WO1998028971A3 - Toxicite de la beta-amyloide - Google Patents
Toxicite de la beta-amyloide Download PDFInfo
- Publication number
- WO1998028971A3 WO1998028971A3 PCT/US1997/023819 US9723819W WO9828971A3 WO 1998028971 A3 WO1998028971 A3 WO 1998028971A3 US 9723819 W US9723819 W US 9723819W WO 9828971 A3 WO9828971 A3 WO 9828971A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- beta
- transgenic animals
- vivo visualization
- amyloid toxicity
- visualization
- Prior art date
Links
- 238000001727 in vivo Methods 0.000 title abstract 3
- 230000009261 transgenic effect Effects 0.000 title abstract 3
- 238000012800 visualization Methods 0.000 title abstract 3
- 230000006974 Aβ toxicity Effects 0.000 title 1
- 241001465754 Metazoa Species 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 231100000331 toxic Toxicity 0.000 abstract 2
- 230000002588 toxic effect Effects 0.000 abstract 2
- 230000007082 Aβ accumulation Effects 0.000 abstract 1
- 241000244203 Caenorhabditis elegans Species 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
- A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
- A01K67/0335—Genetically modified worms
- A01K67/0336—Genetically modified Nematodes, e.g. Caenorhabditis elegans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/70—Invertebrates
- A01K2227/703—Worms, e.g. Caenorhabdities elegans
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Environmental Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU56192/98A AU5619298A (en) | 1997-01-03 | 1997-12-31 | Beta-amyloid toxicity |
EP97952623A EP0948612A2 (fr) | 1997-01-03 | 1997-12-31 | Toxicite de la beta-amyloide |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77864597A | 1997-01-03 | 1997-01-03 | |
US8022297P | 1997-01-03 | 1997-01-03 | |
US08/778,645 | 1997-01-03 | ||
US60/080,222 | 1997-01-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998028971A2 WO1998028971A2 (fr) | 1998-07-09 |
WO1998028971A3 true WO1998028971A3 (fr) | 1998-10-29 |
Family
ID=26763238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/023819 WO1998028971A2 (fr) | 1997-01-03 | 1997-12-31 | Toxicite de la beta-amyloide |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0948612A2 (fr) |
AU (1) | AU5619298A (fr) |
WO (1) | WO1998028971A2 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1294450B1 (it) * | 1997-08-28 | 1999-03-25 | Consiglio Nazionale Ricerche | Animali transgenici per lo studio di agenti tossici chimici fisici o biologici |
AU6291899A (en) * | 1998-10-09 | 2000-05-01 | Regents Of The University Of California, The | Viable prp (prion protein) transgenic animals and methods of use |
DE19849073A1 (de) * | 1998-10-24 | 2000-04-27 | Aventis Pharma Gmbh | Transgener C. elegans als Modellorganismus für Untersuchungen zur Alzheimer'schen Krankheit |
EP1141359B1 (fr) | 1998-12-17 | 2006-10-04 | Xenogen Corporation | Evaluation non-invasive d'une reponse physiologique chez un mammifere |
GB9906018D0 (en) * | 1999-03-16 | 1999-05-12 | Devgen Nv | Expression of DNA or proteins in C.elegans |
AU2589500A (en) * | 1999-09-03 | 2001-04-10 | Xenogen Corporation | Targeting constructs and transgenic animals produced therewith |
US6867348B1 (en) | 1999-12-16 | 2005-03-15 | Xenogen Corporation | Methods and compositions for screening for angiogenesis modulating compounds |
IT1311335B1 (it) | 1999-12-21 | 2002-03-12 | Otc Optical Technologies Ct S | Procedimento e dispositivo per realizzare reticoli in fibra ottica. |
JP3354918B2 (ja) | 2000-06-08 | 2002-12-09 | 佑子 若松 | 透明メダカ |
