WO1998029142A1 - Pansements chirurgicaux ameliores et leur procede de preparation - Google Patents

Pansements chirurgicaux ameliores et leur procede de preparation Download PDF

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Publication number
WO1998029142A1
WO1998029142A1 PCT/GB1997/002677 GB9702677W WO9829142A1 WO 1998029142 A1 WO1998029142 A1 WO 1998029142A1 GB 9702677 W GB9702677 W GB 9702677W WO 9829142 A1 WO9829142 A1 WO 9829142A1
Authority
WO
WIPO (PCT)
Prior art keywords
dressing
fabric
analgesic
therapeutic agents
activated
Prior art date
Application number
PCT/GB1997/002677
Other languages
English (en)
Inventor
Selwyn Everest-Todd
Original Assignee
Everest-Todd Research And Development Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Everest-Todd Research And Development Limited filed Critical Everest-Todd Research And Development Limited
Priority to AU44685/97A priority Critical patent/AU4468597A/en
Publication of WO1998029142A1 publication Critical patent/WO1998029142A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

Definitions

  • This invention relates to improved surgical dressing and a method of preparing same, in particular a method of spraying pharmaceuticals .
  • analgesic and therapeutic agents in contact with the perturbed tissue. This may be accomplished by impregnating one or more layers of the dressing with such agents. It has been found to be particularly beneficial for such agents to include polysaccharides and oligosaccharides.
  • analgesic, therapeutic and/or biocidal material is essential in the production of impregnated fabrics for the manufacture of items for medical or sanitary use and the present invention seeks to provide a dressing meeting this criterion.
  • spraying fabric with solutions or suspensions of the agents is effectively accomplished by the adoption of a method developed for precision application of pesticides known as electrostatic spraying.
  • This method has been found to produce textiles with a uniform dosage of the desired agent. It has been found to be particularly beneficial in the application of certain oligosaccharides to fabric used to form wound dressings.
  • the analgesic effect of the oligosaccharide is dependent on the availability of the molecule in the region of the arachidonic acid generated by perturbed tissue.
  • a preferred method of application is to use a 'Microstat' electrostatic sprayer (Horstine Farmery) which, briefly, operates by producing droplets of the solution to be applied by means of a spinning disc tubine. Electric charge is applied to the solution as it is pumped onto the turbine where it is atomised and directed downwards by the turbine towards a treatment table carrying the product to be treated. The droplets carry a negative charge and are attracted to the product which is earthed.
  • This apparatus was developed for applying pestices to produce, we have surprisingly found that it produces dressings with very even application of pharmaceuticals.
  • a dressing which contains, in different areas, analgesic and therapeutic agents which are activated prior to or during use.
  • the analgesic and therapeutic agents may be activated in situ by blood from the perturbed tissue, or by sterile water immediately before use. Activation by sterile water is currently the preferred method in the treatment of burns.
  • the dressing may comprise layers of fabric each treated with a specific agent.
  • the layer of fabric which will be in direct contact with the wound is that impregnated with the analgesic, e.g. an oligo-saccharide, such as a cyclodextrin.
  • the analgesic e.g. an oligo-saccharide, such as a cyclodextrin.
  • the therapeutic agents present in the secondary layer or layers are able to diffuse through to the perturbed tissue where they stimulate tissue regeneration.
  • the therapeutic agent may be a glucosamine absorbed on the fabric.
  • Other absorbants than textiles can be employed, e.g. foamed plastics materials.
  • the fabrics can be prepared separately and brought together as a dressing.
  • the principle involved is the prevention of the formation of leukotrienes and other lipoxygenase products, which are responsible for pain and inflammation, by the clathration of arachidonic acid which is released in perturbed tissue.
  • the molecular cavity in cyclodextrins should be free.
  • Combinations of cyclodextrins and glucosamine would require formulation as aqueous solution for application to fabric; therefore the acid salt of glucosamine necessary for water solubility could be clathrated by the cyclodextrins.
  • the water soluble cyclodextrin is available for clathrating the arachidonic acid generated in the perturbed tissue.
  • colloidal suspensions of the active material By using a precise application technique it is possible to use colloidal suspensions of the active material at high concentration therefore reducing the quantity of liquid employed. This is particularly advantageous as -cyclodextrin has a low solubility and the poly acetyl glucosamines are insoluble in water. Both materials may be prepared as colloidal suspensions and benefit from electrostatic application by the ability of the technique to obtain uniform treatment with low liquor volume.
