WO1997046101A1

WO1997046101A1 - Pesticides based on cyclic polysiloxanes

Info

Publication number: WO1997046101A1
Application number: PCT/EP1997/002622
Authority: WO
Inventors: Jochen Kalbe; Andreas Turberg
Original assignee: Bayer Aktiengesellschaft
Priority date: 1996-06-03
Filing date: 1997-05-22
Publication date: 1997-12-11
Also published as: AU3091497A; DE19622190A1

Abstract

The invention concerns pesticides based on cyclic polysiloxanes and arthropodicidal active substances.

Description

Pesticide based on cyclic poysiloxanes

The present invention relates to pesticides based on cyclic polysiloxanes mixed with arthropodicidal active ingredients

Cyclic polysiloxanes with 4 and 5 siloxane units of insecticide were known to be effective. It was also known that polysiloxanes can be used to spray insects by spraying (US Pat. No. 4,654,328). However, these active compounds do not show any lasting action

The invention therefore relates to the following mixtures and agents

1 pesticide based on cyclic poysiloxanes of the formula

(I)

- (S, R - O) -

in which

R for identical or different radicals of the group methyl, ethyl,

Propyl stands,

n stands for integers from 3 to 6,

in a mixture with arthropodicidal agents

2 agents according to 1 (above), characterized in that it contains predominantly as part of the formula (I) compounds in which the index n = 5

3 agents according to 1 (above), characterized in that in the cyclic polysiloxanes of the formula (I)

(- (SiR -o, .-, -? ,

in which

R for identical or different radicals of the group methyl, ethyl,

Propyl stands

n stands for integers from 3 to 6,

the constituents of the formula (I) with the indices 4 and 5 in the weight ratio

n = 4 <85% (weight) n = 5> 15% (weight)

available.

4. Mixture according to 3 (above), characterized in that the constituents of the formula (I) with the indices 4 and 5 in the weight ratio

n = 4 75% by weight n = 5 25% by weight

available.

Preferred arthropodicidal agents for the agents according to the invention are preferred

Insecticides, especially parasiticides for use on animals. The insecticides include agonists or antagonists of the nicotinergic acetylcholine receptors of insects, ivermectins and avermectins as well as phosphorus-containing compounds such as phosphoric or phosphonic acid esters, natural and synthetic pyrethroids, carbamates, amidines, juvenile hormones and juvenoid synthetic

Active ingredients.

The agonists or antagonists of the nicotinergic acetylcholine receptors of insects include the compounds known from the following publications:

European Patent Application Nos. 464 830, 428 941, 425 978, 386 565, 383 091, 375 907, 364 844, 315 826, 259 738, 254 859, 235 725, 212 600,

192 060, 163 855, 154 178, 136 636, 303 570, 302 833, 306 696, 189 972, 455,000, 135,956, 471,372, 302,389; German Offenlegungsschriften No. 3 639 877, 3 712 307; Japanese Patent Application Laid-Open No. 03 220 176,

02 207 083, 63 307 857, 63 287 764, 03 246 283, 04 9371, 03 279 359,

03 255 072; U.S. Patent Nos. 5,034,524, 4,948,798, 4,918,086, 5,039,686, 5,034,404; PCT applications No. WO 91/17659, 91/4965; French

Application No. 2 61 1 1 14; Brazilian application No. 88 03 621.

Reference is hereby expressly made to the methods, processes, formulas and definitions described in these publications and to the individual preparations and compounds described therein.

These compounds can preferably be represented by the general formula (II)

in which

R represents hydrogen, optionally substituted radicals from the group acyl, al yl, aryl, aralkyl, heteroaryl or heteroarylalkyl;

A for a monofunctional group from the series hydrogen, acyl, alkyl,

Aryl or a bifunctional group which is linked to the radical Z,

E represents an electron withdrawing group;

X represents the radicals -CH = or = N-, the radical -CH = instead of an H-

Atom can be linked to the radical Z;

Z for a monofunctional group from the series alkyl, -OR, -SR, RN stands for a bifunctional group that is associated with the

R

Radical A or the radical X is linked

Compounds of the formula (II) in which the radicals have the following meaning are particularly preferred

R represents hydrogen and also optionally substituted radicals from the

Series acyl, alkyl, aryl, aralkyl, heteroaryl, heteroaryl alkyl

Formyl, alkylcarbonyl, arylcarbonyl, alkylsulfonyl, arylsulfonyl, (alkyl-) - (aryl-) - phosphoryl, which in turn can be substituted, may be mentioned as acyl radicals

Examples of alkyl which may be mentioned are C ₁ -C ₄ -alkyl, in particular C ₄ -C ₄ alkyl

Methyl, ethyl, l-propyl, sec - or t-butyl, which in turn can be substituted.

