WO1997041895A3 - TREATMENT OF ASTHMA WITH TNFR-Ig - Google Patents

TREATMENT OF ASTHMA WITH TNFR-Ig Download PDF

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Publication number
WO1997041895A3
WO1997041895A3 PCT/EP1997/002256 EP9702256W WO9741895A3 WO 1997041895 A3 WO1997041895 A3 WO 1997041895A3 EP 9702256 W EP9702256 W EP 9702256W WO 9741895 A3 WO9741895 A3 WO 9741895A3
Authority
WO
WIPO (PCT)
Prior art keywords
asthma
treatment
binding protein
tnfr
chimeric tnfα
Prior art date
Application number
PCT/EP1997/002256
Other languages
French (fr)
Other versions
WO1997041895A2 (en
Inventor
Louis Martin Renzetti
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to JP09539522A priority Critical patent/JP2000510113A/en
Priority to EP97921849A priority patent/EP0910413A2/en
Priority to BR9708928-1A priority patent/BR9708928A/en
Priority to CA002253557A priority patent/CA2253557A1/en
Priority to AU27764/97A priority patent/AU725408B2/en
Publication of WO1997041895A2 publication Critical patent/WO1997041895A2/en
Publication of WO1997041895A3 publication Critical patent/WO1997041895A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention is directed to a method of combatting asthma with a composition containing an effective amount of a chimeric TNFα-binding protein which comprises the soluble part of the p55 TNF receptor and all domains except the first domain of the heavy chain constant region of a human IgG1 or IgG3 and to the use of such a chimeric TNFα-binding protein for the preparation of a medicament for the treatment of asthma.
PCT/EP1997/002256 1996-05-08 1997-05-02 TREATMENT OF ASTHMA WITH TNFR-Ig WO1997041895A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP09539522A JP2000510113A (en) 1996-05-08 1997-05-02 Treatment of asthma with TNFR-Ig
EP97921849A EP0910413A2 (en) 1996-05-08 1997-05-02 TREATMENT OF ASTHMA WITH TNFR-Ig
BR9708928-1A BR9708928A (en) 1996-05-08 1997-05-02 Treatment of asthma with tnfr-ig
CA002253557A CA2253557A1 (en) 1996-05-08 1997-05-02 Treatment of asthma with tnfr-ig
AU27764/97A AU725408B2 (en) 1996-05-08 1997-05-02 Treatment of asthma with TNFR-Ig

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1684296P 1996-05-08 1996-05-08
US60/016,842 1996-05-08

Publications (2)

Publication Number Publication Date
WO1997041895A2 WO1997041895A2 (en) 1997-11-13
WO1997041895A3 true WO1997041895A3 (en) 1998-03-12

Family

ID=21779275

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/002256 WO1997041895A2 (en) 1996-05-08 1997-05-02 TREATMENT OF ASTHMA WITH TNFR-Ig

Country Status (15)

Country Link
EP (1) EP0910413A2 (en)
JP (1) JP2000510113A (en)
KR (1) KR20000010825A (en)
CN (1) CN1233189A (en)
AR (1) AR007020A1 (en)
AU (1) AU725408B2 (en)
BR (1) BR9708928A (en)
CA (1) CA2253557A1 (en)
CO (1) CO4820397A1 (en)
HR (1) HRP970224A2 (en)
MA (1) MA24169A1 (en)
PE (1) PE70698A1 (en)
TR (1) TR199802238T2 (en)
WO (1) WO1997041895A2 (en)
ZA (1) ZA973843B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2316545A1 (en) * 1997-12-29 1999-07-08 Regeneron Pharmaceuticals, Inc. Novel nucleic acid and polypeptide with homology to the tnf-receptors
TR200504220T2 (en) * 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Active lymphotoxin-beta receptor immunoglobulin chime A method for high level expression and purification of purified protein proteins and a method for purification of active lymphotoxin-beta receptor immunoglobulin chimeric proteins.
US20040220103A1 (en) 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
US20010021380A1 (en) * 1999-04-19 2001-09-13 Pluenneke John D. Soluble tumor necrosis factor receptor treatment of medical disorders
ES2304602T3 (en) * 2003-02-28 2008-10-16 Ares Trading S.A. LIQUID FORMULATIONS OF THE UNION PROTEIN TO THE TBP-1 TUMOR NECROSIS FACTOR.
TWI374935B (en) * 2004-08-27 2012-10-21 Pfizer Ireland Pharmaceuticals Production of α-abeta
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
MX2009004134A (en) 2006-10-20 2009-08-12 Biogen Idec Inc Treatment of demyelinating disorders.

