WO1998019555A1 - Fat with specific antisclerosis effects - Google Patents

Fat with specific antisclerosis effects Download PDF

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Publication number
WO1998019555A1
WO1998019555A1 PCT/CZ1997/000038 CZ9700038W WO9819555A1 WO 1998019555 A1 WO1998019555 A1 WO 1998019555A1 CZ 9700038 W CZ9700038 W CZ 9700038W WO 9819555 A1 WO9819555 A1 WO 9819555A1
Authority
WO
WIPO (PCT)
Prior art keywords
units
weight
fat
cholesterol
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CZ1997/000038
Other languages
English (en)
French (fr)
Inventor
Jir^¿í S^¿IMEK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MILO OLOMOUC AS
Original Assignee
MILO OLOMOUC AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MILO OLOMOUC AS filed Critical MILO OLOMOUC AS
Priority to EA199800624A priority Critical patent/EA199800624A1/ru
Priority to EE9800212A priority patent/EE9800212A/xx
Priority to EP97909116A priority patent/EP0918466A1/en
Priority to SK930-98A priority patent/SK93098A3/sk
Priority to PL97327668A priority patent/PL327668A1/xx
Publication of WO1998019555A1 publication Critical patent/WO1998019555A1/en
Priority to LVP-98-156A priority patent/LV12174B/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D7/00Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A23D7/0056Spread compositions
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D7/00Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/015Reducing calorie content; Reducing fat content, e.g. "halvarines"
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00Other edible oils or fats, e.g. shortenings or cooking oils
    • A23D9/007Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides

