WO1998028444A3 - Customized oligonucleotide microchips as multiple biosensors - Google Patents
Customized oligonucleotide microchips as multiple biosensors Download PDFInfo
- Publication number
- WO1998028444A3 WO1998028444A3 PCT/US1997/023778 US9723778W WO9828444A3 WO 1998028444 A3 WO1998028444 A3 WO 1998028444A3 US 9723778 W US9723778 W US 9723778W WO 9828444 A3 WO9828444 A3 WO 9828444A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biosensors
- oligonucleotides
- customized
- microchip
- multiple biosensors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU57160/98A AU5716098A (en) | 1996-12-23 | 1997-12-19 | Customized oligonucleotide microchips as multiple biosensors |
EP97953408A EP0951569A2 (en) | 1996-12-23 | 1997-12-19 | Customized oligonucleotide microchips as multiple biosensors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78002696A | 1996-12-23 | 1996-12-23 | |
US08/780,026 | 1996-12-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998028444A2 WO1998028444A2 (en) | 1998-07-02 |
WO1998028444A3 true WO1998028444A3 (en) | 1998-12-17 |
Family
ID=25118334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/023778 WO1998028444A2 (en) | 1996-12-23 | 1997-12-19 | Customized oligonucleotide microchips as multiple biosensors |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0951569A2 (en) |
AU (1) | AU5716098A (en) |
WO (1) | WO1998028444A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7655129B2 (en) | 1998-06-23 | 2010-02-02 | Osmetech Technology Inc. | Binding acceleration techniques for the detection of analytes |
US8486247B2 (en) | 1999-04-21 | 2013-07-16 | Osmetch Technology, Inc. | Use of microfluidic systems in the electrochemical detection of target analytes |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5952172A (en) | 1993-12-10 | 1999-09-14 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US5824473A (en) | 1993-12-10 | 1998-10-20 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US6071699A (en) | 1996-06-07 | 2000-06-06 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US6096273A (en) | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
US7160678B1 (en) | 1996-11-05 | 2007-01-09 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
US7393645B2 (en) | 1996-11-05 | 2008-07-01 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
US7045285B1 (en) | 1996-11-05 | 2006-05-16 | Clinical Micro Sensors, Inc. | Electronic transfer moieties attached to peptide nucleic acids |
US6458584B1 (en) * | 1996-12-23 | 2002-10-01 | University Of Chicago | Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable |
US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
US6686150B1 (en) | 1998-01-27 | 2004-02-03 | Clinical Micro Sensors, Inc. | Amplification of nucleic acids with electronic detection |
US6740518B1 (en) | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
AU1241000A (en) | 1998-10-27 | 2000-05-15 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
US6391937B1 (en) | 1998-11-25 | 2002-05-21 | Motorola, Inc. | Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers |
US6821770B1 (en) | 1999-05-03 | 2004-11-23 | Gen-Probe Incorporated | Polynucleotide matrix-based method of identifying microorganisms |
EP1177318B1 (en) * | 1999-05-03 | 2008-02-13 | Gen-Probe Incorporated | Polynucleotide matrix-based method of identifying microorganisms |
EP1925678B1 (en) * | 1999-05-03 | 2009-07-22 | Gen-Probe Incorporated | Polynucleotide matrix-based method of identifying microorganisms |
WO2001007665A2 (en) | 1999-07-26 | 2001-02-01 | Clinical Micro Sensors, Inc. | Sequence determination of nucleic acids using electronic detection |
