WO1997036996A2 - Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom - Google Patents
Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom Download PDFInfo
- Publication number
- WO1997036996A2 WO1997036996A2 PCT/EP1997/001446 EP9701446W WO9736996A2 WO 1997036996 A2 WO1997036996 A2 WO 1997036996A2 EP 9701446 W EP9701446 W EP 9701446W WO 9736996 A2 WO9736996 A2 WO 9736996A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biomass
- process according
- compound
- dry matter
- dried
- Prior art date
Links
- 239000002028 Biomass Substances 0.000 title claims abstract description 222
- 238000000034 method Methods 0.000 title claims abstract description 121
- 230000008569 process Effects 0.000 title claims abstract description 89
- 150000001875 compounds Chemical class 0.000 title claims abstract description 83
- 230000000813 microbial effect Effects 0.000 title claims abstract description 25
- 238000002955 isolation Methods 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims description 5
- 239000008187 granular material Substances 0.000 claims abstract description 91
- 238000001035 drying Methods 0.000 claims abstract description 69
- 238000001125 extrusion Methods 0.000 claims abstract description 47
- 238000005469 granulation Methods 0.000 claims abstract description 21
- 230000003179 granulation Effects 0.000 claims abstract description 21
- 239000002245 particle Substances 0.000 claims description 78
- 244000005700 microbiome Species 0.000 claims description 38
- 238000000855 fermentation Methods 0.000 claims description 28
- 230000004151 fermentation Effects 0.000 claims description 28
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 25
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 19
- 150000002632 lipids Chemical class 0.000 claims description 19
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 17
- 241000233866 Fungi Species 0.000 claims description 15
- SGTYQWGEVAMVKB-NXCFDTQHSA-N [(2s,3s,4r)-2-acetamido-3,4-diacetyloxyoctadecyl] acetate Chemical compound CCCCCCCCCCCCCC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](NC(C)=O)COC(C)=O SGTYQWGEVAMVKB-NXCFDTQHSA-N 0.000 claims description 13
- 241000195493 Cryptophyta Species 0.000 claims description 11
- 241000235575 Mortierella Species 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 9
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims description 9
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims description 9
- 229960004844 lovastatin Drugs 0.000 claims description 9
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 9
- 238000000926 separation method Methods 0.000 claims description 9
- 235000021342 arachidonic acid Nutrition 0.000 claims description 8
- 229940114079 arachidonic acid Drugs 0.000 claims description 8
- 241000907999 Mortierella alpina Species 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 6
- 230000020477 pH reduction Effects 0.000 claims description 6
- 241000199912 Crypthecodinium cohnii Species 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
- 235000013350 formula milk Nutrition 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims description 4
- 241000235388 Mucorales Species 0.000 claims description 4
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 4
- 235000021466 carotenoid Nutrition 0.000 claims description 4
- 150000001747 carotenoids Chemical class 0.000 claims description 4
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 4
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 4
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 4
- 241000228212 Aspergillus Species 0.000 claims description 3
- 241000235548 Blakeslea Species 0.000 claims description 3
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims description 3
- 238000004898 kneading Methods 0.000 claims description 3
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 3
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims description 2
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims description 2
- VGMFHMLQOYWYHN-UHFFFAOYSA-N Compactin Natural products OCC1OC(OC2C(O)C(O)C(CO)OC2Oc3cc(O)c4C(=O)C(=COc4c3)c5ccc(O)c(O)c5)C(O)C(O)C1O VGMFHMLQOYWYHN-UHFFFAOYSA-N 0.000 claims description 2
- 241000199914 Dinophyceae Species 0.000 claims description 2
- 241000235400 Phycomyces Species 0.000 claims description 2
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims description 2
- AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 claims description 2
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims description 2
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 claims description 2
- BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 229960002965 pravastatin Drugs 0.000 claims description 2
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims description 2
- 239000011343 solid material Substances 0.000 claims description 2
- 238000000638 solvent extraction Methods 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 238000000605 extraction Methods 0.000 abstract description 95
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 90
- 235000010633 broth Nutrition 0.000 description 58
- 239000002904 solvent Substances 0.000 description 40
- 239000003921 oil Substances 0.000 description 34
- 235000019198 oils Nutrition 0.000 description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 31
- 239000000463 material Substances 0.000 description 19
- 238000001914 filtration Methods 0.000 description 16
- 238000005325 percolation Methods 0.000 description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
- 238000005054 agglomeration Methods 0.000 description 15
- 230000002776 aggregation Effects 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 15
- 239000012065 filter cake Substances 0.000 description 15
- 239000012530 fluid Substances 0.000 description 15
- 238000009928 pasteurization Methods 0.000 description 15
- 239000000047 product Substances 0.000 description 15
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 13
- 239000000843 powder Substances 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 12
- 238000001694 spray drying Methods 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000007921 spray Substances 0.000 description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- 230000003647 oxidation Effects 0.000 description 9
- 238000007254 oxidation reaction Methods 0.000 description 9
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 8
- 230000015556 catabolic process Effects 0.000 description 8
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 8
- 238000006731 degradation reaction Methods 0.000 description 8
- 239000012528 membrane Substances 0.000 description 8
- 239000011715 vitamin B12 Substances 0.000 description 8
- 229930003779 Vitamin B12 Natural products 0.000 description 7
- 230000008901 benefit Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 235000019163 vitamin B12 Nutrition 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 238000003801 milling Methods 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 239000002002 slurry Substances 0.000 description 6
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 5
