WO1998019555A1 - Fat with specific antisclerosis effects - Google Patents
Fat with specific antisclerosis effects Download PDFInfo
- Publication number
- WO1998019555A1 WO1998019555A1 PCT/CZ1997/000038 CZ9700038W WO9819555A1 WO 1998019555 A1 WO1998019555 A1 WO 1998019555A1 CZ 9700038 W CZ9700038 W CZ 9700038W WO 9819555 A1 WO9819555 A1 WO 9819555A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- units
- weight
- fat
- cholesterol
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
- A23D7/0056—Spread compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/015—Reducing calorie content; Reducing fat content, e.g. "halvarines"
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
Definitions
- This invention relates to fat with specific antisclerosis effects, especially to consumed fat, margarine, halvarine or vegetable butter, containing on partly at least 25 percent basic fat phase, which consists of oil and/or hardened vegetable oil and possibly an additional animal fat, and partly containing the additives which decreases cholesterol level and/or reduces the development of cholesterol in the blood.
- hyperhpoproteinemie One of the basic factors affecting the incidence of diseases involving atherosclerosis is hyperhpoproteinemie. It has been recently found that up to 90 percent of population is showing signs of cholesterol increase in the blood, especially LDL cholesterol.
- chemotherapeutic treatment using hypolipidemics that then directly affects the area of synthesis of cholesterol or LDL cholesterol during metabolic proceses.
- the said chemotherapeutics are applied according to the medical prescription combined or not with other supporting substances such as vitamins e.g. vitamin A, vitamin B,E.
- the shortcomming of the said application of hypolipidemics is, that they are used after the high level of cholesterol has already caused health problems. In addition it is necessary to these substances in relatively high doses and under dostor's supervision.
- the purpose of the invention is to prevent hypercholesterolemy by spreading the above said hypolipidemics widely among the population so as to avoid their consequential medical prescription.
- This purpose solved the subject-matter of the invention, which is a fat with specific antisclerosis effects, especially to consumed fat, margarine, halvarine or vegetable butter, containing partly at least 25 percent basic fat phase, which consists of oil and/or hardened vegetable oil and possibly an additional animal fat, partly the additive which decreases cholesterol level and/or reduces the development of cholesterol in the blood.
- the nature of this invention is, that the additive which decreases cholesterol level and/or reduces the development of cholesterol in the blood is created by hypolipidemics from a group of essential phosphoUpides and/or vitamin PP, alternative by its derivates and/or by statins.
- fat mixture of 1.000 units of weight contains 250 to 995 units of weight of fat phase, up to 4,5 units of weight of hypolipidemics and up to 12,5 units of weight of additives, with the reminder being completed of water.
- fat mixture of 1.000 units of weight contains 250 to 995 units of weight of fat phase, 0,5 to 20 units weight of essential phosphoUpides, up to 5 units of weight of other vitamins, up to 40 units of weight of emulgators and up to 5,9 units of weight of other additives, with the reminder being completed of water, or that fat mixture of 1.000 units of weight contains 250 to 995 units of weight of fat phase, 0,5 to 20 units of weight of vitamin PP or its derivates, up to 5 units of weight of other vitamins, up to 40 units of weight of emulgators, up to 40 units of weight of gelatine and/or modified starches and/or pectines, up to 17 units of weight of other additives, with the reminder being completed of water, or finaly that fat mixture of 1.000 units of weight contains 250 to 995 units of weight of fat phase, 0,1 to 5 units of weight of statins, up to 5 units of weight of other vitamins, up to 5 units of weight of flavourings, up to 40 units of weight of
- the advantage of the appUed substances from a group of hypoUpidemics according to the invention is, that its defined substances form organic part in the consumed fats, margarines, halvarines or vegetable butters and are through the mediation of them appUed in a small and at the same time unharmful or supportive quantitives consumed in common fats and foods in the course of the day, that contain such fats.
- Another considerable advantage of the fats consisted according to the invention is, that they mosty forms water/fat or fat/water emulsion, which are not commonly used for high tempetature preparing of other foods and therefore they are not exposed to such temperature changes, that could deteriorate additives.
- the basic fat component according to the invention mentioned in the following examples is formed by liquid and/or hardened vegetable oU such as rapessed oil, sunflower oil, soybean oil, palm oil or palmolein, or its combinations and alternati- velly with other vegetable oils, that are made of products of vegetable origin by analogic technical processing by pressing and/or extracting. It is possible to add a little animal fat, formed mainly of milk fat, liquid or hardened fat or tallow, to said mixture. Optionally, those components, or sam of them, could be replaced by analogic animal fats without effects to the invention.