KR100348786B1 (en) * | 1999-10-01 | 2002-08-17 | 엘지전자주식회사 | Method for detecting nucleic acids, detector for nucleic acids and method for producing the same |
EP1261716A2 (en) * | 1999-11-16 | 2002-12-04 | Apollo Biotechnology, Inc. | Method for rapid and accurate identification of microorganisms |
US6878517B1 (en) * | 1999-12-15 | 2005-04-12 | Congra Grocery Products Company | Multispecies food testing and characterization organoleptic properties |
JP3871846B2 (en) * | 2000-03-10 | 2007-01-24 | 日立ソフトウエアエンジニアリング株式会社 | Hybridization reaction detection method and detection apparatus |
US7875442B2 (en) | 2000-03-24 | 2011-01-25 | Eppendorf Array Technologies | Identification and quantification of a plurality of biological (micro)organisms or their components |
EP1136566A1 (en) * | 2000-03-24 | 2001-09-26 | Facultés Universitaires Notre-Dame de la Paix | Method and kit for detection and/or quantification of homologus nucleotide sequences on arrays |
US7829313B2 (en) | 2000-03-24 | 2010-11-09 | Eppendorf Array Technologies | Identification and quantification of a plurality of biological (micro)organisms or their components |
US7205104B2 (en) | 2000-03-24 | 2007-04-17 | Eppendorf Array Technologies Sa (Eat) | Identification of biological (micro) organisms by detection of their homologous nucleotide sequences on arrays |
US7202026B2 (en) | 2000-03-24 | 2007-04-10 | Eppendorf Array Technologies Sa (Eat) | Identification of a large number of biological (micro)organisms groups at different levels by their detection on a same array |
FR2815043B1 (en) * | 2000-10-05 | 2005-09-16 | Skuld Tech | RAPID METHOD OF DETECTION OF ORGANISMS IN A SAMPLE |
FR2816958B1 (en) * | 2000-11-17 | 2004-11-26 | Biomerieux Sa | METHOD FOR THE ANALYSIS OF THE GENETIC PREDISPOSITION OF A PATIENT WITH INSULIN-DEPENDENT DIABETES, DEVICE SUITABLE FOR ITS IMPLEMENTATION AND SET OF AMPLIFICATION PRIMERS SUITABLE FOR SUCH A PROCESS |
US6960298B2 (en) | 2001-12-10 | 2005-11-01 | Nanogen, Inc. | Mesoporous permeation layers for use on active electronic matrix devices |
FR2833969A1 (en) * | 2001-12-20 | 2003-06-27 | Ct Medico Chirurgical De Tronq | Biochip that carries high purity molecular probes, useful e.g. for diagnosis, specifically of breast cancer, and for analysis of DNA repair |
FR2833968A1 (en) * | 2001-12-20 | 2003-06-27 | Ct Medico Chirurgical De Tronq | Thematic biochip, useful e.g. for diagnosis, particularly of breast cancer, and treatment selection, comprises thematic probes and probes for interpretation |
WO2003062418A1 (en) * | 2002-01-25 | 2003-07-31 | Olympus Corporation | Method and apparatus for detecting nucleic acid data |
EP1524320A1 (en) * | 2003-10-15 | 2005-04-20 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Rapid determination and quantification of mycoplasma contamination using DNA chip technology |
GB0326079D0 (en) | 2003-11-07 | 2003-12-10 | Rue De Int Ltd | Security device |
US7338763B2 (en) | 2004-06-02 | 2008-03-04 | Eppendorf Array Technologies S.A. | Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays |
DE602005023705D1 (en) * | 2004-11-18 | 2010-11-04 | Eppendorf Array Technologies | REAL-TIME PCR OF TARGETS ON A MICROARRAY |
EP1762628B1 (en) | 2005-09-13 | 2008-03-12 | Eppendorf Array Technologies SA | Detection method of homologous sequences differing by one base on a microarray |
EP1981985A4 (en) * | 2006-01-05 | 2009-11-11 | Simons Haplomics Ltd | Microarray methods |
US20110059859A1 (en) * | 2008-05-09 | 2011-03-10 | Zhiping Liu | Molecule Detecting System |
EP3387154A4 (en) | 2015-12-09 | 2019-05-15 | Intuitive Biosciences, Inc. | Automated silver enhancement system |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989011548A1 (en) * | 1988-05-20 | 1989-11-30 | Cetus Corporation | Immobilized sequence-specific probes |
