WO1998022141A3 - Effets renforces pour therapeutique associee a l'haptene - Google Patents
Effets renforces pour therapeutique associee a l'haptene Download PDFInfo
- Publication number
- WO1998022141A3 WO1998022141A3 PCT/US1997/018475 US9718475W WO9822141A3 WO 1998022141 A3 WO1998022141 A3 WO 1998022141A3 US 9718475 W US9718475 W US 9718475W WO 9822141 A3 WO9822141 A3 WO 9822141A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- enhanced effects
- hapten conjugated
- conjugate
- half life
- vivo half
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97949336A EP1027073A2 (fr) | 1996-11-19 | 1997-11-06 | Effets renforces pour therapeutique associee a l'haptene |
AU72983/98A AU7298398A (en) | 1996-11-19 | 1997-11-06 | Enhanced effects for hapten conjugated therapeutics |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75267196A | 1996-11-19 | 1996-11-19 | |
US08/752,671 | 1996-11-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998022141A2 WO1998022141A2 (fr) | 1998-05-28 |
WO1998022141A3 true WO1998022141A3 (fr) | 1999-01-07 |
Family
ID=25027301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/018475 WO1998022141A2 (fr) | 1996-11-19 | 1997-11-06 | Effets renforces pour therapeutique associee a l'haptene |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1027073A2 (fr) |
AU (1) | AU7298398A (fr) |
WO (1) | WO1998022141A2 (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000022112A1 (fr) | 1998-10-13 | 2000-04-20 | The University Of Georgia Research Foundation, Inc. | Peptides bioactifs stabilises, procedes d'identification, synthese et utilisation |
US20030190740A1 (en) | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
WO2001032207A1 (fr) * | 1998-10-30 | 2001-05-10 | United States Army Medical Research And Materiel Command | Procede permettant d'appliquer une immunotherapie active/passive |
JP2003518075A (ja) * | 1999-12-24 | 2003-06-03 | ジェネンテック・インコーポレーテッド | 生理活性化合物の消失半減期延長のための方法及び組成物 |
EP1757311B1 (fr) * | 1999-12-24 | 2009-02-11 | Genentech, Inc. | Méthodes et compositions pour la prolongation de la demi-période d'élimination de composés bioactifs |
CN100560131C (zh) | 2001-10-22 | 2009-11-18 | 斯克里普斯研究学院 | 抗体靶向化合物 |
EP1888640B1 (fr) | 2005-05-18 | 2012-03-14 | Ablynx N.V. | Nanocorps ameliores utilises contre le facteur-alpha de necrose tumorale |
WO2008074840A2 (fr) | 2006-12-19 | 2008-06-26 | Ablynx N.V. | Séquences d'acides aminés dirigées contre une métalloprotéinase de la famille adam et polypeptides les comprenant à des fins de traitement de maladies et troubles liés à adam |
EP2557090A3 (fr) | 2006-12-19 | 2013-05-29 | Ablynx N.V. | Séquences d'acides aminés dirigées contre les GPCR et polypeptides les comprenant pour le traitement de maladies et de troubles liés au GPCR |
WO2009124931A2 (fr) | 2008-04-07 | 2009-10-15 | Ablynx Nv | Séquences d'acides aminés dirigées contre les voies notch et leurs utilisations |
CA2731617A1 (fr) | 2008-07-22 | 2010-01-28 | Maria Joao Saraiva | Sequences d'acides amines dirigees contre des recepteurs de desactiveurs multicibles et polypeptides |
US8748581B2 (en) | 2009-04-10 | 2014-06-10 | Ablynx N.V. | Anti-IL-6R polypeptides and pharmaceutical compositions thereof |
SG176095A1 (en) | 2009-06-05 | 2011-12-29 | Ablynx Nv | Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections |
EP2507262A1 (fr) | 2009-11-30 | 2012-10-10 | Ablynx N.V. | Séquences d'acides aminés améliorées dirigées contre le virus syncytial respiratoire humain (hrsv) et polypeptides comprenant celles-ci pour la prévention et/ou le traitement d'infections du tractus respiratoire |
EP2513145B1 (fr) | 2009-12-14 | 2018-01-24 | Ablynx N.V. | Domaines variables uniques de liaison anti-ox40l, construits et application therapeutique |
WO2011083140A1 (fr) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Domaines variables simples d'immunoglobuline dirigés contre le cxcr4 doués d'une meilleure activité thérapeutique et produits de recombinaison les comprenant |
US9120855B2 (en) | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
EP3546483A1 (fr) | 2010-05-20 | 2019-10-02 | Ablynx N.V. | Matériaux biologiques associés à her3 |
EP2638068B1 (fr) | 2010-11-08 | 2018-12-26 | Novartis AG | Polypeptides se liant aux récepteurs de cxcr2 |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
JP2014525736A (ja) | 2011-06-23 | 2014-10-02 | アブリンクス エン.ヴェー. | IgEに対する免疫グロブリン単一可変ドメイン |
US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