Phenyl, naphthyl, in particular phenyl, may be mentioned as aryl

Phenylmethyl and phenethyl may be mentioned as aralkyl

Heteroaryl with up to 10 ring atoms and N,

O, S, in particular N, as heteroatoms. Thiophenyl, furyl, thiazolyl, imidazolyl, pyridyl, benzthiazolyl may be mentioned individually

Examples of heteroaryl alkyl are heteroarylmethyl, heteroarylethyl having up to 6 ring atoms and N, O, S, in particular N, as heteroatoms

Examples of substituents which may be mentioned are preferred

Alkyl having preferably 1 to 4, in particular 1 or 2, carbon atoms, such as methyl, ethyl, n- and i-propyl and n-, i- and t-butyl, alkoxy with preferably 1 to 4, in particular 1 or 2, carbon atoms, such as methoxy, ethoxy, n- and i-propyloxy and n-, I- and t-butyloxy, alkylthio with preferably 1 to 4, in particular 1 or 2, carbon atoms, such as methyl thio, ethylthio, n- and i-propylthio and n-, i- and t-butylthio, haloalkyl preferably having 1 to 4, in particular 1 or 2, carbon atoms and preferably 1 to 5, in particular I to 3, halogen atoms, the halogen atoms being identical or are different and stand as halogen atoms, preferably fluorine, chlorine or bromine, in particular fluorine, such as trifluoromethyl; Hydroxy; Halogen, preferably fluorine, chlorine, bromine and iodine, especially fluorine, chlorine and bromine; Cyano, nitro, amino, monoalkyl and dialkylamino with preferably 1 to 4, in particular 1 or 2 carbon atoms per alkyl group, such as methylamino, methylethylamino, n- and i-propylamino and methyl-n-butylamino, carboxyl, Carbalkoxy with preferably 2 to 4, in particular 2 or 3 carbon atoms, such as carbomethoxy and carboethoxy, sulfo (-SO ₃ H); Alkylsulfonyl with preferably 1 to 4, especially 1 or 2 carbon atoms, such as methylsulfonyl and ethylsulfonyl, arylsulfonyl with preferably 6 or 10 aryl carbon atoms, such as phenylsulfonyl, and also heteroarylamino and heteroarylalkylamino such as chloropyridylamino and chloropyridylmethylamino

A particularly preferably represents hydrogen and optionally substituted radicals from the series acyl, alkyl, aryl, which preferably have the meanings given for R. A furthermore stands for a bifunctional group. Optionally substituted alkylene with 1-4, in particular 1-2, carbon atoms may be mentioned, the substituents listed above being the substituents and the alkylene groups being heteroatoms from the series N, O, S can be interrupted

A and Z, together with the atoms to which they are attached, form a saturated or unsaturated heterocyclic ring. The heterocyclic ring may contain a further 1 or 2 identical or different hetero atoms and / or hetero groups. Oxygen is preferably a hetero atom , Sulfur or nitrogen and, as hetero groups, N-alkyl, alkyl of the N-alkyl group preferably containing 1 to 4, in particular 1 or 2, carbon atoms. Alkyl, methyl, ethyl, n- and I-

Propyl and n-, i- and t-butyl called The heterocych ring contains 5 to 7, preferably 5 or 6 ring members Examples of the heterocyclic ring are pyrrolidine, piperidine, piperazine, hexamethyleneimine, hexahydro-l, 3,5-triazione, morpholine, which may optionally be substituted by methyl

E stands for an electron-withdrawing radical, in particular NO ₂ , CN, haloalkylcarbonyl such as 1,5-halogeno-carbonyl, in particular COCF

X stands for -CH = or -N =

Z stands for optionally substituted radicals alkyl, -OR, -SR, -NRR, where

R and the substituents preferably have the meaning given above

In addition to the ring mentioned above, Z can be attached together with the atom

__ l _ which it is bound and the rest

form a saturated or unsaturated heterocyclic ring in the place of X. The heterocychic ring can contain a further 1 or 2 identical or different heteroatoms and / or hetero groups. The hetero atoms are preferably oxygen, sulfur or nitrogen and as

