WO1997025074A3 - Cellular and serum protein anchors for diagnostic imaging - Google Patents

Cellular and serum protein anchors for diagnostic imaging Download PDF

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Publication number
WO1997025074A3
WO1997025074A3 PCT/US1997/000176 US9700176W WO9725074A3 WO 1997025074 A3 WO1997025074 A3 WO 1997025074A3 US 9700176 W US9700176 W US 9700176W WO 9725074 A3 WO9725074 A3 WO 9725074A3
Authority
WO
WIPO (PCT)
Prior art keywords
mammalian vascular
diagnostically
cellular
image
bifunctional
Prior art date
Application number
PCT/US1997/000176
Other languages
French (fr)
Other versions
WO1997025074A2 (en
Inventor
Alan M Ezrin
Allen Krantz
Original Assignee
Redcell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Redcell Inc filed Critical Redcell Inc
Priority to JP9525337A priority Critical patent/JP2000504316A/en
Priority to AU15277/97A priority patent/AU713616B2/en
Priority to EP97901362A priority patent/EP0814850A1/en
Publication of WO1997025074A2 publication Critical patent/WO1997025074A2/en
Publication of WO1997025074A3 publication Critical patent/WO1997025074A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Methods of non-invasive diagnosis are provided employing bifunctional anchor molecules. The bifunctional anchor molecules have a functional group capable of activation which, when activated, may form a covalent bond with a reactive functionality on a target protein present in the mammalian vascular system, thereby 'anchoring' the molecule to that target protein. The bifunctional anchors are also conjugated, either directly or indirectly, to a diagnostic agent of interest which provides the ability to diagnostically and non-invasively image the mammalian vascular space. Vascular targets include both cellular- and noncellular-associated proteins present in the mammalian vascular system. The methods find use for numerous applications arising from the ability to diagnostically image the mammalian vascular space over an extended period of time or to preferentially diagnostically image only a specific cell type or compartment of the mammalian vascular space.
PCT/US1997/000176 1996-01-12 1997-01-07 Cellular and serum protein anchors for diagnostic imaging WO1997025074A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP9525337A JP2000504316A (en) 1996-01-12 1997-01-07 Cellular and serum protein anchors for diagnostic imaging
AU15277/97A AU713616B2 (en) 1996-01-12 1997-01-07 Cellular and serum protein anchors for diagnostic imaging
EP97901362A EP0814850A1 (en) 1996-01-12 1997-01-07 Cellular and serum protein anchors for diagnostic imaging

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58891296A 1996-01-12 1996-01-12
US08/588,912 1996-01-12

Publications (2)

Publication Number Publication Date
WO1997025074A2 WO1997025074A2 (en) 1997-07-17
WO1997025074A3 true WO1997025074A3 (en) 1997-11-13

Family

ID=24355824

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/000176 WO1997025074A2 (en) 1996-01-12 1997-01-07 Cellular and serum protein anchors for diagnostic imaging

Country Status (5)

Country Link
EP (1) EP0814850A1 (en)
JP (1) JP2000504316A (en)
AU (1) AU713616B2 (en)
CA (1) CA2215152A1 (en)
WO (1) WO1997025074A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69806066T2 (en) * 1997-11-07 2003-02-06 Conjuchem, Inc. AFFINITY MARKER FOR HUMAN SERUM ALBUMIN
ATE473759T1 (en) 1998-05-22 2010-07-15 Univ Leland Stanford Junior BIFUNCTIONAL MOLECULES AND THERAPIES BASED THERAPIES.
ES2209885T3 (en) 1999-05-17 2004-07-01 Conjuchem, Inc. LONG-TERM INSULINOTROPIC PEPTIDES.
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
AU2044001A (en) 1999-11-19 2001-05-30 Board Of Trustees Of The Leland Stanford Junior University Targeted bifunctional molecules and therapies based thereon
CA2436399A1 (en) 2001-02-16 2002-08-29 Conjuchem Inc. Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders
DE602004027000D1 (en) 2003-01-17 2010-06-17 Advanced Proteome Therapeutics Method for identifying activated polymer complexes for secondary site-specific modification of protein target groups.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2390408A1 (en) * 1977-05-11 1978-12-08 Philips France 8-Hydroxy-quinoline salts labelled with radioactive isotope - for diagnosis of disorders of the cardiovascular system
WO1982000203A1 (en) * 1980-07-09 1982-01-21 Avrameas S Method for detecting and metering a biological substance by erythroadsorption
EP0387154A1 (en) * 1989-03-08 1990-09-12 Pierre Fabre Medicament Aerosol compositions for the imaging, diagnosis and targetted therapy of inflamed and tumoral focuses
FR2660864A1 (en) * 1990-04-13 1991-10-18 Guerbet Sa CONTRAST COMPOSITION, PROCESS FOR PREPARING THE SAME, AND IMAGING APPLICATION.
FR2698272A1 (en) * 1992-11-20 1994-05-27 Cis Bio Int Radio-labelling of cells esp. granulocytes - using technetium-99m nitride complex contg. di:thiocarbamate ligands.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2390408A1 (en) * 1977-05-11 1978-12-08 Philips France 8-Hydroxy-quinoline salts labelled with radioactive isotope - for diagnosis of disorders of the cardiovascular system
WO1982000203A1 (en) * 1980-07-09 1982-01-21 Avrameas S Method for detecting and metering a biological substance by erythroadsorption
EP0387154A1 (en) * 1989-03-08 1990-09-12 Pierre Fabre Medicament Aerosol compositions for the imaging, diagnosis and targetted therapy of inflamed and tumoral focuses
FR2660864A1 (en) * 1990-04-13 1991-10-18 Guerbet Sa CONTRAST COMPOSITION, PROCESS FOR PREPARING THE SAME, AND IMAGING APPLICATION.
FR2698272A1 (en) * 1992-11-20 1994-05-27 Cis Bio Int Radio-labelling of cells esp. granulocytes - using technetium-99m nitride complex contg. di:thiocarbamate ligands.

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KURANTSIN-MILLS J ET AL: "INDIUM-111 OXINE LABELED ERYTHROCYTES: CELLULAR DISTRIBUTION AND EFFLUX KINETICS OF THE LABEL", INTERNATIONAL JOURNAL OF RADIATION APPLICATIONS AND INSTRUMENTATION PART B: NUCLEAR MEDICINE AND BIOLOGY, vol. 16, no. 8, 1 January 1989 (1989-01-01), pages 821 - 823, 825 - 827, XP000100535 *
PROULX A ET AL: "A KIT FOR LABELLING ERYTHROCYTES OR LEUKOCYTES WITH TECHNETIUM-99M", INTERNATIONAL JOURNAL OF RADIATION APPLICATIONS AND INSTRUMENTATION PART B: NUCLEAR MEDICINE AND BIOLOGY, vol. 17, no. 5, 1 January 1990 (1990-01-01), pages 515 - 517, XP000135537 *

Also Published As

Publication number Publication date
AU1527797A (en) 1997-08-01
AU713616B2 (en) 1999-12-09
CA2215152A1 (en) 1997-07-17
JP2000504316A (en) 2000-04-11
WO1997025074A2 (en) 1997-07-17
EP0814850A1 (en) 1998-01-07

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