WO1997023594A1 - Compositions nettoyantes - Google Patents

Compositions nettoyantes Download PDF

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Publication number
WO1997023594A1
WO1997023594A1 PCT/US1996/020067 US9620067W WO9723594A1 WO 1997023594 A1 WO1997023594 A1 WO 1997023594A1 US 9620067 W US9620067 W US 9620067W WO 9723594 A1 WO9723594 A1 WO 9723594A1
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Prior art keywords
composition according
acid
ppg
alkyl
titanium dioxide
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PCT/US1996/020067
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English (en)
Inventor
Merryl Lisa Walker
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The Procter & Gamble Company
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Publication of WO1997023594A1 publication Critical patent/WO1997023594A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C11D3/046—Salts
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/12—Water-insoluble compounds
    • C11D3/1213—Oxides or hydroxides, e.g. Al2O3, TiO2, CaO or Ca(OH)2
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/61—Surface treated

Definitions

  • the present invention relates to personal cleansing compositions which both cleanse the skin and which exhibit enhanced antimicrobial activity.
  • antimicrobial agents are known in the art for use in cosmetic products, e.g. phenoxy isopropanol, octopirox, zinc oxide. It is also known to use metal ions, such as silver, copper, and zinc ions for use as antimicrobial agents.
  • EP-A-0251753 discloses an antimicrobial composition
  • an antimicrobial composition comprising an antimicrobial silver compound deposited on a physiologically inert oxidic synthetic material.
  • the synthetic material is particulate, has an extended surface area, and may be selected from oxides of titanium, magnesium, aluminium, silicon, cerium, zirconium, hafnium, niobium and tantalum as well as calcium hydroxyapatite and barium sulphate.
  • the antimicrobial compound is described as being suitable for topical use, for impregnation of fibrous or absorbent substrates such as bandages or wound-dressings or for impregnation into medical appliances such as catheters.
  • compositions which provide cleansing properties and improved anti-acne and antimicrobial efficacy at very low levels of antimicrobial active, i.e. lower levels than generally used with, for example, phenoxy isopropanol or octopirox.
  • a cleansing composition comprising:
  • an antimicrobial agent comprises a silver compound deposited on an inert particulate support material;
  • compositions of the invention provide cleansing efficacy and enhanced antimicrobial and/or anti-acne efficacy.
  • compositions of the present invention comprise emulsifier, antimicrobial agent and water.
  • a first essential ingredient of the compositions of the present invention is an emulsifier.
  • the emulsifier is present in the compositions herein at a level of from about 0.1 % to about 30% , preferably from about 1 % to about 20%, more preferably from about 1 % to about 15% by weight of composition. Even though the term "emulsifier" is used herein to describe these materials, this term is not intended to exclude those emulsifiers which also have surfactant properties.
  • the emulsifier is selected from amphoteric, zwitterionic, nonionic, anionic and cationic surfactants and mixtures thereof. Suitable emulsifiers for use herein are disclosed in prior patents and other references. See McCutcheon's, Detergents and Emulsifiers, North American Edition (1986), published by Allured Publishing Corporation; US-A-5011681, US- A-4421769 and US-A-3755560.
  • emulsifier chosen will depend upon the pH of the composition and the other components present. Suitable emulsifier types include tetra- alkyl ammonium salts, esters of glycerin, esters of propylene glycol, fatty acid esters of polyethylene glycol, fatty acid esters of polypropylene glycol, esters of sorbitol, esters of sorbitan anhydrides, carboxylic acid copolymers, esters and ethers of glucose, ethoxylated ethers, ethoxylated alcohols, alkyl phosphates, polyoxyethylene fatty ether phosphates, fatty acid amides, acyl lactylates, soaps and mixtures thereof.
  • Suitable herein, especially when the emulsions have a pH from about 2 to about 7, are cationic emulsifiers.
  • a wide variety of cationic emulsifiers and surfactants useful herein are disclosed in U.S. Patent No. 5,151,209, to McCall et al., issued September 29, 1992; U.S. Patent No. 5,151,210, to Steuri et al., issued September 29, 1992; U.S. Patent No. 5,120,532, to Wells et al., issued June 9, 1992; U.S. Patent No. 4,387,090, to Bolich, issued June 7, 1983;; U.S. Patent 3,155,591, Spotifyr, issued November 3, 1964; U.S. Patent No.
  • cationic emulsifiers useful herein include cationic ammonium salts such as those having the formula:
  • R is selected from an alkyl group having from about 12 to about 22 carbon atoms, or aromatic, aryl or alkaryl groups having from about 12 to about 22 carbon atoms;
  • R , R , and R are independently selected from hydrogen, an alkyl group having from about 1 to about 22 carbon atoms, or aromatic, aryl or alkaryl groups having from about 12 to about 22 carbon atoms;
  • X is an anion selected from chloride, bromide, iodide, acetate, phosphate, nitrate, sulfate, methyl sulfate, ethyl sulfate, tosylate, lactate, citrate, glycolate, and mixtures thereof.
  • the alkyl groups can also contain ether linkages, or hydroxy or amino group substituents (e.g., the alkyl groups can contain polyethylene glycol and polypropylene glycol moieties).
  • R is an alkyl group having from about 12 to about 22 carbon atoms; R is selected from H or an alkyl group having from about 1 to about 22 carbon atoms; R and R are independently selected from H or an alkyl group having from about 1 to about 3 carbon atoms; and X is as described in the previous paragraph.
  • R is an alkyl group having from about 12 to about 22 carbon atoms; R , R , and R are selected from H or an alkyl group having from about 1 to about 3 carbon atoms; and X is as described previously.