Hetero groups N-alkyl, the alkyl or N-alkyl group preferably containing 1 to 4, in particular 1 or 2, carbon atoms. The alkyls are methyl, ethyl, n- and l-propyl and n-, I- and t-butyl The heterocych ring contains 5 to 7, preferably 5 or 6 ring members

Examples of the heterocyclic ring are pyrrolidine, piperidine,

Piperazine, hexamethyleneimine, morpholine and N-methylpiperazine called

Compounds of the general formulas (III) and (IV) may be mentioned as very particularly preferred compounds which can be used according to the invention

Subst.

in which

n represents 1 or 2,

Subst stands for one of the substituents listed above, in particular for halogen, very particularly for chlorine,

A, Z, X and E have the meanings given above,

The following connections are specifically mentioned:

Imidacloprid

CH.

AKD 1022

CH ₃

Ti3 04

The phosphoric or phosphoric acid esters include:

0-ethyl-0- (8-quinolyl) phenylthiophosphate (Quintiofos),

0.0-diethyl-0- (3-chloro-4-methyl-7-coumarinyl) thiophosphate (Coumaphos),

0,0-diethyl-O-phenylglyoxylonitrile oxime thiophosphate (phoxime),

0.0-diethyl-O-cyanochlorobenzaldoxime thiophosphate (chlorophoxime), , 0-DιethyI-0- (4-bromo-2,5-dιchlorophenyl) phosphorothionate (bromophos-ethyl),

, 0,0 ', 0'-tetraethyl-S, S'-methylene-di (phosphorodionothonate) (ethion),

2,3-p-Dιoxanedιthiol-S, S-bis (0,0-dιethylphosphorodithιonat,

2-chloro-l- (2,4-dichlorophenyl) vinyl diethyl phosphate (chlorfenvinphos),

0.0-dimethyl-0- (3-methyl-4-methylthiophenyl) thionophosphoric acid ester

(Fenthion)

The carbamates include

2-isopropoxyphenylmethyl carbamate (propoxur),

1-naphthyl-N-methyl carbamate (carbaryl)

Compounds of the formula V include the synthetic pyrethroids

in which

R ¹ and R ^{2 represent} halogen, optionally halogen-substituted alkyl, optionally halogen-substituted phenyl,

R 'represents hydrogen or CN,

R ^"represents hydrogen or halogen,

R ^{1 represents} hydrogen or halogen,

Synthetic pyrethroids of the formula V in which are preferred R ^{1 represents} halogen, in particular fluorine, chlorine, bromine,

R ² for halogen, in particular fluorine, chlorine, bromine, tπhalomethyl,

Phenyl, chlorophenyl,

R ^ represents hydrogen or CN,

R ^{4 represents} hydrogen or fluorine,

R ^{"1 represents} hydrogen

Synthetic pyrethroids of the formula V in which are particularly preferred

R ^{1 represents} chlorine,

R ^{2 represents} chlorine, trifluoromethyl, p-chlorophenyl,

R * stands for CN,

R ^{4 represents} hydrogen or fluorine,

R- stands for hydrogen

Compounds of the formula V may be mentioned in particular

R ^{1 represents} chlorine,

R ^{2 represents} chlorine or p-chlorophenyl,

R 'stands for CN,

R ^{4 represents} fluorine in the 4-position,

R ^{5 represents} hydrogen The following may be mentioned in detail:

3- [2- (4-chlorophenyl) -2-chlorovinyl] -2,2-dimethyl-cyclo-propanecarboxylic acid [(α-cyano-4-fluoro-3-phenoxy) benzyl] ester (flumethrin),

2,2-dimethyl-3- (2,2-dichlorovinyl) -cyclopropanecarboxylic acid-α-cyano (4-fluoro-3-phenoxy) -benzyl ester (cyfluthrin) and its enantiomers and stereoisomers,

α-cyano-3-phenoxybenzyl (+) - cis, trans-3- (2,2-dibromovinyl) -2,2-dimethylcyclopropanecarboxylate (deltamethrin),

2,2-dimethyl-3- (2,2-dichlorovinyl) -cyclopropanecarboxylic acid-α-cyano-3-phenoxybenzyl ester (cypermethrin),

3-phenoxybenzyl (±) -cis, trans-3- (2,2-dichlorovinyl) -2,2-dimethylcyclopropane carboxylate (permethrin),

α- (p-Cl-phenyl) -isovaleric acid-α-cyano-3-phenoxy-benzyl ester (fenvalerate),

2-Cyano-3-phenoxybenzyl-2- (2-chloro-α, α, α-trifluoro-p-toluidino) -3-methylbutyrate (fluvalinate).