Definitions

  • This invention relates to fat with specific antisclerosis effects, especially to consumed fat, margarine, halvarine or vegetable butter, containing on partly at least 25 percent basic fat phase, which consists of oil and/or hardened vegetable oil and possibly an additional animal fat, and partly containing the additives which decreases cholesterol level and/or reduces the development of cholesterol in the blood.
  • hyperhpoproteinemie One of the basic factors affecting the incidence of diseases involving atherosclerosis is hyperhpoproteinemie. It has been recently found that up to 90 percent of population is showing signs of cholesterol increase in the blood, especially LDL cholesterol.
  • chemotherapeutic treatment using hypolipidemics that then directly affects the area of synthesis of cholesterol or LDL cholesterol during metabolic proceses.
  • the said chemotherapeutics are applied according to the medical prescription combined or not with other supporting substances such as vitamins e.g. vitamin A, vitamin B,E.
  • the shortcomming of the said application of hypolipidemics is, that they are used after the high level of cholesterol has already caused health problems. In addition it is necessary to these substances in relatively high doses and under dostor's supervision.
  • the purpose of the invention is to prevent hypercholesterolemy by spreading the above said hypolipidemics widely among the population so as to avoid their consequential medical prescription.
  • This purpose solved the subject-matter of the invention, which is a fat with specific antisclerosis effects, especially to consumed fat, margarine, halvarine or vegetable butter, containing partly at least 25 percent basic fat phase, which consists of oil and/or hardened vegetable oil and possibly an additional animal fat, partly the additive which decreases cholesterol level and/or reduces the development of cholesterol in the blood.
  • the nature of this invention is, that the additive which decreases cholesterol level and/or reduces the development of cholesterol in the blood is created by hypolipidemics from a group of essential phosphoUpides and/or vitamin PP, alternative by its derivates and/or by statins.
  • fat mixture of 1.000 units of weight contains 250 to 995 units of weight of fat phase, up to 4,5 units of weight of hypolipidemics and up to 12,5 units of weight of additives, with the reminder being completed of water.
  • fat mixture of 1.000 units of weight contains 250 to 995 units of weight of fat phase, 0,5 to 20 units weight of essential phosphoUpides, up to 5 units of weight of other vitamins, up to 40 units of weight of emulgators and up to 5,9 units of weight of other additives, with the reminder being completed of water, or that fat mixture of 1.000 units of weight contains 250 to 995 units of weight of fat phase, 0,5 to 20 units of weight of vitamin PP or its derivates, up to 5 units of weight of other vitamins, up to 40 units of weight of emulgators, up to 40 units of weight of gelatine and/or modified starches and/or pectines, up to 17 units of weight of other additives, with the reminder being completed of water, or finaly that fat mixture of 1.000 units of weight contains 250 to 995 units of weight of fat phase, 0,1 to 5 units of weight of statins, up to 5 units of weight of other vitamins, up to 5 units of weight of flavourings, up to 40 units of weight of
  • the advantage of the appUed substances from a group of hypoUpidemics according to the invention is, that its defined substances form organic part in the consumed fats, margarines, halvarines or vegetable butters and are through the mediation of them appUed in a small and at the same time unharmful or supportive quantitives consumed in common fats and foods in the course of the day, that contain such fats.
  • Another considerable advantage of the fats consisted according to the invention is, that they mosty forms water/fat or fat/water emulsion, which are not commonly used for high tempetature preparing of other foods and therefore they are not exposed to such temperature changes, that could deteriorate additives.
  • the basic fat component according to the invention mentioned in the following examples is formed by liquid and/or hardened vegetable oU such as rapessed oil, sunflower oil, soybean oil, palm oil or palmolein, or its combinations and alternati- velly with other vegetable oils, that are made of products of vegetable origin by analogic technical processing by pressing and/or extracting. It is possible to add a little animal fat, formed mainly of milk fat, liquid or hardened fat or tallow, to said mixture. Optionally, those components, or sam of them, could be replaced by analogic animal fats without effects to the invention.
  • liquid and/or hardened vegetable oU such as rapessed oil, sunflower oil, soybean oil, palm oil or palmolein, or its combinations and alternati- velly with other vegetable oils, that are made of products of vegetable origin by analogic technical processing by pressing and/or extracting. It is possible to add a little animal fat, formed mainly of milk fat, liquid or hardened fat or tallow, to said mixture. Optionally, those components, or
  • the basic fat phase applied in the foUowing examples is illustrated in the following types:
  • the examplatory types of structure of fat phases are indicated by letters A to D, that correspond with the mixture mentioned above to simplify the following examples.
  • the basic fat phase be enriched by the fat and/or by water soluble form of particular hypoUpidemics according to the invention, or its combination.
  • Example 1 Fat of which 1000 g contains
  • Example 2 Fat of which 1000 g contains
  • Example 3 Fat of which 1000 g contains
  • Example 4 Fat of which 1000 g contains
  • Example 6 Fat of which 1000 g contains 400 g of fat phase type B 10 g of essential phosphoUpides 10 g of emulgators 10 g of salt 0,5 g of kalium sorbate 0,5 g of vitamin E 0,1 g of vitamin A 568,9 g of water
  • Example 7 Fat of which 1000 g contains 995 g of fat phase type D 5 g of vitamin PP and/or its derivates
  • Example 8 Fat of which 1000 g contains
  • Example 9 Fat of which 1000 g contains
  • Example 10 Fat of which 1000 g contains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Edible Oils And Fats (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
PCT/CZ1997/000038 1996-11-07 1997-10-30 Fat with specific antisclerosis effects Ceased WO1998019555A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EA199800624A EA199800624A1 (ru) 1996-11-07 1997-10-30 Жир со специфическим противосклеротическим воздействием
EE9800212A EE9800212A (et) 1996-11-07 1997-10-30 Spetsiifilise antisklerootilise toimega rasvaine
EP97909116A EP0918466A1 (en) 1996-11-07 1997-10-30 Fat with specific antisclerosis effects
SK930-98A SK93098A3 (en) 1996-11-07 1997-10-30 Fat with specific antisclerosis effects
PL97327668A PL327668A1 (en) 1996-11-07 1997-10-30 Fat having specific antisclerotic effect
LVP-98-156A LV12174B (en) 1996-11-07 1998-07-27 FATS WITH SPECIFIC ANTI-CELLULOTIC EFFECTS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ963268A CZ326896A3 (cs) 1996-11-07 1996-11-07 Tuk se specifickými protisklerotickými účinky
CZPV3268-96 1996-11-07

Publications (1)

Publication Number Publication Date
WO1998019555A1 true WO1998019555A1 (en) 1998-05-14

Family

ID=5466435

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ1997/000038 Ceased WO1998019555A1 (en) 1996-11-07 1997-10-30 Fat with specific antisclerosis effects

Country Status (10)

Country Link
EP (1) EP0918466A1 (cs)
CZ (1) CZ326896A3 (cs)
EA (1) EA199800624A1 (cs)
EE (1) EE9800212A (cs)
HU (1) HUP0001100A3 (cs)
LT (1) LT4528B (cs)
LV (1) LV12174B (cs)
PL (1) PL327668A1 (cs)
SK (1) SK93098A3 (cs)
WO (1) WO1998019555A1 (cs)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT4734B (lt) 2000-01-21 2000-11-27 Alfridas Putramentas Aliejų kompozicija
WO2002064809A3 (en) * 2001-02-09 2003-04-24 Unilever Nv Process for the preparation of one or more statins by fermentation
WO2005104864A1 (en) * 2004-04-28 2005-11-10 Unilever N.V. Edible oil containing statins
WO2006021293A1 (en) * 2004-08-23 2006-03-02 Unilever N.V. Composition comprising statin