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 5
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 5
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 5
- 239000000428 dust Substances 0.000 description 5
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 5
- 238000001704 evaporation Methods 0.000 description 5
- 230000008020 evaporation Effects 0.000 description 5
- 239000004744 fabric Substances 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 229930001119 polyketide Natural products 0.000 description 5
- 241000235553 Blakeslea trispora Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 240000008042 Zea mays Species 0.000 description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 4
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 4
- 235000013734 beta-carotene Nutrition 0.000 description 4
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 4
- 239000011648 beta-carotene Substances 0.000 description 4
- 229960002747 betacarotene Drugs 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 229940090949 docosahexaenoic acid Drugs 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 150000002634 lipophilic molecules Chemical class 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- 125000000830 polyketide group Chemical group 0.000 description 4
- -1 vitamin B12) Natural products 0.000 description 4
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- 241000944206 Celtis trinervia Species 0.000 description 3
- 241000207199 Citrus Species 0.000 description 3
- 241000199913 Crypthecodinium Species 0.000 description 3
- 244000292604 Salvia columbariae Species 0.000 description 3
- 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 description 3
- 235000001498 Salvia hispanica Nutrition 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 241001276012 Wickerhamomyces ciferrii Species 0.000 description 3
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 235000014167 chia Nutrition 0.000 description 3
- 235000020971 citrus fruits Nutrition 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 3
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 3
- 235000009973 maize Nutrition 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- ZNBNBTIDJSKEAM-NISBWGIBSA-N (2s,3r,4r)-4-[(2s,5r,7s,8r,9s)-7-hydroxy-2-[(2r,5s)-5-[(2r,3s,5r)-5-[(2s,3s,5r,6r)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-2-methyl-3-propanoyloxypentanoic a Chemical compound C1[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC(=O)CC)[C@H](C)C(O)=O)O[C@]11O[C@](C)([C@@H]2O[C@@](C)(CC2)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)CC1 ZNBNBTIDJSKEAM-NISBWGIBSA-N 0.000 description 2
- 241001474374 Blennius Species 0.000 description 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
- 229930105110 Cyclosporin A Natural products 0.000 description 2
- 108010036949 Cyclosporine Proteins 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- RWWSBGHRGAQGJE-UHFFFAOYSA-N Laidlomycin Natural products CC(C(CCC(=O)O)C(C)C(=O)O)C1OC2(CCC(C)(O2)C3CCC(C)(O3)C4OC(CC4C)C5OC(O)(CO)C(C)CC5C)CC(O)C1C RWWSBGHRGAQGJE-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- 241000235648 Pichia Species 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229960001265 ciclosporin Drugs 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000010779 crude oil Substances 0.000 description 2
- 229930182912 cyclosporin Natural products 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 229940098330 gamma linoleic acid Drugs 0.000 description 2
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 2
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 229960004561 laidlomycin Drugs 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 238000003828 vacuum filtration Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 description 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 241001465318 Aspergillus terreus Species 0.000 description 1
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 1
- 235000007319 Avena orientalis Nutrition 0.000 description 1
- 244000075850 Avena orientalis Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010011416 Croup infectious Diseases 0.000 description 1
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241001480508 Entomophthora Species 0.000 description 1
- 244000024675 Eruca sativa Species 0.000 description 1
- 235000014755 Eruca sativa Nutrition 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- 241000081271 Phaffia rhodozyma Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000186429 Propionibacterium Species 0.000 description 1
- 241000233639 Pythium Species 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 1
- 238000010793 Steam injection (oil industry) Methods 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 241000187747 Streptomyces Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 235000013793 astaxanthin Nutrition 0.000 description 1
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 1
- 239000001168 astaxanthin Substances 0.000 description 1
- 229940022405 astaxanthin Drugs 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000002599 biostatic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011118 depth filtration Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000008394 flocculating agent Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000013586 microbial product Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 238000011020 pilot scale process Methods 0.000 description 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000002459 polyene antibiotic agent Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 150000003881 polyketide derivatives Chemical class 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001174 sulfone group Chemical group 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 125000005457 triglyceride group Chemical group 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 238000007738 vacuum evaporation Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/02—Pretreatment
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/005—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor after treatment of microbial biomass not covered by C12N1/02 - C12N1/08
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/42—Cobalamins, i.e. vitamin B12, LLD factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Virology (AREA)
- Animal Husbandry (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT97916373T ATE249514T1 (en) | 1996-03-28 | 1997-03-21 | METHOD FOR PRODUCING GRANULAR MICROBIAL BIOMASS AND OBTAINING VALUABLE COMPONENTS FROM MICROBIAL BIOMASS |
DE69724782.1T DE69724782T3 (en) | 1996-03-28 | 1997-03-21 | Process for producing granular microbial biomass and obtaining valuable components from microbial biomass |
DK97916373.0T DK0906414T4 (en) | 1996-03-28 | 1997-03-21 | PROCESS FOR THE PREPARATION OF A granular MICROBIAL BIOMASS AND ISOLATION OF VALUABLE COMPOUNDS THENCE |
CN971942110A CN1226923B (en) | 1996-03-28 | 1997-03-21 | Process for preparing granular microbial biomass and isolation of valuable compounds therefrom |
ES97916373.0T ES2205202T5 (en) | 1996-03-28 | 1997-03-21 | Procedure for the preparation of a granular microbial biomass and isolation of valuable compounds contained in it |