The amidines include:

3-methyl-2- [2,4-dimethylphenylimino] thiazoline

2- (4-chloro-2-methylphenylimino) -3-methylthiazolidine

2- (4-chloro-2-methylphenylimino) -3- (isobutyl-l-enyl) thiazolidine

1,5-bis (2,4-dimethylphenyl) -3-methyl-1,3,5-triazapenta-1,4-diene (Amitraz).

Juvenile hormones or juvenile hormone-like substances include substituted diaryl ethers, benzoyl ureas and triazine derivatives. Juvenile hormones and juvenile hormone-like substances include in particular compounds of the following formulas:

The substituted diaryl ethers include, in particular, substituted alkoxydiphenyl ethers or diphenyl methanes of the general formula VI

in which

R ^{1 represents} hydrogen, halogen, alkyl, alkoxy, alkylthio, haloalkyl, haloalkoxy, haloalkylthio, dioxyalkylene, dioxyhalogenalkylene, CN, NO ₂ , alkenyl, alkynyl, alkoxyalkyl, alkoxyalkoxy, hydroxyalkoxy,

R ^{2 represents} the radicals specified for R ¹ ,

R ^{3 represents} the radicals specified for R ¹ ,

R ^{4 represents} hydrogen, alkyl, haloalkyl or halogen,

R ^{-1 represents} the radicals specified for R ⁴ ,

Het stands for optionally substituted heteroaryl, which does not have the

Hetero atom is bound to the rest of the rest,

X, Y independently of one another represent -O-, -S-

Z represents -O-, -S-, -CH ₂ -, -CHCH ₃ -, -C (CH ₃ ) ₂ -,

m and n independently of one another represent 0, 1, 2, 3 but their sum is equal to or greater than 2.

Compounds of the formula VI are particularly preferred

in which

R ^{1 is} hydrogen, methyl, trifluoromethyl, methoxy, trifluoromethoxy, chlorine, fluorine R ^~ stands for hydrogen,

R ^{1 represents} hydrogen, fluorine, chlorine, methyl,

R ^{4 represents} hydrogen or methyl,

R ^{5 represents} methyl, ethyl, trifluoromethyl or hydrogen,

Het is pyridyl or pyridazinyl which are optionally substituted by

Fluorine, chlorine, methyl, NO ₂ , methoxy, methylmercapto,

X stands for O,

Y stands for O,

Z represents O, CH ₂ or -C (CH ₃ ) ₂ -,

m represents 1,

n stands for 1

The following compounds may be mentioned in detail

Benzoylureas include compounds of the formula VII

in which

R represents halogen,

R ^{1 represents} hydrogen or halogen, R ^{3 represents} hydrogen, halogen or C 1 -C ₄ -alkyl,

R ⁴ for halogen, l -5-halogen-C _1.4 -alkyl, C _{] .4} -alkoxy, l -S-halogen-C, ^ - alkoxy, C ₁ . ₄ alkylthio, l -5-halogeno-C, _.4- alkylthio, phenoxy or

Pyπdyloxy which may optionally be substituted by halogen,

C-alkyl, l -5-halogen-C ₁ . _4- alkyl, C _1.4 -alkoxy, l-5-halo-C, _.4 -alkoxy,

C _{] .4} -Alkylthιo, 1-5-halo-C _{] .4} -alkylthιo May be mentioned in particular

46101

19

The triazines include compounds of the formula (VIII)

NH R,

N ^ (VIII)

R - HN ^' N ^' ^" NH - R,

wherein

R represents cyclopropyl or isopropyl;

R-, hydrogen, halogen, C _] -C ₁₂ alkylcarbonyl _; Cyclopropylcarbonyl, C, -C _p - alkyl carbamoyl, C, -C _p alkylthiocarbamoyl or C ₂ -C ₆ alkenyl carbamoyl means, and

R ₃ for hydrogen, C _r C ₁₂ alkyl, cyclopropyl, C ₂ -C ₆ alkenyl, C, -C _{] 2} alkylcarbonyl, cyclopropylcarbonyl, C _j -Cp alkylcarbamoyl, C _r C _p alkylthio carbamoyl or C ₂ -C -alkenylcarbamoyl and their acid addition salts, which are non-toxic to warm-blooded animals.

