06 2023-03-15 Ajax Therapeutics, Inc. 6-hétéroaryloxy benzimidazoles et azabenzimidazoles en tant qu'inhibiteurs de jak2
TW202241889A (zh) 2020-12-23 2022-11-01 美商雅捷可斯治療公司 作為ｊａｋ２抑制劑之６－雜芳基氧基苯并咪唑及氮雜苯并咪唑
WO2023086319A1 (fr) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. 6-hetero-aryloxy-benzimidazoles et azabenzimidazoles en tant qu'inhibiteurs de jak2

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2839989A1 (de) * 1978-09-14 1980-04-03 Hoechst Ag Substituierte bisbenzimidazolylverbindungen, ihre herstellung und ihre verwendung
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
JP2002514162A (ja) * 1996-07-08 2002-05-14 デュポン ファーマシューティカルズ カンパニー Ｘａ因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体
NZ500029A (en) * 1997-04-07 2001-02-23 Axys Pharm Inc Compounds and compositions of carboxamide derivatives associated with the treatment of rheumatoid arthritis, conjunctivitis and/ or syncytial virus infections

Also Published As

Publication number Publication date
WO1999026932A1 (fr) 1999-06-03

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