  • R is alternatively R CO-(CH ) -, wherein R is an alkyl group having from about 12 to about " 22 carbon atoms, and n is an integer from about 2 to about 6, more preferably from about 2 to about 4, and most preferably from about 2 to about 3.
  • Noniimiting examples of these cationic emulsifiers include stearamidopropyl PG- dimonium chloride phosphate, stearamidopropyl ethyldimonium ethosulfate, stearamidopropyl dimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride, stearamidopropyl dimethyl ammonium lactate, and mixtures thereof.
  • Noniimiting examples of quaternary ammonium salt cationic emulsifiers include those selected from the group consisting of cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, lauryl dimethyl ammonium bromide, stearyl dimethyl ammonium bromide, cetyl trimethyl ammonium chloride, cetyl trimethyl ammonium bromide, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, lauryl trimethyl ammonium bromide, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium
  • Additional quaternary ammonium salts include those wherein the C 12 to C22 alkyl carbon chain is derived from a tallow fatty acid or from a coconut fatty acid.
  • tallow refers to an alkyl group derived from tallow fatty acids (usually hydrogenated tallow fatty acids), which generally have mixtures of alkyl chains in the C16 to C18 range.
  • coconut refers to an alkyl group derived from a cocunt fatty acid, which generally have mixtures of alkyl chains in the C 12 to C 14 range.
  • Examples of quaternary ammonium salts derived from these tallow and cococut sources include ditallow dimethyl ammonium chlroide, ditallow dimehtyl ammomum methyl sulfate, di(hydrogenated tallow) dimethyl ammonium chloride, di(hydrogenated tallow) dimethyl ammonium acetate, ditallow dipropyl ammonium phosphate, ditallow dimethyl ammonium nitrate, di(coconutalkyl)dimethyl ammonium chloride, di(coconutalkyl)dimethyl ammonium bromide, tallow ammonium chloride, coconut ammonium chloride, stearamidopropyl PG-dimonium chloride phosphate, stearamidopropyl ethyldimonium ethosulfate, stearamidopropyl dimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl
  • More preferred cationic emulsifiers are those selected from the group consisting of dilauryl dimethyl ammoniun chloride, distearyl dimethyl ammonium chloride, dimyristyl dimethyl ammomum chloride, dipalmityl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearamidopropyl PG-dimonium chloride phosphate, stearamidopropyl ethyldimonium ethosulfate, stearamidopropyl dimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride, stearamidopropyl dimethyl ammonium lactate, and mixtures thereof.
  • Most preferred cationic emulsifiers are those selected from the group consisting of dilauryl dimethyl ammoniun chloride, distearyl dimethyl ammonium chloride, dimyristyl dimethyl ammonium chloride, dipalmityl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, and mixtures thereof.
  • HLB hydrophilic lipophilic balance
  • the high HLB nonionic emulsifiers include any of the well-known nonionic emulsifiers that have an HLB of from about 6 to about 18, preferably from about 8 to about 18, and more preferably from about 10 to about 18. These high HLB nonionic emulsifiers do not include those emulsifiers with HLB values less than 6, as described below. Typical of these high HLB nonionic emulsifiers are ethoxylated or propoxylated, preferably ethoxylated, alcohols and alkyl phenols, with the alcohol derivatives being preferred. In general, these alcohol derivatives contain a straight or branched chain alkyl group in the C , preferably C , more preferably C , range and generally contain from about
  • ethoxylated and propoxylated alcohols preferably from arjout 6 to about 25, ethylene oxide or propylene oxide groups.
  • ethoxylated and propoxylated alcohols the ethoxylated derivatives are most preferred.
  • Preferred for use herein are polyethylene oxide ethers derived from lauryl alcohol, cetyl alcohol, oleyl alcohol, stearyl alcohol, isostearyl alcohol, myristyl alcohol, behenyl alcohol, and mixtures thereof.
  • polyoxyethylene 10 cetyl ether known by the CTFA designation as ceteth- 10
  • polyoxyethylene (21) stearyl ether known by the CTFA designation steareth-21
  • coconut alkyl polyethoxy late 6.5
  • decyl polyethoxy late (6) and mixtures thereof.
  • the low HLB nonionic emulsifiers are defined herein as any of the well known nonionic emulsifiers having an HLB value from about 1 to about, but not greater than or equal to, 6. These low HLB nonionic emulsifiers do not include the high HLB nonionic emulsifer described above.
  • these low HLB nonionic emulsifiers are ethoxylated alcohols with the alcohol derivatives being preferred.
  • these alcohol derivatives contain a straight or branched chain alkyl group in the C , preferably C , more preferably C , range, and generally contain from about 1 to about 5 ethylene oxide groups per molecule.
  • Some noniimiting examples of these low HLB nonionic emulsifiers useful herein include stearic acid ethoxylated with 1 mole of ethylene oxide (i.e. steareth- 1), steareth-2, steareth-3, steareth-4, steareth-5, ceteth- 1, cetheth- 2, ceteth-3, ceteth-4, ceteth-5, laureth- 1, laureth-2, laureth-3, laureth-4, laureth-5, and mixtures thereof.
