WO1998021341B1 - Method for the recombinant production of 1,3-propanediol - Google Patents
Method for the recombinant production of 1,3-propanediolInfo
- Publication number
- WO1998021341B1 WO1998021341B1 PCT/US1997/020873 US9720873W WO9821341B1 WO 1998021341 B1 WO1998021341 B1 WO 1998021341B1 US 9720873 W US9720873 W US 9720873W WO 9821341 B1 WO9821341 B1 WO 9821341B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein
- nucleic acid
- acid encoding
- microorganism
- seq
- Prior art date
Links
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-Propanediol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 title claims abstract 22
- 229920000166 polytrimethylene carbonate Polymers 0.000 title claims abstract 11
- 108090000623 proteins and genes Proteins 0.000 claims abstract 24
- 102000004169 proteins and genes Human genes 0.000 claims abstract 24
- 101710044921 A1G_03605 Proteins 0.000 claims abstract 16
- 101710016786 P/C Proteins 0.000 claims abstract 16
- 101700068398 PABT Proteins 0.000 claims abstract 16
- 101710045114 PX Proteins 0.000 claims abstract 16
- 101700028070 VPX Proteins 0.000 claims abstract 16
- 101700085341 YTSF Proteins 0.000 claims abstract 16
- 108010065027 Propanediol Dehydratase Proteins 0.000 claims abstract 7
- 108010025885 glycerol dehydratase Proteins 0.000 claims abstract 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 6
- 229910052799 carbon Inorganic materials 0.000 claims abstract 6
- 244000005700 microbiome Species 0.000 claims 29
- 108020004707 nucleic acids Proteins 0.000 claims 24
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 229940035437 1,3-propanediol Drugs 0.000 claims 8
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 6
- 241000193403 Clostridium Species 0.000 claims 6
- 241000235648 Pichia Species 0.000 claims 6
- 241000607142 Salmonella Species 0.000 claims 6
- 206010039447 Salmonellosis Diseases 0.000 claims 6
- 241000228212 Aspergillus Species 0.000 claims 3
- 241000193830 Bacillus <bacterium> Species 0.000 claims 3
- 241000588923 Citrobacter Species 0.000 claims 3
- 241000235035 Debaryomyces Species 0.000 claims 3
- 241000588914 Enterobacter Species 0.000 claims 3
- 241000588722 Escherichia Species 0.000 claims 3
- 241000235649 Kluyveromyces Species 0.000 claims 3
- 241000186660 Lactobacillus Species 0.000 claims 3
- 229940039696 Lactobacillus Drugs 0.000 claims 3
- 241000589350 Methylobacter Species 0.000 claims 3
- 241000235395 Mucor Species 0.000 claims 3
- 241000589516 Pseudomonas Species 0.000 claims 3
- 241000235070 Saccharomyces Species 0.000 claims 3
- 241000235346 Schizosaccharomyces Species 0.000 claims 3
- 241000187747 Streptomyces Species 0.000 claims 3
- 241000235017 Zygosaccharomyces Species 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 230000036499 Half live Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 abstract 1
Abstract
The present invention provides an improved method for the production of 1,3-propanediol from a variety of carbon sources is an organism comprising DNA encoding protein X of a dehydratase or protein X in combination with at least one of protein 1, protein 2 and protein 3. The protein X may be isolated from a diol dehydratase or a glycerol dehydratase. The present invention also provides host cells comprising protein X that are capable of increased production of 1,3-propanediol.
Claims
1. An improved method for the production of 1 ,3-propanediol from a microorganism comprising the steps of: a) obtaining a recombinant microorganism capable of producing 1 ,3- propanediol, said microorganism comprising at least one nucleic acid encoding a dehydratase activity and a nucleic acid encoding protein X; and b) culturing the recombinant microorganism in the presence of at least one carbon source capable of being converted to 1 ,3 propanediol in said transformed microorganism and under conditions suitable for the production of 1 ,3 propanediol wherein the carbon source is selected from the group consisting of monosaccharides, oligosaccharides, polysaccharides, and a one carbon substrate.
2. The method of Claim 1 wherein said recombinant microorganism comprises at least one nucleic acid encoding a protein selected from the group consisting of protein 1 , protein 2 and protein 3.
3. The method of Claim 1 further comprising the step of recovering the 1 ,3 propanediol.
4. The method of Claim 1 wherein the nucleic acid encoding protein X is isolated from a glycerol dehydratase gene cluster.
5. The method of Claim 1 wherein the nucleic acid encoding protein X is isolated from a diol dehydratase gene cluster.
6. The method of Claim 4 wherein the glycerol dehydratase gene cluster is from an organism selected from the genera consisting of Kiebsiella and Citrobactor.
7. The method of Claim 5 wherein the diol dehydratase gene cluster is from an organism selected from the genera consisting of Kiebsiella, Clostridium and Salmonella.
8. The method of Claim 1 wherein the nucleic acid encoding a dehydratase activity is heterologous to the organism.
9. The method of Claim 1 wherein the nucleic acid encoding a dehydratase activity is homologous to the organism. ΓÇö 106 ΓÇö
10. The method of Claim 1 wherein the recombinant microorganism is selected from the group of genera consisting of Citrobacter, Enterobacter, Clostridium, Kiebsiella, Aerobacter, Lactobacillus, Aspergillus, Saccharomyces, Schizosaccharomyces, Zygo saccharomyces, Pichia, Kluyveromyces, Candida, Hansenula, Debaryomyces, Mucor, Torulopsis, Methylobacter, Escherichia, Salmonella, Bacillus, Streptomyces and Pseudomonas.