  • the wound contact layer of fabric may be coated with the analgesic compound cyclodextrin.
  • Control of infection and healing may be brought about by the amino polysaccharides.
  • a variety of articles may be produced from the precise treatment of distinct materials to fabrics generally referred to as personal hygiene or sanitary wear.
  • a solution containing -cyclodextrin at a concentration equivalent to 2.0% wt/vol was applied to a 100% polyester fabric using a Microstat low volume spray applicator.
  • the speed of travel by the fabric was 20 metres per minute with a spray volume rate of 90ml per minute. With a fabric 1.5 metres wide this produced a chemical concentration on the finished material of 6 ⁇ g cm "2 .
  • a solution containing 2.0% wt/vol of ⁇ -cyclodextrin was applied to a 100% polyester fabric by an hydraulic sprayer nozzle and the minimum volume necessary to produce a uniform spray pattern namely 150 ml per minute. With fabric size and speed of travel similar to those in Example I the mean concentration of ⁇ -cyclodextrin in the fabric was 7.5 ⁇ g cm "2 .
  • Example III A solution containing 4.0% wt/vol of glucosamine hydrochloride was applied in the manner described in Example I to a 100% polyester non-woven fabric resulting in a dosage level within the fabric of 12 ⁇ g cm '2 . Examination for uniformity gave a maximum variation of 5%. The low moisture content of the treated fabric permitted drying to be accomplished with a line speed of 20 metres per minute.
  • Fabric produced as in Example III was used to enclose pads of super absorbent fibre 1mm thick and 9cm square generated from Oasis polymer. These pads were then enclosed in 10cm x 10cm sections of fabric produced as in Example I and the edges of the formed pads were heat-sealed. Following sterilisation pads were immersed in 100 ml of sterile water and applied to second degree burns and lightly bandaged in place. This treatment resulting in relief from pain and stimulation of healing.
  • Wound dressings were produced from fabric treated as in Example I or Example II and formed as heat bonded pads enclosing one or two layers of fabric as described in Example III.
  • a liquid containing 4.0% wt/vol of a micro cyrstaline glucosamine was applied int he manner described in Example I to 100% polypropylene non-woven fabric resulting in a meant concentration on the fabric of 12 ⁇ g cm "2 . Following application the fabric was air dried at normal line speed of 20 metres per minute.
  • a liquid containing micronised poly-N-acetyl-D-glucosamine at a concentration of 5.0% w/v was applied to a 100% polyester non-woven fabric in the manner described in Example I. Drying of the fabric was at the normal line speed of 20 meters per minute.
  • the theoretical deposition of poly-N-acetyl-D- glucosamine was 15 ⁇ g cm "2 or 0.25% in the weight of the fabric; analysis revealed a mean concentration of 0.25% with a level of uniformity of plus or minus 2.0%
  • Fabric produced as described in Example VI was used to enclose pads of super absorbent fibre 1mm thick and 8cm square, generated from Oasis polymer. These pads were then enclosed in fabric generated as in Example I to produce dressings 10cm square. Following packing and sterilisation the dressings were employed in the treatment of wounds.
  • Fabric produced as in Example VII was used to enclose pads of fibre 1mm thick and 9cm square generated from Oasis polymer. These pads were then enclosed in fabric produced as described in Example I forming dressings 10cm square.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Pansement contenant, dans différentes zones, des agents analgésiques et thérapeutiques qui sont activés avant ou pendant la mise en application. Ces agents peut être activés sur place par le sang provenant du tissu blessé ou par de l'eau stérile immédiatement avant utilisation. Ce pansement peut comporter des couches de tissu traitées chacune par un agent spécifique. De préférence, la couche de tissu qui sera en contact direct avec la blessure est celle qui est imprégnée par l'analgésique. Les agents thérapeutiques présents dans la ou les deuxièmes couches sont capables de se diffuser à travers le pansement afin d'atteindre le tissu blessé au niveau duquel ils peuvent stimuler la régénération tissulaire. On peut utiliser d'autres absorbants que des textiles, par exemple, des matières plastiques en mousse. On peut préparer ces tissus séparément et les rassembler afin de constituer le pansement.
PCT/GB1997/002677 1996-12-27 1997-10-01 Pansements chirurgicaux ameliores et leur procede de preparation WO1998029142A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU44685/97A AU4468597A (en) 1996-12-27 1997-10-01 Improved surgical dressings and method of preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9626963.4 1996-12-27
GBGB9626963.4A GB9626963D0 (en) 1996-12-27 1996-12-27 Improved surgical dressings and method of preparation