US7741098B2 (en) | 2001-11-27 | 2010-06-22 | Nexyte Ab | Production of eukaryotic proteins and nucleic acid molecules in C. elegans |
FR2840320B1 (fr) * | 2002-05-30 | 2007-07-20 | Centre Nat Rech Scient | Embryons transgeniques de xenope et leurs utilisations pour la detection de perturbateurs endocriniens, et procedes correspondants |
GB0517977D0 (en) * | 2005-09-02 | 2005-10-12 | Birkeland Innovasjon As | Transgenic animal model for identifying modulators of protein kinase |
DE102007035238A1 (de) * | 2007-07-27 | 2009-01-29 | Christian-Albrechts-Universität Zu Kiel | Biologisches Effektmonitoring mittels transgener Hydra |
WO2011017319A1 (fr) | 2009-08-03 | 2011-02-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Méthodes de traitement de troubles associés à la polymérisation d'une protéine |
US9072772B2 (en) | 2009-11-05 | 2015-07-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of treating disorders associated with protein aggregation |
US8809617B2 (en) * | 2009-11-05 | 2014-08-19 | The University of Pittsburgh—Of the Commonwealth System of Higher Education | Automated high-content live animal drug screening using C. elegans |
CN104920307B (zh) * | 2015-06-19 | 2018-01-26 | 安徽省农业科学院农业工程研究所 | 一种适用于单粒子微束装置的秀丽小杆线虫固定方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993023533A1 (fr) * | 1992-05-08 | 1993-11-25 | Exemplar Corporation | Test in vivo de medicaments anti-neoplasiques |
CA2088379A1 (fr) * | 1993-01-29 | 1994-07-30 | University Of British Columbia | Systemes biologiques comportant des genes inductibles par le stress et proteines decelables pour la biosurveillance et la toxicologie environnementale |
WO1995011968A1 (fr) * | 1993-10-27 | 1995-05-04 | Athena Neurosciences, Inc. | Animaux transgeniques hebergeant un gene allele app presentant une mutation suedoise |
-
1997
- 1997-12-31 AU AU56192/98A patent/AU5619298A/en not_active Abandoned
- 1997-12-31 WO PCT/US1997/023819 patent/WO1998028971A2/fr not_active Application Discontinuation
- 1997-12-31 EP EP97952623A patent/EP0948612A2/fr not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993023533A1 (fr) * | 1992-05-08 | 1993-11-25 | Exemplar Corporation | Test in vivo de medicaments anti-neoplasiques |
CA2088379A1 (fr) * | 1993-01-29 | 1994-07-30 | University Of British Columbia | Systemes biologiques comportant des genes inductibles par le stress et proteines decelables pour la biosurveillance et la toxicologie environnementale |
WO1995011968A1 (fr) * | 1993-10-27 | 1995-05-04 | Athena Neurosciences, Inc. | Animaux transgeniques hebergeant un gene allele app presentant une mutation suedoise |
Non-Patent Citations (4)
Title |
---|
CHALFIE M ET AL: "GREEN FLUORESCENT PROTEIN AS A MARKER FOR GENE EXPRESSION", SCIENCE, vol. 263, no. 5148, 11 February 1994 (1994-02-11), pages 802 - 805, XP002003599 * |
LINK, C.D.: "Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 92, no. 20, 26 September 1995 (1995-09-26), WASHINGTON US, pages 9368 - 9372, XP002065639 * |
LINK, C.D.: "Transgenic Caenorhabditis elegans as model system to study amyloid formation and toxicity", NEUROBIOLOGY OF AGING, vol. 15, no. suppl. 1, 29 July 1994 (1994-07-29), pages S33, XP002065640 * |
MOSS, J. B. ET AL.: "Green fluorescent protein marks skeletal muscle in murine cell lines and zebrafish", GENE, vol. 173, no. 1, 1996, AMSTERDAM NL, pages 89 - 98, XP002065641 * |
Also Published As
Publication number | Publication date |
---|---|
AU5619298A (en) | 1998-07-31 |
WO1998028971A2 (fr) | 1998-07-09 |
EP0948612A2 (fr) | 1999-10-13 |
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