11. The method of Claim 10 wherein the microorganism is selected from the group consisting of E.coli and Kiebsiella spp.
12. The method of Claim 1 wherein the nucleic acid encoding protein X is stably maintained in the host genome.
13. The method of Claim 2 wherein at least one nucleic acid encoding a protein selected from protein 1 , protein 2 and protein 3 is stably maintained in the host genome.
14. The method of Claim 1 wherein the carbon source is glucose.
15. The method of Claim 1 wherein the nucleic acid encoding protein X has the sequence as shown in SEQ ID NO: 59.
16. The method of Claim 2 wherein protein 1 has the sequence as shown in SEQ ID NO: 60 or SEQ ID NO: 61.
17. The method of Claim 2 wherein protein 2 has the sequence as shown in SEQ ID NO: 62 or SEQ ID NO: 63.
18. The method of Claim 2 wherein protein 3 has the sequence as shown in SEQ ID NO:64 or SEQ ID NO: 65.
19. A recombinant microorganism capable of producing 1 ,3-propanediol from a carbon source said recombinant microorganism comprising a) at least one nucleic acid encoding a dehydratase activity; b) at least one nucleic acid encoding a glycerol-3-phosphatase; and c) at least one nucleic acid encoding protein X.
20. The recombinant microorganism of Claim 19 further comprising d) at least one nucleic acid encoding a protein selected from the group consisting of protein 1 , protein 2 and protein 3. ΓÇö 107 ΓÇö
21. The recombinant microorganism of Claim 19 selected from the group consisting of Citrobacter, Enterobacter, Clostridium, Kiebsiella, Aerobacter, Lactobacillus, Aspergillus, Saccharomyces, Schizosaccharomyces, Zygosaccharomyces, Pichia, Kluyveromyces, Candida, Hansenula, Debaryomyces, Mucor, Torulopsis, Methylobacter, Escherichia, Salmonella, Bacillus, Streptomyces and Pseudomonas.
22. The recombinant microorganism of Claim 19 wherein the nucleic acid encoding protein X is isolated from a glycerol dehydratase gene cluster.
23. The recombinant microorganism of Claim 19 wherein the nucleic acid encoding protein X is isolated from a diol dehydratase gene cluster.
24. The recombinant microorganism of Claim 22 wherein the glycerol dehydratase gene cluster is from an organism selected from the genera consisting of Kiebsiella and Citrobactor.
25. The recombinant microorganism of Claim 23 wherein the diol dehydratase gene cluster is from an organism selected from the genera consisting of Kiebsiella, Clostridium and Salmonella.
26. The recombinant microorganism of Claim 19 wherein said dehydratase activity is heterologous to said microorganism.
27. The recombinant microorganism of Claim 19 wherein said dehydratase activity is homologous to said microorganism.
28. The recombinant microorganism of Claim 19 wherein the nucleic acid encoding protein X has the sequence as shown in SEQ ID NO: 59.
29. The recombinant microorganism of Claim 20 wherein protein 1 has the sequence as shown in SEQ ID NO: 60 or SEQ ID NO: 61.
30. The recombinant microorganism of Claim 20 wherein protein 2 has the sequence as shown in SEQ ID NO: 62 or SEQ ID NO: 63. ΓÇö 108 ΓÇö
31. The recombinant of Claim 20 wherein protein 3 has the sequence as shown in SEQ ID: 64 or SEQ ID NO: 65.
32. A method for extending the half-life of dehydratase activity in a transformed microorganism capable of producing 1 ,3-propanediol and containing at least one nucleic acid encoding a dehydratase activity, comprising the step of introducing a nucleic acid encoding protein X into said microorganism and culturing under conditions suitable for production of 1 ,3- propanediol.
33. The method of Claim 32 wherein the nucleic acid encoding the dehydratase activity is heterologous to said microorganism.
34. The method of Claim 32 wherein the nucleic acid encoding the dehydratase activity is homologous to said microorganism.
35. The method of Claim 32 wherein the nucleic acid encoding protein X is isolated from a glycerol dehydratase gene cluster.
36. The method of Claim 32 wherein the nucleic acid encoding protein X is isolated from a diol dehydratase gene cluster.
37. The method of Claim 35 wherein the glycerol dehydratase gene cluster is from an organism selected from the genera consisting of Kiebsiella and Citrobactor.
38. The method of Claim 34 wherein the diol dehydratase gene cluster is from an organism selected from the genera consisting of Kiebsiella, Clostridium and Salmonella.
39. The method of Claim 32 wherein the microorganism is selected from the group consisting of Citrobacter, Enterobacter, Clostridium, Kiebsiella, Aerobacter, Lactobacillus, Aspergillus, Saccharomyces, Schizosaccharomyces, Zygosaccharomyces, Pichia, Kluyveromyces, Candida, Hansenula, Debaryomyces, Mucor, Torulopsis, Methylobacter, Escherichia, Salmonella, Bacillus, Streptomyces and Pseudomonas.
40. The method of Claim 32 further comprising the step of introducing at least one nucleic acid encoding protein 1 , protein 2 or protein 3 into said microorganism.
