WO1997047237A1 - Apparatus for analyzing hrv signals (heart rate variation) - Google Patents
Apparatus for analyzing hrv signals (heart rate variation) Download PDFInfo
- Publication number
- WO1997047237A1 WO1997047237A1 PCT/DK1997/000257 DK9700257W WO9747237A1 WO 1997047237 A1 WO1997047237 A1 WO 1997047237A1 DK 9700257 W DK9700257 W DK 9700257W WO 9747237 A1 WO9747237 A1 WO 9747237A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- unit
- alarm
- expression
- heartbeats
- memory unit
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/0245—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals
Definitions
- the present invention relates to an apparatus for registratmg and analysing heartbeat variations (HRV, Heart Rate Variability) .
- WO 94/27497 belonging to the applicant company, discloses a highly relevant technique for an accurate determination of the heart rate variations, in particular with respect to a precise determination of the time intervals between the important "R peaks" in a relevant cardiogram.
- the apparatus is not or at least not alone used for a more or less instantaneous monitoring of the relevant data or combination of data, but is equipped in such a manner that it may be programmed to interprete the measuring results and react, e.g. by signalling a simple alarm, whenever the measurement is indicative of a changed condition that can be recognized as a preliminary stage of a forthcoming, noticeable physiological or neurological change or, respectively, a tendency for such a change to occur.
- This heading typically refers to the said approching attacks, typically diabetic and epileptic attacks, but also attacks of a psychic nature such as with manic-depressive persons. Even though it is possible, based on available research results, to indicate general lines for the manner in which the HRV pattern will change by an approaching attack, it is still - so far - practically impossible to predict how the change should be with a specific person in order to qualify for an alarm function. It will be important, therefore, if in an initial phase it is possible to obtain a registration of not only the normal HRV pattern, but also of the pattern in connection with a commencing attack, as it is then possible to interpolate for determining a suitable prewarning threshold. More about this below.
- warning should amount to such a short notice that in practice it should involve a momentary reaction, decidedly as an alarm.
- a relevant example pertains to the finding that in connection with surgical operations situations may occur in which the patient has not been sufficiently anaesthetized to be fully insensible, though sufficiently to be unable to react towards the surroundings in case of a sensed pain. This creates stress with the patient, and it should of course be avoided.
- the R-R intervals are registered as a function of the time over a period of time, e.g. during the course of a sleep or another "normal period", e.g. just over a few minutes.
- the variations are located in a rather sharply limited "lump area", but in connection with e.g. manic-depressive attacks (and even ahead of these) the intervals appear with a much larger spreading.
- the invention is based on the consideration that in using any of these kinds of registration it is possible to determine certain threshold values that may be read into a memory of the signal processing system so as to give rise to a relevant utterance, whether a harsh alarm or a discrete indication, when one or more of the actual registrations coincide with the relevant threshold, which, in the signal processing system, will be present as a more or less complex algorithm.
- the detailed technique is concerned, already well known principles may be used, so in the present connection it is deemed unnecessary to examplify this in more detail .
- the determination of the threshold complexes may present difficulties inasfar as there is aimed at a reaction to a change of condition already prior to the change occurring in a directly detectable manner.
- it may be a relevant procedure to effect, during a course of supervising of a patient, a reading in of a command signal to the signal processing unit of the apparatus as soon as it is experienced, from outside or by the patient, that a change of condition is initiated, given by initial symptoms of the change. Based thereon, it will be possible to interpolate to a point at which it is relevant to make the HRV analysis provide for a prewarning of the forthcoming change, and the relevant threshold combination may then be adjusted correspondingly.
- the alarm function or signalling will have to be based on the fact that, empirically or in general, a connection has been found between the normal HRV pattern and such deviations therefrom which will justify an intervention or at least an increased attention from the surroundings. It will be a further possibility that the total parameter picture can be completed with further measuring data such as expressions for the person's blood pressure, respiration, etc.
- the threshold keeper function of the invention will be perfectly applicable in clinical practice, where it is even possible to operate with more different threshold definitions at the same time, e.g. both for the anaesthesia depth and for the said death risk, whereby the requirements as to the attention of the supervising personel can be considerably decreased. Likewise it will be possible, e.g. in connection with mentally afflicted persons, to observe changes in the course of the suffering and, based thereon, draw conclusions with respect to a reasonable thresholding. These experiences, in turn, might then be usable for the threshold programming of a person related, portable apparatus .