  • Preferred low HLB nonionic emulsifiers are steareth- 1, steareth-2, steareth-3, ceteth- 1, ceteth-2, cetheth-3, laureth- 1, laureth-2, laureth-3, and mixtures thereof. More preferred are steareth- 1, steareth-2, steareth-3, ceteth- 1, ceteth-2, cetheth-3, laureth- 1, laureth-2, laureth-3, and mixtures thereof. More preferred are steareth- 1, steareth-2, steareth-3, ceteth- 1, ceteth-2, cetheth-3, laureth- 1, laureth-2, laureth-3, and mixtures thereof. More preferred are steareth-
  • ceteth-2 ceteth-2, laureth-2, and mixtures thereof. Most preferred is steareth-2, which is available commercially as Brij 72 from ICI Americas.
  • Amphoteric surfactants suitable for use in the compositions of the invention include:
  • R ⁇ is C7-C22 alkyl or alkenyl
  • R2 is hydrogen or CH2Z
  • each Z is independently CO2M or CH2CO2M
  • M is H, alkali metal, alkaline earth metal, ammonium or alkanolammonium; and/or ammonium derivatives of formula (IV)
  • R ⁇ , R2 and Z are as defined above;
  • n, m, p, and q are numbers from 1 to 4, and Rj and M are independently selected from the groups specified above;
  • Suitable amphoteric surfactants of type (a) are marketed under the trade name Miranol and Empigen and are understood to comprise a complex mixture of species.
  • Miranols have been described as having the general formula III, although the CTFA Cosmetic Ingredient Dictionary, 3rd Edition indicates the non-cyclic strucmre IV while the 4th Edition indicates yet another structural isomer in which R2 is O-linked rather than N-linked.
  • CTFA Cosmetic Ingredient Dictionary, 3rd Edition indicates the non-cyclic strucmre IV while the 4th Edition indicates yet another structural isomer in which R2 is O-linked rather than N-linked.
  • a complex mixmre of cyclic and non- cyclic species is likely to exist and both definitions are given here for sake of completeness.
  • Preferred for use herein, however, are the non-cyclic species.
  • amphoteric surfactants of type (a) include compounds of formula III and/or IV in which Rj is CgH ⁇ (especially iso-capryl), C9H19 and C11H23 alkyl.
  • Rj is CgH ⁇ (especially iso-capryl), C9H19 and C11H23 alkyl.
  • Rj is CgH ⁇ (especially iso-capryl), C9H19 and C11H23 alkyl.
  • Rj is CgH ⁇ (especially iso-capryl), C9H19 and C11H23 alkyl.
  • materials suitable for use in the present invention include cocoamphocarboxypropionate, cocoamphocarboxy propionic acid, and especially cocoamphoacetate and cocoamphodiacetate (otherwise referred to as cocoamphocarboxyglycinate).
  • Specific commercial products include those sold under the trade names of Ampholak 7TX (sodium carboxy methyl tallow polypropyl amine), Empigen CDL60 and CDR 60 (Albright & Wilson), Miranol H2M Cone. Miranol C2M Cone. N.P., Miranol C2M Cone.
  • Miranol C2M SF Miranol CM Special (Rh ⁇ ne-Poulenc); Alkateric 2CIB (Alkaril Chemicals); Amphoterge W-2 (Lonza, Inc.); Monateric CDX-38, Monateric CSH-32 (Mona Industries); Rewoteric AM-2C (Rewo Chemical Group); and Schercotic MS-2 (Scher Chemicals).
  • amphoteric surfactants of this type are manufactured and sold in the form of electroneutral complexes with, for example, hydroxide counterions or with anionic sulfate or sulfonate surfactants, especially those of the sulfated Cg- C 8 alcohol, CS-CJS ethoxylated alcohol or Cg-Cis acyl glyceride types.
  • anionic sulfate or sulfonate surfactants especially those of the sulfated Cg- C 8 alcohol, CS-CJS ethoxylated alcohol or Cg-Cis acyl glyceride types.
  • compositions which are essentially free of (non-ethoxylated) sulfated alcohol surfactants are based herein on the uncomplexed forms of the surfactants, any anionic surfactant counterions being considered as part of the overall anionic surfactant component content.
  • amphoteric surfactants of type (b) include N-alkyl polytrimethylene poly-, carboxymethylamines sold under the trade names Ampholak X07 and Ampholak 7CX by Berol Nobel and also salts, especially the triethanolammonium salts and salts of N-lauryl-beta-amino propionic acid and N-lauryl-imino-dipropionic acid.
  • Such materials are sold under the trade name Deriphat by Henkel and Mirataine by Rh ⁇ ne- Poulenc.
  • compositions herein can also contain from about 0.1 % to about 20%, more preferably from about 0.1 % to about 10%, and especially from about 1 % to about 8% of a zwitterionic surfactant.
  • Water-soluble auxiliary betaine surfactants suitable for inclusion in the compositions of the present invention include alkyl betaines of the formula R5R6R7N+ (CH2) n 02M (VIII) and amido betaines of the formula (IX)
  • R5 is Ci 1-C22 alkyl or alkenyl
  • R and R ⁇ are independently C1-C3 alkyl
  • M is H
  • alkali metal alkaline earth metal
  • n, m are each numbers from 1 to 4.
  • Preferred betaines include cocoamidopropyldimethylcarboxymethyl betaine, laurylamidopropyldimethylcarboxymethyl betaine and Tego betaine (RTM).
  • Water-soluble auxiliary sultaine surfactants suitable for inclusion in the compositions of the present invention include alkyl sultaines of the formula
  • R is C7 to C22 alkyl or alkenyl
  • R2 and R3 are independently Ci to C3 alkyl
  • M is H, alkali metal, alkaline earth metal, ammonium or alkanolammonium
  • m and n are numbers from 1 to 4.
  • Preferred for use herein is coco amido propylhydroxy sultaine.