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI9714313-8A BR9714313B1 (en) | 1996-11-13 | 1997-11-13 | METHOD FOR THE PRODUCTION OF 1,3-PROPANODIOL RECOMBINANTS |
| NZ335392A NZ335392A (en) | 1996-11-13 | 1997-11-13 | Method for the recombinant production of 1,3-propanediol |
| AU55076/98A AU735080B2 (en) | 1996-11-13 | 1997-11-13 | Method for the recombinant production of 1,3-propanediol |
| DE69736070T DE69736070T2 (en) | 1996-11-13 | 1997-11-13 | Recombinant method of preparation of 1,3-propanediol |
| JP52287098A JP2001503636A (en) | 1996-11-13 | 1997-11-13 | Method for recombinant production of 1,3-propanediol |
| DK97951433T DK0946732T3 (en) | 1996-11-13 | 1997-11-13 | Process for the Recombinant Preparation of 1,3-Propanediol |
| US09/308,207 US6953684B2 (en) | 1996-11-13 | 1997-11-13 | Method for the recombinant production of 1,3-propanediol |
| CA002270906A CA2270906A1 (en) | 1996-11-13 | 1997-11-13 | Method for the recombinant production of 1,3-propanediol |
| EP97951433A EP0946732B1 (en) | 1996-11-13 | 1997-11-13 | Method for the recombinant production of 1,3-propanediol |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3060196P | 1996-11-13 | 1996-11-13 | |
| US60/030,601 | 1996-11-13 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1998021341A2 WO1998021341A2 (en) | 1998-05-22 |
| WO1998021341A3 WO1998021341A3 (en) | 1998-06-25 |
| WO1998021341B1 true WO1998021341B1 (en) | 1998-07-30 |
Family
ID=21854996
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/020292 WO1998021339A1 (en) | 1996-11-13 | 1997-11-10 | Method for the production of 1,3-propanediol by recombinant organisms |
| PCT/US1997/020873 WO1998021341A2 (en) | 1996-11-13 | 1997-11-13 | Method for the recombinant production of 1,3-propanediol |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/020292 WO1998021339A1 (en) | 1996-11-13 | 1997-11-10 | Method for the production of 1,3-propanediol by recombinant organisms |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6013494A (en) |
| EP (2) | EP0942989B1 (en) |
| JP (2) | JP4327909B2 (en) |
| KR (1) | KR100509310B1 (en) |
| CN (2) | CN1236063C (en) |
| AT (2) | ATE452979T1 (en) |
| AU (2) | AU733534B2 (en) |
| BR (2) | BR9712761B1 (en) |
| CA (2) | CA2269088C (en) |
| DE (2) | DE69739715D1 (en) |
| DK (1) | DK0946732T3 (en) |
| ES (1) | ES2336858T3 (en) |
| ID (1) | ID21487A (en) |
| IL (2) | IL129722A0 (en) |
| MY (1) | MY131754A (en) |
| NZ (1) | NZ335392A (en) |
| WO (2) | WO1998021339A1 (en) |
| ZA (1) | ZA9710194B (en) |
Families Citing this family (168)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| ID21487A (en) * | 1996-11-13 | 1999-06-17 | Du Pont | METHOD OF MAKING 1,3 - PROPANDIOL WITH RECOMBINANT ORGANISM |
| CA2625060A1 (en) | 1996-11-13 | 1998-05-22 | E.I. Du Pont De Nemours And Company | Method for the production of glycerol by recombinant organisms |
| CA2311601C (en) | 1997-12-02 | 2008-07-08 | E.I. Du Pont De Nemours And Company | Method for the production of glycerol by recombinant organisms |
| GB9806762D0 (en) * | 1998-03-31 | 1998-05-27 | Neutec Pharma Plc | Treatment and diagnosis of staphylococcal infections |
| US7074608B1 (en) | 1998-05-12 | 2006-07-11 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for coenzyme B12 synthesis |
| US6432686B1 (en) | 1998-05-12 | 2002-08-13 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport |
| DE69938105T2 (en) | 1998-08-04 | 2009-01-29 | Metabolix, Inc., Cambridge | PREPARATION OF POLYHYDROXYALKANOATES FROM POLYOLES |
| US6468773B1 (en) * | 1999-05-19 | 2002-10-22 | Genencor International, Inc. | Mutant 1,3-propandiol dehydrogenase |
| FR2796081B1 (en) | 1999-07-09 | 2003-09-26 | Agronomique Inst Nat Rech | PROCESS FOR THE PREPARATION OF 1,3-PROPANEDIOL BY A MICROORGANISM RECOMBINANT IN THE ABSENCE OF COENZYME B12 OR ONE OF ITS PRECURSORS |
| EP1586647A1 (en) * | 1999-08-18 | 2005-10-19 | E.I. du Pont de Nemours and Company | Process for the biological production of 1,3-propanediol with high titer |
| JP4716634B2 (en) * | 1999-08-18 | 2011-07-06 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | Biological production of 1,3-propanediol with high titer |
| DE60030403D1 (en) * | 1999-08-30 | 2006-10-12 | Wisconsin Alumni Res Found | Preparation of 3-Hydroxypropionic Acid in Recombinant Organisms |
| US6803218B1 (en) | 1999-09-24 | 2004-10-12 | Genencor Intl., Inc. | Enzymes which dehydrate glycerol |
| FR2800751B1 (en) | 1999-11-09 | 2003-08-29 | Roquette Freres | PROCESS FOR THE PRODUCTION OF 1.3 PROPANEDIOL BY FERMENTATION |
