WO1998042319A3 - Compositions non aqueuses pour administration par voie orale - Google Patents

Compositions non aqueuses pour administration par voie orale Download PDF

Info

Publication number
WO1998042319A3
WO1998042319A3 PCT/EP1998/001580 EP9801580W WO9842319A3 WO 1998042319 A3 WO1998042319 A3 WO 1998042319A3 EP 9801580 W EP9801580 W EP 9801580W WO 9842319 A3 WO9842319 A3 WO 9842319A3
Authority
WO
WIPO (PCT)
Prior art keywords
oil
oral administration
aqueous compositions
biologically active
soluble
Prior art date
Application number
PCT/EP1998/001580
Other languages
English (en)
Other versions
WO1998042319A2 (fr
Inventor
Den Braak Maarten Van
Original Assignee
Smithkline Beecham Plc
Den Braak Maarten Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, Den Braak Maarten Van filed Critical Smithkline Beecham Plc
Priority to AU70371/98A priority Critical patent/AU7037198A/en
Priority to EP98916998A priority patent/EP0973503A2/fr
Publication of WO1998042319A2 publication Critical patent/WO1998042319A2/fr
Publication of WO1998042319A3 publication Critical patent/WO1998042319A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des compositions essentiellement non aqueuses, qui sont adaptées pour être administrées par voie orale et qui contiennent une huile biologiquement active ou un ingrédient soluble dans l'huile ou une huile biologiquement active ou un ingrédient soluble dans l'huile se présentant sous forme de dispersion dans une huile pouvant servir de véhicule. Ces compositions sont dispersées dans un émulsifiant physiologiquement acceptable ou un mélange émulsifiant ayant un rapport hydrophile-lipophile situé entre 10 et 18 et elles sont encapsulées dans une capsule soluble dans le suc gastrique. L'invention concerne également la production et l'utilisation de ces compositions nouvelles pour le maintien et/ou la promotion de la santé.
PCT/EP1998/001580 1997-03-20 1998-03-13 Compositions non aqueuses pour administration par voie orale WO1998042319A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU70371/98A AU7037198A (en) 1997-03-20 1998-03-13 Non-aqueous compositions for oral administration
EP98916998A EP0973503A2 (fr) 1997-03-20 1998-03-13 Compositions non aqueuses pour administration par voie orale

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9705813.5A GB9705813D0 (en) 1997-03-20 1997-03-20 Novel compositions
GB9705813.5 1997-03-20

Publications (2)

Publication Number Publication Date
WO1998042319A2 WO1998042319A2 (fr) 1998-10-01
WO1998042319A3 true WO1998042319A3 (fr) 1998-12-17

Family

ID=10809593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/001580 WO1998042319A2 (fr) 1997-03-20 1998-03-13 Compositions non aqueuses pour administration par voie orale

Country Status (5)

Country Link
EP (1) EP0973503A2 (fr)
AU (1) AU7037198A (fr)
GB (1) GB9705813D0 (fr)
WO (1) WO1998042319A2 (fr)
ZA (1) ZA982334B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0101198D0 (en) 2001-01-17 2001-02-28 Scherer Technologies Inc R P Ingestible compositions containing an odoriferous oil
FR2861261B1 (fr) * 2003-10-22 2007-11-16 Adisseo France Sas Procede zootechnique pour l'administation d'un derive de vitamine e et formulation

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58128141A (ja) * 1982-01-26 1983-07-30 Sumitomo Chem Co Ltd 自己乳化分散型カロチノイド類含有ソフトカプセル剤の製法
JPS6067424A (ja) * 1983-09-22 1985-04-17 Nisshin Flour Milling Co Ltd 制癌剤
EP0196085A2 (fr) * 1985-03-28 1986-10-01 Eisai Co., Ltd. Compositions à absorption améliorée contenant de l'ubidécarénone
FR2643263A1 (fr) * 1989-02-23 1990-08-24 Glaxo Canada Composition pharmaceutique a base de ranitidine
WO1991002520A1 (fr) * 1989-08-17 1991-03-07 Cortecs Limited Compositions pharmaceutiques
WO1994006310A1 (fr) * 1992-09-15 1994-03-31 Smithkline Beecham Plc Nouvelles compositions
DE4322826A1 (de) * 1993-07-08 1995-01-12 Galenik Labor Freiburg Gmbh Pharmazeutisches Präparat
EP0670166A2 (fr) * 1994-03-01 1995-09-06 Eli Lilly And Company Compositions pharmaceutiques administrables par voie buccale
RU2043339C1 (ru) * 1993-02-25 1995-09-10 Научно-производственное товарищество "АКВА-МДТ" Способ получения раствора бета-каротина и композиция на основе бета-каротина для витаминизации и окрашивания пищевых продуктов
WO1995024832A1 (fr) * 1994-03-15 1995-09-21 Smithkline Beecham Plc Compositions stables, optiquement transparentes
JPH08259451A (ja) * 1995-03-24 1996-10-08 Lion Corp 天然カロチノイドを包含した多芯型構造のマイクロカプセル又はその用途
WO1997010725A1 (fr) * 1995-09-23 1997-03-27 Smithkline Beecham Plc Nouveau procede