  • Water-soluble auxiliary amine oxide surfactants suitable for inclusion in the compositions of the present invention include alkyl amine oxide R5R6R7NO and amido amine oxides of the formula (XI) «6
  • R5 is Cn to C22 alkyl or alkenyl
  • R and R7 are independently Ci to C3 alkyl
  • M is H, alkali metal, alkaline earth metal, ammonium or alkanolammonium
  • m is a number from 1 to 4.
  • Preferred amine oxides include cocoamidopropylamine oxide, lauryl dimethyl amine oxide and myristyl dimethyl amine oxide.
  • Suitable anionic surfactants suitable for use herein can generally be described as mild synthetic detergent surfactants and include ethoxylated alkyl sulfates, alkyl glyceryl ether sulfonates, methyl acyl taurates, fatty acyl glycinates, N-acyl glutamates, acyl isethionates, alkyl sulfosuccinates, alpha-sulfonated fatty acids, their salts and/or their esters, alkyl ethoxy carboxylates, alkyl phosphate esters, ethoxylated alkyl phosphate esters, acyl sarcosinates and fatty acid/protein condensates, and mixmres thereof.
  • Alkyl and/or acyl chain lengths for these surfactants are C8-C22, preferably C10-C18 more preferably C12-C14.
  • Particularly preferred are the alkyl sulfates containing from about 2 to 6, preferably 2 to 4 moles of ethylene oxide, such as sodium laureth-2 sulfate, sodium laureth-3 sulfate and magnesium sodium laureth- 3.6 sulfate.
  • the anionic surfactant contains at least about 50%, especially at least about 75% by weight of ethoxylated alkyl sulfate.
  • the compositions comprise a mixmre of anionic and betaine emulsifiers, preferably in a ratio of betaine : anionic in the range of from about 5: 1 to about 1:1.
  • a second essential ingredient of the compositions herein is an antimicrobial agent.
  • the antimicrobial agent herein is in the form of a silver compound deposited on an inert particulate support material.
  • the support material is selected from oxides of titanium, magnesium, aluminium, silicon, cerium, zirconium, hafnium, niobium, and tantalum, calcium hydroxy apatite and barium sulphate.
  • said silver compound is selected from AgCl, AgBr, Ag2C ⁇ 3, AgOH and Ag3P ⁇ 4.
  • the antimicrobial agent is present in the compositions herein in an amount of from about 0.00001 % to about 5%, preferably from about 0.0001 % to about 3 %, more preferably from about 0.0001 % to about 1 %, and especially from about 0.0001 % to about 0.1 % by weight of composition.
  • the antimicrobial agent is present in the water phase.
  • the support material is titanium dioxide, preferably in one or more of the crystalline forms anatase, rutile or brookite.
  • such antimicrobial agents may be prepared by suspending the support material in an aqueous solution of a soluble metal compound and reacting this suspension with a compound containing the anion of a desired antimicrobial metal salt.
  • a compound containing the anion of a desired antimicrobial metal salt for example, titanium dioxide may be suspended in an aqueous solution of silver nitrate and reacted with silver chloride to precipitate silver chloride on the titanium dioxide.
  • the antimicrobial metal source may be employed alone or in combination with further antimicrobial agents, for instance zinc salts such as zinc oxide, and organic antimicrobial agents such as piroctone olamine and phenoxy isopropanol .
  • the antimicrobial metal source i.e. the silver compound, may be present in an amount of from about 0.5% to about 75%, preferably from about 0.5% to about 50%, and especially from about 5% to about 30% by weight of the antimicrobial agent.
  • the particulate support material has an average particle size of less than about 25 micrometres.
  • the particle size is between about 0.01 and 15 micrometres.
  • the particles have an open mo ⁇ hology.
  • each particle comprises an agglomeration of crystallites having open spaces between the crystallites.
  • the particles are roughly spherical clusters of crystallites.
  • the particles exhibit some irregularity of shape.
  • titanium dioxide is used to provide the crystallites
  • the primary crystal size will preferably be between 0.005 micrometres and 5 micrometres, preferably between 0.01 micrometres and 1 micrometre.
  • the support material has a mean surface area of from about 1 to about 300m2/g.
  • a preferred antimicrobial agent for use herein is JMAC TD supplied by Johnson Matthey. Also suitable for use herein is JMAC also supplied by Johnson Matthey.
  • compositions herein preferably further comprise from about 0.1 % to about 10%, preferably from about 0.1 % to about 5%, especially from about 1 % to about 3 % by weight of skin care active.
  • useful skin care actives include the keratolytics such as salicylic acid, and resorcinol; retinoids such as retinoic acid and its derivatives (e.g., cis and trans); antibiotics and antimicrobials such as benzoyl peroxide, octopirox, erythromycin and its metal complexes (e.g., zinc erythromycin), tetracyclin, 2,4,4' -trichloro-2' -hydroxy diphenyl ether, 3,4,4'- trichlorobanilide, azelaic acid and its derivatives, phenoxyethanol, phenoxypropanol, phenoxy isopropanol, ethyl acetate, clindamycin and meclocycline; sebostats
  • NSAIDS non-steroidal anti-inflammatory actives
  • NSAIDS include the following categories: propionic acid derivatives; acetic acid derivatives; fenamic acid derivatives; biphenylcarboxylic acid derivatives; and oxicams. All of these NSAIDS are fully described in the U.S. Patent 4,985,459 to Sunshine et al., issued January 15, 1991, incorporated by reference herein.
  • NSAIDS examples include acetyl salicylic acid, acetaminophen, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pi ⁇ rofen, ca ⁇ rofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen and bucloxic acid.