| FR2801058B1 (en) | 1999-11-16 | 2002-01-18 | Roquette Freres | PROCESS FOR THE PURIFICATION OF 1,3-PROPANEDIOL FROM A FERMENTATION MEDIUM |
| US6617478B2 (en) | 2000-11-29 | 2003-09-09 | Samsung Electronics Co., Ltd. | Process for preparing a 1,3-alkandiol from 3-hydroxyester |
| EP1211234A3 (en) | 2000-11-29 | 2003-11-26 | Samsung Electronics Co., Ltd. | Process for preparing 1,3-alkandiols from 3-hydroxyesters |
| ATE432338T1 (en) * | 2002-01-18 | 2009-06-15 | Novozymes As | ALANINE 2,3-AMINOMUTASE |
| JP2005523020A (en) | 2002-04-22 | 2005-08-04 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | Promoter and plasmid systems for genetic engineering |
| BR0311449A (en) * | 2002-05-08 | 2005-03-15 | Basf Plant Science Gmbh | A process for increasing the total oil content in a plant organism or a tissue, organ, part, cell, or propagating material, transgenic expression cassette, transgenic vector, transgenic plant organism, or tissue, organ, part, cell, or material. propagation, and use of them |
| ATE527344T1 (en) | 2002-08-16 | 2011-10-15 | Danisco Us Inc | NEW VARIANTS OF CELLULASE CBH1 FROM HYPOCREA JECORINA |
| MXPA05003382A (en) | 2002-10-04 | 2005-06-22 | Du Pont | Process for the biological production of 1,3-propanediol with high yield. |
| AU2003277276A1 (en) | 2002-10-04 | 2004-05-04 | Genencor International, Inc. | Improved production of bacterial strains cross reference to related applications |
| AU2003287625A1 (en) | 2002-11-06 | 2004-06-03 | University Of Florida | Materials and methods for the efficient production of acetate and other products |
| CN102031265A (en) | 2002-12-16 | 2011-04-27 | 纳幕尔杜邦公司 | B-12 dependent dehydratases with improved reaction kinetics |
| US20040234649A1 (en) * | 2003-03-10 | 2004-11-25 | Broin And Associates, Inc. | Method for producing ethanol using raw starch |
| US20050233030A1 (en) | 2004-03-10 | 2005-10-20 | Broin And Associates, Inc. | Methods and systems for producing ethanol using raw starch and fractionation |
| US7767788B2 (en) * | 2003-03-21 | 2010-08-03 | The Research Foundation Of State University Of New York | Folding protein functioning as a molecular switch |
| US7459299B2 (en) | 2003-04-01 | 2008-12-02 | Danisco A/S, Genencor Division | Variant Humicola grisea CBH1.1 |
| US7056439B2 (en) * | 2003-05-06 | 2006-06-06 | Tate & Lyle Ingredidents Americas, Inc. | Process for producing 1, 3-propanediol |
| BRPI0410685B8 (en) * | 2003-05-06 | 2017-05-30 | Du Pont | 1,3-propanediol purification processes and composition |
| CN102174490B (en) | 2003-11-21 | 2016-09-28 | 丹尼斯科美国公司 | Granular starch hydrolyzing enzymes expression in trichoderma and the method from granular starch substrates generation glucose |
| US20050239181A1 (en) * | 2004-03-10 | 2005-10-27 | Broin And Associates, Inc. | Continuous process for producing ethanol using raw starch |
| EP1731604A4 (en) * | 2004-03-26 | 2007-04-04 | Nippon Catalytic Chem Ind | Process for producing 1,3-propanediol and/or 3-hydroxypropionic acid |
| EP2292749A3 (en) * | 2004-07-30 | 2011-12-21 | Novozymes A/S | Alanine 2, 3 aminomutases |
| CN101094917B (en) | 2004-12-30 | 2012-04-25 | 金克克国际有限公司 | Variant hypocrea jecorina cbh2 cellulases |
| EP1869197A2 (en) * | 2005-04-12 | 2007-12-26 | E.I. Dupont De Nemours And Company | Treatment of biomass to obtain ethanol |
| US7781191B2 (en) * | 2005-04-12 | 2010-08-24 | E. I. Du Pont De Nemours And Company | Treatment of biomass to obtain a target chemical |
| US20070029252A1 (en) * | 2005-04-12 | 2007-02-08 | Dunson James B Jr | System and process for biomass treatment |
| WO2006119386A2 (en) * | 2005-05-02 | 2006-11-09 | Broin And Associates, Inc. | Methods and systems for producing ethanol using raw starch and fractionation |
| US7524660B2 (en) | 2005-05-05 | 2009-04-28 | E.I. Du Pont De Nemours And Company | Utilization of fructose in microbial production strains |
| CN1327001C (en) * | 2005-06-03 | 2007-07-18 | 清华大学 | Method for producing 1,3-propylene glycol through using glycerin of by-product from biologic diesel oil |
| WO2006138437A2 (en) * | 2005-06-16 | 2006-12-28 | Wabash Technologies, Inc. | Pedal assembly having a hysteresis mechanism |
| CN100427605C (en) * | 2005-06-17 | 2008-10-22 | 清华大学 | Mehtod for producing 1,3-propanediol and 2,3-cis-butanediol from crude starch material |
| US7919289B2 (en) | 2005-10-10 | 2011-04-05 | Poet Research, Inc. | Methods and systems for producing ethanol using raw starch and selecting plant material |
| DE102005048818A1 (en) | 2005-10-10 | 2007-04-12 | Degussa Ag | Microbiological production of 3-hydroxypropionic acid |
| EP1948814B1 (en) | 2005-10-26 | 2018-11-21 | Butamax (TM) Advanced Biofuels LLC | Fermentive production of four carbon alcohols |
