FR2390408A1 - 8-Hydroxy-quinoline salts labelled with radioactive isotope - for diagnosis of disorders of the cardiovascular system - Google Patents

8-Hydroxy-quinoline salts labelled with radioactive isotope - for diagnosis of disorders of the cardiovascular system

Info

Publication number
FR2390408A1
FR2390408A1 FR7714396A FR7714396A FR2390408A1 FR 2390408 A1 FR2390408 A1 FR 2390408A1 FR 7714396 A FR7714396 A FR 7714396A FR 7714396 A FR7714396 A FR 7714396A FR 2390408 A1 FR2390408 A1 FR 2390408A1
Authority
FR
France
Prior art keywords
labelled
radioactive isotope
hydroxy
blood
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7714396A
Other languages
French (fr)
Inventor
Groupe De Recherche Pour Grami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Signify France SAS
Original Assignee
Philips France SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips France SAS filed Critical Philips France SAS
Priority to FR7714396A priority Critical patent/FR2390408A1/en
Publication of FR2390408A1 publication Critical patent/FR2390408A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1203—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules in a form not provided for by groups A61K51/1206 - A61K51/1296, e.g. cells, cell fragments, viruses, virus capsides, ghosts, red blood cells, viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Virology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Water soluble salts of oxine (8-hydroxy quinoline), or its halogenated or sulphonated derivs. are labelled with a radioactive isotope as follows: the salt is dissolved in distilled water, adjusted to pH 7-8, and mixed with an aqs. soln. contg. the radioactive isotope. Used for determining blood hematic volume, sites of thrombo-embolism, detection of abscesses, etc. The labelled products are easier to prepare than other labelled products for such diagnoses. Pref. radioactive sources are '''In and 113mIn. In an example, erythrocytes from 5 ml blood were suspended in 2 ml physiological serum, and mixed with oxine sulphate labelled with 113mIn (2mCi). This mixture was left for 10 mins., suspended in plasma medium, and injected into the patient's vascular system. The blood volume was calculated and found to give an identical result with that found using 99mTc and 51Cr.
FR7714396A 1977-05-11 1977-05-11 8-Hydroxy-quinoline salts labelled with radioactive isotope - for diagnosis of disorders of the cardiovascular system Withdrawn FR2390408A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7714396A FR2390408A1 (en) 1977-05-11 1977-05-11 8-Hydroxy-quinoline salts labelled with radioactive isotope - for diagnosis of disorders of the cardiovascular system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7714396A FR2390408A1 (en) 1977-05-11 1977-05-11 8-Hydroxy-quinoline salts labelled with radioactive isotope - for diagnosis of disorders of the cardiovascular system

Publications (1)

Publication Number Publication Date
FR2390408A1 true FR2390408A1 (en) 1978-12-08

Family

ID=9190656

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7714396A Withdrawn FR2390408A1 (en) 1977-05-11 1977-05-11 8-Hydroxy-quinoline salts labelled with radioactive isotope - for diagnosis of disorders of the cardiovascular system

Country Status (1)

Country Link
FR (1) FR2390408A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017355A2 (en) * 1979-03-21 1980-10-15 AMERSHAM INTERNATIONAL plc Indium-111 oxine complex composition
FR2474314A1 (en) * 1979-12-31 1981-07-31 Byk Mallinckrodt Cil Bv AQUEOUS RADIOLOGICAL ASSAY SOLUTION FOR HOT BLOOD ANIMALS
EP0096871A2 (en) * 1982-06-14 1983-12-28 Yale University Composition for imaging blood cells
WO1991014664A1 (en) * 1990-03-23 1991-10-03 Robert Charles Hider Metal complexes
WO1997025074A2 (en) * 1996-01-12 1997-07-17 Redcell Canada, Inc. Cellular and serum protein anchors for diagnostic imaging

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017355A2 (en) * 1979-03-21 1980-10-15 AMERSHAM INTERNATIONAL plc Indium-111 oxine complex composition
EP0017355A3 (en) * 1979-03-21 1981-01-28 Amersham International Plc Indium-iii oxine complex composition
US4335095A (en) * 1979-03-21 1982-06-15 The Radiochemical Centre Limited Indium-111 oxine complex composition
FR2474314A1 (en) * 1979-12-31 1981-07-31 Byk Mallinckrodt Cil Bv AQUEOUS RADIOLOGICAL ASSAY SOLUTION FOR HOT BLOOD ANIMALS
EP0096871A2 (en) * 1982-06-14 1983-12-28 Yale University Composition for imaging blood cells
EP0096871A3 (en) * 1982-06-14 1984-03-28 Yale University Composition for imaging blood cells
WO1991014664A1 (en) * 1990-03-23 1991-10-03 Robert Charles Hider Metal complexes
WO1997025074A2 (en) * 1996-01-12 1997-07-17 Redcell Canada, Inc. Cellular and serum protein anchors for diagnostic imaging
WO1997025074A3 (en) * 1996-01-12 1997-11-13 Redcell Inc Cellular and serum protein anchors for diagnostic imaging

Similar Documents

Publication Publication Date Title
EP0063002B1 (en) Radiolabelled peptides derived from crosslinked fibrin for locating thrombi and injectable compositions thereof
Holtzman et al. Studies on the rate of release and turnover of ceruloplasmin and apoceruloplasmin in rat plasma
EP0111415B1 (en) Process for making lyophilized radiographic imaging kit
US4416865A (en) Radiopharmaceuticals for localization of thromboembolic disease
GB1253339A (en) Preparation of a prothrombin complex
Wahl et al. Thrombocytopenia associated with antiheparin antibody
Fenn et al. The exchange of radioactive potassium with body potassium
JPS542343A (en) Radioactive diagnostic agent labelled with tecnetium 99m and production thereof
Jasin Mechanism of trapping of immune complexes in joint collagenous tissues.
US4443426A (en) Blood agent
Mager et al. Turnover of purine nucleotides in rabbit erythrocytes I. Studies in vivo
US3897309A (en) Process for removing pyrogenic material from aqueous solutions
Astedt No crossreaction between circulating plasminogen activator and urokinase
FR2390408A1 (en) 8-Hydroxy-quinoline salts labelled with radioactive isotope - for diagnosis of disorders of the cardiovascular system
US4057615A (en) Method of tagging excipients with 99M technetium
Salem et al. Heparin induced thrombocytopenia. variable dependent platelet aggregating factor
US3574818A (en) Diagnostic for rheumatism
England et al. Studies on the transcobalamins
US5455021A (en) Isotopic tracer composition and method for making and using same
Harwig et al. In vivo behavior of 99mTc-fibrinogen and its potential as a thrombus-imaging agent
Landaw et al. Decreased surface charge and accelerated senescence of red blood cells following neuraminidase treatment
Miller et al. Influence of phenytoin on theophylline clearance
JPS6058927A (en) Blood platelet preparation labeled with radioactive isotope
Egberg et al. On fibrin distribution in organs of dogs during defibrination with the thrombin-like enzyme from Bothrops atrox
Fiehn et al. Macrocreatine kinase in plasma: A cause for a false positive CK-MB immunoinhibition test

Legal Events

Date Code Title Description
ST Notification of lapse