- liquid and/or hardened vegetable oU such as rapessed oil, sunflower oil, soybean oil, palm oil or palmolein, or its combinations and alternati- velly with other vegetable oils, that are made of products of vegetable origin by analogic technical processing by pressing and/or extracting. It is possible to add a little animal fat, formed mainly of milk fat, liquid or hardened fat or tallow, to said mixture. Optionally, those components, or
- the basic fat phase applied in the foUowing examples is illustrated in the following types:
- the examplatory types of structure of fat phases are indicated by letters A to D, that correspond with the mixture mentioned above to simplify the following examples.
- the basic fat phase be enriched by the fat and/or by water soluble form of particular hypoUpidemics according to the invention, or its combination.
- Example 1 Fat of which 1000 g contains
- Example 2 Fat of which 1000 g contains
- Example 3 Fat of which 1000 g contains
- Example 4 Fat of which 1000 g contains
- Example 6 Fat of which 1000 g contains 400 g of fat phase type B 10 g of essential phosphoUpides 10 g of emulgators 10 g of salt 0,5 g of kalium sorbate 0,5 g of vitamin E 0,1 g of vitamin A 568,9 g of water
- Example 7 Fat of which 1000 g contains 995 g of fat phase type D 5 g of vitamin PP and/or its derivates
- Example 8 Fat of which 1000 g contains
- Example 9 Fat of which 1000 g contains
- Example 10 Fat of which 1000 g contains
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Edible Oils And Fats (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EA199800624A EA199800624A1 (ru) | 1996-11-07 | 1997-10-30 | Жир со специфическим противосклеротическим воздействием |
| EE9800212A EE9800212A (et) | 1996-11-07 | 1997-10-30 | Spetsiifilise antisklerootilise toimega rasvaine |
| EP97909116A EP0918466A1 (en) | 1996-11-07 | 1997-10-30 | Fat with specific antisclerosis effects |
| SK930-98A SK93098A3 (en) | 1996-11-07 | 1997-10-30 | Fat with specific antisclerosis effects |
| PL97327668A PL327668A1 (en) | 1996-11-07 | 1997-10-30 | Fat having specific antisclerotic effect |
| LVP-98-156A LV12174B (en) | 1996-11-07 | 1998-07-27 | FATS WITH SPECIFIC ANTI-CELLULOTIC EFFECTS |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ963268A CZ326896A3 (cs) | 1996-11-07 | 1996-11-07 | Tuk se specifickými protisklerotickými účinky |
| CZPV3268-96 | 1996-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1998019555A1 true WO1998019555A1 (en) | 1998-05-14 |
Family
ID=5466435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CZ1997/000038 Ceased WO1998019555A1 (en) | 1996-11-07 | 1997-10-30 | Fat with specific antisclerosis effects |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0918466A1 (cs) |
| CZ (1) | CZ326896A3 (cs) |
| EA (1) | EA199800624A1 (cs) |
| EE (1) | EE9800212A (cs) |
| HU (1) | HUP0001100A3 (cs) |
| LT (1) | LT4528B (cs) |
| LV (1) | LV12174B (cs) |
| PL (1) | PL327668A1 (cs) |
| SK (1) | SK93098A3 (cs) |
| WO (1) | WO1998019555A1 (cs) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT4734B (lt) | 2000-01-21 | 2000-11-27 | Alfridas Putramentas | Aliejų kompozicija |
| WO2002064809A3 (en) * | 2001-02-09 | 2003-04-24 | Unilever Nv | Process for the preparation of one or more statins by fermentation |
| WO2005104864A1 (en) * | 2004-04-28 | 2005-11-10 | Unilever N.V. | Edible oil containing statins |
| WO2006021293A1 (en) * | 2004-08-23 | 2006-03-02 | Unilever N.V. | Composition comprising statin |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2133508A1 (en) * | 1971-04-15 | 1972-12-01 | Inst Biochimie | 4-thiazolidinecarboxylic acid derivs - with in vivo thiol liberating activity |
| DE2607654A1 (de) * | 1975-03-05 | 1976-09-16 | Hoffmann La Roche | Vitaminierungsverfahren |
| FR2466459A1 (fr) * | 1979-10-05 | 1981-04-10 | Fabre Sa Pierre | Esters phenoxy isobutyriques d'hydroxy nicotinamides et leurs sels, leur procede de preparation et leur application en therapeutique |