| US8273558B2 (en) | 2005-10-26 | 2012-09-25 | Butamax(Tm) Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US9303225B2 (en) | 2005-10-26 | 2016-04-05 | Butamax Advanced Biofuels Llc | Method for the production of isobutanol by recombinant yeast |
| CN100392071C (en) * | 2005-12-05 | 2008-06-04 | 中国农业大学 | Engineered bacterium lacking lactic acid production path and its construction method and uses |
| CN100463968C (en) * | 2006-01-27 | 2009-02-25 | 华侨大学 | Process for preparing 1,3-propylene glycol and dihydroxy acetone by bio-catalytic conversion of glycerol |
| CN101379184B (en) * | 2006-02-06 | 2011-12-14 | 帝斯曼知识产权资产管理有限公司 | Novel oxidoreductases and uses thereof |
| US20070202062A1 (en) * | 2006-02-10 | 2007-08-30 | Workman Tanya L | Natural deodorant compositions comprising renewably-based, biodegradable 1,3-propanediol |
| US20070275139A1 (en) * | 2006-02-10 | 2007-11-29 | Melissa Joerger | Food compositions comprising renewably-based, biodegradable1,3-propanediol |
| CN1935991B (en) * | 2006-06-21 | 2010-05-12 | 南宁中诺生物工程有限责任公司 | Clostridium perfringen glycerol dehydrase gene, and its 1,3-propylene glycol producing method |
| JP5130811B2 (en) * | 2006-07-19 | 2013-01-30 | 東レ株式会社 | Process for producing 1,3-propanediol by continuous fermentation |
| DE102006039203B4 (en) | 2006-08-22 | 2014-06-18 | Evonik Degussa Gmbh | Process for the preparation of crystallization-purified acrylic acid from hydroxypropionic acid and apparatus therefor |
| CA2665448A1 (en) * | 2006-10-31 | 2008-05-08 | Metabolic Explorer | Process for the biological production of 1,3-propanediol from glycerol with high yield |
| WO2008052596A1 (en) * | 2006-10-31 | 2008-05-08 | Metabolic Explorer | Process for the biological production of n-butanol with high yield |
| WO2008061187A1 (en) * | 2006-11-15 | 2008-05-22 | Dupont Tate & Lyle Bio Products Company, Llc | Preservative compositions comprising renewably-based, biodegradable 1,3-propanediol |
| DE102007015583A1 (en) | 2007-03-29 | 2008-10-02 | Albert-Ludwigs-Universität Freiburg | An enzyme for the production of methylmalonyl-coenzyme A or ethylmalonyl-coenzyme A and its use |
| CN101130782B (en) * | 2007-07-23 | 2011-01-26 | 江南大学 | Construction method for producing 1,3-trimethylene glycol regrouping saccharomyces cerevisiae with glucose as substrate |
| US7819976B2 (en) * | 2007-08-22 | 2010-10-26 | E. I. Du Pont De Nemours And Company | Biomass treatment method |
| US7807419B2 (en) * | 2007-08-22 | 2010-10-05 | E. I. Du Pont De Nemours And Company | Process for concentrated biomass saccharification |
| US20090053800A1 (en) * | 2007-08-22 | 2009-02-26 | Julie Friend | Biomass Treatment Apparatus |
| US8445236B2 (en) * | 2007-08-22 | 2013-05-21 | Alliance For Sustainable Energy Llc | Biomass pretreatment |
| DE102007041862A1 (en) | 2007-09-03 | 2009-03-19 | Evonik Degussa Gmbh | Microbiological production of isoprenoids |
| AU2008300548B2 (en) | 2007-09-21 | 2015-04-09 | Basf Plant Science Gmbh | Plants with increased yield |
| CN101205541B (en) * | 2007-10-18 | 2010-12-08 | 北京化工大学 | Recombinant expression carrier and method for high-yield of 1,3-propanediol by fermenting glycerin using host cell converted thereby |
| US8048624B1 (en) | 2007-12-04 | 2011-11-01 | Opx Biotechnologies, Inc. | Compositions and methods for 3-hydroxypropionate bio-production from biomass |
| MX2010006679A (en) | 2007-12-17 | 2010-11-30 | Univ Amsterdam | Light-driven co2 reduction to organic compounds to serve as fuels or as industrial half products by an autotroph containing a fermentative gene cassette. |
| DE102007060705A1 (en) | 2007-12-17 | 2009-06-18 | Evonik Degussa Gmbh | ω-aminocarboxylic acids or their lactams, producing, recombinant cells |
| EP2628795A1 (en) | 2008-06-06 | 2013-08-21 | Danisco US Inc. | Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials |
| DE102008002715A1 (en) | 2008-06-27 | 2009-12-31 | Evonik Röhm Gmbh | 2-hydroxyisobutyric acid producing recombinant cell |
| DE102008041299A1 (en) | 2008-08-18 | 2010-02-25 | Evonik Degussa Gmbh | Novel, universally applicable addiction system |
| WO2010031083A2 (en) * | 2008-09-15 | 2010-03-18 | Opx Biotechnologies, Inc. | Methods, systems and compositions related to reduction of conversions of microbially produced 3-hydroxypropionic acid (3-hp) to aldehyde metabolites |
| US8409839B2 (en) | 2008-12-10 | 2013-04-02 | Direvo Industrial Biotechnology Gmbh | Polypeptides having cellobiohydrolase II activity |
