WO1998032863A3 - Mammalian thioredoxin - Google Patents

Mammalian thioredoxin Download PDF

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Publication number
WO1998032863A3
WO1998032863A3 PCT/GB1998/000263 GB9800263W WO9832863A3 WO 1998032863 A3 WO1998032863 A3 WO 1998032863A3 GB 9800263 W GB9800263 W GB 9800263W WO 9832863 A3 WO9832863 A3 WO 9832863A3
Authority
WO
WIPO (PCT)
Prior art keywords
mammalian thioredoxin
thioredoxin
mammalian
methods
relates
Prior art date
Application number
PCT/GB1998/000263
Other languages
French (fr)
Other versions
WO1998032863A2 (en
Inventor
Giannis Spyrou
Original Assignee
Karobio Ab
Dean John Paul
Giannis Spyrou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karobio Ab, Dean John Paul, Giannis Spyrou filed Critical Karobio Ab
Priority to JP53176098A priority Critical patent/JP2001510997A/en
Priority to EP98901415A priority patent/EP1012296A2/en
Priority to CA002279241A priority patent/CA2279241A1/en
Priority to AU57745/98A priority patent/AU5774598A/en
Publication of WO1998032863A2 publication Critical patent/WO1998032863A2/en
Publication of WO1998032863A3 publication Critical patent/WO1998032863A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

This invention relates to a thioredoxin and to methods for its use.
PCT/GB1998/000263 1997-01-28 1998-01-28 Mammalian thioredoxin WO1998032863A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP53176098A JP2001510997A (en) 1997-01-28 1998-01-28 Mammalian thioredoxin
EP98901415A EP1012296A2 (en) 1997-01-28 1998-01-28 Mammalian thioredoxin
CA002279241A CA2279241A1 (en) 1997-01-28 1998-01-28 Mammalian thioredoxin
AU57745/98A AU5774598A (en) 1997-01-28 1998-01-28 Mammalian thioredoxin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9701710.7A GB9701710D0 (en) 1997-01-28 1997-01-28 Mammalian protein
GB9701710.7 1997-01-28

Publications (2)

Publication Number Publication Date
WO1998032863A2 WO1998032863A2 (en) 1998-07-30
WO1998032863A3 true WO1998032863A3 (en) 1998-11-05

Family

ID=10806693

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/000263 WO1998032863A2 (en) 1997-01-28 1998-01-28 Mammalian thioredoxin

Country Status (7)

Country Link
EP (1) EP1012296A2 (en)
JP (1) JP2001510997A (en)
KR (1) KR20000070582A (en)
AU (1) AU5774598A (en)
CA (1) CA2279241A1 (en)
GB (1) GB9701710D0 (en)
WO (1) WO1998032863A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4790891B2 (en) * 2000-02-02 2011-10-12 オリエンタル酵母工業株式会社 Thioredoxin composition stable in solution and process for its preparation
DE60138385D1 (en) * 2000-06-29 2009-05-28 Mei Co Ltd REMEDIES FOR THE TREATMENT OF DISEASES OF THE SEHNERV
FR2823221B1 (en) 2001-04-06 2004-04-02 Univ Pasteur SEQUENCES ASSOCIATED WITH RETINAL DEGENERATION AND APPLICATIONS
JP4925155B2 (en) * 2002-06-10 2012-04-25 レドックス・バイオサイエンス株式会社 Retinal nerve cell function recovery agent
CN1906126A (en) * 2003-12-15 2007-01-31 Nano-C公司 High-efficiency fullerene-based radical scavengers
WO2005087249A1 (en) * 2004-03-11 2005-09-22 Kurume University Protease inhibitor and preventives or remedies for diseases
CN104062294A (en) * 2014-07-11 2014-09-24 青岛千士医疗科技有限公司 Method for detecting mitochondria damage of epithelial cells of bronchia/lung
WO2019168364A1 (en) * 2018-03-02 2019-09-06 사회복지법인 삼성생명공익재단 Method for upregulation of thioredoxin expression in stem cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0425821A1 (en) * 1989-09-29 1991-05-08 Ajinomoto Co., Inc. The use of human ADF (=Adult T-cell leukemia-derived factor) for producing a medicament

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0425821A1 (en) * 1989-09-29 1991-05-08 Ajinomoto Co., Inc. The use of human ADF (=Adult T-cell leukemia-derived factor) for producing a medicament

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
EMBL Database Entry HS898283 Accession number N41898; 27 January 1996 HILLIER L. ET AL.:"The WashU-Merck EST Project" *
EMBL Database Entry MMW027 Accession number W91027; 9 July 1996 MARRA M. ET AL.:"The WashU-HHMI Mouse EST Project" *
GIANNIS SPYROU ET AL.: "Cloning and expression of a novel mammalian thioredoxin", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 5, 31 January 1997 (1997-01-31), MD US, pages 2936 - 2941, XP002067405 *
HARIHARAN J ET AL: "Alternative forms of the human thioredoxin mRNA: identification and characterization", GENE, vol. 173, no. 2, 16 September 1996 (1996-09-16), pages 265-270, XP004043228 *
JOHANNA BODENSTEIN ET AL.: "characterization of two thioredoxins in pig heart including a new mitochondrial protein", ZEITSCHRIFT FÜR NATURFORSCHUNG, vol. 46, no. 3-4, 1991, pages 270 - 279, XP002067404 *
SHOJI WATABE ET AL.: "SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 249, no. 1, October 1997 (1997-10-01), pages 52 - 60, XP002067406 *
XILIN REN ET AL.: "Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione", BIOCHEMISTRY, vol. 32, no. 37, 21 September 1993 (1993-09-21), EASTON, PA US, pages 9701 - 9708, XP002067403 *

Also Published As

Publication number Publication date
KR20000070582A (en) 2000-11-25
EP1012296A2 (en) 2000-06-28
GB9701710D0 (en) 1997-03-19
CA2279241A1 (en) 1998-07-30
JP2001510997A (en) 2001-08-07
AU5774598A (en) 1998-08-18
WO1998032863A2 (en) 1998-07-30

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