WO1997047237A1 - Appareil d'analyse de signaux des variations de frequence cardiaque - Google Patents

Appareil d'analyse de signaux des variations de frequence cardiaque Download PDF

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Publication number
WO1997047237A1
WO1997047237A1 PCT/DK1997/000257 DK9700257W WO9747237A1 WO 1997047237 A1 WO1997047237 A1 WO 1997047237A1 DK 9700257 W DK9700257 W DK 9700257W WO 9747237 A1 WO9747237 A1 WO 9747237A1
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WO
WIPO (PCT)
Prior art keywords
unit
alarm
expression
heartbeats
memory unit
Prior art date
Application number
PCT/DK1997/000257
Other languages
English (en)
Inventor
Knud Erik BÆKGAARD
Original Assignee
Bang & Olufsen Technology A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bang & Olufsen Technology A/S filed Critical Bang & Olufsen Technology A/S
Priority to AU31657/97A priority Critical patent/AU3165797A/en
Priority to EP97927010A priority patent/EP0906057A1/fr
Publication of WO1997047237A1 publication Critical patent/WO1997047237A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/0245—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals

Definitions

  • the present invention relates to an apparatus for registratmg and analysing heartbeat variations (HRV, Heart Rate Variability) .
  • WO 94/27497 belonging to the applicant company, discloses a highly relevant technique for an accurate determination of the heart rate variations, in particular with respect to a precise determination of the time intervals between the important "R peaks" in a relevant cardiogram.
  • the apparatus is not or at least not alone used for a more or less instantaneous monitoring of the relevant data or combination of data, but is equipped in such a manner that it may be programmed to interprete the measuring results and react, e.g. by signalling a simple alarm, whenever the measurement is indicative of a changed condition that can be recognized as a preliminary stage of a forthcoming, noticeable physiological or neurological change or, respectively, a tendency for such a change to occur.
  • This heading typically refers to the said approching attacks, typically diabetic and epileptic attacks, but also attacks of a psychic nature such as with manic-depressive persons. Even though it is possible, based on available research results, to indicate general lines for the manner in which the HRV pattern will change by an approaching attack, it is still - so far - practically impossible to predict how the change should be with a specific person in order to qualify for an alarm function. It will be important, therefore, if in an initial phase it is possible to obtain a registration of not only the normal HRV pattern, but also of the pattern in connection with a commencing attack, as it is then possible to interpolate for determining a suitable prewarning threshold. More about this below.
  • warning should amount to such a short notice that in practice it should involve a momentary reaction, decidedly as an alarm.
  • a relevant example pertains to the finding that in connection with surgical operations situations may occur in which the patient has not been sufficiently anaesthetized to be fully insensible, though sufficiently to be unable to react towards the surroundings in case of a sensed pain. This creates stress with the patient, and it should of course be avoided.
  • the R-R intervals are registered as a function of the time over a period of time, e.g. during the course of a sleep or another "normal period", e.g. just over a few minutes.
  • the variations are located in a rather sharply limited "lump area", but in connection with e.g. manic-depressive attacks (and even ahead of these) the intervals appear with a much larger spreading.
  • the invention is based on the consideration that in using any of these kinds of registration it is possible to determine certain threshold values that may be read into a memory of the signal processing system so as to give rise to a relevant utterance, whether a harsh alarm or a discrete indication, when one or more of the actual registrations coincide with the relevant threshold, which, in the signal processing system, will be present as a more or less complex algorithm.
  • the detailed technique is concerned, already well known principles may be used, so in the present connection it is deemed unnecessary to examplify this in more detail .
  • the determination of the threshold complexes may present difficulties inasfar as there is aimed at a reaction to a change of condition already prior to the change occurring in a directly detectable manner.
  • it may be a relevant procedure to effect, during a course of supervising of a patient, a reading in of a command signal to the signal processing unit of the apparatus as soon as it is experienced, from outside or by the patient, that a change of condition is initiated, given by initial symptoms of the change. Based thereon, it will be possible to interpolate to a point at which it is relevant to make the HRV analysis provide for a prewarning of the forthcoming change, and the relevant threshold combination may then be adjusted correspondingly.
  • the alarm function or signalling will have to be based on the fact that, empirically or in general, a connection has been found between the normal HRV pattern and such deviations therefrom which will justify an intervention or at least an increased attention from the surroundings. It will be a further possibility that the total parameter picture can be completed with further measuring data such as expressions for the person's blood pressure, respiration, etc.
  • the threshold keeper function of the invention will be perfectly applicable in clinical practice, where it is even possible to operate with more different threshold definitions at the same time, e.g. both for the anaesthesia depth and for the said death risk, whereby the requirements as to the attention of the supervising personel can be considerably decreased. Likewise it will be possible, e.g. in connection with mentally afflicted persons, to observe changes in the course of the suffering and, based thereon, draw conclusions with respect to a reasonable thresholding. These experiences, in turn, might then be usable for the threshold programming of a person related, portable apparatus .
  • a relevant supervising apparatus e.g. to the shape and size of a bracelet
  • a relevant reaction e.g. an alarm function
  • the apparatus can produce an informative showing referring e.g. to the stress condition of the body without any associated alarm effect. As mentioned, this may incur a valuable information e.g. to sportsmen.
  • the apparatus may be extended with an integrated or separately added equipment for recording of alarms or other threshold surpassings or registered tendencies, aiming at a later analysis of the supervised course of events, optionally also for recordal of the ECG signal about an alarm moment of time.
  • the apparatus may be connected to a supervising network (telephone, radio, mobile phone, internet etc.) for simplex or duplex communication with a supervising central .
  • Fig. 1 is an elementary picture of an ECG signal
  • Fig. 2 a) -c) is a graphical representation of typical courses of measurements
  • Fig. 3 is a block diagram for further illustration of the invention.
  • the signal shown in Fig. 1 is the well known ECG curve with the characteristic peaks Q, R and S. It is in particularly the R peaks, which in the present connection are detected and analysed with respect to the variations in their temporal spacings.
  • Fig 2 shows three different, but interrelated expressions for the relevant signal analysis.
  • Fig. 2a shows the variation of the R-R intervals over a time period of any suitable duration.
  • Fig. 2b shows a so-called scattergram, in which each interval is shown as a function of the previous interval, providing for an easy survey over the regulating ability of the heart as related to themeter balance.
  • Fig. 2c expresses a completed frequency analysis, preferably an FFT analysis, of the R peaks, where the two maxima A and B are representative for the condition in the sympathetic and the parasympathetic nervous system, respectively.
  • Fig. 3 shows the principal design of an apparatus according to the invention.
  • the detected ECG signal is cleansed for various noise in a unit 2, and non-acceptable information signals are suppressed in a filter 4.
  • a unit 6 operates to effect an adaptive estimation of the quality and characteristic features of the signal relative to a reference signal model, and in a unit 8 the signal expression is formed for comparison with a programmed threshold expression, such that an output signal can be produced based on a pattern recognition principle.
  • a last stage 10 it is re-examined whether the estimation result can be correct, based on general rules and basic physiological conditions, and if the result is accepted in this stage the signal which actuates the associated alarm or display will be generated.
  • the apparatus may be adapted as an interpreter of different signal expressions, e.g. such that no expert knowledge will be required for interpreting an information indicative of the body being approaching a higher or a lower degree of stress.
  • an interpretation ability my well be used in clinical equipment, while in a person specific apparatus it may be still more relevant in that the apparatus may already have useful previous informations in its memory.