  • steroidal anti-inflammatory drugs including hydrocortisone and the like.
  • Topical anesthetics examples include lidocaine, bupivacaine, chlo ⁇ rocaine, dibucaine, etidocaine, mepivacaine, tetracaine, dyclonine, hexylcaine, procaine, cocaine, ketamine, pramoxine, phenol, and pharmaceutically acceptable salts thereof.
  • Antimicrobial and antifungal actives examples include b-lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 3,4,4'- trichlorobanilide, phenoxyethanol, phenoxy propanol, phenoxy isopropanol, doxycycline, capreomycin, chlorhexidine, chlortetracycline, oxytetracycline, clindamycin, ethambutol, hexamidine isethionate, metronidazole, pentamidine, gentamicin, kanamycin, lineomycin, methacycline, methenamine, minocycline, neomycin, netilmicin, paromomycin, streptomycin, tobramycin, miconazole, te
  • Sunscreening actives A wide variety of sunscreening actives are useful herein, and include those described in U.S. Patent No. 5,087,445, to Haffey et al., issued February 11, 1992; U.S. Patent No. 5,073,372, to Turner et al., issued December 17, 1991; U.S. Patent No. 5,073,371, to Turner et al. issued December 17, 1991; and Segarin, et al., at Chapter VIII, pages 189 et seq., of Cosmetics Science and Technology, all of which are inco ⁇ orated herein by reference in their entirety.
  • Noniimiting examples of sunscreen actives include those selected from the group consisting of 2-ethylhexyl p-methoxy cinnamate, 2-ethylhexyl N,N- dimethyl-p-aminobenzoate, p-aminobenzoic acid, 2-phenylbenzimidazole- 5-sulfonic acid, octocrylene, oxybenzone, homomenthyl salicylate, octyl salicylate, 4,4'-methoxy-t-butyldibenzoylmethane, 4-iso ⁇ ropyl dibenzoylmethane, 3-benzylidene camphor, 3-(4-methylbenzylidene) camphor, and mixmres thereof.
  • sunscreening agents disclosed therein have, in a single molecule, two distinct chromophore moieties which exhibit different ultra ⁇ violet radiation abso ⁇ tion spectra.
  • One of the chromophore moieties absorbs predominantly in the UVB radiation range and the other absorbs strongly in the UVA radiation range.
  • sunscreens include those selected from the group consisting of 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2,4- dihydroxy benzophenone, 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester with 4-hydroxydibenzoylmethane, 4-N,N-(2- ethylhexyl)methylaminobenzoic acid ester of 2-hydroxy-4-(2- hydroxy ethoxy )benzophenone , 4-N , N-(2-ethylhexy l)-methy laminobenzoic acid ester of 4-(2-hydroxyethoxy)dibenzoylmethane, and mixmres thereof.
  • actives useful herein include those selected from the group consisting of salicylic acid, 3-hydroxy benzoic acid, 4-hydroxy benzoic acid, acetyl salicylic acid, 2-hydroxybutanoic acid, 2- hydroxypentanoic acid, 2-hydroxyhexanoic acid, cis-retinoic acid, trans- retinoic acid, azelaic acid, arachidonic acid, benzoylperoxide, tetracyclin, ibuprofen, naproxen, hydrocortisone, acetominophen, erythromycin, zinc erythromycin, resorcinol, phenoxyethanol, phenoxypropanol, phenoxy isopropanol, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 3,4,4'- trichlorocarbanilide, octopirox, lidocaine hydrochloride, clotrimazole, miconazole, neocycin
  • actives useful herein include those selected from the group consisting of salicylic acid, acetyl salicylic acid, cis-retinoic acid, trans- retinoic acid, azelaic acid, tetracyclin, ibuprofen, naproxen, acetominophen, hydrocortisone, erythromycin, zinc erythromycin, resorcinol, phenoxyethanol, phenoxypropanol, phenoxy isopropanol, 2,4,4 '-trichloro-2' -hydroxy diphenyl ether, 3,4,4'-trichlorocarbanilide, octopirox, 2-ethylhexyl p-methoxycinnamate, 2-ethylhexyl N,N-dimethyl- p-aminobenzoate, 2-phenylbenzimidazole-5-sulfonic acid, octocrylene, oxybenzone, homomenthyl salicylic acid
  • actives useful herein include those selected from the group consisting of salicylic acid, cis- retinoic acid, trans-retinoic acid, azelaic acid, erythromycin, resorcinol, ibuprofen, naproxen, hydrocortisone, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 3,4,4'- trichlorocarbanilide, 2-ethylhexyl p-methoxycinnamate, 2-ethylhexyl N,N- dimethyl-p-aminobenzoate, 2-phenylbenzimidazole-5-sulfonic acid, octocrylene, oxybenzone, homomenthyl salicylate, octyl salicylate, 4,4*- methoxy-t-butyldibenzoylmethane, 4-isoprop
  • compositions of the present invention are preferably in the form of a water-in-oil or an oil-in-water emulsion, most preferably in the form of an oil-in-water emulsion. These emulsions are typically used with water to cleanse the skin. Upon rinsing with water, these compositions are removed from the skin surface along with associated dirt, oils, bacteria, and other foreign material, and leave the antimicrobial active and other skin care actives on the skin.
  • the oil-in-water emulsions herein have desirable aesthetic properties, such as a rich and creamy, yet non-greasy, skin feel. These emulsions can span a broad range of consistencies from thin lotions to heavy creams. These emulsions typically have viscosities ranging from about 100 cps to about 500,000 cps, more preferably from about 1000 cps to about 150,000 cps, and most preferably from about 5000 cps to about 100,000 cps.