AU25050/97A AU733734B2 (en) | 1996-03-28 | 1997-03-21 | Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom |
CA002250575A CA2250575C (en) | 1996-03-28 | 1997-03-21 | Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom |
EP97916373.0A EP0906414B2 (en) | 1996-03-28 | 1997-03-21 | Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom |
JP53488297A JP4545235B2 (en) | 1996-03-28 | 1997-03-21 | Process for producing granular microbial biomass and isolation of valuable compounds from the biomass |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96200837 | 1996-03-28 | ||
EP96200837.1 | 1996-03-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997036996A2 true WO1997036996A2 (en) | 1997-10-09 |
WO1997036996A3 WO1997036996A3 (en) | 1998-01-22 |
Family
ID=8223823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/001446 WO1997036996A2 (en) | 1996-03-28 | 1997-03-21 | Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom |
Country Status (14)
Country | Link |
---|---|
EP (3) | EP1369474A1 (en) |
JP (5) | JP4545235B2 (en) |
CN (6) | CN1715394A (en) |
AR (1) | AR006424A1 (en) |
AT (1) | ATE249514T1 (en) |
AU (1) | AU733734B2 (en) |
CA (2) | CA2250575C (en) |
CL (1) | CL1997000593A1 (en) |
DE (1) | DE69724782T3 (en) |
DK (1) | DK0906414T4 (en) |
ES (1) | ES2205202T5 (en) |
ID (1) | ID16503A (en) |
WO (1) | WO1997036996A2 (en) |
ZA (1) | ZA972706B (en) |
Cited By (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0960943A1 (en) * | 1996-12-27 | 1999-12-01 | Suntory Limited | Media for culturing microorganisms and process for producing unsaturated fatty acids or lipids containing the same |
WO1999065327A1 (en) * | 1998-06-17 | 1999-12-23 | Dsm N.V. | Microbial arachidonic acid (ara) for use in marine feed |
WO2000001839A1 (en) * | 1998-07-03 | 2000-01-13 | Cosmoferm B.V. | Improved microbial strains producing sphingoid bases |
EP0986960A1 (en) * | 1998-09-15 | 2000-03-22 | Dsm N.V. | Mucorales fungi for use in preparation of textured products for foodstuffs |
EP0990694A1 (en) * | 1997-06-11 | 2000-04-05 | Idemitsu Petrochemical Co., Ltd. | Method for extracting fat-soluble components from microbial cells |
WO2000046175A1 (en) * | 1999-02-03 | 2000-08-10 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
US6238714B1 (en) * | 1999-05-05 | 2001-05-29 | Degussa-Huls Ag | Feedstuff additive which contains D-pantothenic acid and/or its salts and a process for the preparation thereof |
EP1133926A1 (en) * | 2000-03-17 | 2001-09-19 | Dsm N.V. | Foodstuffs containing mucorales fungi |
US6319528B1 (en) * | 1999-05-05 | 2001-11-20 | Degussa Aktiengesellschaft | Feedstuff additive which contains D-pantothenic acid and/or its salts and a process for the preparation thereof |
WO2002006203A1 (en) * | 2000-07-14 | 2002-01-24 | Dsm N.V. | Process for the recovery of shikimic acid |
EP1178103A1 (en) * | 2000-08-02 | 2002-02-06 | Dsm N.V. | Purifying crude pufa oils |
US6368644B1 (en) * | 2000-07-04 | 2002-04-09 | Degussa Ag | Pourable feed additives containing D-pantothenic acid and/or salts thereof, and process for their preparation |
WO2002089604A2 (en) * | 2001-05-04 | 2002-11-14 | Marlow Foods Limited | Edible fungi ingredient |
WO2003034816A1 (en) | 2001-10-19 | 2003-05-01 | Dsm Ip Assets B.V. | Pufas in eggs |
US6682913B1 (en) | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
EP1513922A1 (en) | 2002-06-19 | 2005-03-16 | DSM IP Assets B.V. | Pasteurisation process for microbial cells and microbial oil |
WO2006069668A1 (en) * | 2004-12-23 | 2006-07-06 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Method for producing a raw oil from mixtures of micro-organisms and plants, oil produced according to said method and specific uses of the thus produced oil and, optionally, additional refined oil |
WO2006136539A1 (en) * | 2005-06-23 | 2006-12-28 | Dsm Ip Assets B.V. | Process for obtaining lipid from cells |
WO2006085672A3 (en) * | 2005-02-08 | 2007-04-26 | Suntory Ltd | Production of polyunsaturated fatty acids using novel cell treatment method |
EP1803451A1 (en) | 1998-10-15 | 2007-07-04 | DSMIP Assets B.V. | Pufa supplements |
CN1328369C (en) * | 1999-02-03 | 2007-07-25 | 药物研究所有限公司 | Preparing pravastatin |
EP1903883A2 (en) * | 2005-07-01 | 2008-04-02 | Martek Biosciences Corporation | Polyunsaturated fatty acid-containing oil product and uses and production thereof |
US7431952B2 (en) * | 2000-08-02 | 2008-10-07 | Dsm Ip Assets B.V. | Isolation of microbial oils |
EP1194583B1 (en) * | 1999-07-14 | 2009-02-11 | The University of Hull | Culture of microorganisms for the synthesis of a polyunsatured fatty acid |
US7635492B2 (en) | 2001-05-04 | 2009-12-22 | Marlow Foods Limited | Edible fungi |
EP2239028A1 (en) * | 2001-12-12 | 2010-10-13 | Martek Biosciences Corporation | Extraction and Winterization of Lipids From Oilseed and Microbial Sources |
US8039030B2 (en) | 2005-07-01 | 2011-10-18 | Martek Biosciences Corporation | Microwaveable popcorn and methods of making |
EP2418214A1 (en) | 2006-12-22 | 2012-02-15 | Novozymes A/S | Use of polypeptides against diseases caused by protozoans |
US8241868B2 (en) | 2005-02-08 | 2012-08-14 | Nippon Suisan Kaisha, Ltd. | Production of polyunsaturated fatty acids using cell treatment method |
US8703172B2 (en) | 2003-01-20 | 2014-04-22 | Nederlandse Organizatie voor Toegepastnatuurwetenschappelijk Onderzoek TNO | Sphingolipids for improvement of the composition of the intestinal flora |
WO2014122092A1 (en) | 2013-02-05 | 2014-08-14 | Evonik Industries Ag | Improving the bioavailability of useful materials from microorganisms |
WO2014122087A1 (en) | 2013-02-05 | 2014-08-14 | Evonik Industries Ag | Improving the bioavailability of useful materials from microorganisms by means of a rotor-stator system for cell disruption |
WO2015082688A1 (en) * | 2013-12-06 | 2015-06-11 | Dsm Ip Assets B.V. | Biomass formulation |
WO2015091851A1 (en) * | 2013-12-20 | 2015-06-25 | Xellia Pharmaceuticals Aps | Process for the preparation of tiacumicin |
US20150218484A1 (en) * | 2011-02-11 | 2015-08-06 | E I Du Pont De Nemours And Company | Method for obtaining a lipid-containing composition from microbial biomass |
WO2016050552A1 (en) | 2014-10-02 | 2016-04-07 | Evonik Degussa Gmbh | Process for producing a pufa-containing biomass which has high cell stability |
EP2285823B1 (en) | 2008-06-09 | 2016-04-27 | Danisco US Inc. | Recovery of insoluble enzyme from fermentation broth and formulation of insoluble enzyme |
WO2017006031A1 (en) * | 2015-07-08 | 2017-01-12 | Institut National De La Recherche Agronomique | Method for producing fatty acids from microorganisms |
WO2017105231A1 (en) * | 2015-12-16 | 2017-06-22 | Ibema Biezenmortel B.V. | Dried protozoa compositions and methods of obtaining such |
US9745538B2 (en) | 2013-12-20 | 2017-08-29 | MARA Renewables Corporation | Methods of recovering oil from microorganisms |
US20170298318A1 (en) * | 2014-10-02 | 2017-10-19 | Evonik Degussa Gmbh | Method for producing a granular biomass which contains an oxidation-sensitive valuable substance |
WO2018011286A1 (en) | 2016-07-13 | 2018-01-18 | Evonik Degussa Gmbh | Method of separating lipids from a lysed lipids containing biomass |