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2133508A1 (en) * 1971-04-15 1972-12-01 Inst Biochimie 4-thiazolidinecarboxylic acid derivs - with in vivo thiol liberating activity
DE2607654A1 (de) * 1975-03-05 1976-09-16 Hoffmann La Roche Vitaminierungsverfahren
FR2466459A1 (fr) * 1979-10-05 1981-04-10 Fabre Sa Pierre Esters phenoxy isobutyriques d'hydroxy nicotinamides et leurs sels, leur procede de preparation et leur application en therapeutique
RO81579A2 (ro) * 1981-01-20 1983-04-29 Intreprinderea De Medicamente "Biofarm",Ro Granule cu efect hepatoprotector hipocolesterolemiant si reconfortantgeneral
EP0148303A1 (de) * 1984-01-11 1985-07-17 von Mletzko, Armin, Dr. Diätetikum
FR2704556A1 (fr) * 1993-04-30 1994-11-04 Rhone Poulenc Rorer Sa Virus recombinants et leur utilisation en thérapie génique.
WO1996034855A1 (en) * 1995-05-01 1996-11-07 Scotia Holdings Plc Fatty acid esters as bioactive compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL166991B1 (pl) 1991-05-03 1995-07-31 Raision Margariini Oy Sposób wytwarzania substancji obnizajacej poziom cholesterolu w surowicy krwi PL PL PL

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2133508A1 (en) * 1971-04-15 1972-12-01 Inst Biochimie 4-thiazolidinecarboxylic acid derivs - with in vivo thiol liberating activity
DE2607654A1 (de) * 1975-03-05 1976-09-16 Hoffmann La Roche Vitaminierungsverfahren
FR2466459A1 (fr) * 1979-10-05 1981-04-10 Fabre Sa Pierre Esters phenoxy isobutyriques d'hydroxy nicotinamides et leurs sels, leur procede de preparation et leur application en therapeutique
RO81579A2 (ro) * 1981-01-20 1983-04-29 Intreprinderea De Medicamente "Biofarm",Ro Granule cu efect hepatoprotector hipocolesterolemiant si reconfortantgeneral
EP0148303A1 (de) * 1984-01-11 1985-07-17 von Mletzko, Armin, Dr. Diätetikum
FR2704556A1 (fr) * 1993-04-30 1994-11-04 Rhone Poulenc Rorer Sa Virus recombinants et leur utilisation en thérapie génique.
WO1996034855A1 (en) * 1995-05-01 1996-11-07 Scotia Holdings Plc Fatty acid esters as bioactive compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8350, Derwent World Patents Index; Class A96, AN 83-842468, XP002056772 *
H. GYLLING ET AL.: "Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men", JOURNAL OF LIPID RESEARCH, vol. 37, no. 8, 1996, pages 1776 - 1785, XP002056770 *
L. ROZEWICKA ET AL.: "Effect of essential phospholipids on the lipid content in the liver and myocardium of rats fed a high-fat diet", FOLIA BIOLOGICA, vol. 26, no. 4, 1978, KRAKOW, POLAND, pages 249 - 255, XP002056771 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT4734B (lt) 2000-01-21 2000-11-27 Alfridas Putramentas Aliejų kompozicija
WO2002064809A3 (en) * 2001-02-09 2003-04-24 Unilever Nv Process for the preparation of one or more statins by fermentation
WO2005104864A1 (en) * 2004-04-28 2005-11-10 Unilever N.V. Edible oil containing statins
WO2006021293A1 (en) * 2004-08-23 2006-03-02 Unilever N.V. Composition comprising statin

Also Published As

Publication number Publication date
SK93098A3 (en) 1999-01-11
EP0918466A1 (en) 1999-06-02
HUP0001100A2 (hu) 2000-08-28
EE9800212A (et) 1998-12-15
LT98096A (en) 1999-02-25
LV12174A (lv) 1998-12-20
CZ326896A3 (cs) 1998-05-13
LT4528B (lt) 1999-07-26
EA199800624A1 (ru) 1998-12-24
PL327668A1 (en) 1998-12-21
HUP0001100A3 (en) 2001-02-28
LV12174B (en) 1999-05-20

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