Abstract

La recherche de base a démontré qu'en rapport avec l'apparition de changements caractéristiques et critiques survenant dans certains états physiologiques, par exemple une teneur sanguine en sucre décroissant de manière dangereuse chez des patients diabétiques, on constatait l'apparition de certains changements marqués et préalables dans le schéma des variations de fréquence cardiaque du patient. Dans l'optique de l'invention, nous avons tiré profit de cette constatation pour mettre au point un appareil, par exemple du type montre bracelet, qui détecte couramment les battements du coeur d'une personne et forme une expression du schéma des variations des 10 à 50 derniers battements. Cet appareil possède un module codé à l'aide de l'expression annonciatrice du changement approprié, ainsi qu'un module d'alarme activé si ou lorsque cette expression coïncide avec l'expression correspondante détectée. Ainsi le patient possède l'opportunité de prendre des mesures pour contrarier ce changement préalablement annoncé en temps réel. On peut également utiliser cet appareil dans des indications de stress du corps, afin d'obtenir des informations utiles, par exemple, à des sportifs hautement entraînés, et permettre à ceux-ci d'éviter le surmenage.
PCT/DK1997/000257 1996-06-12 1997-06-12 Appareil d'analyse de signaux des variations de frequence cardiaque WO1997047237A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU31657/97A AU3165797A (en) 1996-06-12 1997-06-12 Apparatus for analyzing hrv signals (heart rate variation)
EP97927010A EP0906057A1 (fr) 1996-06-12 1997-06-12 Appareil d'analyse de signaux des variations de frequence cardiaque

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK65496 1996-06-12
DK0654/96 1996-06-12

Publications (1)

Publication Number Publication Date
WO1997047237A1 true WO1997047237A1 (fr) 1997-12-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1997/000257 WO1997047237A1 (fr) 1996-06-12 1997-06-12 Appareil d'analyse de signaux des variations de frequence cardiaque

Country Status (3)

