WO1998028004A1 - Particule de l'hepatite delta contenant un immunogene de proteine de fusion - Google Patents
Particule de l'hepatite delta contenant un immunogene de proteine de fusion Download PDFInfo
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- WO1998028004A1 WO1998028004A1 PCT/AU1997/000884 AU9700884W WO9828004A1 WO 1998028004 A1 WO1998028004 A1 WO 1998028004A1 AU 9700884 W AU9700884 W AU 9700884W WO 9828004 A1 WO9828004 A1 WO 9828004A1
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- Prior art keywords
- virus
- hdag
- protein
- immunogenic polypeptide
- hcv
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- 230000009870 specific binding Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- XETCRXVKJHBPMK-MJSODCSWSA-N trehalose 6,6'-dimycolate Chemical compound C([C@@H]1[C@H]([C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](COC(=O)C(CCCCCCCCCCC3C(C3)CCCCCCCCCCCCCCCCCC)C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)O2)O)O1)O)OC(=O)C(C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC XETCRXVKJHBPMK-MJSODCSWSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Particule de type viral destinée à être utilisée dans le traitement ou la prévention d'au moins une infection due à un micro-organisme. Ladite particule comprend au moins un polypeptide antigène et/ou immunogène ou une partie dudit polypeptide extrait du micro-organisme, fusionné avec au moins les 19 derniers acides aminés de la séquence terminale COOH de la grande protéine du virus de l'hépatite D (L-HDAg), ladite protéine de fusion étant au moins partiellement enveloppée par l'antigène de surface de l'hépatite B (HBsAg).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU78716/98A AU7871698A (en) | 1996-12-24 | 1997-12-24 | Hepatitis delta particle containing a fusion protein immunogen |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPO4341A AUPO434196A0 (en) | 1996-12-24 | 1996-12-24 | An improved therapeutic |
| AUPO4341 | 1996-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1998028004A1 true WO1998028004A1 (fr) | 1998-07-02 |
Family
ID=3798649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/AU1997/000884 WO1998028004A1 (fr) | 1996-12-24 | 1997-12-24 | Particule de l'hepatite delta contenant un immunogene de proteine de fusion |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AUPO434196A0 (fr) |
| WO (1) | WO1998028004A1 (fr) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000028009A1 (fr) * | 1998-11-11 | 2000-05-18 | Melbourne Health | Compositions biologiques, leurs constituants et leurs applications |
| WO2001002551A2 (fr) * | 1999-06-30 | 2001-01-11 | Evotec Oai Ag | Particules de type viral, preparation et utilisation de ces dernieres, de preference dans le criblage pharmaceutique et la genomique fonctionnelle |
| WO2002010416A1 (fr) * | 2000-07-31 | 2002-02-07 | The Crown In The Right Of The Queensland Department Of Health | Particules de type virus ameliorees fondees sur une petite proteine d'enveloppe provenant de l'hepatite b (aghbs) |
| AU2001276182B2 (en) * | 2000-07-31 | 2006-05-04 | Monash University | Improved virus like particles based on small envelope protein from hepatitis B (HBsAg-S) |
| EP1219705B1 (fr) * | 2000-12-29 | 2007-11-28 | Evotec AG | Particules du type virus, leur préparation et leur utilisation en criblage pharmaceutique et en analyse fonctionelle de génomes |
| US7419802B2 (en) | 1999-06-30 | 2008-09-02 | Evotec Ag | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
| US7476517B2 (en) | 1999-06-30 | 2009-01-13 | Evotec Ag | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
| WO2012174220A1 (fr) | 2011-06-14 | 2012-12-20 | Globeimmune, Inc. | Compositions à base de levure, et procédés de traitement ou de prévention d'une infection par le virus delta de l'hépatite |
| US9029341B2 (en) | 2010-08-17 | 2015-05-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| US10513703B2 (en) | 2014-11-10 | 2019-12-24 | Alnylam Pharmaceuticals, Inc. | Hepatitis B virus (HBV) iRNA compositions and methods of use thereof |
| US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
| AU2019264591B2 (en) * | 2010-08-17 | 2022-05-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| US11492623B2 (en) | 2018-08-13 | 2022-11-08 | Alnylam Pharmaceuticals, Inc. | Hepatitis B virus (HBV) dsRNA agent compositions and methods of use thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991004319A1 (fr) * | 1989-09-25 | 1991-04-04 | Innovir Laboratories, Inc. | Compositions de ribozymes therapeutiques et vecteurs d'expression |