WO2018011275A1 (en) | 2016-07-13 | 2018-01-18 | Evonik Degussa Gmbh | Method for isolating lipids from lipid-containing cells |
WO2018122057A1 (en) | 2016-12-27 | 2018-07-05 | Evonik Degussa Gmbh | Method of isolating lipids from a lipids containing biomass |
WO2019034354A1 (en) | 2017-08-17 | 2019-02-21 | Evonik Degussa Gmbh | Enhanced production of lipids by limitation of at least two limiting nutrient sources |
WO2019048327A1 (en) | 2017-09-05 | 2019-03-14 | Evonik Degussa Gmbh | Method of separating lipids from a lysed lipids containing biomass |
EP3470502A1 (en) | 2017-10-13 | 2019-04-17 | Evonik Degussa GmbH | Method of separating lipids from a lysed lipids containing biomass |
WO2019121752A1 (en) | 2017-12-20 | 2019-06-27 | Evonik Degussa Gmbh | Method of isolating lipids from a lipids containing biomass |
WO2019122030A1 (en) | 2017-12-22 | 2019-06-27 | Dsm Ip Assets B.V. | Method of separating lipids from a lysed lipids containing biomass |
US10342772B2 (en) | 2013-12-20 | 2019-07-09 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
US10364207B2 (en) | 2013-12-20 | 2019-07-30 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
EP3527664A1 (en) | 2018-02-15 | 2019-08-21 | Evonik Degussa GmbH | Method of isolating lipids from a lipids containing biomass |
US10392578B2 (en) | 2010-06-01 | 2019-08-27 | Dsm Ip Assets B.V. | Extraction of lipid from cells and products therefrom |
WO2019185938A2 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted chroman-6-ols with extended lipophilic side chains |
WO2019185940A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Use of twin-chromanols as antioxidants |
WO2019185888A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of tocopherols |
WO2019185910A2 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted 2h-chromens and their derivatives |
WO2019185941A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted chroman-6-ols with extended lipophilic side chains |
WO2019185904A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Chroman-6-ols with an extended lipophilic side chain in position 2, their manufacture and use |
WO2019185894A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted chroman-6-ols |
WO2019185891A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted chroman-6-ols |
WO2019185939A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Use of twin-chromanols as antioxidants in oil |
WO2019185889A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of carnosic acid |
WO2019185898A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted 2h-chromens and their derivatives |
WO2019185942A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Use of tocotrienols as antioxidants |
US10472316B2 (en) | 2013-12-20 | 2019-11-12 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
WO2019219443A1 (en) | 2018-05-15 | 2019-11-21 | Evonik Operations Gmbh | Method of isolating lipids from a lipids containing biomass with aid of hydrophobic silica |
WO2019219396A1 (en) | 2018-05-15 | 2019-11-21 | Evonik Operations Gmbh | Method of isolating lipids from a lysed lipids containing biomass by emulsion inversion |
US10531679B2 (en) | 2013-07-16 | 2020-01-14 | Evonik Degussa, GmbH | Method for drying biomass |
US10619175B2 (en) | 2014-10-02 | 2020-04-14 | Evonik Operations Gmbh | Process for producing a PUFA-containing feedstuff by extruding a PUFA-containing biomass |
WO2020094750A1 (en) | 2018-11-09 | 2020-05-14 | Evonik Operations Gmbh | Method for producing a biomass with an increased content of polyunsaturated fatty acids |
WO2020094751A1 (en) | 2018-11-09 | 2020-05-14 | Evonik Operations Gmbh | Method for producing a biomass which can be easily broken down and which has an increased content of polyunsaturated fatty acids |
WO2021019101A1 (en) * | 2019-08-01 | 2021-02-04 | Dsm Ip Assets B.V. | Beta-carotene fermentation method |
EP3562925B1 (en) * | 2016-12-27 | 2021-03-10 | Evonik Operations GmbH | Method of isolating lipids from a lipids containing biomass |
US11001782B2 (en) | 2013-12-20 | 2021-05-11 | Dsm Nutritional Products Ag | Methods of recovering oil from microorganisms |
US11124736B2 (en) | 2013-12-20 | 2021-09-21 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
WO2021254863A1 (en) | 2020-06-18 | 2021-12-23 | Evonik Operations Gmbh | Method of isolating lipids from a lipids containing biomass |
US11324234B2 (en) | 2014-10-02 | 2022-05-10 | Evonik Operations Gmbh | Method for raising animals |
US11464244B2 (en) | 2014-10-02 | 2022-10-11 | Evonik Operations Gmbh | Feedstuff of high abrasion resistance and good stability in water, containing PUFAs |
US11814665B2 (en) | 2017-08-17 | 2023-11-14 | Evonik Operations Gmbh | Enhanced production of lipids by limitation of at least two limiting nutrient sources |
WO2024052504A1 (en) * | 2022-09-09 | 2024-03-14 | The Protein Brewery B.V. | Granulate comprisig particles of fungal biomass |
US11946017B2 (en) | 2016-07-13 | 2024-04-02 | Evonik Operations Gmbh | Method of separating lipids from a lysed lipids containing biomass |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0906414T4 (en) * | 1996-03-28 | 2015-11-16 | Dsm Ip Assets Bv | PROCESS FOR THE PREPARATION OF A granular MICROBIAL BIOMASS AND ISOLATION OF VALUABLE COMPOUNDS THENCE |
US6338866B1 (en) * | 2000-02-15 | 2002-01-15 | Applied Food Biotechnology, Inc. | Pet foods using algal or fungal waste containing fatty acids |
KR101569013B1 (en) * | 2009-02-16 | 2015-11-16 | 삼성전자주식회사 | Method for Pretreating and Saccharifying Marine Algae Biomass |
WO2010104922A1 (en) * | 2009-03-10 | 2010-09-16 | Srs Energy | Algae biomass fractionation |
EP3622828B1 (en) * | 2009-04-14 | 2022-11-16 | Corbion Biotech, Inc. | Novel microalgal food compositions |
WO2011073427A1 (en) | 2009-12-17 | 2011-06-23 | Shell Internationale Research Maatschappij B.V. | Process for producing hydrocarbons from microbial lipids |
TWI411677B (en) * | 2009-12-21 | 2013-10-11 | Ind Tech Res Inst | Apparatus for continuous extraction of microalgae, methods of continuous extraction, drying and disruption |
CA2794854A1 (en) * | 2010-04-06 | 2011-10-13 | Heliae Development, Llc | Methods of and systems for producing biofuels |
US20120329138A1 (en) * | 2010-12-23 | 2012-12-27 | Shell Oil Company | Process for separation of a mixture containing a microbial substance and a liquid |
EP2675906A1 (en) * | 2011-02-16 | 2013-12-25 | Solix Biosystems, Inc. | Compositions and methods for leach extraction of microorganisms |
AU2012240608A1 (en) * | 2011-04-06 | 2013-09-19 | Heliae Development, Llc | Methods of producing biofuels, chlorophylls and carotenoids |
CN106977394A (en) * | 2016-12-01 | 2017-07-25 | 烟台固特丽生物科技股份有限公司 | A kind of technique of the low colourity arachidonic acid oil of rapid extraction |
AU2018225557A1 (en) * | 2017-02-22 | 2019-09-19 | Cargill, Incorporated | Purification of DHA containing oils |
MX2022011034A (en) * | 2020-03-06 | 2022-10-13 | The Protein Brewery B V | Pasteurisation of microbial biomass suitable for food applications. |
KR20230100375A (en) * | 2021-12-28 | 2023-07-05 | 씨제이제일제당 (주) | Method for producing biomass granule with improved flowability |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1923529A1 (en) * | 1968-05-29 | 1969-12-04 | Ingtech Zentralbuero Veb | Purification of fermentation products |