| WO2010080489A1 (en) * | 2008-12-19 | 2010-07-15 | E. I. Du Pont De Nemours And Company | Ozone treatment of biomass to enhance enzymatic saccharification |
| US8450094B1 (en) | 2009-03-03 | 2013-05-28 | Poet Research, Inc. | System for management of yeast to facilitate the production of ethanol |
| US9068206B1 (en) | 2009-03-03 | 2015-06-30 | Poet Research, Inc. | System for treatment of biomass to facilitate the production of ethanol |
| US8815552B2 (en) | 2009-03-03 | 2014-08-26 | Poet Research, Inc. | System for fermentation of biomass for the production of ethanol |
| US20100233771A1 (en) * | 2009-03-03 | 2010-09-16 | Mcdonald William F | System for pre-treatment of biomass for the production of ethanol |
| MX2011012841A (en) | 2009-06-03 | 2012-01-27 | Danisco Inc | Cellulase variants with improved expression, activity and/or stability, and use thereof. |
| US8809027B1 (en) | 2009-09-27 | 2014-08-19 | Opx Biotechnologies, Inc. | Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase |
| CN102695799A (en) | 2009-09-27 | 2012-09-26 | Opx生物工艺学公司 | Method for producing 3-hydroxypropionic acid and other products |
| US8852903B2 (en) | 2009-10-23 | 2014-10-07 | E I Du Pont De Nemours And Company | Co-metabolism of fructose and glucose in microbial production strains |
| DE102009046623A1 (en) | 2009-11-11 | 2011-05-12 | Evonik Röhm Gmbh | Use of a protein homologous to a MeaB protein to increase the enzymatic activity of a 3-hydroxycarboxylic acid CoA mutase |
| DE102010014680A1 (en) | 2009-11-18 | 2011-08-18 | Evonik Degussa GmbH, 45128 | Cells, nucleic acids, enzymes and their use, as well as methods for producing sophorolipids |
| WO2011063363A2 (en) * | 2009-11-20 | 2011-05-26 | Opx Biotechnologies, Inc. | Production of an organic acid and/or related chemicals |
| US20110136190A1 (en) * | 2009-12-04 | 2011-06-09 | E. I. Du Pont De Nemours And Company | Recombinant bacteria for producing glycerol and glycerol-derived products from sucrose |
| US8034592B2 (en) * | 2009-12-10 | 2011-10-11 | The Curators Of The University Of Missouri | Fossil fuel-free process of lignocellulosic pretreatment with biological hydrogen production |
| MX2012009142A (en) | 2010-02-11 | 2012-11-30 | Metabolix Inc | Process for gamma-butyrolactone production. |
| KR101144235B1 (en) * | 2010-02-25 | 2012-05-10 | 한국과학기술연구원 | Method for producing butanol using bioethanol waste fermented solution |
| CN103003414A (en) * | 2010-04-19 | 2013-03-27 | 札幌啤酒株式会社 | Novel microorganism, and hydrogen production process, 1,3-propanediol production process and biodiesel liquid waste treatment method each using the microorganism |
| US8906235B2 (en) | 2010-04-28 | 2014-12-09 | E I Du Pont De Nemours And Company | Process for liquid/solid separation of lignocellulosic biomass hydrolysate fermentation broth |
| US8721794B2 (en) | 2010-04-28 | 2014-05-13 | E I Du Pont De Nemours And Company | Production of high solids syrup from lignocellulosic biomass hydrolysate fermentation broth |
| KR101220499B1 (en) * | 2010-05-25 | 2013-01-10 | 한국생명공학연구원 | Method for Preparing 3-Hydroxypropionic Acid from Glycerol with High Yield |
| EP3235907B1 (en) | 2010-07-12 | 2023-06-21 | Inbiose N.V. | Metabolically engineered organisms for the production of added value bio-products |
| DE102010032484A1 (en) | 2010-07-28 | 2012-02-02 | Evonik Goldschmidt Gmbh | Cells and methods for producing rhamnolipids |
| WO2012031166A2 (en) * | 2010-09-01 | 2012-03-08 | Eric Knight | Expression of steady state metabolic pathways |
| US8129170B1 (en) | 2010-12-06 | 2012-03-06 | E.I. Du Pont De Nemours And Company | Recombinant bacteria having the ability to metabolize sucrose |
| CN103649321B (en) * | 2011-04-05 | 2019-07-16 | 拉勒曼德匈牙利流动性管理有限责任公司 | For the method by product yield and yield in addition alternately electron acceptor improvement microorganism |
| CA2830978C (en) | 2011-04-13 | 2016-01-05 | Elc Management Llc | Conditioning agents for personal care compositions |
| WO2012142169A2 (en) | 2011-04-13 | 2012-10-18 | Elc Management Llc | Mild anionic surfactants suitable for personal care compositions |
| FR2976949B1 (en) | 2011-06-21 | 2015-08-28 | Sanofi Sa | PROCESS FOR PREPARING GENETICALLY TRANSFORMED YEAS CAPABLE OF PRODUCING A HIGH TITLE MOLECULE OF INTEREST |
| US8829206B2 (en) | 2011-06-24 | 2014-09-09 | Eastman Chemical Company | Production of cyclic acetals or ketals using solid acid catalysts |
| US9388105B2 (en) | 2011-06-24 | 2016-07-12 | Eastman Chemical Company | Production of hydroxy ether hydrocarbons by liquid phase hydrogenolysis of cyclic acetals or cyclic ketals |