In particular,

Particularly noteworthy are the arthropodicidal active ingredients with the comnon names Propoxur, Cyfluthπn, Flumethπn, Pyπproxyfen, Methoprene, Diazinon, Amitraz, Fenthion, Imidaclopπd, Ti 435, AKD 1022, Ti 304, Tπflumuron, Ivermectin, Avermectin

The active substances are present in the compositions in m concentrations of 0.1 to 20% by weight, preferably between 1 to 10% by weight.

The agents according to the invention have considerable practical advantages. Their action on pests is immediate, that is, the consumer sees them

The control measure is carried out directly

The agents according to the invention sometimes show considerably better tolerability compared to the use of the individual active ingredients The compositions according to the invention are suitable for controlling animal pests, preferably arthropods, in particular insects and arachnids, which occur in agriculture, in forests, in the protection of stored goods and materials and in the hygiene sector. They are resistant to normally sensitive and resistant species and to all or some of them Developmental stages effective The pests mentioned above include

From the order of the Isopoda, for example Oniscus asellus, Armadillidium vulgare,

Porcelli o scaber

From the order of the Diplopoda e.g. Blaniulus guttulatus From the order of the Chilopoda eg Geophilus carpophagus, Scutigera spec

From the order of the Symphyla e.g. Scutigerella immaculata

From the order of the Thysanura, for example Lepisma saccharina

From the order of the Collembola, for example Onychiurus armatus

From the order of the Orthoptera e.g. Blatta orientalis, Periplaneta americana, Leucophaea maderae, Blattella germanica, Acheta domesticus, Gryllotalpa spp,

Locusta migratoria migratorioides, Melanoplus differentiahs, Schistocerca gregaria

From the order of the Dermaptera e.g. Forficula auπculaπa

From the order of the Isoptera e.g. Reticulitermes spp.

From the order of the Anoplura e.g. Pediculus humanus corporis, Haematopinus spp, Linognathus spp

From the order of the Mallophaga, for example Tπchodectes spp, Damalinea spp

From the order of the Thysanoptera e.g. Hercinothrips femoralis, Thrips tabaci

From the order of the Heteroptera, for example Eurygaster spp, Dysdercus intermedius,

Piesma quadrata, Cimex lectularius, Rhodnius prolixus, Triatoma spp From the order of the Homoptera e.g. Aleurodes brassicae, Bemisia tabaci,

Trialeurodes vaporariorum, Aphis gossypii, Brevicoryne brassicae, Cryptomyzus ribis, Aphis fabae, Aphis pomi, Eriosoma lamgerum, Hyalopterus arundinis,

Phylloxera vastatrix, Pemphigus spp, Macrosiphum avenae, Myzus spp, Phorodon humuli, Rhopalosiphu padi, Empoasca spp, Euscelis bilobatus, Nephotettix cincticeps, Lecanium corni, Saissetia oleae, Laodelphax striatellidium, Aspelocidium syllabus, Nilaparocidium lp

From the order of the Lepidoptera, for example Pectinophora gossypiella, Bupalus piniaπus, Cheimatobia brumata, Lithocolletis blancardella, Hyponomeuta padella, Plutella maculipennis, Malacosoma neustπa, Euproctis chrysorrhoea, Lymantria spp Bucculatrix thurberiella, Phyllocnistis citrella, Agrotis spp, Euxoa spp, Feltia spp., Earias insulana, Heliothis spp, Laphygma exica, Prodisiaiappeaia, Spodiaia triappaia, Spodiaia triappia, Spodiaia triappaia, Spodiaia triappaia Carpocapsa pomonella, Pieris spp, Chilo spp, Pyrausta nubilalis, Ephestia kuehniella, Galleria mellonella, Tineola bisselliella, Tinea pellionella, Hofmannophila pseudospretella, Cacoecia podana, Capua reticulana, Choristoneura fumiferanuell, viralia, triaxialia, Clysia

From the order of the Coleoptera e.g. Anobiu punctatum, Rhizopertha dominica, Bruchidius obtectus, Acanthoscelides obtectus, Hylotrupes bajulus, Agelastica alni,

Leptinotarsa decemlineata, Phaedon cochleariae, Diabrotica spp, Psylliodes chrysocephala, Epilachna varivestis, Atomaria spp., Oryzaephilus surinamensis, Anthonomus spp, Sitophilus spp, Otiorrhynchus Sulcatushidpphidpphidispphppisidpphidisidpphidispphidispphidispphcpphc, spp spp, Lyctus spp., Meligethes aeneus, Ptinus spp,