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417563A2 (en) * 1989-09-12 1991-03-20 F. Hoffmann-La Roche Ag TNF-binding proteins
WO1994006476A1 (en) * 1992-09-15 1994-03-31 Immunex Corporation Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
EP0619372A1 (en) * 1993-03-29 1994-10-12 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Tumor necrosis factor muteins
WO1996003141A1 (en) * 1994-07-22 1996-02-08 F. Hoffmann-La Roche Ag Pharmaceutical compositions comprising a chimaeric tnf binding protein
WO1996039488A1 (en) * 1995-06-06 1996-12-12 Genentech, Inc. Process for controlling sialylation of proteins produced by mammalian cell culture
WO1997022364A1 (en) * 1995-12-18 1997-06-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem FCε-PE CHIMERIC PROTEIN FOR TARGETED TREATMENT OF ALLERGY RESPONSES, A METHOD FOR ITS PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
US5684222A (en) * 1993-01-22 1997-11-04 Ontario Cancer Institute Mutant mouse having a disrupted TNFRp55

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417563A2 (en) * 1989-09-12 1991-03-20 F. Hoffmann-La Roche Ag TNF-binding proteins
WO1994006476A1 (en) * 1992-09-15 1994-03-31 Immunex Corporation Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
US5684222A (en) * 1993-01-22 1997-11-04 Ontario Cancer Institute Mutant mouse having a disrupted TNFRp55
EP0619372A1 (en) * 1993-03-29 1994-10-12 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Tumor necrosis factor muteins
WO1996003141A1 (en) * 1994-07-22 1996-02-08 F. Hoffmann-La Roche Ag Pharmaceutical compositions comprising a chimaeric tnf binding protein
WO1996039488A1 (en) * 1995-06-06 1996-12-12 Genentech, Inc. Process for controlling sialylation of proteins produced by mammalian cell culture
WO1997022364A1 (en) * 1995-12-18 1997-06-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem FCε-PE CHIMERIC PROTEIN FOR TARGETED TREATMENT OF ALLERGY RESPONSES, A METHOD FOR ITS PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
AM. J. RESPIR. CELL MOL. BIOL. (1996), 14(5), 454-460 CODEN: AJRBEL;ISSN: 1044-1549, 1996 *
CHEMICAL ABSTRACTS, vol. 125, no. 1, 1 July 1996, Columbus, Ohio, US; abstract no. 8022, GATER, PAUL R. ET AL: "Inhibition of Sephadex-induced lung injury in the rat by Ro 45-2081, a tumor necrosis factor receptor fusion protein" XP002051460 *
CHEMICAL ABSTRACTS, vol. 125, no. 11, 9 September 1996, Columbus, Ohio, US; abstract no. 140442, RENZETTI, LOUIS M. ET AL: "Pharmacological evidence for tumor necrosis factor as a mediator of allergic inflammation in the airways" XP002051459 *
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; RENZETTI L M ET AL: "Ro 45-2081, a TNF receptor fusion protein, prevents inflammatory responses in the airways.", XP002051462 *
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; RENZETTI L M ET AL: "Tumor necrosis factor ( TNF ) blockade with shTNFR-IgG1 inhibits allergic airway inflammation in mice without altering the Th1-Th2 cytokine profile.", XP002051461 *
DATABASE EMBASE ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; XP002051463 *
INFLAMMATION RESEARCH 46 (SUPPL. 2). 1997. S143-S144. ISSN: 1023-3830 *
J. PHARMACOL. EXP. THER. (1996), 278(2), 847-853 CODEN: JPETAB;ISSN: 0022-3565, 1996 *
JOINT MEETING OF THE AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AND THE CLINICAL IMMUNOLOGY SOCIETY, SAN FRANCISCO, CALIFORNIA, USA, FEBRUARY 21-26, 1997. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 9 *
MACARI, DAVID M. T. ET AL: "Priming of eosinophil recruitment in vivo by LPS pretreatment", J. IMMUNOL. (1996), 157(4), 1684-1692 CODEN: JOIMA3;ISSN: 0022-1767, 1996, XP002051457 *
P.R. GATER ET AL.: "Ro 45-2081, a TNF receptor fusion protein, prevents inflammatory responses in the airways.", AGENTS AND ACTIONS SUPPLEMENTS, vol. 49, 1997, pages 67 - 71, XP008059759 *
RENZETTI L ET AL: "Attenuation of allergic airway inflammation using Ro 45-2081, a TNFR -IgG1 fusion protein.", EXPERIMENTAL BIOLOGY 95, PART II, ATLANTA, GEORGIA, USA, APRIL 9-13, 1995. FASEB JOURNAL ISSN: 0892-6638, vol. 9, no. 4, 10 March 1995 (1995-03-10), pages A684, XP002051458 *

Also Published As

Publication number Publication date
BR9708928A (en) 2000-05-09
MA24169A1 (en) 1997-12-31
PE70698A1 (en) 1998-11-18
CO4820397A1 (en) 1999-07-28
KR20000010825A (en) 2000-02-25
EP0910413A2 (en) 1999-04-28
CN1233189A (en) 1999-10-27
AR007020A1 (en) 1999-10-13
TR199802238T2 (en) 1999-02-22
HRP970224A2 (en) 1998-04-30
AU2776497A (en) 1997-11-26
ZA973843B (en) 1997-11-10
AU725408B2 (en) 2000-10-12
WO1997041895A2 (en) 1997-11-13
JP2000510113A (en) 2000-08-08
CA2253557A1 (en) 1997-11-13

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