FR2210662A1 (en) * | 1972-12-19 | 1974-07-12 | British Petroleum Co | |
GB1466853A (en) * | 1973-05-22 | 1977-03-09 | Simon Rosedowns Ltd | Extraction |
US4056638A (en) * | 1975-06-16 | 1977-11-01 | E. I. Du Pont De Nemours And Company | Dielectric drying of fungal material and resultant textured product |
DD150627A1 (en) * | 1980-05-07 | 1981-09-09 | Klaus Triems | PROCESS FOR OBTAINING AND SOLVENT EXTRACTION OF SOLIDS |
EP0322227A2 (en) * | 1987-12-21 | 1989-06-28 | Suntory Limited | Process for production of bishomo-gamma-linolenic acid |
WO1991011918A1 (en) * | 1990-02-13 | 1991-08-22 | Martek Corporation | Docosahexaenoic acid, methods for its production and compounds containing the same |
WO1992012711A1 (en) * | 1991-01-24 | 1992-08-06 | Martek Corporation | Microbial oil mixtures and uses thereof |
WO1993020183A1 (en) * | 1992-03-27 | 1993-10-14 | Universal Foods Corporation | Method for producing beta-carotene using a fungal mated culture |
WO1994029292A1 (en) * | 1993-06-08 | 1994-12-22 | Krka Tovarna Zdravil P.O. | Process for the isolation of lovastatin |
EP0688871A2 (en) * | 1994-06-24 | 1995-12-27 | Quest International B.V. | Preparation of phytosphingosine derivative |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB882634A (en) † | 1958-05-09 | 1961-11-15 | Rose Downs & Thompson Ltd | An improved process for the preparation of vegetable matter for solvent extraction |
US3297731A (en) † | 1963-05-06 | 1967-01-10 | Ralston Purina Co | Method of pelletizing and extracting oils from oleaginous comminuted matter |
US3958027A (en) | 1974-06-14 | 1976-05-18 | Simon-Rosedowns Limited | Extraction |
US4277733A (en) † | 1979-03-05 | 1981-07-07 | Westinghouse Electric Corp. | Slip recovery system for wound rotor motor |
DE3161370D1 (en) † | 1980-08-13 | 1983-12-15 | Ici Plc | Extraction of poly(beta-hydroxy butyric acid) |
EP0155420B1 (en) * | 1984-02-09 | 1988-03-23 | The Agency of Industrial Science and Technology | A method for the preparation of a fungal body and a lipid rich in gamma-linolenic acid therefrom |
GB8413837D0 (en) † | 1984-05-31 | 1984-07-04 | Simon Rosedowns Ltd | Preparing vegetable oil seed meal |
DE3587044T2 (en) † | 1985-01-22 | 1993-06-03 | Agency Ind Science Techn | METHOD FOR PRODUCING LIPIDS FROM FUNGUS MATERIALS. |
EP0202409A3 (en) † | 1985-03-25 | 1989-02-01 | Miles Inc. | A process for the production of viable and stable dry microorganisms for food and agricultural purposes |
CN1033205C (en) * | 1985-10-19 | 1996-11-06 | 日清制油株式会社 | Method for producing feed for fry |
FR2599597B1 (en) † | 1986-06-10 | 1990-04-27 | Croix Fils Ets | PROCESS AND PLANT FOR OBTAINING FOOD FLOUR FROM OIL SEEDS |
DK199887D0 (en) * | 1987-04-15 | 1987-04-15 | Danisco Bioteknologi As | yeast strain |
JPS6438007A (en) * | 1987-04-28 | 1989-02-08 | Lion Corp | Skin external preparation |
US5340594A (en) † | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Food product having high concentrations of omega-3 highly unsaturated fatty acids |
JP2664452B2 (en) * | 1988-12-23 | 1997-10-15 | サントリー株式会社 | Fish and shellfish feed |
JPH0423979A (en) * | 1990-05-18 | 1992-01-28 | Kobe Steel Ltd | Methane-producing bacterium and production of vitamin b12 using same bacterium |
FR2674865A1 (en) * | 1991-04-02 | 1992-10-09 | Bioprox Ste Angevine Biotechno | Process for the preparation of a liquid concentrate of lactic acid, concentrate obtained and its use in the food industry |
GB9111900D0 (en) * | 1991-06-03 | 1991-07-24 | Efamol Holdings | Fatty acid compositions |
DE69210892T2 (en) * | 1991-07-11 | 1996-10-02 | Idemitsu Petrochemical Co | Dry cell fragments containing triglycerides and process for their preparation |
JPH05123114A (en) * | 1991-11-08 | 1993-05-21 | Taiyo Fishery Co Ltd | Feed for fishes |
DE4219360C2 (en) † | 1992-06-12 | 1994-07-28 | Milupa Ag | Process for the production of lipids with a high proportion of long-chain, highly unsaturated fatty acids |
CA2121986A1 (en) * | 1993-04-26 | 1994-10-27 | Daizo Takeuchi | Processes for culturing marine microalgae and producing docosahexaenoic acid using the same |
JPH078215A (en) * | 1993-04-30 | 1995-01-13 | Kawasaki Steel Corp | Marine microalgal food raw material containing docosahexaenoic acid and its production |
JPH0775556A (en) * | 1993-09-09 | 1995-03-20 | Nisshin Oil Mills Ltd:The | Culture of alga containing docosahexaenoic acid |
JPH07252493A (en) * | 1994-03-16 | 1995-10-03 | Kawasaki Steel Corp | Method for separating and purifying docosahexaenoic ester from marine fine algae |
US6582941B1 (en) | 1995-04-17 | 2003-06-24 | Japan As Represented By Director-General Of Agency Of Industrial Science And Technology | Microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms |
DK0906414T4 (en) * | 1996-03-28 | 2015-11-16 | Dsm Ip Assets Bv | PROCESS FOR THE PREPARATION OF A granular MICROBIAL BIOMASS AND ISOLATION OF VALUABLE COMPOUNDS THENCE |
-
1997
- 1997-03-21 DK DK97916373.0T patent/DK0906414T4/en active
- 1997-03-21 EP EP03019664A patent/EP1369474A1/en not_active Withdrawn
- 1997-03-21 CA CA002250575A patent/CA2250575C/en not_active Expired - Lifetime
- 1997-03-21 CN CNA2005100688807A patent/CN1715394A/en active Pending
- 1997-03-21 EP EP97916373.0A patent/EP0906414B2/en not_active Expired - Lifetime
- 1997-03-21 CN CN2010102216036A patent/CN101928213B/en not_active Expired - Lifetime
- 1997-03-21 AT AT97916373T patent/ATE249514T1/en not_active IP Right Cessation
- 1997-03-21 AU AU25050/97A patent/AU733734B2/en not_active Expired
- 1997-03-21 WO PCT/EP1997/001446 patent/WO1997036996A2/en active IP Right Grant
- 1997-03-21 CN CN201410226142.XA patent/CN104017734A/en active Pending
- 1997-03-21 CN CN2011101381083A patent/CN102304036A/en active Pending
- 1997-03-21 CN CN2011101381045A patent/CN102351678A/en active Pending
- 1997-03-21 EP EP10174938A patent/EP2264142A3/en not_active Withdrawn
- 1997-03-21 JP JP53488297A patent/JP4545235B2/en not_active Expired - Lifetime
- 1997-03-21 DE DE69724782.1T patent/DE69724782T3/en not_active Expired - Lifetime
- 1997-03-21 CA CA002579516A patent/CA2579516A1/en not_active Expired - Lifetime
- 1997-03-21 ES ES97916373.0T patent/ES2205202T5/en not_active Expired - Lifetime
- 1997-03-21 CN CN971942110A patent/CN1226923B/en not_active Expired - Lifetime
- 1997-03-26 AR ARP970101240A patent/AR006424A1/en unknown
- 1997-03-27 ZA ZA9702706A patent/ZA972706B/en unknown
- 1997-03-27 CL CL1997000593A patent/CL1997000593A1/en unknown
- 1997-03-27 ID IDP971051A patent/ID16503A/en unknown
-
2007
- 2007-10-24 JP JP2007276642A patent/JP4958729B2/en not_active Expired - Lifetime
-
2009
- 2009-12-11 JP JP2009281790A patent/JP2010099075A/en active Pending
-
2010
- 2010-09-27 JP JP2010215028A patent/JP2011004765A/en active Pending
-
2013
- 2013-09-11 JP JP2013188180A patent/JP2013252148A/en not_active Ceased
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1923529A1 (en) * | 1968-05-29 | 1969-12-04 | Ingtech Zentralbuero Veb | Purification of fermentation products |
FR2210662A1 (en) * | 1972-12-19 | 1974-07-12 | British Petroleum Co | |
