AU1175497A - A class of oligonucleotides, therapeutically useful as antitumoural agents - Google Patents
A class of oligonucleotides, therapeutically useful as antitumoural agentsInfo
- Publication number
- AU1175497A AU1175497A AU11754/97A AU1175497A AU1175497A AU 1175497 A AU1175497 A AU 1175497A AU 11754/97 A AU11754/97 A AU 11754/97A AU 1175497 A AU1175497 A AU 1175497A AU 1175497 A AU1175497 A AU 1175497A
- Authority
- AU
- Australia
- Prior art keywords
- oligonucleotides
- class
- therapeutically useful
- antitumoural agents
- antitumoural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI95A2539 | 1995-12-04 | ||
IT95MI002539A IT1277025B1 (en) | 1995-12-04 | 1995-12-04 | CLASS OF PHOSPHODIESTERIC OLIGONUCLEOTIDES WITH CYTOTOXIC ACTIVITY PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE |
PCT/EP1996/005388 WO1997020924A1 (en) | 1995-12-04 | 1996-12-04 | A class of oligonucleotides, therapeutically useful as antitumoural agents |
Publications (1)
Publication Number | Publication Date |
---|---|
AU1175497A true AU1175497A (en) | 1997-06-27 |
Family
ID=11372654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU11754/97A Abandoned AU1175497A (en) | 1995-12-04 | 1996-12-04 | A class of oligonucleotides, therapeutically useful as antitumoural agents |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU1175497A (en) |
IT (1) | IT1277025B1 (en) |
WO (1) | WO1997020924A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030032610A1 (en) | 1996-06-03 | 2003-02-13 | Gilchrest Barbara A. | Method to inhibit cell growth using oligonucleotides |
CA2383001A1 (en) | 1999-12-10 | 2001-06-14 | Anticancer, Inc. | Methods for introducing genes into mammalian subjects |
US20020091095A1 (en) | 1999-12-13 | 2002-07-11 | Phillips Nigel C. | Modulation of Fas and FasL expression |
MXPA02005842A (en) | 1999-12-13 | 2003-10-14 | Bioniche Life Sciences Inc | Therapeutically useful synthetic oligonucleotides. |
JP2004507469A (en) * | 2000-08-29 | 2004-03-11 | バイオニケ ライフ サイエンシーズ インコーポレイテッド | Regulation of FAS and FASL expression |
WO2002020052A1 (en) * | 2000-09-08 | 2002-03-14 | Aventis Pasteur | Use of lipopeptides for immunotherapy of hiv-positive subjects |
DE10230692A1 (en) * | 2002-07-08 | 2004-02-12 | Epigenomics Ag | Methods and nucleic acids for the analysis of methylation patterns within the DD3 gene |
US7511131B2 (en) | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
US7598227B2 (en) | 2003-04-16 | 2009-10-06 | Isis Pharmaceuticals Inc. | Modulation of apolipoprotein C-III expression |
US20050287558A1 (en) | 2004-05-05 | 2005-12-29 | Crooke Rosanne M | SNPs of apolipoprotein B and modulation of their expression |
CA2603688A1 (en) * | 2005-04-04 | 2006-10-12 | Trustees Of Boston University | Methods of protection from oxidative stress |
KR20090128494A (en) | 2007-03-24 | 2009-12-15 | 겐자임 코포레이션 | Administering antisense oligonucleotides complementary to human apolipoprotein b |
US9107933B2 (en) | 2009-03-16 | 2015-08-18 | Isis Pharmaceuticals, Inc. | Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III |
EP2480669B1 (en) * | 2009-09-25 | 2017-11-08 | CuRNA, Inc. | Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity |
WO2011081884A1 (en) * | 2009-12-14 | 2011-07-07 | Massachusetts Institute Of Technology | Systems and methods related to optical nanosensors including photoluminescent nanostructures |
IT1405761B1 (en) | 2010-09-13 | 2014-01-24 | Univ Degli Studi Trieste | GT APTAMERIC OLIGONUCLEOTIDS AND THEIR USE AS ANTI-HUMAN AGENTS |
BR112013027479A8 (en) | 2011-04-27 | 2017-10-03 | Isis Pharmaceuticals Inc | USE OF A COMPOUND COMPRISING A MODIFIED OLIGONUCLEOTIDE TARGETED AT APOCIII |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994007367A1 (en) * | 1992-09-29 | 1994-04-14 | Apollon, Inc. | Anti-viral oligomers that bind polypurine tracts of single-stranded rna or rna-dna hybrids |
WO1995026190A1 (en) * | 1994-03-25 | 1995-10-05 | Akira Kaji | Novel anti-hiv drug |
AU3636995A (en) * | 1994-10-07 | 1996-05-02 | Pharmagenics, Inc. | Bridged and unbridged quadruplex/duplex oligonucleotides |
EP0810882A4 (en) * | 1995-02-09 | 1999-05-19 | Icn Pharmaceuticals | Methods and compositions for regulation of cd28 expression |
-
1995
- 1995-12-04 IT IT95MI002539A patent/IT1277025B1/en active IP Right Grant
-
1996
- 1996-12-04 WO PCT/EP1996/005388 patent/WO1997020924A1/en active Application Filing
- 1996-12-04 AU AU11754/97A patent/AU1175497A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ITMI952539A0 (en) | 1995-12-04 |
IT1277025B1 (en) | 1997-11-04 |
WO1997020924A1 (en) | 1997-06-12 |
ITMI952539A1 (en) | 1997-06-04 |
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