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58128141A (ja) * 1982-01-26 1983-07-30 Sumitomo Chem Co Ltd 自己乳化分散型カロチノイド類含有ソフトカプセル剤の製法
JPS6067424A (ja) * 1983-09-22 1985-04-17 Nisshin Flour Milling Co Ltd 制癌剤
EP0196085A2 (fr) * 1985-03-28 1986-10-01 Eisai Co., Ltd. Compositions à absorption améliorée contenant de l'ubidécarénone
FR2643263A1 (fr) * 1989-02-23 1990-08-24 Glaxo Canada Composition pharmaceutique a base de ranitidine
WO1991002520A1 (fr) * 1989-08-17 1991-03-07 Cortecs Limited Compositions pharmaceutiques
WO1994006310A1 (fr) * 1992-09-15 1994-03-31 Smithkline Beecham Plc Nouvelles compositions
RU2043339C1 (ru) * 1993-02-25 1995-09-10 Научно-производственное товарищество "АКВА-МДТ" Способ получения раствора бета-каротина и композиция на основе бета-каротина для витаминизации и окрашивания пищевых продуктов
DE4322826A1 (de) * 1993-07-08 1995-01-12 Galenik Labor Freiburg Gmbh Pharmazeutisches Präparat
EP0670166A2 (fr) * 1994-03-01 1995-09-06 Eli Lilly And Company Compositions pharmaceutiques administrables par voie buccale
WO1995024832A1 (fr) * 1994-03-15 1995-09-21 Smithkline Beecham Plc Compositions stables, optiquement transparentes
JPH08259451A (ja) * 1995-03-24 1996-10-08 Lion Corp 天然カロチノイドを包含した多芯型構造のマイクロカプセル又はその用途
WO1997010725A1 (fr) * 1995-09-23 1997-03-27 Smithkline Beecham Plc Nouveau procede

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 118, no. 8, 22 February 1993, Columbus, Ohio, US; abstract no. 66767, XP002080683 *
DATABASE WPI Week 8336, Derwent World Patents Index; AN 83-756026 [25], XP002080686 *
DATABASE WPI Week 8522, Derwent World Patents Index; AN 85-130926 [25], XP002080685 *
DATABASE WPI Week 9621, Derwent World Patents Index; AN 96-207700 [21], XP002080684 *
DATABASE WPI Week 9650, Derwent World Patents Index; AN 96-502632, XP002080687 *
S.K.COLE ET AL.: "STUDIES USING A NONIONIC SURFACTANT-CONTAINING DRUG DELIVERY SYSTEM DESIGNED FOR HARD GELATIN CAPSULE COMPATIBILITY", INT. J. PHARM., vol. 88, no. 1-3, 1992, pages 211 - 220 *

Also Published As

Publication number Publication date
ZA982334B (en) 1998-12-01
GB9705813D0 (en) 1997-05-07
EP0973503A2 (fr) 2000-01-26
AU7037198A (en) 1998-10-20
WO1998042319A2 (fr) 1998-10-01

Similar Documents

Publication Publication Date Title
CA2024291A1 (fr) Dispositif de dosage et preparation et utilisation de celui-ci
TW288979B (fr)
ZA936729B (en) Compositions of oil-soluble ingredients for use in health
IL115445A0 (en) Solid pharmaceutical compositions comprising an excipeint capable of binding water and their preparation
ES2053549T3 (es) Un proceso para la preparacion de una formulacion farmaceutica apropiada para inhalacion.
IL86221A (en) Sustained release microencapsulated drugs and methods for the preparation thereof
CA2339992A1 (fr) Comprime se desagregeant dans la bouche pour former une pulpe visqueuse
DE60019239D1 (de) Fettlösliche Vitamine enthaltende Zusammensetzungen
BG104742A (en) Lipophilic microparticles containing a protein drug or antigen and formulation comprising same
CA2299420A1 (fr) Compositions pharmaceutiques contenant de la vitamine d et du calcium, leur preparation et leur utilisation therapeutique
CA2342587A1 (fr) Preparation de liberation prolongee de medicament a effet durable
WO2003018064A3 (fr) Compositions de medicaments lipophiles
WO1998042319A3 (fr) Compositions non aqueuses pour administration par voie orale
WO2000010525A3 (fr) Composition gelatineuse de poisson utilisee comme ingredient dans des comprimes
IE831030L (en) Benzopyrans and benzothiopyrans
CA2314112A1 (fr) Procede de preparation d'une formulation pharmaceutique
WO1999043299A3 (fr) Formulations orales pour medicaments hydrophiles
WO2002076411A3 (fr) Agent dermatologique pour le traitement des lesions cutanees, particulierement des brulures
MX9603038A (es) Emulsiones de aceite en agua.
IT1317871B1 (it) Sistemi terapeutici per forme farmaceutiche orali di principi attiviaventi sfavorevoli caratteristiche organolettiche.
AU2002317162A1 (en) Liposomally encapsulated hydrophobic active ingredients with a high active ingredient content greater than 50 % and method for the production of pharmaceutical preparations containing liposomally encapsulated hydrophobic active ingredients

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1998916998

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09381259

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1998916998

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998544420

Format of ref document f/p: F

NENP Non-entry into the national phase

Ref country code: CA

WWW Wipo information: withdrawn in national office

Ref document number: 1998916998

Country of ref document: EP