GB1466853A (en) * | 1973-05-22 | 1977-03-09 | Simon Rosedowns Ltd | Extraction |
US4056638A (en) * | 1975-06-16 | 1977-11-01 | E. I. Du Pont De Nemours And Company | Dielectric drying of fungal material and resultant textured product |
DD150627A1 (en) * | 1980-05-07 | 1981-09-09 | Klaus Triems | PROCESS FOR OBTAINING AND SOLVENT EXTRACTION OF SOLIDS |
EP0322227A2 (en) * | 1987-12-21 | 1989-06-28 | Suntory Limited | Process for production of bishomo-gamma-linolenic acid |
WO1991011918A1 (en) * | 1990-02-13 | 1991-08-22 | Martek Corporation | Docosahexaenoic acid, methods for its production and compounds containing the same |
WO1992012711A1 (en) * | 1991-01-24 | 1992-08-06 | Martek Corporation | Microbial oil mixtures and uses thereof |
WO1993020183A1 (en) * | 1992-03-27 | 1993-10-14 | Universal Foods Corporation | Method for producing beta-carotene using a fungal mated culture |
WO1994029292A1 (en) * | 1993-06-08 | 1994-12-22 | Krka Tovarna Zdravil P.O. | Process for the isolation of lovastatin |
EP0688871A2 (en) * | 1994-06-24 | 1995-12-27 | Quest International B.V. | Preparation of phytosphingosine derivative |
Non-Patent Citations (5)
Title |
---|
DATABASE WPI Week 9210 Derwent Publications Ltd., London, GB; AN 92-077323 XP002035614 & JP 04 023 979 A (KOBE STEEL LTD) , 28 January 1992 * |
JAREONKITMONGKOL S ET AL: "PRODUCTION OF AN EICOSAPENTAENOIC ACID-CONTAINING OIL BY A DELTA-12 DESATURASE-DEFECTIVE MUTANT OF MORTIERELLA-ALPINA 1S-4" JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, 70 (2). 1993. 119-123., XP000676339 * |
JAREONKITMONGKOL S ET AL: "PRODUCTION OF DIHOMO-GAMMA-LINOLENIC ACID BY A DELTA-5 DESATURASE-DEFECTIVE MUTANT OF MORTIERELLA-ALPINA 1S-4" APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 58 (7). 1992. 2196-2200., XP000676362 * |
KYLE D J; RATLEDGE C ED.: "Industrial applications of single cell oils." 1992 , AMERICAN OIL CHEMISTS SOCIETY , CHAMPAIGN XP002044902 see page 61; figures 5-14 * |
See also references of EP0906414A2 * |
Cited By (138)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2308988A1 (en) * | 1996-12-27 | 2011-04-13 | Suntory Holdings Limited | Media for culturing microorganisms and process for producing unsaturated fatty acids or lipids containing the same |
EP0960943A4 (en) * | 1996-12-27 | 2004-09-08 | Suntory Ltd | Media for culturing microorganisms and process for producing unsaturated fatty acids or lipids containing the same |
EP0960943A1 (en) * | 1996-12-27 | 1999-12-01 | Suntory Limited | Media for culturing microorganisms and process for producing unsaturated fatty acids or lipids containing the same |
EP0990694A1 (en) * | 1997-06-11 | 2000-04-05 | Idemitsu Petrochemical Co., Ltd. | Method for extracting fat-soluble components from microbial cells |
EP0990694A4 (en) * | 1997-06-11 | 2001-10-10 | Idemitsu Petrochemical Co | Method for extracting fat-soluble components from microbial cells |
US6638561B1 (en) | 1998-06-17 | 2003-10-28 | Dsm N.V. | Microbial arachidonic acid (ARA) for use in marine feed |
WO1999065327A1 (en) * | 1998-06-17 | 1999-12-23 | Dsm N.V. | Microbial arachidonic acid (ara) for use in marine feed |
WO2000001839A1 (en) * | 1998-07-03 | 2000-01-13 | Cosmoferm B.V. | Improved microbial strains producing sphingoid bases |
GB2357421B (en) * | 1998-09-15 | 2002-02-06 | Dsm Nv | Mucorales fungi for use in preperation of foodstuffs |
AU764133B2 (en) * | 1998-09-15 | 2003-08-14 | Dsm Ip Assets B.V. | Mucorales fungi for use in preparation of foodstuffs |
EP0986960A1 (en) * | 1998-09-15 | 2000-03-22 | Dsm N.V. | Mucorales fungi for use in preparation of textured products for foodstuffs |
GB2357421A (en) * | 1998-09-15 | 2001-06-27 | Dsm Nv | Mucorales fungi for use in preperation of foodstuffs |
WO2000015045A1 (en) * | 1998-09-15 | 2000-03-23 | Dsm N.V. | Mucorales fungi for use in preparation of foodstuffs |
US7045160B1 (en) | 1998-09-15 | 2006-05-16 | Dsm N.V. | Mucorales fungi for use in preparation of foodstuffs |
EP1803451A1 (en) | 1998-10-15 | 2007-07-04 | DSMIP Assets B.V. | Pufa supplements |
CN1328369C (en) * | 1999-02-03 | 2007-07-25 | 药物研究所有限公司 | Preparing pravastatin |
US6750366B2 (en) | 1999-02-03 | 2004-06-15 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
US6696599B2 (en) | 1999-02-03 | 2004-02-24 | Institute For Drug Research, Ltd. | Microbial process for preparing pravastatin |
US6682913B1 (en) | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
WO2000046175A1 (en) * | 1999-02-03 | 2000-08-10 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
US6319528B1 (en) * | 1999-05-05 | 2001-11-20 | Degussa Aktiengesellschaft | Feedstuff additive which contains D-pantothenic acid and/or its salts and a process for the preparation thereof |
US6238714B1 (en) * | 1999-05-05 | 2001-05-29 | Degussa-Huls Ag | Feedstuff additive which contains D-pantothenic acid and/or its salts and a process for the preparation thereof |
EP1194583B1 (en) * | 1999-07-14 | 2009-02-11 | The University of Hull | Culture of microorganisms for the synthesis of a polyunsatured fatty acid |
EP1133926A1 (en) * | 2000-03-17 | 2001-09-19 | Dsm N.V. | Foodstuffs containing mucorales fungi |
GB2377943A (en) * | 2000-03-17 | 2003-01-29 | Dsm Nv | Foodstuffs containing mucorales fungi |
WO2001067886A1 (en) * | 2000-03-17 | 2001-09-20 | Dsm N.V. | Foodstuffs containing mucorales fungi |
US6368644B1 (en) * | 2000-07-04 | 2002-04-09 | Degussa Ag | Pourable feed additives containing D-pantothenic acid and/or salts thereof, and process for their preparation |
US6596327B2 (en) | 2000-07-04 | 2003-07-22 | Degussa Ag | Pourable feed additives containing D-pantothenic acid and/or salts thereof, and process for their preparation |
US6479084B2 (en) | 2000-07-04 | 2002-11-12 | Degussa Ag | Pourable feed additives containing D-pantothenic acid and/or salts thereof, and process for their preparation |
WO2002006203A1 (en) * | 2000-07-14 | 2002-01-24 | Dsm N.V. | Process for the recovery of shikimic acid |
EP1178103A1 (en) * | 2000-08-02 | 2002-02-06 | Dsm N.V. | Purifying crude pufa oils |
US7431952B2 (en) * | 2000-08-02 | 2008-10-07 | Dsm Ip Assets B.V. | Isolation of microbial oils |
WO2002010322A1 (en) * | 2000-08-02 | 2002-02-07 | Dsm N.V. | Purifying crude pufa oils |
WO2002089604A3 (en) * | 2001-05-04 | 2003-02-06 | Marlow Foods Ltd | Edible fungi ingredient |
GB2390528B (en) * | 2001-05-04 | 2005-11-23 | Marlow Foods Ltd | Edible fungi ingredient |
GB2390528A (en) * | 2001-05-04 | 2004-01-14 | Marlow Foods Ltd | Edible fungi ingredient |
US8672245B2 (en) | 2001-05-04 | 2014-03-18 | Marlow Foods Limited | Edible fungi |
WO2002089604A2 (en) * | 2001-05-04 | 2002-11-14 | Marlow Foods Limited | Edible fungi ingredient |
US7635492B2 (en) | 2001-05-04 | 2009-12-22 | Marlow Foods Limited | Edible fungi |
WO2003034816A1 (en) | 2001-10-19 | 2003-05-01 | Dsm Ip Assets B.V. | Pufas in eggs |
US8012354B2 (en) | 2001-12-12 | 2011-09-06 | Martek Biosciences Corporation | Extraction and winterization of lipids from oilseed and microbial sources |
EP2239028A1 (en) * | 2001-12-12 | 2010-10-13 | Martek Biosciences Corporation | Extraction and Winterization of Lipids From Oilseed and Microbial Sources |
