WO1998037181A3 - Gene de sous-unite catalytique de telomerase et proteine codee - Google Patents

Gene de sous-unite catalytique de telomerase et proteine codee Download PDF

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Publication number
WO1998037181A3
WO1998037181A3 PCT/US1998/003404 US9803404W WO9837181A3 WO 1998037181 A3 WO1998037181 A3 WO 1998037181A3 US 9803404 W US9803404 W US 9803404W WO 9837181 A3 WO9837181 A3 WO 9837181A3
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WO
WIPO (PCT)
Prior art keywords
catalytic subunit
malignancy
telomerase
encoded protein
subunit gene
Prior art date
Application number
PCT/US1998/003404
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English (en)
Other versions
WO1998037181A2 (fr
Inventor
Christopher M Counter
Matthew Meyerson
Robert A Weinberg
Original Assignee
Whitehead Biomedical Inst
Christopher M Counter
Matthew Meyerson
Robert A Weinberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Whitehead Biomedical Inst, Christopher M Counter, Matthew Meyerson, Robert A Weinberg filed Critical Whitehead Biomedical Inst
Publication of WO1998037181A2 publication Critical patent/WO1998037181A2/fr
Publication of WO1998037181A3 publication Critical patent/WO1998037181A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Cette invention concerne de l'ADN isolé codant la sous-unité catalytique d'une holoenzyme de télomérase eucaryotique telle que la sous-unité catalytique d'une holoenzyme de télomérase humaine ou de levure; le transcript d'ARN qui est exprimé dans des tumeurs humaines primitives, des lignées cellulaires cancéreuses et des tissus télomérase-positifs; et la protéine de sous-unité catalytique codée. L'invention concerne également des procédés qui permettent d'évaluer le caractère malin des cellules ou la probabilité accrue que les cellules deviennent malignes et des méthodes de diagnostic ou facilitant le diagnostic du développement du caractère malin des cellules chez un individu.
PCT/US1998/003404 1997-02-20 1998-02-20 Gene de sous-unite catalytique de telomerase et proteine codee WO1998037181A2 (fr)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US3875097P 1997-02-20 1997-02-20
US60/038,750 1997-02-20
US4715197P 1997-05-20 1997-05-20
US60/047,151 1997-05-20
US5454997P 1997-08-01 1997-08-01
US60/054,549 1997-08-01
US5576297P 1997-08-14 1997-08-14
US60/055,762 1997-08-14
US6432297P 1997-10-30 1997-10-30
US60/064,322 1997-10-30

Publications (2)

Publication Number Publication Date
WO1998037181A2 WO1998037181A2 (fr) 1998-08-27
WO1998037181A3 true WO1998037181A3 (fr) 1999-02-18

Family

ID=27534674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/003404 WO1998037181A2 (fr) 1997-02-20 1998-02-20 Gene de sous-unite catalytique de telomerase et proteine codee

Country Status (1)

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WO (1) WO1998037181A2 (fr)

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DE19681033D2 (de) 1995-11-16 1999-03-18 Michael W Dahm Verfahren zur Quantifizierung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
US6777203B1 (en) 1997-11-19 2004-08-17 Geron Corporation Telomerase promoter driving expression of therapeutic gene sequences
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
WO1998014592A2 (fr) 1996-10-01 1998-04-09 Geron Corporation Transcriptase inverse de la telomerase
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
JP2002508662A (ja) * 1997-06-20 2002-03-19 バイエル・アクチエンゲゼルシヤフト ヒトテロメラーゼの触媒サブユニット並びにその診断的及び治療的使用
CN1270634A (zh) 1997-07-01 2000-10-18 卡姆比亚生物系统有限责任公司 脊椎动物端粒酶基因和蛋白质及其用途
EP1571215A3 (fr) * 1997-07-01 2007-10-31 Cambia Biosystems LLC Gènes et protéines de télomérases de vertèbres et leurs utilisations
US7378244B2 (en) 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
WO1999027113A1 (fr) * 1997-11-26 1999-06-03 Geron Corporation Transcriptase inverse de telomerase de souris
WO1999035261A1 (fr) 1998-01-08 1999-07-15 Chugai Seiyaku Kabushiki Kaisha Nouveau gene presentant un motif de transcriptase inverse
DE19804372A1 (de) 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
EP0990701A4 (fr) * 1998-03-26 2001-12-12 Kyowa Hakko Kogyo Kk Anticorps monoclonal contre une sous-unite catalytique de telomerase humaine
JP2002509716A (ja) 1998-03-31 2002-04-02 ユニバーシティ テクノロジー コーポレイション テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
DE69934426T2 (de) 1998-10-29 2007-10-04 Whitehead Institute For Biomedical Research, Cambridge KREBSIMMUNTHERAPIE UND KREBSDIAGNOSE UNTER VERWENDUNG UNIVERSELLER TUMORASSOZIIERTER ANTIGENE EINSCHLIESSLICH hTERT
US6825397B1 (en) 1998-11-09 2004-11-30 Pioneer Hi-Bred International, Inc. LEC1 trancriptional activator nucleic acids and methods of use thereof
JP2002530436A (ja) * 1998-11-25 2002-09-17 ジェネティカ インコーポレイテッド 増殖能を増強しかつ複製老化を防止する方法及び試薬
US6399384B1 (en) * 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
KR100801764B1 (ko) * 1999-09-17 2008-02-05 레뉴런 리미티드 세포의 조건부 불멸화
US6492171B2 (en) 2000-05-16 2002-12-10 Isis Pharmaceuticals, Inc. Antisense modulation of TERT expression
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
AU2001282290A1 (en) * 2000-08-17 2002-03-04 University Of Wales College Of Medicine Htert-immortalised cell lines, their preparation and use
US7078491B1 (en) * 2000-09-21 2006-07-18 Amgen Inc. Selective binding agents of telomerase
GB0125773D0 (en) * 2001-10-26 2001-12-19 Reneuron Ltd Constructs
US20050089895A1 (en) * 2003-08-13 2005-04-28 Cheung Siu T. Compositions and methods for prognosis and therapy of liver cancer
ES2376010T3 (es) 2006-10-12 2012-03-08 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. Prote�?na de fusión de transcriptasa inversa de la telomerasa, nucleótidos que la codifican y usos de la misma.
US10689652B2 (en) 2013-10-02 2020-06-23 The Regents Of The University Of California Methods for immortalization of epithelial cells
WO2017062517A1 (fr) * 2015-10-06 2017-04-13 The Regents Of The University Of California Arn non codants liés à l'immortalité ainsi que compositions et procédés associés