| US9056313B2 (en) | 2011-06-24 | 2015-06-16 | Eastman Chemical Company | Catalysts for the production of hydroxy ether hydrocarbons by vapor phase hydrogenolysis of cyclic acetals and ketals |
| US9000229B2 (en) | 2011-06-24 | 2015-04-07 | Eastman Chemical Company | Production of hydroxy ether hydrocarbons by vapor phase hydrogenolysis of cyclic acetals and ketals |
| US8969598B2 (en) | 2011-06-24 | 2015-03-03 | Eastman Chemical Company | Production of cyclic acetals or ketals using liquid-phase acid catalysts |
| US8829207B2 (en) | 2011-06-24 | 2014-09-09 | Eastman Chemical Company | Production of cyclic acetals by reactive distillation |
| US8785697B2 (en) | 2011-06-24 | 2014-07-22 | Eastman Chemical Company | Nickel modified catalyst for the production of hydroxy ether hydrocarbons by vapor phase hydrogenolysis of cyclic acetals and ketals |
| EP2540834A1 (en) | 2011-06-29 | 2013-01-02 | Metabolic Explorer | Method for the preparation of 1,3-propanediol |
| JP2013013353A (en) * | 2011-07-01 | 2013-01-24 | Daicel Corp | Method for producing 1,3-propanediol |
| JP2013070675A (en) * | 2011-09-28 | 2013-04-22 | Daicel Corp | Method for culturing recombinant bacterium producing alkyl diol |
| DE102012201360A1 (en) | 2012-01-31 | 2013-08-01 | Evonik Industries Ag | New cell capable of forming rhamnolipid compound, which is useful for the production of cosmetic, dermatological or pharmaceutical formulations, of plant protection formulations and of care and cleaning agents and surfactant concentrates |
| US8686114B2 (en) | 2012-03-05 | 2014-04-01 | E I Du Pont De Nemours And Company | Variant sucrose transporter polypeptides |
| US9017961B2 (en) | 2012-03-05 | 2015-04-28 | E.I. Du Pont De Nemours And Company | Recombinant bacteria comprising novel sucrose transporters |
| CN102634543A (en) * | 2012-05-04 | 2012-08-15 | 杭玉玲 | Method for producing 1,3-propylene glycol by using microbial fermentation |
| BR112014030203B1 (en) | 2012-06-08 | 2021-10-13 | Cj Cheiljedang Corporation | PROCESS FOR THE PRODUCTION OF BIO-BASED ACRYLIC ACID PRODUCTS |
| CN104718282A (en) | 2012-08-10 | 2015-06-17 | Opx生物工艺学公司 | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| KR101437040B1 (en) * | 2012-08-17 | 2014-09-02 | 삼성전자 주식회사 | METHOD OF PRODUCITON FOR 1,3-PROPANDIOL BY ADDING osmoprotective substance AND MEDIUM FOR PRODUCITON OF 1,3-PROPANDIOL |
| CA2882276C (en) * | 2012-08-28 | 2016-11-01 | Lanzatech New Zealand Limited | Recombinant microorganisms expressing a stereospecific diol dehydratase enzyme |
| CA2892786A1 (en) | 2012-12-12 | 2014-06-19 | Danisco Us Inc. | Variants of cellobiohydrolases |
| US20140178954A1 (en) | 2012-12-20 | 2014-06-26 | E I Du Pont De Nemours And Company | Expression of xylose isomerase activity in yeast |
| WO2014127053A2 (en) | 2013-02-13 | 2014-08-21 | Metabolix, Inc. | Process for ultra pure chemical production from biobased raw starting materials |
| US8669076B1 (en) | 2013-03-11 | 2014-03-11 | E I Du Pont De Nemours And Company | Cow rumen xylose isomerases active in yeast cells |
| US9187743B2 (en) | 2013-03-11 | 2015-11-17 | E I Du Pont De Nemours And Company | Bacterial xylose isomerases active in yeast cells |
| US20140273105A1 (en) | 2013-03-12 | 2014-09-18 | E I Du Pont De Nemours And Company | Gradient pretreatment of lignocellulosic biomass |
| HUE045200T2 (en) * | 2013-03-14 | 2019-12-30 | Du Pont | Glycerol 3- phosphate dehydrogenase for butanol production |
| US10584860B2 (en) * | 2013-03-14 | 2020-03-10 | Ideal Industries, Llc | Linear light fixture with interchangeable light engine unit |
| WO2014160262A1 (en) | 2013-03-14 | 2014-10-02 | Abengoa Bioenergy New Technologies, Llc | Methods for converting cellulosic waste to bioproducts |
| US10047383B2 (en) | 2013-03-15 | 2018-08-14 | Cargill, Incorporated | Bioproduction of chemicals |
| CA2905602A1 (en) | 2013-03-15 | 2014-09-18 | Sarah M. Hoyt | Flash evaporation for product purification and recovery |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| EP3022310B1 (en) | 2013-07-19 | 2019-10-16 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| WO2015034948A1 (en) | 2013-09-03 | 2015-03-12 | Myriant Corporation | A process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol |
| CN105531373A (en) * | 2013-09-06 | 2016-04-27 | 密苏里州立大学校董 | Conversion of glycerol to 1,3-propanediol under haloalkaline conditions |
| US20150147786A1 (en) | 2013-11-24 | 2015-05-28 | E I Du Pont De Nemours And Company | High force and high stress destructuring for starch biomass processing |
| KR101532736B1 (en) | 2014-02-24 | 2015-07-09 | 한국생명공학연구원 | Methods for Peparing 1,3-Propanediol Using Variant of Microorganism Deleted 2,3-Butanediol Synthesis Gene |
