WO1997046681A3 - Galanin receptor galr2 - Google Patents

Galanin receptor galr2 Download PDF

Info

Publication number
WO1997046681A3
WO1997046681A3 PCT/US1997/009787 US9709787W WO9746681A3 WO 1997046681 A3 WO1997046681 A3 WO 1997046681A3 US 9709787 W US9709787 W US 9709787W WO 9746681 A3 WO9746681 A3 WO 9746681A3
Authority
WO
WIPO (PCT)
Prior art keywords
galanin
receptor protein
activity
nucleic acid
protein
Prior art date
Application number
PCT/US1997/009787
Other languages
French (fr)
Other versions
WO1997046681A2 (en
Inventor
Brian T Bloomquist
Michael L Mccaleb
Linda J Cornfield
Yoo-Warren Heeja
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Priority to JP50086798A priority Critical patent/JP2002506341A/en
Priority to CA002256523A priority patent/CA2256523A1/en
Priority to EP97929814A priority patent/EP0907734A2/en
Priority to AU33784/97A priority patent/AU3378497A/en
Publication of WO1997046681A2 publication Critical patent/WO1997046681A2/en
Publication of WO1997046681A3 publication Critical patent/WO1997046681A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a novel galanin receptor protein, the GalR2 receptor. Also provided are the nucleic acid sequences encoding this novel receptor protein as well as methods for using this protein and its nucleic acid sequence, and methods useful for developing and identifying compounds for the treatment of diseases and disorders in which galanin is implicated. The importance of this discovery is manifested in the effects of galanin, which include antinociceptive activity, smooth muscle contraction, cardiovascular activity, pituitary hormone release, cognition, and increased food intake. Thus, this receptor protein is useful for screening for galanin agonist and antagonist activity for controlling these conditions.
PCT/US1997/009787 1996-06-05 1997-06-05 GALANIN RECEPTOR GalR2 WO1997046681A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP50086798A JP2002506341A (en) 1996-06-05 1997-06-05 Galanin receptor GalR2
CA002256523A CA2256523A1 (en) 1996-06-05 1997-06-05 Galanin receptor galr2
EP97929814A EP0907734A2 (en) 1996-06-05 1997-06-05 GALANIN RECEPTOR GalR2
AU33784/97A AU3378497A (en) 1996-06-05 1997-06-05 Galanin receptor galr2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/665,034 1996-06-05
US08/665,034 US6410686B1 (en) 1996-06-05 1996-06-05 Galanin receptor 2 protein

Publications (2)

Publication Number Publication Date
WO1997046681A2 WO1997046681A2 (en) 1997-12-11
WO1997046681A3 true WO1997046681A3 (en) 1998-02-26

Family

ID=24668442

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/009787 WO1997046681A2 (en) 1996-06-05 1997-06-05 GALANIN RECEPTOR GalR2

Country Status (4)

Country Link
US (1) US6410686B1 (en)
JP (1) JP2002506341A (en)
AU (1) AU3378497A (en)
WO (1) WO1997046681A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2112238T1 (en) 1996-01-24 1998-04-01 Synaptic Pharma Corp NUCLEIC ACID.
US5972624A (en) * 1996-01-24 1999-10-26 Synaptic Pharmaceutical Corporation Method of identifying ligands which bind recombinant galanin receptor (GALR2)
SE9602822D0 (en) * 1996-07-19 1996-07-19 Astra Pharma Inc New receptor
US6329197B2 (en) 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
WO1998029440A1 (en) 1996-12-27 1998-07-09 Merck & Co., Inc. Mouse galanin receptor galr2 and nucleotides encoding same
EP1037913A4 (en) 1997-12-17 2002-11-20 Merck & Co Inc Galanin receptor galr3 and nucleotides encoding same
US6337206B1 (en) 1997-12-18 2002-01-08 Merck & Co., Inc. Nucleic acid encoding mouse galanin receptor (GALR2)
WO2003018770A2 (en) * 2001-08-27 2003-03-06 Tularik Inc. Amplified oncogenes and their involvement in cancer
WO2006047302A1 (en) 2004-10-21 2006-05-04 Transtech Pharma, Inc. Bissulfonamide compounds as agonists of galr1, compositions, and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022608A1 (en) * 1994-02-17 1995-08-24 Rhone-Poulenc Rorer S.A. Galanin receptor, nucleic acids, transformed cells and uses thereof
EP0711830A2 (en) * 1994-10-13 1996-05-15 Takeda Chemical Industries, Ltd. Human and murine galanin receptor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2112238T1 (en) 1996-01-24 1998-04-01 Synaptic Pharma Corp NUCLEIC ACID.
SE9602822D0 (en) 1996-07-19 1996-07-19 Astra Pharma Inc New receptor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022608A1 (en) * 1994-02-17 1995-08-24 Rhone-Poulenc Rorer S.A. Galanin receptor, nucleic acids, transformed cells and uses thereof
EP0711830A2 (en) * 1994-10-13 1996-05-15 Takeda Chemical Industries, Ltd. Human and murine galanin receptor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WYNICK D ET AL: "Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor.", PROC NATL ACAD SCI U S A, MAY 1 1993, 90 (9) P4231-5, UNITED STATES, XP002051694 *

Also Published As

Publication number Publication date
US6410686B1 (en) 2002-06-25
JP2002506341A (en) 2002-02-26
AU3378497A (en) 1998-01-05
WO1997046681A2 (en) 1997-12-11

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