Niptus hololeucus, Gibbium psylloides, Tribolium spp, Tenebno mohtor, Agriotes spp, Conoderus spp., Melolontha melolontha, Amphimallon solstitialis, Costelytra zealandica

From the order of the Hymenoptera e.g. Diprion spp, Hoplocampa spp, Lasius spp, Monomorium pharaonis, Vespa spp

From the order of Diptera, for example Aedes spp, Anopheles spp, Culex spp, Drosophila melanogaster, Musca spp, Fannia spp, Calliphora erythrocephala, Lucilia spp, Chrysomyia spp., Cuterebra spp, Gastrophilus spp., Hyppobosca spp., Stomoxyspp ., Hypoderma spp, Tabanus spp, Tannia spp, Bibio hortulanus, Oscinella frit, Phorbia spp., Pegomyia hyoscyami, Ceratitis capitata,

Dacus oleae, Tipula paludosa.

From the order of the Siphonaptera e.g. Xenopsylla cheopis, Ceratophyllus spp From the order of the Arachnida e.g. Scorpio maurus, Latrodectus mactans From the order of the Acaπna z B Acarus siro, Argas spp, Ornithodoros spp, Dermanyssus gallinae, Eriophyes ribis, Phyllivoraopilil, Phyllivoraopil

Rhipicephalus spp, Amblyomma spp, Hyalomma spp, Ixodes spp, Psoroptes sp, Chorioptes spp., Sarcoptes spp, Tarsonemus spp, Bryobia praetiosa, Panonychus spp, Tetranychus spp With favorable warm-blood toxicity, the agents are suitable for controlling animal pests, such as arthropods, preferably insects, arachnids, which occur in livestock farming and animal breeding in farm animals, breeding, zoo, laboratory, experimental and hobby animals. They are against all or individual stages of development of the pests and against resistant and normally sensitive types of

Pests effective.

The pests include:

From the order of the anoplura e.g. Haematopinus spp., Linognathus spp., Solenopotes spp., Pediculus spp., Pthirus spp .; from the order of the Mallophaga e.g. Trimenopon spp., Menopon spp.,

Eomenacanthus spp., Menacanthus spp., Trichodectes spp., Felicola spp.,

Damalinea spp., Bobiola spp .; from the order of the Diptera e.g. Chrysops spp., Tabanus spp., Musca spp.,

Hydrotaea spp., Muscina spp., Haematobosca spp., Haematobia spp., Stomoxys spp., Fannia spp., Glossina spp., Lucilia spp., Calliphora spp., Auchmeromyia spp.,

Cardylobia spp., Cochiomyia spp., Chrysomyia spp., Sarcophaga spp., Wohlfartia spp., Gaserophilus spp., Oesteromyia spp., Oedemagena sp., Hypoderma spp.,

Oestrus spp., Rhinoestrus spp., Melophagus spp., Hippobosca spp.

From the order of the Siphonaptera e.g. Ctenocephalides spp., Echidnophaga spp., Ceratophyllus spp.

From the order of the metastigmata e.g. Hyalomma spp., Rhipicephalus spp., Boophilus spp., Ambyomma spp., Haemophysalis spp., Dermacentor spp., Ixodes spp., Argas spp., Ornithodorus spp., Otobius spp .; from the order of the mesastigmata e.g. Dermanyssus spp., Ornithonyssus spp., Pneumonyssus spp.

From the order of the prostigmata e.g. Cheyletiella spp., Psorergates spp., Myobia spp., Demdex spp., Neotrombicula spp .;

Domestic and farm animals include mammals such as cattle, sheep, goats, "horses, pigs, dogs, cats, camels, water buffalo, donkeys, rabbits, Fallow deer, reindeer, fur animals such as mink, chinchilla, raccoon, birds such as chickens, turkeys, pheasants, geese, ducks.

Laboratory and experimental animals include e.g. Mice, rats, guinea pigs, golden hamsters, dogs and cats.

Hobby animals include e.g. Dogs and cats.

The agents according to the invention can also be used in closed rooms such as apartments, halls or the like. deploy. They are particularly suitable for controlling animal pests and nuisances that occur in the household.

These include flies, mosquitoes, wasps, ants, cockroaches, and silverfish.

The agents according to the invention are used directly or in the form of suitable preparations dermally or by treating their environment.