Publications (1)

Publication Number Publication Date
WO1998029142A1 true WO1998029142A1 (fr) 1998-07-09

Family

ID=10805068

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/002677 WO1998029142A1 (fr) 1996-12-27 1997-10-01 Pansements chirurgicaux ameliores et leur procede de preparation

Country Status (3)

Country Link
AU (1) AU4468597A (fr)
GB (1) GB9626963D0 (fr)
WO (1) WO1998029142A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009782A1 (fr) * 2000-07-27 2002-02-07 Avery Dennison Corporation Pansements non adherents pour blessures renfermant des cyclodextrines
WO2006007844A1 (fr) 2004-07-16 2006-01-26 Coloplast A/S Dispositif de soin des plaies

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0253539A2 (fr) * 1986-07-17 1988-01-20 Imperial Chemical Industries Plc Procédé de pulvérisation
WO1989002754A1 (fr) * 1987-09-22 1989-04-06 Coloplast A/S Matiere de pansement pour le traitement de blessures, et corpuscules destines a etre utilises dans la production d'une telle matiere
WO1989012471A1 (fr) * 1988-06-24 1989-12-28 Britcair Limited Pansement pour plaies
EP0562864A1 (fr) * 1992-03-25 1993-09-29 JOHNSON & JOHNSON MEDICAL, INC. Eponges hétéromorphes contenant des substances actives
RU2031661C1 (ru) * 1993-07-16 1995-03-27 Научно-производственное предприятие "Экомедсервис" Средство для лечения ран и оказания первой медицинской помощи
GB2307176A (en) * 1995-11-15 1997-05-21 Todd Selwyn Everest Anti-inflammatory clathrating agents for topical use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0253539A2 (fr) * 1986-07-17 1988-01-20 Imperial Chemical Industries Plc Procédé de pulvérisation
WO1989002754A1 (fr) * 1987-09-22 1989-04-06 Coloplast A/S Matiere de pansement pour le traitement de blessures, et corpuscules destines a etre utilises dans la production d'une telle matiere
WO1989012471A1 (fr) * 1988-06-24 1989-12-28 Britcair Limited Pansement pour plaies
EP0562864A1 (fr) * 1992-03-25 1993-09-29 JOHNSON & JOHNSON MEDICAL, INC. Eponges hétéromorphes contenant des substances actives
RU2031661C1 (ru) * 1993-07-16 1995-03-27 Научно-производственное предприятие "Экомедсервис" Средство для лечения ран и оказания первой медицинской помощи
GB2307176A (en) * 1995-11-15 1997-05-21 Todd Selwyn Everest Anti-inflammatory clathrating agents for topical use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 9544, Derwent World Patents Index; Class A96, AN 95-342809, XP002054000 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009782A1 (fr) * 2000-07-27 2002-02-07 Avery Dennison Corporation Pansements non adherents pour blessures renfermant des cyclodextrines
WO2006007844A1 (fr) 2004-07-16 2006-01-26 Coloplast A/S Dispositif de soin des plaies

Also Published As

Publication number Publication date
AU4468597A (en) 1998-07-31
GB9626963D0 (en) 1997-02-12

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