Citations (6)

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WO1993023572A1 (fr) * 1992-05-13 1993-11-25 University Of Texas Southwestern Medical Center At Dallas Therapie et diagnostic des etats pathologiques lies a la longueur du telomere et/ou a l'activite de la telomerase
WO1996001835A1 (fr) * 1994-07-07 1996-01-25 Geron Corporation Telomerase mammifere
WO1996012811A2 (fr) * 1994-10-20 1996-05-02 Arch Development Corporation Constituants de levure-telomerase et leurs procedes d'utilisation
WO1998001542A1 (fr) * 1996-07-08 1998-01-15 The Regents Of The University Of California Telomerase humaine
GB2317891A (en) * 1996-10-01 1998-04-08 Geron Corp hTRT, the reverse transcriptase subunit of human telomerase
WO1998021343A1 (fr) * 1996-11-15 1998-05-22 Amgen Inc. Genes codant des proteines de telomerase

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023572A1 (fr) * 1992-05-13 1993-11-25 University Of Texas Southwestern Medical Center At Dallas Therapie et diagnostic des etats pathologiques lies a la longueur du telomere et/ou a l'activite de la telomerase
WO1996001835A1 (fr) * 1994-07-07 1996-01-25 Geron Corporation Telomerase mammifere
WO1996012811A2 (fr) * 1994-10-20 1996-05-02 Arch Development Corporation Constituants de levure-telomerase et leurs procedes d'utilisation
WO1998001542A1 (fr) * 1996-07-08 1998-01-15 The Regents Of The University Of California Telomerase humaine
GB2317891A (en) * 1996-10-01 1998-04-08 Geron Corp hTRT, the reverse transcriptase subunit of human telomerase
WO1998021343A1 (fr) * 1996-11-15 1998-05-22 Amgen Inc. Genes codant des proteines de telomerase

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
COUNTER C M ET AL: "The catalytic subunit of yeast telomerase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 94, no. 17, 1997, WASHINGTON US, pages 9202 - 9207, XP002071610 *
GREIDER C W: "TELOMERE LENGTH REGULATION", ANNUAL REVIEW OF BIOCHEMISTRY, vol. 65, 1996, PALO ALTO US, pages 337 - 365, XP002056801 *
HARRINGTON L ET AL: "HUMAN TELOMERASE CONTAINS EVOLUTIONARILY CONSERVED CATALYTIC AND STRUCTURAL SUBUNITS", GENES AND DEVELOPMENT, vol. 11, no. 23, 1 December 1997 (1997-12-01), COLD SPRING HARBOUR US, pages 3109 - 3115, XP002061269 *
LENDVAY T S ET AL: "Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes", GENETICS, vol. 144, no. 4, 1996, BETHESDA US, pages 1399 - 1412, XP002071608 *
LINGNER J ET AL: "Reverse transcriptase motifs in the catalytic subunit of telomerase", SCIENCE., vol. 276, no. 5312, 25 April 1997 (1997-04-25), LANCASTER, PA US, pages 561 - 567, XP002071609 *
MEYERSON M ET AL: "HEST2, THE PUTATIVE HUMAN TELOMERASE CATALYTIC SUBUNIT GENE, IS UP-REGULATED IN TUMOR CELLS AND DURING IMMORTALIZATION", CELL, vol. 90, no. 4, 22 August 1997 (1997-08-22), NA US, pages 785 - 795, XP002056804 *
NAKAMURA T M ET AL: "TELOMERASE CATALYTIC SUBUNIT HOMOLOGS FROM FISSION YEAST AND HUMAN", SCIENCE., vol. 277, 15 August 1997 (1997-08-15), LANCASTER, PA US, pages 955 - 959, XP002056803 *

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