WO1990015157A1 (en) * | 1989-05-31 | 1990-12-13 | Gene-Trak Systems | Universal eubacteria nucleic acid probes and methods |
WO1995000530A1 (en) * | 1993-06-25 | 1995-01-05 | Affymax Technologies N.V. | Hybridization and sequencing of nucleic acids |
US5462855A (en) * | 1990-05-09 | 1995-10-31 | Bayer Aktiengesellschaft | Method for the detection and quantitative determination of nitrosomonas strains in wastewaters or soils |
WO1996008582A2 (en) * | 1994-09-12 | 1996-03-21 | Bergeron Michel G | Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
US5552270A (en) * | 1991-03-18 | 1996-09-03 | Institut Molekulyarnoi Biologii Imeni V.A. | Methods of DNA sequencing by hybridization based on optimizing concentration of matrix-bound oligonucleotide and device for carrying out same |
WO1996036733A1 (en) * | 1995-05-19 | 1996-11-21 | Akzo Nobel N.V. | Nucleic acid primers for amplification of a mycobacteria rna template |
-
1997
- 1997-12-19 AU AU57160/98A patent/AU5716098A/en not_active Abandoned
- 1997-12-19 EP EP97953408A patent/EP0951569A2/en not_active Withdrawn
- 1997-12-19 WO PCT/US1997/023778 patent/WO1998028444A2/en active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989011548A1 (en) * | 1988-05-20 | 1989-11-30 | Cetus Corporation | Immobilized sequence-specific probes |
WO1990015157A1 (en) * | 1989-05-31 | 1990-12-13 | Gene-Trak Systems | Universal eubacteria nucleic acid probes and methods |
US5462855A (en) * | 1990-05-09 | 1995-10-31 | Bayer Aktiengesellschaft | Method for the detection and quantitative determination of nitrosomonas strains in wastewaters or soils |
US5552270A (en) * | 1991-03-18 | 1996-09-03 | Institut Molekulyarnoi Biologii Imeni V.A. | Methods of DNA sequencing by hybridization based on optimizing concentration of matrix-bound oligonucleotide and device for carrying out same |
WO1995000530A1 (en) * | 1993-06-25 | 1995-01-05 | Affymax Technologies N.V. | Hybridization and sequencing of nucleic acids |
WO1996008582A2 (en) * | 1994-09-12 | 1996-03-21 | Bergeron Michel G | Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
WO1996036733A1 (en) * | 1995-05-19 | 1996-11-21 | Akzo Nobel N.V. | Nucleic acid primers for amplification of a mycobacteria rna template |
Non-Patent Citations (8)
Title |
---|
BORMAN S: "DNA CHIPS COME OF AGE AFTER PERIOD OF GESTATION, TECHNOLOGY FOR GENETIC ANALYSIS IS BLOSSOMING", CHEMICAL AND ENGINEERING NEWS, vol. 74, no. 50, 9 December 1996 (1996-12-09), pages 42/43, XP000633458 * |
CHEE M ET AL: "ACCESSING GENETIC INFORMATION WITH HIGH-DENSITY DNA ARRAYS", SCIENCE, vol. 274, 25 October 1996 (1996-10-25), pages 610 - 614, XP002022508 * |
DROBYSHEV ET AL.: "SEQUENCE ANALYSIS BY HYBRIDIZATION WITH OLIGONUCLEOTIDE MICROCHIP: IDENTIFICATION OF BETA-THALASSEMIA MUTATIONS", GENE, vol. 188, no. 1, March 1997 (1997-03-01), pages 45 - 52, XP002064990 * |
ERLICH, HENRY A. ET AL: "HLA DNA typing", PCR PROTOC.: GUIDE METHODS APPL. (1990), 259-71. EDITOR(S): INNIS, MICHAEL A. PUBLISHER: ACADEMIC, SAN DIEGO, CALIF. CODEN: 56TMAY, XP002079984 * |
GUSCHIN ET AL.: "OLIGONUCLEOTIDE MICROCHIPS AS GENOSENSORS FOR DETERMINATIVE AND ENVIROMENTAL STUDIES IN MICROBIOLOGY", APPLIED AND ENVIROMENTAL MICROBIOLOGY, vol. 63, no. 6, June 1997 (1997-06-01), pages 2397 - 2402, XP002064989 * |
MIRZABEKOV ET AL.: "DNA SEQUENCING BY HYBRIDIZTION- A MEGASEQUENCING METHOD AND A DIAGNOSTIC TOOL?", TIBTECH, vol. 1994, no. 12, 1994, pages 27 - 32, XP002064988 * |
SHALON D ET AL: "A DNA MICROARRAY SYSTEM FOR ANALYZING COMPLEX DNA SAMPLES USING TWO-COLOR FLUORESCENT PROBE HYBRIDIZATION", GENOME RESEARCH, vol. 6, no. 7, 1 July 1996 (1996-07-01), pages 639 - 645, XP000597095 * |
