WO1997029103A3 - Synthesis of omeprazole-type pyridine derivatives and intermediates thereof - Google Patents
Synthesis of omeprazole-type pyridine derivatives and intermediates thereof Download PDFInfo
- Publication number
- WO1997029103A3 WO1997029103A3 PCT/CA1997/000081 CA9700081W WO9729103A3 WO 1997029103 A3 WO1997029103 A3 WO 1997029103A3 CA 9700081 W CA9700081 W CA 9700081W WO 9729103 A3 WO9729103 A3 WO 9729103A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- omeprazole
- intermediates
- synthesis
- pyridine derivatives
- type pyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
- C07C329/04—Esters of monothiocarbonic acids
- C07C329/06—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU15383/97A AU1538397A (en) | 1996-02-06 | 1997-02-05 | Synthesis of omeprazole-type pyridine derivatives and intermediates thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2,168,939 | 1996-02-06 | ||
CA 2168939 CA2168939A1 (en) | 1996-02-06 | 1996-02-06 | Synthesis of pharmaceutically useful pyridine derivatives |
CA2,173,820 | 1996-04-10 | ||
CA 2173820 CA2173820A1 (en) | 1996-04-10 | 1996-04-10 | Synthesis of pharmaceutically useful pyridine derivatives and intermediates for such pyridine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997029103A2 WO1997029103A2 (en) | 1997-08-14 |
WO1997029103A3 true WO1997029103A3 (en) | 1997-10-23 |
Family
ID=25678329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1997/000081 WO1997029103A2 (en) | 1996-02-06 | 1997-02-05 | Synthesis of omeprazole-type pyridine derivatives and intermediates thereof |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU1538397A (en) |
WO (1) | WO1997029103A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6350876B2 (en) | 1998-01-26 | 2002-02-26 | Kuraray Co., Ltd. | 4-chloro-3,5-dimethyl-2-sulfonyl pyridines |
KR100396431B1 (en) * | 1998-01-26 | 2003-09-02 | 가부시키가이샤 구라레 | Method for producing 2-sulfonylpyridine derivatives and method for producing 2-[((2-pyridyl)methyl)thio]-1h-benzimidazole derivatives |
DE10140492A1 (en) | 2001-08-17 | 2003-08-14 | Gruenenthal Gmbh | Hydrates of optionally substituted 2- (2-pyridinyl) methylthio-1H-benzimidazoles and process for their preparation |
US7683177B2 (en) | 2003-06-10 | 2010-03-23 | Teva Pharmaceutical Industries Ltd | Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole |
JP5355893B2 (en) | 2004-12-16 | 2013-11-27 | シプラ・リミテッド | Method for producing pantoprazole sodium |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0005129A1 (en) * | 1978-04-14 | 1979-10-31 | Aktiebolaget Hässle | Substituted pyridylsulfinylbenzimidazoles having gastric acid secretion properties, pharmaceutical preparations containing same, and intermediates for their preparation |
EP0484265A1 (en) * | 1990-10-31 | 1992-05-06 | Centro Genesis Para La Investigacion, S.L. | A process for the preparation of omeprazol |
US5292885A (en) * | 1989-08-11 | 1994-03-08 | Isochem | Pyranone, process for its preparation, its use in the preparation of a new pyridinone and a process for the preparation of same |
US5374730A (en) * | 1993-11-04 | 1994-12-20 | Torcan Chemical Ltd. | Preparation of omeprazole and lansoprazole |
-
1997
- 1997-02-05 WO PCT/CA1997/000081 patent/WO1997029103A2/en active Application Filing
- 1997-02-05 AU AU15383/97A patent/AU1538397A/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0005129A1 (en) * | 1978-04-14 | 1979-10-31 | Aktiebolaget Hässle | Substituted pyridylsulfinylbenzimidazoles having gastric acid secretion properties, pharmaceutical preparations containing same, and intermediates for their preparation |
US5292885A (en) * | 1989-08-11 | 1994-03-08 | Isochem | Pyranone, process for its preparation, its use in the preparation of a new pyridinone and a process for the preparation of same |
EP0484265A1 (en) * | 1990-10-31 | 1992-05-06 | Centro Genesis Para La Investigacion, S.L. | A process for the preparation of omeprazol |
US5374730A (en) * | 1993-11-04 | 1994-12-20 | Torcan Chemical Ltd. | Preparation of omeprazole and lansoprazole |
Non-Patent Citations (2)
Title |
---|
KOSER ET AL: "One-step alpha-tosylation of ketones with [Hydroxytosyloxy)iodo]benzene", J.ORG.CHEM., vol. 47, no. 12, 1982, pages 2487 - 2489, XP000653641 * |
LEY ET AL: "Ultrasonic formation and reactions of sodium phenylselenide", TETRAHEDRON, vol. 42, no. 19, 1986, pages 5365 - 5368, XP000652161 * |
Also Published As
Publication number | Publication date |
---|---|
AU1538397A (en) | 1997-08-28 |
WO1997029103A2 (en) | 1997-08-14 |
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