WO1998023632A1 - An optimal procedure for isolation of mutant mitochondrial alleles - Google Patents
An optimal procedure for isolation of mutant mitochondrial alleles Download PDFInfo
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- WO1998023632A1 WO1998023632A1 PCT/US1997/021274 US9721274W WO9823632A1 WO 1998023632 A1 WO1998023632 A1 WO 1998023632A1 US 9721274 W US9721274 W US 9721274W WO 9823632 A1 WO9823632 A1 WO 9823632A1
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- WIPO (PCT)
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- dna
- mutations
- seq
- buffy coat
- cellular dna
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97951451A EP0888378A4 (en) | 1996-11-27 | 1997-11-26 | An optimal procedure for isolation of mutant mitochondrial alleles |
JP10524745A JP2001500020A (en) | 1996-11-27 | 1997-11-26 | Optimal procedure for isolation of mutant mitochondrial alleles |
AU55091/98A AU715293B2 (en) | 1996-11-27 | 1997-11-26 | An optimal procedure for isolation of mutant mitochondrial alleles |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US08/757,438 | 1996-11-27 | ||
US08/757,438 US6027883A (en) | 1994-03-30 | 1996-11-27 | Optimal procedure for isolation of mutant mitochondrial alleles |
Publications (1)
Publication Number | Publication Date |
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WO1998023632A1 true WO1998023632A1 (en) | 1998-06-04 |
Family
ID=25047823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/021274 WO1998023632A1 (en) | 1996-11-27 | 1997-11-26 | An optimal procedure for isolation of mutant mitochondrial alleles |
Country Status (6)
Country | Link |
---|---|
US (1) | US6027883A (en) |
EP (1) | EP0888378A4 (en) |
JP (1) | JP2001500020A (en) |
AU (1) | AU715293B2 (en) |
CA (1) | CA2244101A1 (en) |
WO (1) | WO1998023632A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000061819A2 (en) * | 1999-04-14 | 2000-10-19 | California Institute Of Technology | Methods of detection and modulation of age-related mutations |
WO2000063441A2 (en) * | 1999-04-20 | 2000-10-26 | Mitokor | Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease |
WO2005056573A1 (en) * | 2002-06-10 | 2005-06-23 | 1304854 Ontario Ltd. | Complete mitochondrial genome sequences as a diagnostic tool for the health sciences |
EP1812793A2 (en) * | 2004-11-15 | 2007-08-01 | Quantomix Ltd. | Device and method for analysis of a metabolic malady |
US8008008B2 (en) | 2005-04-18 | 2011-08-30 | Mitomics Inc. | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
US10308987B2 (en) | 2005-04-18 | 2019-06-04 | Mdna Life Sciences Inc. | 3.4 kb mitochondrial DNA deletion for use in the detection of cancer |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5919618A (en) | 1993-08-16 | 1999-07-06 | Massachusetts Institute Of Technology | Genes determining cellular senescence in yeast |
US8642284B1 (en) | 1999-12-15 | 2014-02-04 | Massachusetts Institute Of Technology | Methods for identifying agents that alter NAD-dependent deacetylation activity of a SIR2 protein |
US7452664B2 (en) * | 1999-12-15 | 2008-11-18 | Massachusetts Institute Of Technology | Methods for identifying agents which alter histone protein acetylation |
US7572575B2 (en) | 2000-12-13 | 2009-08-11 | Massachusetts Institute Of Technology | SIR2 activity |
US20050136429A1 (en) * | 2003-07-03 | 2005-06-23 | Massachusetts Institute Of Technology | SIRT1 modulation of adipogenesis and adipose function |
DE60330399D1 (en) * | 2003-07-29 | 2010-01-14 | All India Inst Med | TRICHMICROSCOPY, CULTURE AND POLYMERASE CHAIN REACTION USING PROCESSED CLINICAL SAMPLES AND KIT THEREOF |
US20070099830A1 (en) | 2005-04-21 | 2007-05-03 | Massachusetts Institute Of Technology | Sirt4 activities |
DE102005047736B4 (en) * | 2005-09-29 | 2008-08-14 | Aj Innuscreen Gmbh | Method and system for isolating nucleic acids from any complex starting materials |
WO2007146023A1 (en) * | 2006-06-06 | 2007-12-21 | Massachusetts Institute Of Technology | Cholesterol-regulating complex of sirt1 and lxr and methods of use |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5185244A (en) * | 1989-12-08 | 1993-02-09 | Emory University | Genetic test for hereditary neuromuscular disease |
US5192659A (en) * | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
US5565323A (en) * | 1994-03-30 | 1996-10-15 | Mitokor | Cytochrome oxidase mutations aiding diagnosis of sporadic alzheimer's disease |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2136059T5 (en) * | 1989-02-13 | 2005-02-16 | Geneco Pty. Ltd. | DETECTION OF A SEQUENCE OF NUCLEIC ACIDS OR A CHANGE IN THE SAME. |