Country Link
EP (1) EP0906057A1 (fr)
AU (1) AU3165797A (fr)
WO (1) WO1997047237A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1059064A3 (fr) * 1999-06-09 2003-01-15 Colin Corporation Appareil moniteur de profondeur d'anesthésie
DE10233149A1 (de) * 2002-07-22 2004-02-12 Ganimed Gmbh Digitales, elektronisches Diagnose-Verfahren und Meßeinrichtung zu seiner Durchführung
GB2401949A (en) * 2003-05-19 2004-11-24 Ge Med Sys Information Tech Comparison of patient data to a physiological mathematical model
DE102005027944A1 (de) * 2005-06-16 2007-01-04 Siemens Ag Verfahren und Vorrichtung zum verbesserten EKG-Triggering
CN103020472A (zh) * 2012-12-27 2013-04-03 中国科学院深圳先进技术研究院 基于约束估计的生理信号质量评估方法和系统
CN105832341A (zh) * 2016-03-11 2016-08-10 深圳还是威健康科技有限公司 一种监控运动强度的方法及智能手环
CN108042107A (zh) * 2017-11-28 2018-05-18 南京邮电大学 一种ppg信号伪差校正方法
DE102021004609A1 (de) 2021-09-11 2023-03-16 Eques Consulting GmbH Vorrichtung und damit durchführbares Verfahren zur non-invasiven Konzentrationsbestimmung von Komponenten im menschlichen Blutkreislauf und Verwendung des Verfahrens.

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105997054B (zh) * 2016-06-22 2019-07-09 天津理工大学 一种心电信号预分析的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3759248A (en) * 1971-02-08 1973-09-18 Spacelabs Inc Cardiac arrythmia detector
US3841315A (en) * 1973-03-14 1974-10-15 Eagle Monitor Syst Method and apparatus for continuously monitoring heartbeat rate
EP0209804A2 (fr) * 1985-07-25 1987-01-28 Paolo Rossi Appareil destiné à la surveillance continue de grandeurs cardio-respiratoires comprenant un capteur implantable
EP0565084A2 (fr) * 1992-04-09 1993-10-13 Spacelabs Medical, Inc. Méthode et système pour analyser la variabilité du rythme cardiaque

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3759248A (en) * 1971-02-08 1973-09-18 Spacelabs Inc Cardiac arrythmia detector
US3841315A (en) * 1973-03-14 1974-10-15 Eagle Monitor Syst Method and apparatus for continuously monitoring heartbeat rate
EP0209804A2 (fr) * 1985-07-25 1987-01-28 Paolo Rossi Appareil destiné à la surveillance continue de grandeurs cardio-respiratoires comprenant un capteur implantable
EP0565084A2 (fr) * 1992-04-09 1993-10-13 Spacelabs Medical, Inc. Méthode et système pour analyser la variabilité du rythme cardiaque

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1059064A3 (fr) * 1999-06-09 2003-01-15 Colin Corporation Appareil moniteur de profondeur d'anesthésie
DE10233149A1 (de) * 2002-07-22 2004-02-12 Ganimed Gmbh Digitales, elektronisches Diagnose-Verfahren und Meßeinrichtung zu seiner Durchführung
GB2401949A (en) * 2003-05-19 2004-11-24 Ge Med Sys Information Tech Comparison of patient data to a physiological mathematical model
GB2401949B (en) * 2003-05-19 2007-02-14 Ge Med Sys Information Tech Method and apparatus for monitoring using a mathematical model
DE102005027944A1 (de) * 2005-06-16 2007-01-04 Siemens Ag Verfahren und Vorrichtung zum verbesserten EKG-Triggering
US7620441B2 (en) 2005-06-16 2009-11-17 Siemens Aktiengesellschaft Method and device for improved ECG triggering
CN1879556B (zh) * 2005-06-16 2010-12-01 西门子公司 改进心电图触发的方法及装置
CN103020472A (zh) * 2012-12-27 2013-04-03 中国科学院深圳先进技术研究院 基于约束估计的生理信号质量评估方法和系统
CN103020472B (zh) * 2012-12-27 2015-12-09 中国科学院深圳先进技术研究院 基于约束估计的生理信号质量评估方法和系统
CN105832341A (zh) * 2016-03-11 2016-08-10 深圳还是威健康科技有限公司 一种监控运动强度的方法及智能手环
CN108042107A (zh) * 2017-11-28 2018-05-18 南京邮电大学 一种ppg信号伪差校正方法
DE102021004609A1 (de) 2021-09-11 2023-03-16 Eques Consulting GmbH Vorrichtung und damit durchführbares Verfahren zur non-invasiven Konzentrationsbestimmung von Komponenten im menschlichen Blutkreislauf und Verwendung des Verfahrens.

Also Published As

Publication number Publication date
AU3165797A (en) 1998-01-07
EP0906057A1 (fr) 1999-04-07

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