  • the emulsion compositions herein can span a wide range of pH values and can be acidic, basic, or neutral, depending on the particular active or actives employed.
  • the pH of the composition should be carefully chosen so that it is at or below the pKa of the active.
  • the pKa value for a compound is that pH value at which the material is 50 percent dissociated or ionized to yield its conjugate base and a proton (or hydrated proton).
  • the pH of the formulation is below the pKa of the active, it is belived that the active will exist primarily in its un-ionized form which should enhance its subsequent deposition onto the skin.
  • salicylic acid has a reported pKa of 2.97 at 19 C in aqueous solution. Therefore, it would be useful to formulate salicylic acid containing compositions at or below a pH of about 2.97 in order to suppress ionization and maximize deposition from the emulsion. See CRC Handbook of Chemistrv and Phvsics. 57th Edition, page D-150 (1976).
  • salicylic acid containing compositions the should be from about 2 to about 7, more preferably from about 2.5 to about 5, even more preferably from about 2.5 to about 4, and most preferably from about 2.5 to about 3.
  • buffers can be utilized to help maintain the pH of the emulsion compositions, these are not required components, but are merely optional.
  • compositions of the present invention comprise from about 0.1 % to about 25%, preferably from about 0.1 % to about 15%, and more preferably from about 6% to about 10% of an alkoxylated ether which is useful for solubilizing the active ingredients in the oil phase of oil-in-water emulsions.
  • the alkoxylated ethers and diethers useful herein generally have a solubility in water of less than about 1 gram per about 100 grams of water at 25 C. These compounds are typically formulated into the oil phase of oil-in-water emulsions as described in the Examples below. Mixmres of alkoxylated ethers and diethers can be used herein.
  • the alkoxylated ethers useful herein can be described by the following general formula:
  • R is selected from the group consisting of H and C1-C30 straight chain or branched chain alkyl
  • m is an integer from 0 to about 6
  • R' is selected from the group consisting of methyl and ethyl
  • n is an integer from about 3 to about 30.
  • R is selected from the group consisting of C2-C25 straight chain or branched alkyl, m is an integer from 0 to about 2, R' is methyl, and n is an integer from about 5 to about 25. More preferably R is selected from the group consisting of C2-C20 straight chain or branched chain alkyl, m is an integer from 0 to about 1, R' is methyl, and n is an integer from about 10 to about 20.
  • Noniimiting examples of classes of alkoxylated ethers useful herein include propoxylated and butoxylated ethers of alcohols and polyols. These compounds can be described as PPG and PBG alkyl ethers wherein the PPG and PBG are commonly used designations for polypropylene glycol and polybutylene glycol, respectively. The average number of PPG or PBG groups in these ethers is commonly given by a number designation after the PPG or PBG. For example, PPG- 14 butyl ether, would designate a polypropylene glycol ether of butanol wherein the molecule has on average 14 propylene glycol units.
  • Noniimiting examples of alkoxylated ethers useful herein include PPG- 10 butyl ether, PPG-11 butyl ether, PPG-12 butyl ether, PPG-13 butyl ether, PPG-14 butyl ether, PPG-15 butyl ether, PPG-16 butyl ether, PPG-17 butyl ether, PPG- 18 butyl ether, PPG- 19 butyl ether, PPG-20 butyl ether, PPG-22 butyl ether, PPG-24 butyl ether, PPG-30 butyl ether, PPG- 11 stearyl ether, PPG- 15 stearyl ether, PPG-10 oleyl ether, PPG-7 lauryl ether, PPG-30 isocetyl ether, PPG- 10 glyceryl ether, PPG- 15 glyceryl ether, PPG-10 butyleneglycol ether, PPG-15 butylene glycol ether, PPG- 27 glyce
  • Preferred alkoxylated ethers are those selected from the group consisting of PPG-14 butyl ether, PPG-15 stearyl ether, PPG-11 stearyl ether, PPG- 20 oleyl ether, and mixmres thereof.
  • More preferred alkoxylated ethers are those selected from the group consisting of PPG-14 butyl ether, PPG-15 stearyl ether, and mixtures thereof.
  • PPG- 14 butyl ether is available under the tradename Fluid AP from Union Carbide Co ⁇ oration.
  • PPG 15 stearyl ether is available under the tradename Arlamol E from ICI Americas Co ⁇ oration.
  • alkoxylated diethers are also useful herein. These compounds can be represented by the general formula:
  • each R" is selected from the group consisting of methyl and ethyl
  • p is an integer from about 1 to about 6
  • each q and r are independently selected so that their sum is an integer from about 3 to about 30.
  • R" is methyl
  • p is an integer from about 2 to about 4
  • each q and r are independently selected so that their sum is an integer from about 5 to about 25.
  • More preferably R" is methyl, p is an integer from 2 to about 4, and each q and r are independently selected so that their sum is an integer from about 10 to about 20.
  • Noniimiting examples of alkoxylated diethers useful herein include those selected from the group consisting of PPG-10 1,4-butanediol diether, PPG- 12 1,4-butanediol diether, PPG-14 1,4-butanediol diether, PPG-2 butanediol diether, PPG-10 1,6-hexanediol diether, PPG-12 1,6-hexanediol diether, PPG- 14 hexanediol diether, PPG-20 hexanediol diether, and mixmres thereof.
  • Preferred are those selected from the group consisting of PPG- 10 1,4-butanediol diether, PPG- 12 1 ,4-butanediol diether, PPG- 10 1 ,6-hexandiol diether, and PPG- 12 hexanediol diether, and mixmres thereof. More preferred is PPG-10 1,4-butanediol diether. This compound is commercially available under the tradename Macol 57 from PPG/Mazer Corporation.