US5296349A (en) * | 1990-06-14 | 1994-03-22 | Emory University | Molecular genetic test for myoclonic epilepsy |
US5494794A (en) * | 1992-10-20 | 1996-02-27 | Emory University | Detection of mitochondrial DNA mutations associated with Alzheimer's disease and Parkinson's disease |
US5506101A (en) * | 1993-06-30 | 1996-04-09 | Cedars-Sinai Medical Center | Method for detection of susceptibility mutations for ototoxic deafness |
AU5296496A (en) * | 1995-03-24 | 1996-10-16 | Mitokor | Mutation detection by differential primer extension of mutant and wildtype target sequences |
-
1996
- 1996-11-27 US US08/757,438 patent/US6027883A/en not_active Expired - Fee Related
-
1997
- 1997-11-26 WO PCT/US1997/021274 patent/WO1998023632A1/en not_active Application Discontinuation
- 1997-11-26 EP EP97951451A patent/EP0888378A4/en not_active Withdrawn
- 1997-11-26 JP JP10524745A patent/JP2001500020A/en active Pending
- 1997-11-26 CA CA002244101A patent/CA2244101A1/en not_active Abandoned
- 1997-11-26 AU AU55091/98A patent/AU715293B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5192659A (en) * | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
US5185244A (en) * | 1989-12-08 | 1993-02-09 | Emory University | Genetic test for hereditary neuromuscular disease |
US5565323A (en) * | 1994-03-30 | 1996-10-15 | Mitokor | Cytochrome oxidase mutations aiding diagnosis of sporadic alzheimer's disease |
Non-Patent Citations (6)
Title |
---|
ANNALS OF NEUROLOGY, 1989, Vol. 26, PARKER et al., "Abnormalities of the Electron Transport Chain in Idiopathic Parkinson's Disease", pages 719-723. * |
EPILEPSIA, 1994, Vol. 35, WALLACE et al., "Mitochondrial DNA Mutations in Epilepsy and Neurological Disease", pages S43-S50. * |
JOURNAL OF INFECTIOUS DISEASES, December 1991, Vol. 164, GINGERAS et al., "Use of Self-Sustained Sequence Replication Amplification Reaction to Analyze and Detect Mutations in Zidovudine-Resistant Human Immunodeficiency Virus", pages 1066-1074. * |
NEUROLOGY, August 1990, Vol. 40, PARKER et al., "Cytochrome Oxidase Deficiency in Alzheimer's Disease", pages 1302-1303. * |
PROC. NATL. ACAD. SCI. U.S.A., November 1990, Vol. 87, NICKERSON et al., "Automated DNA Diagnostics Using an ELISA-Based Oligonucleotide Ligation Assay", pages 8923-8927. * |
See also references of EP0888378A4 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000061819A2 (en) * | 1999-04-14 | 2000-10-19 | California Institute Of Technology | Methods of detection and modulation of age-related mutations |
WO2000061819A3 (en) * | 1999-04-14 | 2002-02-21 | California Inst Of Techn | Methods of detection and modulation of age-related mutations |
US6462190B1 (en) | 1999-04-14 | 2002-10-08 | California Institute Of Technology | Polynucleotides and kits for detection of an age-related mutation |
WO2000063441A2 (en) * | 1999-04-20 | 2000-10-26 | Mitokor | Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease |
WO2000063441A3 (en) * | 1999-04-20 | 2002-03-14 | Mitokor | Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease |
WO2005056573A1 (en) * | 2002-06-10 | 2005-06-23 | 1304854 Ontario Ltd. | Complete mitochondrial genome sequences as a diagnostic tool for the health sciences |
EP1812793A2 (en) * | 2004-11-15 | 2007-08-01 | Quantomix Ltd. | Device and method for analysis of a metabolic malady |
EP1812793A4 (en) * | 2004-11-15 | 2008-04-16 | Quantomix Ltd | Device and method for analysis of a metabolic malady |
US8008008B2 (en) | 2005-04-18 | 2011-08-30 | Mitomics Inc. | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
US9745632B2 (en) | 2005-04-18 | 2017-08-29 | Mdna Life Sciences Inc. | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
US10308987B2 (en) | 2005-04-18 | 2019-06-04 | Mdna Life Sciences Inc. | 3.4 kb mitochondrial DNA deletion for use in the detection of cancer |
US10907213B2 (en) | 2005-04-18 | 2021-02-02 | Mdna Life Sciences Inc. | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
US11111546B2 (en) | 2005-04-18 | 2021-09-07 | Mdna Life Sciences, Inc. | 3.4 KB mitochondrial DNA deletion for use in the detection of cancer |
Also Published As
Publication number | Publication date |
---|---|
EP0888378A1 (en) | 1999-01-07 |
EP0888378A4 (en) | 2000-06-07 |
US6027883A (en) | 2000-02-22 |
JP2001500020A (en) | 2001-01-09 |
CA2244101A1 (en) | 1998-06-04 |
AU5509198A (en) | 1998-06-22 |
AU715293B2 (en) | 2000-01-20 |
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