The dermal application happens e.g. in the form of bathing, diving (dipping), spraying (spraying), pouring on (pour-on or spot-on), washing, shampooing, watering, powdering.

Suitable preparations are:

Solutions or concentrates for administration after dilution, solutions for

Skin use, infusion formulations, gels;

Emulsions and suspensions for dermal use and semi-solid preparations;

Formulations in which the active ingredients are processed in an ointment base or in an oil in water or water in oil emulsion base;

Solid preparations such as powder or dusts, also through microencapsulation of the liquid ingredients. In addition to use on animals, these preparations can also be used in the home, in hygiene or in agriculture

Solutions for use on the skin are dripped on, spread on, rubbed in, sprayed on, sprayed on or applied by dipping (dipping), bathing or washing

The solutions are prepared by dissolving the active ingredients in the cyclic silicones and / or suitable solvents and possibly adding additives such as solubilizers, acids, bases, buffer salts, antioxidants and preservatives

Physiologically contractual solvents such as

Water, alcohols such as ethanol, butanol, benzyl alcohol, glycols, hydrocarbons, propylene glycol, polyethylene glycols, N-methyl-pyrrohdon, and mixtures thereof

The active ingredients can optionally also be dissolved in physiologically acceptable vegetable or synthetic oils

Solvents which may be mentioned are solvents which require the active ingredient to be dissolved in the main solvent or prevent it from precipitating out. Examples are polyvinylpyrrohdon, polyoxyethylated castor oil, polyoxyethylated sorbitan esters

Preservatives are benzyl alcohol, chlorobutanol, p-hydroxybenzoic acid ester, n-butanol

It may be advantageous to add thickeners in the preparation of the solutions. Thickeners are inorganic thickeners such as bentonites, colloidal silica, aluminum monostearate, organic thickeners such as cellulose derivatives, polyvinyl alcohols and their copolymers.

Acrylates and metacrylates Gels that are applied or spread on the skin are produced by adding enough thickening agent to solutions that have been prepared as described above to produce a clear mass with an ointment-like consistency. The thickeners specified above are used as thickeners

Pour-on formulations are poured or sprayed onto limited areas of the skin, the active ingredients being distributed over the surface of the body

Pour-on formulations are prepared by dissolving, suspending or emulsifying the active ingredients in suitable solvents or solvent mixtures that are compatible with the skin.

Antioxidants, light stabilizers, adhesives added

Solvents which may be mentioned are water, alkanols, glycols, polyethylene glycols, polypropylene glycols, glycerol, aromatic alcohols such as benzyl alcohol, phenylethanol, phenoxyethanol, esters such as ethyl acetate, butyl acetate, benzyl benzoate, ethers such as alkylene glycol alkyl ethers such as dipropylene glycol monomethyl ether, diethylene glycol and glycol monoethyl ether , Methyl ethyl ketone, aromatic and / or aliphatic hydrocarbons, vegetable or synthetic oils, DMF, dimethylacetamide, N-methylpyrrolidone, 2-dimethyl-4-oxy-methylene-1, 3-dιoxolan

Dyes are all dyes approved for use on animals, which can be dissolved or suspended

Excipients are also spreading oils such as isopropyl mypstat, dipropylene glycol pelargonate, silicone oils, fatty acid esters, triglycerides, fatty alcohols

Antioxidants are sulfites or metabisulfites such as potassium metabisulfite, ascorbic acid, butylated hydroxytoluene, butylated hydroxyanisole, tocopherol

Light stabilizers are, for example, substances from the class of the benzophenones or

Novantisol acidic Adhesives are, for example, cellulose derivatives, starch derivatives, polyacrylates, natural polymers such as alginates, gelatin.

Emulsions are either water in oil or oil in water.

They are produced by dissolving the active substances either in the hydrophobic or in the hydrophilic phase and using suitable ones

Emulsifiers and optionally other auxiliaries such as dyes, absorption-promoting substances, preservatives, antioxidants, light stabilizers, viscosity-increasing substances, homogenized with the solvent of the other phase

The following may be mentioned as the hydrophobic phase (oils): paraffin oils, silicone oils, natural vegetable oils such as sesame oil, almond oil, castor oil, synthetic triglycerides such as

Caprylic / capric acid bigylceride, triglyceride mixture with vegetable fatty acids of chain length C ₈ , ₂ or other specially selected natural fatty acids, partial glyceride mixtures of saturated or unsaturated fatty acids, which may also contain hydroxyl groups, mono- and diglycerides of C ₈ / C ₁₀ fatty acids.