YERSHOV ET AL.: "DNA ANALYSIS AND DIAGNOSTICS ON OLIGONUCLEOTIDE MICROCHIPS", PNAS, vol. 93, May 1996 (1996-05-01), pages 4913 - 4918, XP002064987 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7655129B2 (en) | 1998-06-23 | 2010-02-02 | Osmetech Technology Inc. | Binding acceleration techniques for the detection of analytes |
US8486247B2 (en) | 1999-04-21 | 2013-07-16 | Osmetch Technology, Inc. | Use of microfluidic systems in the electrochemical detection of target analytes |
US9151746B2 (en) | 1999-04-21 | 2015-10-06 | Osmetech Technology, Inc. | Use of microfluidic systems in the electrochemical detection of target analytes |
US9557295B2 (en) | 1999-04-21 | 2017-01-31 | Osmetech Technology, Inc. | Use of microfluidic systems in the electrochemical detection of target analytes |
Also Published As
Publication number | Publication date |
---|---|
WO1998028444A2 (en) | 1998-07-02 |
AU5716098A (en) | 1998-07-17 |
EP0951569A2 (en) | 1999-10-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1998028444A3 (en) | Customized oligonucleotide microchips as multiple biosensors | |
WO2000066789A3 (en) | Polynucleotide matrix-based method of identifying microorganisms | |
WO2000077260A8 (en) | Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms | |
WO2004053105A3 (en) | Direct SNP detection with unamplified DNA | |
WO2005042759A3 (en) | Expression profiling using microarrays | |
JP2002538785A (en) | Customized oligonucleotide microchips that convert multigene information into simpler patterns are portable and reusable | |
ES8507177A1 (en) | Detection of bacteria by nucleic acid hybridization, labeled probes and test kit therefore. | |
WO2005020795A3 (en) | Method of diagnosis and treatment of pancreatic endocrine neoplasms based on differntial gene expression analysis | |
CA2189941A1 (en) | Fluorescence Polarization Detection of Nucleic Acids | |
EP1196623B8 (en) | Method for detecting single nucleotide polymorphisms | |
WO2005001113A3 (en) | Methods for detecting nucleic acid variations | |
AU1082492A (en) | Diagnostic assays using nucleic acid probes | |
EP1085098A3 (en) | A composition for providing long term stability to cells for diagnostic testing | |
AU2001262767A1 (en) | Diagnosis kit for mycobacterium species identification and drug-resistance detection and manufacturing method thereof | |
BR0112400A (en) | Cation-mediated triplex hybridization assay | |
CA2249643A1 (en) | Assay for chlamydia trachomatis by amplification and detection of chlamydia trachomatis nucleic acid | |
WO1995033854B1 (en) | Use of a specific marker for detection of salmonella with pcr | |
WO2001036683A3 (en) | Method for rapid and accurate identification of microorganisms | |
ATE466101T1 (en) | DIAGNOSTIC TESTS FOR PROKARYOTIC AND EUKARYOTIC ORGANISMS BASED ON NUCLEIC ACID PROBE | |
WO2000065093A3 (en) | In situ hybridization methods for reducing the occurrence of false positives and for targeting multiple microorganisms | |
WO2007129182A3 (en) | Microorganisms detection and enumeration method | |
EP1106683A3 (en) | A method for providing long term stability to cells for diagnostic testing | |
EP1323835A3 (en) | Method for determining biospecies contained in test specimen and kit used for the same | |
CA2451394A1 (en) | Il-4 receptor sequence variation associated with type 1 diabetes | |
WO1998000565A3 (en) | NUCLEIC ACID PRIMERS AND PROBES FOR DETECTING $i(MYCOPLASMA PNEUMONIAE) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1997953408 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1997953408 Country of ref document: EP |