- a relevant supervising apparatus e.g. to the shape and size of a bracelet
- a relevant reaction e.g. an alarm function
- the apparatus can produce an informative showing referring e.g. to the stress condition of the body without any associated alarm effect. As mentioned, this may incur a valuable information e.g. to sportsmen.
- the apparatus may be extended with an integrated or separately added equipment for recording of alarms or other threshold surpassings or registered tendencies, aiming at a later analysis of the supervised course of events, optionally also for recordal of the ECG signal about an alarm moment of time.
- the apparatus may be connected to a supervising network (telephone, radio, mobile phone, internet etc.) for simplex or duplex communication with a supervising central .
- Fig. 1 is an elementary picture of an ECG signal
- Fig. 2 a) -c) is a graphical representation of typical courses of measurements
- Fig. 3 is a block diagram for further illustration of the invention.
- the signal shown in Fig. 1 is the well known ECG curve with the characteristic peaks Q, R and S. It is in particularly the R peaks, which in the present connection are detected and analysed with respect to the variations in their temporal spacings.
- Fig 2 shows three different, but interrelated expressions for the relevant signal analysis.
- Fig. 2a shows the variation of the R-R intervals over a time period of any suitable duration.
- Fig. 2b shows a so-called scattergram, in which each interval is shown as a function of the previous interval, providing for an easy survey over the regulating ability of the heart as related to themeter balance.
- Fig. 2c expresses a completed frequency analysis, preferably an FFT analysis, of the R peaks, where the two maxima A and B are representative for the condition in the sympathetic and the parasympathetic nervous system, respectively.
- Fig. 3 shows the principal design of an apparatus according to the invention.
- the detected ECG signal is cleansed for various noise in a unit 2, and non-acceptable information signals are suppressed in a filter 4.
- a unit 6 operates to effect an adaptive estimation of the quality and characteristic features of the signal relative to a reference signal model, and in a unit 8 the signal expression is formed for comparison with a programmed threshold expression, such that an output signal can be produced based on a pattern recognition principle.
- a last stage 10 it is re-examined whether the estimation result can be correct, based on general rules and basic physiological conditions, and if the result is accepted in this stage the signal which actuates the associated alarm or display will be generated.
- the apparatus may be adapted as an interpreter of different signal expressions, e.g. such that no expert knowledge will be required for interpreting an information indicative of the body being approaching a higher or a lower degree of stress.
- an interpretation ability my well be used in clinical equipment, while in a person specific apparatus it may be still more relevant in that the apparatus may already have useful previous informations in its memory.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97927010A EP0906057A1 (en) | 1996-06-12 | 1997-06-12 | Apparatus for analyzing hrv signals (heart rate variation) |
AU31657/97A AU3165797A (en) | 1996-06-12 | 1997-06-12 | Apparatus for analyzing hrv signals (heart rate variation) |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK0654/96 | 1996-06-12 | ||
DK65496 | 1996-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997047237A1 true WO1997047237A1 (en) | 1997-12-18 |
Family
ID=8096023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK1997/000257 WO1997047237A1 (en) | 1996-06-12 | 1997-06-12 | Apparatus for analyzing hrv signals (heart rate variation) |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0906057A1 (en) |
AU (1) | AU3165797A (en) |
WO (1) | WO1997047237A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1059064A3 (en) * | 1999-06-09 | 2003-01-15 | Colin Corporation | Anesthetic-depth monitor apparatus |
DE10233149A1 (en) * | 2002-07-22 | 2004-02-12 | Ganimed Gmbh | Electronic measurement instrument for detection of heart conditions, especially vestibule or heart flutter, comprises microcontroller and algorithm stored in ROM for pulse signal analysis |