EP2261312A1 (en) * | 2001-12-12 | 2010-12-15 | Martek Biosciences Corporation | Extraction and Winterization of Lipids from Oilseed and Microbial Sources |
US8480904B2 (en) | 2001-12-12 | 2013-07-09 | Dsm Ip Assets B.V. | Extraction and winterization of lipids from oilseed and microbial sources |
US8217151B2 (en) | 2002-06-19 | 2012-07-10 | Dsm Ip Assets B.V. | Pasteurisation process for microbial cells and microbial oil |
US8895708B2 (en) | 2002-06-19 | 2014-11-25 | Dsm Ip Assets B.V. | Pasteurisation process for microbial cells and microbial oil |
US10493174B2 (en) | 2002-06-19 | 2019-12-03 | Dsm Ip Assets B.V. | Pasteurisation process for microbial cells and microbial oil |
EP1513922B2 (en) † | 2002-06-19 | 2015-09-23 | DSM IP Assets B.V. | Pasteurisation process for microbial cells and microbial oil |
US9457108B2 (en) | 2002-06-19 | 2016-10-04 | Dsm Ip Assets B.V. | Pasteurisation process for microbial cells and microbial oil |
EP1513922A1 (en) | 2002-06-19 | 2005-03-16 | DSM IP Assets B.V. | Pasteurisation process for microbial cells and microbial oil |
US8703172B2 (en) | 2003-01-20 | 2014-04-22 | Nederlandse Organizatie voor Toegepastnatuurwetenschappelijk Onderzoek TNO | Sphingolipids for improvement of the composition of the intestinal flora |
CN101133144B (en) * | 2004-12-23 | 2012-02-29 | 努特诺瓦营养产品及食品成分有限公司 | Method for producing a raw oil from mixtures of micro-organisms and plants, oil produced according to said method and specific uses of the thus produced oil and refined oil from the produced oil |
WO2006069668A1 (en) * | 2004-12-23 | 2006-07-06 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Method for producing a raw oil from mixtures of micro-organisms and plants, oil produced according to said method and specific uses of the thus produced oil and, optionally, additional refined oil |
WO2006085672A3 (en) * | 2005-02-08 | 2007-04-26 | Suntory Ltd | Production of polyunsaturated fatty acids using novel cell treatment method |
EP2130923A3 (en) * | 2005-02-08 | 2010-03-03 | Suntory Holdings Limited | Production of polyunsaturated fatty acids using novel cell treatment method |
EP2130923A2 (en) * | 2005-02-08 | 2009-12-09 | Suntory Holdings Limited | Production of polyunsaturated fatty acids using novel cell treatment method |
KR101288078B1 (en) * | 2005-02-08 | 2013-07-22 | 닛폰 스이산 가부시키가이샤 | Production of polyunsaturated fatty acids using novel cell treatment method |
AU2006213188B2 (en) * | 2005-02-08 | 2011-09-01 | Nippon Suisan Kaisha, Ltd. | Production of polyunsaturated fatty acids using novel cell treatment method |
US8241868B2 (en) | 2005-02-08 | 2012-08-14 | Nippon Suisan Kaisha, Ltd. | Production of polyunsaturated fatty acids using cell treatment method |
EP2333094A1 (en) | 2005-02-08 | 2011-06-15 | Nippon Suisan Kaisha, Ltd. | Production of polyunsaturated fatty acids using novel cell treatment method |
EA013637B1 (en) * | 2005-06-23 | 2010-06-30 | ДСМ АйПи АССЕТС Б.В. | Process for obtaining lipid from cells |
WO2006136539A1 (en) * | 2005-06-23 | 2006-12-28 | Dsm Ip Assets B.V. | Process for obtaining lipid from cells |
US8034391B2 (en) | 2005-07-01 | 2011-10-11 | Martek Biosciences Corporation | Polyunsaturated fatty acid-containing oil product and uses and production thereof |
EP1903883A4 (en) * | 2005-07-01 | 2010-06-23 | Martek Biosciences Corp | Polyunsaturated fatty acid-containing oil product and uses and production thereof |
US8753707B2 (en) | 2005-07-01 | 2014-06-17 | Dsm Ip Assets B.V. | Polyunsaturated fatty acid-containing oil product and uses and production thereof |
EP1903883A2 (en) * | 2005-07-01 | 2008-04-02 | Martek Biosciences Corporation | Polyunsaturated fatty acid-containing oil product and uses and production thereof |
US8039030B2 (en) | 2005-07-01 | 2011-10-18 | Martek Biosciences Corporation | Microwaveable popcorn and methods of making |
EP2418214A1 (en) | 2006-12-22 | 2012-02-15 | Novozymes A/S | Use of polypeptides against diseases caused by protozoans |
EP2285823B1 (en) | 2008-06-09 | 2016-04-27 | Danisco US Inc. | Recovery of insoluble enzyme from fermentation broth and formulation of insoluble enzyme |
US10392578B2 (en) | 2010-06-01 | 2019-08-27 | Dsm Ip Assets B.V. | Extraction of lipid from cells and products therefrom |
US20150218484A1 (en) * | 2011-02-11 | 2015-08-06 | E I Du Pont De Nemours And Company | Method for obtaining a lipid-containing composition from microbial biomass |
WO2014122087A1 (en) | 2013-02-05 | 2014-08-14 | Evonik Industries Ag | Improving the bioavailability of useful materials from microorganisms by means of a rotor-stator system for cell disruption |
WO2014122092A1 (en) | 2013-02-05 | 2014-08-14 | Evonik Industries Ag | Improving the bioavailability of useful materials from microorganisms |
US10531679B2 (en) | 2013-07-16 | 2020-01-14 | Evonik Degussa, GmbH | Method for drying biomass |
WO2015082688A1 (en) * | 2013-12-06 | 2015-06-11 | Dsm Ip Assets B.V. | Biomass formulation |
US20160302462A1 (en) * | 2013-12-06 | 2016-10-20 | Dsm Ip Assets B.V. | Biomass formulation |
US11001782B2 (en) | 2013-12-20 | 2021-05-11 | Dsm Nutritional Products Ag | Methods of recovering oil from microorganisms |
CN106164283A (en) * | 2013-12-20 | 2016-11-23 | 赛利亚医药公司 | Prepare the method that platform hooks mycin |
US10472316B2 (en) | 2013-12-20 | 2019-11-12 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
WO2015091851A1 (en) * | 2013-12-20 | 2015-06-25 | Xellia Pharmaceuticals Aps | Process for the preparation of tiacumicin |
US10745642B2 (en) | 2013-12-20 | 2020-08-18 | MARA Renewables Corporation | Methods of recovering oil from microorganisms |
KR20160099098A (en) * | 2013-12-20 | 2016-08-19 | 셀리아 파마슈티칼즈 에이피에스 | Process for the preparation of tiacumicin |
US9745538B2 (en) | 2013-12-20 | 2017-08-29 | MARA Renewables Corporation | Methods of recovering oil from microorganisms |
US9745539B2 (en) | 2013-12-20 | 2017-08-29 | MARA Renewables Corporation | Methods of recovering oil from microorganisms |
US11124736B2 (en) | 2013-12-20 | 2021-09-21 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
KR102355450B1 (en) | 2013-12-20 | 2022-01-24 | 셀리아 파마슈티칼즈 에이피에스 | Process for the preparation of tiacumicin |
US11746363B2 (en) | 2013-12-20 | 2023-09-05 | MARA Renewables Corporation | Methods of recovering oil from microorganisms |
US10364207B2 (en) | 2013-12-20 | 2019-07-30 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
US10342772B2 (en) | 2013-12-20 | 2019-07-09 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
US11324234B2 (en) | 2014-10-02 | 2022-05-10 | Evonik Operations Gmbh | Method for raising animals |
US20170298318A1 (en) * | 2014-10-02 | 2017-10-19 | Evonik Degussa Gmbh | Method for producing a granular biomass which contains an oxidation-sensitive valuable substance |
US10619175B2 (en) | 2014-10-02 | 2020-04-14 | Evonik Operations Gmbh | Process for producing a PUFA-containing feedstuff by extruding a PUFA-containing biomass |
US10842174B2 (en) | 2014-10-02 | 2020-11-24 | Evonik Operations Gmbh | Method for producing biomass which has a high exopolysaccharide content |
WO2016050965A1 (en) | 2014-10-02 | 2016-04-07 | Evonik Degussa Gmbh | Method for producing biomass which has a high exopolysaccharide content |