  • compositions herein are also preferred for use in the compositions herein.
  • a deposition aiding polymer for increasing the deposition of the antimicrobial agent and/or any skin care active present in the composition.
  • the compositions of the present invention preferably comprise from 0% to about 10%, more preferably from about 0.1 % to about 10%, even more preferably from about 0.25% to about 7.5%, and most preferably from about 0.50% to about 5% of a deposition aiding polymer for increasing the deposition of the skin care active ingredient upon the skin.
  • the deposition aiding polymer is believed to aid in the deposition of the active ingredient from the oil phase of the oil-in-water emulsion, thereby depositing the active onto the skin during the cleansing process and helping the active to adhere to the skin during the rinsing process.
  • the deposition aiding polymers useful herein are typically formulated into the oil phase of the oil-in-water emulsions as described in the Examples below.
  • a variety of deposition aiding polymers are useful herein and include those selected from the group consisting of hydroxy-terminated urethane polymers, polypropylene glycols, and mixmres thereof.
  • the weight/weight ratio of the hydroxy-terminated urethane polymer to the polypropylene glycol polymer is from about 1:1.5 to about 1.5:1, preferably from about 1.25: 1 to about 1: 1.25, more preferably from about 1.1:1 to about 1: 1.1, and most preferably about 1:1.
  • Hvdroxy-terminated Urethane Polymers The hydroxy-terminated urethane polymers useful as deposition aids herein are those generally described in U.S. Patent 5,051,260, to Chess et al., issued September 24, 1991; U.S. Patent No. 5,045,317, to Chess et al. issued September 3, 1991; and U.S. Patent No. 4,971,800, to Chess et al., issued November 20, 1990; all of which are inco ⁇ orated by reference herein in their entirety.
  • R represents an alkyl or alkenyl radical having from about one to about 20 carbon atoms, or a cycloalkyi or cycloalkyneyl radical containing form about 5 to about 10 carbon atoms, or a mononuclear or fused ring aryl radical containing from about 6 to about 10 carbon atoms, unsbustimted or substimted with one or more C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy-substimted C1-C6, nitro or amino groups or halogen atoms;
  • R is the same or different alkyl or akenyl radical;
  • m is an integer selected so as to provide an (O-R ) moiety having a molecular weight of from about 40 to about 6000, preferably from about 400 to about 2000; and
  • n and n' are the same or different integers of from 0 to about 30 inclusive, correlated with m so as to provide a hydroxy-terminated
  • the hydroxy-terminated urethane compounds are prepared using standard synthetic techniques from the reaction of linear alkylene or polyalkylene glycols or polyethers with monomeric organic diisocyanates.
  • the linear alkylene or polyalkylene glycols or polyethers are represented by the
  • polyalkylene glycol or polyether reactants include: diethylene glycol, triethylene glycol, PEG-4, PEG-6, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, PEG-32, PEG-40, PPG-9, PPG-12, PPG-15, PPG-17, PPG-20, PPG-26, PPG-30, PPG-34, and polytetramethylene glycols having molecular weights ranging from about 600 to 6000, and the like.
  • the terms "PEG” and "PPG” are commonly used CTFA designations for polyethylene glycol and polypropylene glycol, respectively.
  • R is an alkyl or alkenyl radical having from about one to about 20 carbon atoms, or a cycloalkyi or cycloalkyneyl radical containing form about 5 to about 10 carbon atoms, or a mononuclear or fused ring aryl radical containing from about 6 to about 10 carbon atoms, unsbustimted or substimted with one or more C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy- substimted C1-C6, nitro or amino groups or halogen atoms.
  • Noniimiting examples of diisocyanates are aromatic diisocyanates, such as m- phenylenediisocyanate, p-phenylenediisocyanate, 4-t-butyl-m- phenylenediisocyanate, 4-methoxy-m-phenylenediisocyanate, 4-phenoxy- m-pheny lenediisocyanate , 4-chloro-m-pheny lenediisocyanate , toluenediisocyanates (either as a mixmre of isomers, e.g., the commercially available mixmre of 80% 2,4-toluenediisocyanate and 20% 2,6-toluenediisocyanate, or as the individual isomers themselves), m- xy lylenediisocy anate , p-xy ly lendiisocy anate , cumene-2 ,4-diisocyanate , durenediis
  • a preferred hydroxy-terminated urethane polymer useful herein is poly[oxy(methyl- 1 ,2-ethanediyl)] ,alpha-hydro-omega-hydroxy-, polymer with l,l'methylene-bis-(4-isocyanatocyclohexane).
  • This material is also known by the CTFA designation polyolprepolymer-2 and is commercially available as Topicare 35 A from Penederm Inc. through its distributor Barnet Products Co ⁇ . (Englewood Cliffs, NJ).
  • Polypropylene Glvcols Polypropylene glycols are useful as deposition aiding polymers herein.
  • Polypropylene glycols are polymers which are typically formed from the polymerization of propylene oxide, propylene glycol, propylchlorohydrin, propylbromohydrin, and other related materials. Polypropylene glycols are represented by the following formula.
  • n is an integer from about 10 to about 50, preferably wherein n is an integer from about 15 to about 40, and more preferably wherein n is an integer from about 20 to about 34.
  • the polypropylene glycols are commonly desiginated as PPG's followed by a number indicating the average number of repeating units in the strucmre. For example, PPG-30 would correspond to the above strucmre wherein n has an average value of about 30.