WO2014087010A1 (fr) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | Polypeptides améliorés dirigés contre ige |
NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
WO2018014260A1 (fr) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Protéines de liaison antigènes multi-spécifiques et leurs procédés d'utilisation |
WO2018068201A1 (fr) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Anticorps à domaine unique et ses variants contre ctla-4 |
CA3043515A1 (fr) | 2016-11-16 | 2018-05-24 | Ablynx Nv | Polypeptides de recrutement de lymphocytes t capables de se lier a cd123 et tcr alpha/beta |
EP3630818A1 (fr) | 2017-06-02 | 2020-04-08 | Ablynx NV | Immunoglobulines liant l'aggrécane |
CA3082280A1 (fr) | 2017-12-28 | 2019-07-04 | Nanjing Legend Biotech Co., Ltd. | Anticorps a domaine unique et leurs variants diriges contre tigit |
EP3740507A4 (fr) | 2018-01-15 | 2022-08-24 | Nanjing Legend Biotech Co., Ltd. | Anticorps à domaine unique et des variants de celui-ci dirigés contre pd-1 |
WO2019185040A1 (fr) | 2018-03-30 | 2019-10-03 | Nanjing Legend Biotech Co., Ltd. | Anticorps à domaine unique contre lag-3 et leurs utilisations |
IL305301A (en) | 2021-02-19 | 2023-10-01 | Us Health | Single domain antibodies neutralizing SARS CoV-2 |
WO2024083843A1 (fr) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Séquences d'acides aminés dirigées contre le récepteur de la mélanocortine 4 et polypeptides les comprenant pour le traitement de maladies et de troubles liés à mc4r |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993017699A1 (fr) * | 1992-03-02 | 1993-09-16 | The Board Of Trustees Of The Leland Stanford Junior University | Regulation de l'activite de lymphocytes a l'aide de peptides hla |
DE4238416A1 (de) * | 1992-11-13 | 1994-05-19 | Max Planck Gesellschaft | Bestimmung von Peptidmotiven auf MHC-Molekülen |
WO1995034321A1 (fr) * | 1994-06-16 | 1995-12-21 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation immunitaire a l'aide de fragments de chaine alpha de classe ii |
WO1996035443A1 (fr) * | 1995-05-12 | 1996-11-14 | Sangstat Medical Corporation | Traitement destine a inhiber la progression de maladies auto-immunes |
WO1997024140A1 (fr) * | 1996-01-02 | 1997-07-10 | The Board Of Trustees Of Leland Stanford Junior University | Interaction de proteines hla avec des membres de la famille hsp70 de proteines |
WO1997037690A2 (fr) * | 1996-04-10 | 1997-10-16 | Sangstat Medical Corporation | Conjugues cytomodulants d'elements de paires de liaison specifiques |
-
1997
- 1997-11-06 AU AU72983/98A patent/AU7298398A/en not_active Abandoned
- 1997-11-06 EP EP97949336A patent/EP1027073A2/fr not_active Withdrawn
- 1997-11-06 WO PCT/US1997/018475 patent/WO1998022141A2/fr not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993017699A1 (fr) * | 1992-03-02 | 1993-09-16 | The Board Of Trustees Of The Leland Stanford Junior University | Regulation de l'activite de lymphocytes a l'aide de peptides hla |
DE4238416A1 (de) * | 1992-11-13 | 1994-05-19 | Max Planck Gesellschaft | Bestimmung von Peptidmotiven auf MHC-Molekülen |
WO1995034321A1 (fr) * | 1994-06-16 | 1995-12-21 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation immunitaire a l'aide de fragments de chaine alpha de classe ii |
WO1996035443A1 (fr) * | 1995-05-12 | 1996-11-14 | Sangstat Medical Corporation | Traitement destine a inhiber la progression de maladies auto-immunes |
WO1997024140A1 (fr) * | 1996-01-02 | 1997-07-10 | The Board Of Trustees Of Leland Stanford Junior University | Interaction de proteines hla avec des membres de la famille hsp70 de proteines |
WO1997037690A2 (fr) * | 1996-04-10 | 1997-10-16 | Sangstat Medical Corporation | Conjugues cytomodulants d'elements de paires de liaison specifiques |
Non-Patent Citations (2)
Title |
---|
BUELOW R ET AL: "PROLONGATION OF SKIN ALLOGRAFT SURVIVAL IN MICE FOLLOWING ADMINISTRATION OF ALLOTRAP", TRANSPLANTATION, vol. 59, no. 4, 27 February 1995 (1995-02-27), pages 455 - 460, XP000652975 * |
LUSSOW A R ET AL: "REDIRECTING CIRCULATING ANTIBODIES VIA LIGAND-HAPTEN CONJUGATES ELIMINATES TARGET CELLS IN VIVO", JOURNAL OF IMMUNOTHERAPY: WITH EMPHASIS ON TUMOR IMMUNOLOGY, vol. 19, no. 4, July 1996 (1996-07-01), pages 257 - 265, XP002050531 * |
Also Published As
Publication number | Publication date |
---|---|
AU7298398A (en) | 1998-06-10 |
WO1998022141A2 (fr) | 1998-05-28 |
EP1027073A2 (fr) | 2000-08-16 |
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