| RO81579A2 (ro) * | 1981-01-20 | 1983-04-29 | Intreprinderea De Medicamente "Biofarm",Ro | Granule cu efect hepatoprotector hipocolesterolemiant si reconfortantgeneral |
| EP0148303A1 (de) * | 1984-01-11 | 1985-07-17 | von Mletzko, Armin, Dr. | Diätetikum |
| FR2704556A1 (fr) * | 1993-04-30 | 1994-11-04 | Rhone Poulenc Rorer Sa | Virus recombinants et leur utilisation en thérapie génique. |
| WO1996034855A1 (en) * | 1995-05-01 | 1996-11-07 | Scotia Holdings Plc | Fatty acid esters as bioactive compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL166991B1 (pl) | 1991-05-03 | 1995-07-31 | Raision Margariini Oy | Sposób wytwarzania substancji obnizajacej poziom cholesterolu w surowicy krwi PL PL PL |
-
1996
- 1996-11-07 CZ CZ963268A patent/CZ326896A3/cs unknown
-
1997
- 1997-10-30 EP EP97909116A patent/EP0918466A1/en not_active Withdrawn
- 1997-10-30 SK SK930-98A patent/SK93098A3/sk unknown
- 1997-10-30 PL PL97327668A patent/PL327668A1/xx unknown
- 1997-10-30 EA EA199800624A patent/EA199800624A1/ru unknown
- 1997-10-30 WO PCT/CZ1997/000038 patent/WO1998019555A1/en not_active Ceased
- 1997-10-30 HU HU0001100A patent/HUP0001100A3/hu unknown
- 1997-10-30 EE EE9800212A patent/EE9800212A/xx unknown
-
1998
- 1998-07-23 LT LT98-096A patent/LT4528B/lt not_active IP Right Cessation
- 1998-07-27 LV LVP-98-156A patent/LV12174B/en unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2133508A1 (en) * | 1971-04-15 | 1972-12-01 | Inst Biochimie | 4-thiazolidinecarboxylic acid derivs - with in vivo thiol liberating activity |
| DE2607654A1 (de) * | 1975-03-05 | 1976-09-16 | Hoffmann La Roche | Vitaminierungsverfahren |
| FR2466459A1 (fr) * | 1979-10-05 | 1981-04-10 | Fabre Sa Pierre | Esters phenoxy isobutyriques d'hydroxy nicotinamides et leurs sels, leur procede de preparation et leur application en therapeutique |
| RO81579A2 (ro) * | 1981-01-20 | 1983-04-29 | Intreprinderea De Medicamente "Biofarm",Ro | Granule cu efect hepatoprotector hipocolesterolemiant si reconfortantgeneral |
| EP0148303A1 (de) * | 1984-01-11 | 1985-07-17 | von Mletzko, Armin, Dr. | Diätetikum |
| FR2704556A1 (fr) * | 1993-04-30 | 1994-11-04 | Rhone Poulenc Rorer Sa | Virus recombinants et leur utilisation en thérapie génique. |
| WO1996034855A1 (en) * | 1995-05-01 | 1996-11-07 | Scotia Holdings Plc | Fatty acid esters as bioactive compounds |
Non-Patent Citations (3)
| Title |
|---|
| DATABASE WPI Section Ch Week 8350, Derwent World Patents Index; Class A96, AN 83-842468, XP002056772 * |
| H. GYLLING ET AL.: "Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men", JOURNAL OF LIPID RESEARCH, vol. 37, no. 8, 1996, pages 1776 - 1785, XP002056770 * |
| L. ROZEWICKA ET AL.: "Effect of essential phospholipids on the lipid content in the liver and myocardium of rats fed a high-fat diet", FOLIA BIOLOGICA, vol. 26, no. 4, 1978, KRAKOW, POLAND, pages 249 - 255, XP002056771 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT4734B (lt) | 2000-01-21 | 2000-11-27 | Alfridas Putramentas | Aliejų kompozicija |
| WO2002064809A3 (en) * | 2001-02-09 | 2003-04-24 | Unilever Nv | Process for the preparation of one or more statins by fermentation |
| WO2005104864A1 (en) * | 2004-04-28 | 2005-11-10 | Unilever N.V. | Edible oil containing statins |
| WO2006021293A1 (en) * | 2004-08-23 | 2006-03-02 | Unilever N.V. | Composition comprising statin |
Also Published As
| Publication number | Publication date |
|---|---|
| SK93098A3 (en) | 1999-01-11 |
| EP0918466A1 (en) | 1999-06-02 |
| HUP0001100A2 (hu) | 2000-08-28 |
| EE9800212A (et) | 1998-12-15 |
| LT98096A (en) | 1999-02-25 |
| LV12174A (lv) | 1998-12-20 |
| CZ326896A3 (cs) | 1998-05-13 |
| LT4528B (lt) | 1999-07-26 |
| EA199800624A1 (ru) | 1998-12-24 |
| PL327668A1 (en) | 1998-12-21 |
| HUP0001100A3 (en) | 2001-02-28 |
| LV12174B (en) | 1999-05-20 |
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