-
1996
- 1996-12-24 AU AUPO4341A patent/AUPO434196A0/en not_active Abandoned
-
1997
- 1997-12-24 WO PCT/AU1997/000884 patent/WO1998028004A1/fr active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991004319A1 (fr) * | 1989-09-25 | 1991-04-04 | Innovir Laboratories, Inc. | Compositions de ribozymes therapeutiques et vecteurs d'expression |
Non-Patent Citations (7)
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000028009A1 (fr) * | 1998-11-11 | 2000-05-18 | Melbourne Health | Compositions biologiques, leurs constituants et leurs applications |
| WO2001002551A2 (fr) * | 1999-06-30 | 2001-01-11 | Evotec Oai Ag | Particules de type viral, preparation et utilisation de ces dernieres, de preference dans le criblage pharmaceutique et la genomique fonctionnelle |
| WO2001002551A3 (fr) * | 1999-06-30 | 2001-11-08 | Evotec Biosystems Ag | Particules de type viral, preparation et utilisation de ces dernieres, de preference dans le criblage pharmaceutique et la genomique fonctionnelle |
| US7419802B2 (en) | 1999-06-30 | 2008-09-02 | Evotec Ag | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
| US7476517B2 (en) | 1999-06-30 | 2009-01-13 | Evotec Ag | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
| WO2002010416A1 (fr) * | 2000-07-31 | 2002-02-07 | The Crown In The Right Of The Queensland Department Of Health | Particules de type virus ameliorees fondees sur une petite proteine d'enveloppe provenant de l'hepatite b (aghbs) |
| AU2001276182B2 (en) * | 2000-07-31 | 2006-05-04 | Monash University | Improved virus like particles based on small envelope protein from hepatitis B (HBsAg-S) |
| EP1219705B1 (fr) * | 2000-12-29 | 2007-11-28 | Evotec AG | Particules du type virus, leur préparation et leur utilisation en criblage pharmaceutique et en analyse fonctionelle de génomes |
| AU2011292261B2 (en) * | 2010-08-17 | 2015-05-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| US10793860B2 (en) | 2010-08-17 | 2020-10-06 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (SINA) |
| AU2019264591B2 (en) * | 2010-08-17 | 2022-05-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| US9029341B2 (en) | 2010-08-17 | 2015-05-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| US10407682B2 (en) | 2010-08-17 | 2019-09-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B Virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| US9464290B2 (en) | 2010-08-17 | 2016-10-11 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| US9879262B2 (en) | 2010-08-17 | 2018-01-30 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| US9579377B2 (en) | 2011-06-14 | 2017-02-28 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| US9987352B2 (en) | 2011-06-14 | 2018-06-05 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| EA030381B1 (ru) * | 2011-06-14 | 2018-07-31 | Глоубиммьюн, Инк. | Иммунотерапевтическая композиция, ее применения и способы лечения или профилактики инфекции, вызванной вирусом гепатита дельта |
| WO2012174220A1 (fr) | 2011-06-14 | 2012-12-20 | Globeimmune, Inc. | Compositions à base de levure, et procédés de traitement ou de prévention d'une infection par le virus delta de l'hépatite |
| EP2720716A1 (fr) * | 2011-06-14 | 2014-04-23 | Globeimmune, Inc. | Compositions à base de levure, et procédés de traitement ou de prévention d'une infection par le virus delta de l'hépatite |
| EP2720716A4 (fr) * | 2011-06-14 | 2015-03-11 | Globeimmune Inc | Compositions à base de levure, et procédés de traitement ou de prévention d'une infection par le virus delta de l'hépatite |
| US10513703B2 (en) | 2014-11-10 | 2019-12-24 | Alnylam Pharmaceuticals, Inc. | Hepatitis B virus (HBV) iRNA compositions and methods of use thereof |
| US10640770B2 (en) | 2014-11-10 | 2020-05-05 | Alnylam Pharmaceuticals, Inc. | Hepatitis D virus (HDV) iRNA compositions and methods of use thereof |
| US11060091B2 (en) | 2014-11-10 | 2021-07-13 | Alnylam Pharmaceuticals, Inc. | Hepatitis B virus (HBV) iRNA compositions and methods of use thereof |
| US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
| US11492623B2 (en) | 2018-08-13 | 2022-11-08 | Alnylam Pharmaceuticals, Inc. | Hepatitis B virus (HBV) dsRNA agent compositions and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AUPO434196A0 (en) | 1997-01-23 |
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