Fatty acid esters such as ethyl stearate, di-n-butyryl adipate, lauric acid hexyl ester, dipropylene glycol pelargonate, esters of a branched fatty acid of medium chain length with saturated fatty alcohols of chain length C ₁₆ -C ₁₈ , isopropyl myristate, isopropyl palmitate, caprylic / capric acid esters of saturated fatty alcohol the chain length Cp-C _{) 8} , isopropyl stearate, oleic acid oleyl ester, oleic acid decyl ester, ethyl oleate, lactic acid ethyl ester, waxy fatty acid esters such as dibutyl phthalate, diisopropyl adipate, the latter related ester mixtures including fatty alcohols such as isotridecyl alcohol alcohol, 2-octyl alcohol alcohol, 2-octyl alcohol alcohol, 2-octyl alcohol alcohol.

Fatty acids such as Oleic acid and its mixtures.

The following can be mentioned as the hydrophilic phase: water, alcohols, e.g. Propylene glycol, glycerin, sorbitol and their mixtures.

Be mentioned as emulsifiers: nonionic surfactants, for example polyoxyethylated ^~ castor oil, polyoxyethylated sorbitan monooleate, sorbitan monostearate, glycerol monostearate, Pol yoxy ethyl stearate, alkylphenol; ampholytic surfactants such as di-Na-N-lauryl-β-iminodipropionate or lecithin,

anionic surfactants, such as sodium lauryl sulfate, fatty alcohol ether sulfates, mono / dialkyl polyglycol ether orthophosphoric acid ester monoethanolamine salt, cationic surfactants such as cetyl methyl methyl ammonium chloride

Further auxiliaries which may be mentioned are substances which increase viscosity and stabilize the emulsion, such as carboxymethyl cellulose, methyl cellulose and other cellulose and starch derivatives, polyacrylates, alginates, gelatin, gum arabic, polyvinylpyrrodone, polyvinyl alcohol, copolymers of methyl vinyl ether and maleic anhydride, silica glycols, waxes, polyethylene glycols, waxes, polyethylene glycols, waxes, polyethylene glycols, waxes, polyethylene glycols, waxes, and ethylene glycols or mixtures of the listed substances

Suspensions are produced by suspending the active ingredients in a carrier liquid, optionally with the addition of further auxiliaries such as wetting agents, dyes, absorption-promoting substances, preservatives, antioxidants, light stabilizers

All homogeneous solvents and solvent mixtures are mentioned as carrier liquids

The surfactants specified above may be mentioned as wetting agents (dispersants)

Further additives mentioned are those mentioned above

Semi-solid preparations for dermal administration differ from the suspensions and emulsions described above only in their higher viscosity

To prepare solid preparations, the active ingredients are mixed with suitable carriers, if appropriate with the addition of auxiliaries, and brought into the desired shape All physiologically compatible solid inert substances may be mentioned as carrier substances. All such serve inorganic and organic substances. Inorganic substances are, for example, table salt, carbonates such as calcium carbonate, hydrogen carbonates, aluminum oxides, silicas, clays, precipitated or colloidal silicon dioxide, phosphates

Excipients are preservatives, antioxidants, dyes, which have already been listed above

Other suitable auxiliaries are lubricants and lubricants such as magnesium stearate, stearic acid, talc, bentonite

Ready-to-use preparations contain the active ingredients in concentrations of

1 ppm - 20 weight percent, preferably from 0.01 - 10 weight percent

Preparations which are diluted before use contain the active compounds in concentrations of 0.5 to 90 percent by weight, preferably from 1 to 50 percent by weight

In general, it has been found advantageous to use amounts from about 0.5 to about

50 mg, preferably 1 to 20 mg, of active ingredient per kg of body weight per day to achieve effective results

Agents according to the invention in which the arthropodicidal active ingredient is present in solution in the cyclic polysiloxane are particularly preferred

Claims

1 pesticide based on cyclic poysiloxanes of the formula

(I)

(SiR ₂ - O) -

(I),

in which

R for identical or different radicals of the group methyl, ethyl,

Propyl stands,

n stands for integers from 3 to 6,

in a mixture with arthropodicidal agents.

2 compositions according to claim 1, characterized in that they contain as part of the formula (I) compounds in which the index n = 5.

3 Composition according to claim 1, characterized in that the components of formula (I) with the indices 4 and 5 in the weight ratio

n = 4 85 to 50% by weight n = 5 15 to 50% by weight

available