WO1999015526A3 - N-5,6,7,8-tetrahydro(1,6)naphthyridine-n'-phenylurea derivatives - Google Patents
N-5,6,7,8-tetrahydro(1,6)naphthyridine-n'-phenylurea derivatives Download PDFInfo
- Publication number
- WO1999015526A3 WO1999015526A3 PCT/EP1998/005904 EP9805904W WO9915526A3 WO 1999015526 A3 WO1999015526 A3 WO 1999015526A3 EP 9805904 W EP9805904 W EP 9805904W WO 9915526 A3 WO9915526 A3 WO 9915526A3
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- WO
- WIPO (PCT)
- Prior art keywords
- disorders
- disease
- pain
- epilepsy
- neuralgia
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000512831A JP2001517668A (en) | 1997-09-19 | 1998-09-15 | N-5,6,7,8-tetrahydro (1,6) naphthyridine-N'-phenylurea derivative |
CA002303994A CA2303994A1 (en) | 1997-09-19 | 1998-09-15 | N-5,6,7,8-tetrahydro(1,6)naphthyridine-n'-phenylurea derivatives |
EP98951421A EP1017694A2 (en) | 1997-09-19 | 1998-09-15 | N-5,6,7,8-tetrahydro(1,6)naphthyridine-n'-phenylurea derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9720052.1A GB9720052D0 (en) | 1997-09-19 | 1997-09-19 | Novel compounds |
GB9720052.1 | 1997-09-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999015526A2 WO1999015526A2 (en) | 1999-04-01 |
WO1999015526A3 true WO1999015526A3 (en) | 1999-05-20 |
Family
ID=10819406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1998/005904 WO1999015526A2 (en) | 1997-09-19 | 1998-09-15 | N-5,6,7,8-tetrahydro(1,6)naphthyridine-n'-phenylurea derivatives |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1017694A2 (en) |
JP (1) | JP2001517668A (en) |
CA (1) | CA2303994A1 (en) |
GB (1) | GB9720052D0 (en) |
WO (1) | WO1999015526A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL360944A1 (en) | 2000-10-12 | 2004-09-20 | Merck & Co, Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
CA2425625A1 (en) * | 2000-10-12 | 2002-07-18 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
DE60128936T2 (en) | 2000-10-12 | 2008-04-10 | Merck & Co, Inc. | AZA AND POLYAZA NAPHTHALENYL ACID ACID AMIDE AS HIV INTEGRASE INHIBITORS |
KR20040041178A (en) | 2001-09-26 | 2004-05-14 | 바이엘 파마슈티칼스 코포레이션 | 1,8-naphthyridine derivatives as antidiabetics |
AU2003220170B2 (en) | 2002-03-15 | 2008-12-11 | Merck Sharp & Dohme Corp. | N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as HIV integrase inhibitors |
US8629276B2 (en) * | 2012-02-15 | 2014-01-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
US10065945B2 (en) | 2014-01-24 | 2018-09-04 | Merck Sharp & Dohme Corp. | Isoquinoline derivatives as MGAT2 inhibitors |
WO2020111087A1 (en) * | 2018-11-28 | 2020-06-04 | 武田薬品工業株式会社 | Heterocyclic compound |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1302662B (en) * | 1971-02-04 | |||
FR2377377A1 (en) * | 1977-01-14 | 1978-08-11 | Metabio Joullie Sa | AMIDES DERIVED FROM 3,4,5-TRIMETHOXY BENZENE AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
EP0105821A1 (en) * | 1982-10-05 | 1984-04-18 | Cortial S.A. | N-(aminomethyl-5-oxazolin-2-yl-2)-N'-phenyl ureas |
US4542144A (en) * | 1981-11-16 | 1985-09-17 | Mcneilab Inc. | Anticonvulsant N-aryl-N'-(2-thiazolidinylidene)ureas |
EP0556008A1 (en) * | 1992-02-12 | 1993-08-18 | Shionogi & Co., Ltd. | Condensed imidazopyridine derivatives with psychotropic activity |
WO1994022807A1 (en) * | 1993-04-07 | 1994-10-13 | Neurosearch A/S | Urea and amide derivatives and their use in the control of cell membrane potassium channels |
WO1996039382A1 (en) * | 1995-06-06 | 1996-12-12 | Fujisawa Pharmaceutical Co., Ltd. | Urea derivatives as 5-ht antagonists |
-
1997
- 1997-09-19 GB GBGB9720052.1A patent/GB9720052D0/en not_active Ceased
-
1998
- 1998-09-15 WO PCT/EP1998/005904 patent/WO1999015526A2/en not_active Application Discontinuation
- 1998-09-15 CA CA002303994A patent/CA2303994A1/en not_active Abandoned
- 1998-09-15 JP JP2000512831A patent/JP2001517668A/en active Pending
- 1998-09-15 EP EP98951421A patent/EP1017694A2/en not_active Withdrawn
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1302662B (en) * | 1971-02-04 | |||
FR2377377A1 (en) * | 1977-01-14 | 1978-08-11 | Metabio Joullie Sa | AMIDES DERIVED FROM 3,4,5-TRIMETHOXY BENZENE AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
US4542144A (en) * | 1981-11-16 | 1985-09-17 | Mcneilab Inc. | Anticonvulsant N-aryl-N'-(2-thiazolidinylidene)ureas |
EP0105821A1 (en) * | 1982-10-05 | 1984-04-18 | Cortial S.A. | N-(aminomethyl-5-oxazolin-2-yl-2)-N'-phenyl ureas |
EP0556008A1 (en) * | 1992-02-12 | 1993-08-18 | Shionogi & Co., Ltd. | Condensed imidazopyridine derivatives with psychotropic activity |
WO1994022807A1 (en) * | 1993-04-07 | 1994-10-13 | Neurosearch A/S | Urea and amide derivatives and their use in the control of cell membrane potassium channels |
WO1996039382A1 (en) * | 1995-06-06 | 1996-12-12 | Fujisawa Pharmaceutical Co., Ltd. | Urea derivatives as 5-ht antagonists |
Non-Patent Citations (7)
Title |
---|
ARCH. PHARM., vol. 330, no. 7, 1997, pages 207 - 210 * |
CHEMICAL ABSTRACTS, vol. 67, no. 21, 20 November 1967, Columbus, Ohio, US; abstract no. 99956, XP002095689 * |
CHEMICAL ABSTRACTS, vol. 73, no. 13, 28 September 1970, Columbus, Ohio, US; abstract no. 64728, XP002095688 * |
HEINISCH ET AL: "Synthesis of N-aryl-N'-heteroaryl-substituted urea and thiourea derivatives and evaluation of their anticonvulsant activity", ARCHIV DER PHARMAZIE, vol. 330, no. 7, July 1997 (1997-07-01), pages 207 - 210, XP002087695 * |
M. LAZAROVA ET AL., DOKL. BOLG. AKAD. NAUK., vol. 23, no. 5, 1970, pages 599 - 602 * |
N.S. DOBYCHINA ET AL., IZV. TOMSK. POLITEKH. INST., vol. 151, 1966, pages 85 - 87 * |
PAVIA M R ET AL: "N-PHENYL-N'-PYRIDINYLUREAS AS ANTICONVULSANT AGENTS1", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 2, February 1990 (1990-02-01), pages 854 - 861, XP000604950 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999015526A2 (en) | 1999-04-01 |
GB9720052D0 (en) | 1997-11-19 |
JP2001517668A (en) | 2001-10-09 |
EP1017694A2 (en) | 2000-07-12 |
CA2303994A1 (en) | 1999-04-01 |
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