US11464244B2 (en) | 2014-10-02 | 2022-10-11 | Evonik Operations Gmbh | Feedstuff of high abrasion resistance and good stability in water, containing PUFAs |
WO2016050552A1 (en) | 2014-10-02 | 2016-04-07 | Evonik Degussa Gmbh | Process for producing a pufa-containing biomass which has high cell stability |
WO2017006031A1 (en) * | 2015-07-08 | 2017-01-12 | Institut National De La Recherche Agronomique | Method for producing fatty acids from microorganisms |
FR3038619A1 (en) * | 2015-07-08 | 2017-01-13 | Agronomique Inst Nat Rech | PROCESS FOR OBTAINING FATTY ACIDS FROM MICROORGANISMS |
WO2017105231A1 (en) * | 2015-12-16 | 2017-06-22 | Ibema Biezenmortel B.V. | Dried protozoa compositions and methods of obtaining such |
NL2015964B1 (en) * | 2015-12-16 | 2017-06-30 | Ibema Biezenmortel B V | Dried protozoa compositions. |
WO2018011275A1 (en) | 2016-07-13 | 2018-01-18 | Evonik Degussa Gmbh | Method for isolating lipids from lipid-containing cells |
WO2018011286A1 (en) | 2016-07-13 | 2018-01-18 | Evonik Degussa Gmbh | Method of separating lipids from a lysed lipids containing biomass |
US11946017B2 (en) | 2016-07-13 | 2024-04-02 | Evonik Operations Gmbh | Method of separating lipids from a lysed lipids containing biomass |
US11352651B2 (en) | 2016-12-27 | 2022-06-07 | Evonik Operations Gmbh | Method of isolating lipids from a lipids containing biomass |
EP3562925B1 (en) * | 2016-12-27 | 2021-03-10 | Evonik Operations GmbH | Method of isolating lipids from a lipids containing biomass |
WO2018122057A1 (en) | 2016-12-27 | 2018-07-05 | Evonik Degussa Gmbh | Method of isolating lipids from a lipids containing biomass |
WO2019034354A1 (en) | 2017-08-17 | 2019-02-21 | Evonik Degussa Gmbh | Enhanced production of lipids by limitation of at least two limiting nutrient sources |
US11814665B2 (en) | 2017-08-17 | 2023-11-14 | Evonik Operations Gmbh | Enhanced production of lipids by limitation of at least two limiting nutrient sources |
US11261400B2 (en) | 2017-09-05 | 2022-03-01 | Evonik Operations Gmbh | Method of separating lipids from a lysed lipids containing biomass |
WO2019048327A1 (en) | 2017-09-05 | 2019-03-14 | Evonik Degussa Gmbh | Method of separating lipids from a lysed lipids containing biomass |
EP3470502A1 (en) | 2017-10-13 | 2019-04-17 | Evonik Degussa GmbH | Method of separating lipids from a lysed lipids containing biomass |
US11542220B2 (en) | 2017-12-20 | 2023-01-03 | Evonik Operations Gmbh | Method of isolating lipids from a lipids containing biomass |
WO2019121752A1 (en) | 2017-12-20 | 2019-06-27 | Evonik Degussa Gmbh | Method of isolating lipids from a lipids containing biomass |
WO2019122030A1 (en) | 2017-12-22 | 2019-06-27 | Dsm Ip Assets B.V. | Method of separating lipids from a lysed lipids containing biomass |
EP3527664A1 (en) | 2018-02-15 | 2019-08-21 | Evonik Degussa GmbH | Method of isolating lipids from a lipids containing biomass |
WO2019185891A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted chroman-6-ols |
WO2019185940A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Use of twin-chromanols as antioxidants |
WO2019185889A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of carnosic acid |
WO2019185939A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Use of twin-chromanols as antioxidants in oil |
WO2019185942A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Use of tocotrienols as antioxidants |
WO2019185898A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted 2h-chromens and their derivatives |
WO2019185894A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted chroman-6-ols |
WO2019185904A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Chroman-6-ols with an extended lipophilic side chain in position 2, their manufacture and use |
WO2019185938A2 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted chroman-6-ols with extended lipophilic side chains |
US11447459B2 (en) | 2018-03-29 | 2022-09-20 | Dsm Ip Assets B.V. | Use of substituted chroman-6-ols with extended lipophilic side chains |
WO2019185941A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted chroman-6-ols with extended lipophilic side chains |
WO2019185910A2 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of substituted 2h-chromens and their derivatives |
WO2019185888A1 (en) | 2018-03-29 | 2019-10-03 | Dsm Ip Assets B.V. | Novel use of tocopherols |
US11414621B2 (en) | 2018-05-15 | 2022-08-16 | Evonik Operations Gmbh | Method of isolating lipids from a lipids containing biomass with aid of hydrophobic silica |
WO2019219396A1 (en) | 2018-05-15 | 2019-11-21 | Evonik Operations Gmbh | Method of isolating lipids from a lysed lipids containing biomass by emulsion inversion |
WO2019219443A1 (en) | 2018-05-15 | 2019-11-21 | Evonik Operations Gmbh | Method of isolating lipids from a lipids containing biomass with aid of hydrophobic silica |
US11976253B2 (en) | 2018-05-15 | 2024-05-07 | Evonik Operations Gmbh | Method of isolating lipids from a lysed lipids containing biomass by emulsion inversion |
WO2020094751A1 (en) | 2018-11-09 | 2020-05-14 | Evonik Operations Gmbh | Method for producing a biomass which can be easily broken down and which has an increased content of polyunsaturated fatty acids |
WO2020094750A1 (en) | 2018-11-09 | 2020-05-14 | Evonik Operations Gmbh | Method for producing a biomass with an increased content of polyunsaturated fatty acids |
WO2021019101A1 (en) * | 2019-08-01 | 2021-02-04 | Dsm Ip Assets B.V. | Beta-carotene fermentation method |
WO2021254863A1 (en) | 2020-06-18 | 2021-12-23 | Evonik Operations Gmbh | Method of isolating lipids from a lipids containing biomass |
EP3933016A1 (en) | 2020-06-30 | 2022-01-05 | Evonik Operations GmbH | Method of isolating lipids from a lipids containing biomass |
WO2024052504A1 (en) * | 2022-09-09 | 2024-03-14 | The Protein Brewery B.V. | Granulate comprisig particles of fungal biomass |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0906414B1 (en) | Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom | |
US20150025260A1 (en) | Process for the preparation of a granular microbial biomass and isolation of a compound therefrom | |
AU731785B2 (en) | Preparation of microbial polyunsaturated fatty acid containing oil from pasteurised biomass | |
US6727373B2 (en) | Preparation of microbial polyunsaturated fatty acid containing oil from pasteurised biomass | |
AU771809B2 (en) | Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom | |
AU760175B2 (en) | Preparation of microbial polyunsaturated fatty acid containing oil from pasteurised biomass |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 97194211.0 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN YU AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN YU AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF |
|
ENP | Entry into the national phase |
Ref document number: 2250575 Country of ref document: CA Ref document number: 2250575 Country of ref document: CA Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1997916373 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1997916373 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1997916373 Country of ref document: EP |