| FR3015186A1 (en) * | 2014-03-11 | 2015-06-26 | Antoine Piccirilli | USE OF A COMPOSITION COMPRISING 1,3-PROPANEDIOL AS E-LIQUID |
| EP2949214A1 (en) | 2014-05-26 | 2015-12-02 | Evonik Degussa GmbH | Methods of producing rhamnolipids |
| WO2016007350A1 (en) | 2014-07-09 | 2016-01-14 | Danisco Us Inc. | Preconditioning of lignocellulosic biomass |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| EP3056561A1 (en) | 2015-02-16 | 2016-08-17 | Evonik Degussa GmbH | Microorganisms with reduced enzyme activity |
| CN107208123A (en) | 2015-02-19 | 2017-09-26 | 赢创德固赛有限公司 | Rhamnolipid is synthesized |
| JP6748635B2 (en) * | 2015-04-20 | 2020-09-02 | パイクリスタル株式会社 | Active matrix array device manufacturing method and active matrix array device manufactured thereby |
| CN104774879B (en) * | 2015-04-29 | 2017-10-20 | 大连理工大学 | A kind of method of the propane diols of mixed fungus fermentation glycerol production 1,3 |
| BR112018001855A2 (en) | 2015-07-29 | 2018-09-25 | Abengoa Bioenergia Nuevas Tecnologias Sa | expression of recombinant beta-xylosidase enzymes |
| US9968531B2 (en) | 2015-08-05 | 2018-05-15 | Dupont Tate & Lyle Bio Products Company, Llc | Deodorants containing 1,3-propanediol |
| EP3192866A1 (en) | 2016-01-15 | 2017-07-19 | CIC nanoGUNE - Asociación Centro de Investigación Cooperativa en Nanociencias | Endocellulases and uses thereof |
| BR112018070645A2 (en) | 2016-04-08 | 2019-02-05 | Du Pont | recombinant yeast cells, methods for producing a yeast cell and method for producing a target compound |
| EP3529258A1 (en) | 2016-10-24 | 2019-08-28 | Evonik Degussa GmbH | Cells and method for producing rhamnolipids using alternative glucose transporters |
| EP3529259A1 (en) | 2016-10-24 | 2019-08-28 | Evonik Degussa GmbH | Rhamnolipid-producing cell having reduced glucose dehydrogenase activity |
| CN110494566A (en) | 2017-02-02 | 2019-11-22 | 嘉吉公司 | Generate the genetically modified cell of C6-C10 derivative of fatty acid |
| EP3502126A1 (en) | 2017-12-19 | 2019-06-26 | CIC nanoGUNE - Asociación Centro de Investigación Cooperativa en Nanociencias | Ancestral cellulases and uses thereof |
| KR102103408B1 (en) * | 2018-01-16 | 2020-04-23 | 한국과학기술원 | Variant Microorganism Producing 1,3-propanediol and Method for Preparing 1,3-propanediol Using thereof |
| WO2019152755A1 (en) * | 2018-02-01 | 2019-08-08 | Invista North America S.A.R.L. | Methods and materials for the biosynthesis of beta hydroxy acids and/or derivatives thereof and/or compounds related thereto |
| WO2019154984A1 (en) | 2018-02-09 | 2019-08-15 | Evonik Degussa Gmbh | Lipid production |
| CN111386345B (en) * | 2018-10-30 | 2023-05-16 | 绿色地球研究所株式会社 | Process for producing 1,3-propanediol |
| CN109337852B (en) * | 2018-11-12 | 2020-09-04 | 江南大学 | Application of recombinant Klebsiella in production of 1, 3-propylene glycol |
| CN109370969B (en) * | 2018-11-12 | 2020-09-04 | 江南大学 | Application of recombinant Klebsiella in preparation of 1, 3-propylene glycol |
| CN109750011B (en) * | 2019-02-20 | 2022-05-10 | 中国科学院天津工业生物技术研究所 | Mannose-6-phosphate phosphatase and biological preparation method of mannose |
| CN112625994B (en) * | 2021-01-05 | 2022-04-15 | 清华大学 | Recombinant vibrio natriegens and application thereof |
| CN114806981B (en) * | 2021-01-18 | 2023-05-23 | 中国科学院上海高等研究院 | Application of Klebsiella engineering bacteria in production of 1, 3-propanediol |
| CN114107145B (en) * | 2021-11-04 | 2024-05-07 | 清华大学 | Recombinant microorganism and application thereof in production of 1, 3-propanediol |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3634764A1 (en) | 1986-10-11 | 1988-04-14 | Mueller Haidmann Roland Dipl I | Covering composed of panels |
| DE3734764A1 (en) * | 1987-10-14 | 1989-05-03 | Huels Chemische Werke Ag | Process for the preparation of 1,3-propanediol |
| DE3878564T2 (en) * | 1988-12-12 | 1993-08-19 | Unilever Nv | METHOD FOR THE MICROBIOLOGICAL PRODUCTION OF 1,3-PROPANDIOL FROM GLYCERIN. |
| US5686276A (en) * | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| US5633362A (en) | 1995-05-12 | 1997-05-27 | E. I. Du Pont De Nemours And Company | Production of 1,3-propanediol from glycerol by recombinant bacteria expressing recombinant diol dehydratase |
| US5599689A (en) * | 1995-05-12 | 1997-02-04 | E. I. Du Pont De Nemours And Company | Process for making 1,3-propanediol from carbohydrates using mixed microbial cultures |
| ID21487A (en) * | 1996-11-13 | 1999-06-17 | Du Pont | METHOD OF MAKING 1,3 - PROPANDIOL WITH RECOMBINANT ORGANISM |
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