GB2401949A (en) * | 2003-05-19 | 2004-11-24 | Ge Med Sys Information Tech | Comparison of patient data to a physiological mathematical model |
DE102005027944A1 (en) * | 2005-06-16 | 2007-01-04 | Siemens Ag | Method and apparatus for improved ECG triggering |
CN103020472A (en) * | 2012-12-27 | 2013-04-03 | 中国科学院深圳先进技术研究院 | Physiological signal quality evaluation method and system based on constrained estimation |
CN105832341A (en) * | 2016-03-11 | 2016-08-10 | 深圳还是威健康科技有限公司 | Method for monitoring exercise intensity and intelligent wrist strap |
CN108042107A (en) * | 2017-11-28 | 2018-05-18 | 南京邮电大学 | A kind of PPG signals puppet difference correcting method |
DE102021004609A1 (en) | 2021-09-11 | 2023-03-16 | Eques Consulting GmbH | Device and method that can be carried out with it for the non-invasive determination of the concentration of components in the human bloodstream and use of the method. |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105997054B (en) * | 2016-06-22 | 2019-07-09 | 天津理工大学 | A kind of method of electrocardiosignal preanalysis |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3759248A (en) * | 1971-02-08 | 1973-09-18 | Spacelabs Inc | Cardiac arrythmia detector |
US3841315A (en) * | 1973-03-14 | 1974-10-15 | Eagle Monitor Syst | Method and apparatus for continuously monitoring heartbeat rate |
EP0209804A2 (en) * | 1985-07-25 | 1987-01-28 | Paolo Rossi | Unit with a subcutaneous pick-up for continuously monitoring physiological cardiorespiratory variables |
EP0565084A2 (en) * | 1992-04-09 | 1993-10-13 | Spacelabs Medical, Inc. | A method and system for heart rate variability analysis |
-
1997
- 1997-06-12 AU AU31657/97A patent/AU3165797A/en not_active Abandoned
- 1997-06-12 WO PCT/DK1997/000257 patent/WO1997047237A1/en not_active Application Discontinuation
- 1997-06-12 EP EP97927010A patent/EP0906057A1/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3759248A (en) * | 1971-02-08 | 1973-09-18 | Spacelabs Inc | Cardiac arrythmia detector |
US3841315A (en) * | 1973-03-14 | 1974-10-15 | Eagle Monitor Syst | Method and apparatus for continuously monitoring heartbeat rate |
EP0209804A2 (en) * | 1985-07-25 | 1987-01-28 | Paolo Rossi | Unit with a subcutaneous pick-up for continuously monitoring physiological cardiorespiratory variables |
EP0565084A2 (en) * | 1992-04-09 | 1993-10-13 | Spacelabs Medical, Inc. | A method and system for heart rate variability analysis |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1059064A3 (en) * | 1999-06-09 | 2003-01-15 | Colin Corporation | Anesthetic-depth monitor apparatus |
DE10233149A1 (en) * | 2002-07-22 | 2004-02-12 | Ganimed Gmbh | Electronic measurement instrument for detection of heart conditions, especially vestibule or heart flutter, comprises microcontroller and algorithm stored in ROM for pulse signal analysis |
GB2401949A (en) * | 2003-05-19 | 2004-11-24 | Ge Med Sys Information Tech | Comparison of patient data to a physiological mathematical model |
GB2401949B (en) * | 2003-05-19 | 2007-02-14 | Ge Med Sys Information Tech | Method and apparatus for monitoring using a mathematical model |
DE102005027944A1 (en) * | 2005-06-16 | 2007-01-04 | Siemens Ag | Method and apparatus for improved ECG triggering |
US7620441B2 (en) | 2005-06-16 | 2009-11-17 | Siemens Aktiengesellschaft | Method and device for improved ECG triggering |
CN1879556B (en) * | 2005-06-16 | 2010-12-01 | 西门子公司 | Method and device for improved ECG triggering |
CN103020472A (en) * | 2012-12-27 | 2013-04-03 | 中国科学院深圳先进技术研究院 | Physiological signal quality evaluation method and system based on constrained estimation |
CN103020472B (en) * | 2012-12-27 | 2015-12-09 | 中国科学院深圳先进技术研究院 | Based on physiological signal quality evaluation method and the system of restrained split-flow |
CN105832341A (en) * | 2016-03-11 | 2016-08-10 | 深圳还是威健康科技有限公司 | Method for monitoring exercise intensity and intelligent wrist strap |
CN108042107A (en) * | 2017-11-28 | 2018-05-18 | 南京邮电大学 | A kind of PPG signals puppet difference correcting method |
DE102021004609A1 (en) | 2021-09-11 | 2023-03-16 | Eques Consulting GmbH | Device and method that can be carried out with it for the non-invasive determination of the concentration of components in the human bloodstream and use of the method. |
Also Published As
Publication number | Publication date |
---|---|
AU3165797A (en) | 1998-01-07 |
EP0906057A1 (en) | 1999-04-07 |
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