  • polypropylene glycols useful herein encompass those designated as PPG- 10 through PPG-50, more preferably those designated as PPG- 15 through PPG-40, and most preferably those designated as PPG-20 through PPG-34.
  • An especially preferred PPG for use in the compositions herein is PPG-30, which is sold under the tradename Polyglycol P-4000 and is commercially available from Dow Chemical Co ⁇ oration.
  • compositions of the present invention comprise from 0% to about 10%, preferably from about 0.5% to about 5%, and more preferably from about 1 % to about 4% of a polymeric thickener.
  • thickeners can be employed herein with the choice depending upon the pH of the formulation and other emulsion components chosen. For compositions having a pH from about 2 to about 7, the thickeners should be stable within that pH range, i.e. they should not degrade and should not lose their thickening ability.
  • Preferred thickeners include those selected from the group consisting of crosslinked polyacrylate polymers, alkyl modified hydroxyalkylcellulose polymers, quaternary ammomum hydroxalkyl celluose polymers, and mixmres thereof.
  • crosslinked polyacrylate polymers useful as thickeners include both cationic and nonionic polymers, with the cationics being generally preferred.
  • Examples of useful crosslinked nonionic polyacrylate polymers and crosslinked cationic polyacrylate polymers are those described in U.S. Patent 5,100,660, to Hawe et al., issued March 31, 1992; U.S. Patent 4,849,484, to Heard, issued July 18, 1989; U.S. Patent 4,835,206, to Farrar et al., issued May 30, 1989; U.S. Patent 4,628,078 to Glover et al. issued December 9, 1986; U.S. Patent 4,599,379 to Flesher et al. issued July 8, 1986; and EP 228,868, to Farrar et al., published July 15, 1987; all of which are inco ⁇ orated by reference herein in their entirety.
  • the crosslinked polyacrylate polymers are high molecular weight materials that can be characterized by the general formula: (A) (B) (C) and comprise the monomer units (A) , (B) , and (C) , wherem (A) is a dialkylaminoalkyl acrylate monomer or its quaternary ammonium or acid addition salt, (B) is a dialkylaminoalkyl methacrylate monomer or its quaternary ammonium or acid addition salt, (C) is a monomer that is polymerizable with (A) or (B), for example a monomer having a carbon- carbon double bond or other such polymerizable functional group, 1 is an integer of 0 or greater, m is an integer of 0 or greater, n is an integer of 0 or greater, but where either 1 or m, or both, must be 1 or greater.
  • the (C) monomer can be selected from any of the commonly used monomers. Noniimiting examples of these monomers include ethylene, propylene, butylene, isobutylene, eicosene, maleic anhydride, acrylamide, methacrylamide, maleic acid, acrolein, cyclohexene, ethyl vinyl ether, and methyl vinyl ether. In the cationic polymers of the present invention, (C) is preferably acrylamide.
  • the alkyl portions of the (A) and (B) monomers are short chain length alkyls such as C -C , preferably C -C , more preferably C -C , and most preferably C -C . When quaternzied, the polymers are preferably quaternized with short chain alkyls, i.e., C -C ,
  • the acid addition salts refer to polymers having protonated amino groups. Acid addition salts can be performed through the use of halogen (e.g. chloride), acetic, phosphoric, nitric, citric, or other acids.
  • halogen e.g. chloride
  • crosslinking agent which is most typically a material containing two or more unsaturated functional groups.
  • the crosslinking agent is reacted with the monomer units of the polymer and is inco ⁇ orated into the polymer thereby forming links or covalent bonds between two or more individual polymer chains or between two or more sections of the same polymer chain.
  • suitable crosslinking agents include those selected from the group consisting of methylenebisacrylamides, diallyldialkyl ammonium halides, poly alkenyl polyethers of polyhydric alcohols, allyl acrylates, vinyloxyalkylacrylates, and polyfunctional vinylidenes.
  • crosslinking agents useful herein include those selected from the group consisting of methylenebisacrylamide, ethylene glycol di-(meth)acrylate, di-(meth)acrylamide, cyanomethylacrylate, vinyloxyethylacrylate, vinyloxyethylmethacrylate, allyl pentaerythritol, trimethylolpropane diallylether, allyl sucrose, butadiene, isoprene, divinyl benzene, divinyl naphthalene, ethyl vinyl ether, methyl vinyl ether, and allyl acrylate.
  • Other crosslinkers include formaldehyde and glyoxal.
  • Preferred for use herein as a crosslinking agent is methylenebisacrylamide.
  • crosslinking agent can be employed depending upon the properties desired in the final polymer, e.g. viscosifying effect. Without being limited by theory, it is believed that inco ⁇ oration of a crosslinking agent into these cationic polymers provides a material that is a more effective viscosifying agent without negatives such as stringiness and viscosity breakdown in the presence of electrolytes.
  • the crosslinking agent when present, can comprise from about 1 ppm to about 1000 ppm, preferably from about 5 ppm to about 750 ppm, more preferably from about 25 ppm to about 500 ppm, even more preferably from about 100 ppm to about 500 ppm, and most preferably from about 250 ppm to about about 500 ppm of the total weight of the polymer on a weight/weight basis.
  • the intrinsic viscosity of the crosslinked polymer measured in one molar sodium chloride solution at 25 C, is generally above 6, preferably from about 8 to about 14.
  • the molecular weight (weight average) of the crosslinked polymers hereof is high, and is believed to typically be between about 1 million and about 30 million.
  • the specific molecular weight is not critical and lower or higher weight average molecular weights can be used as long as the polymer retains its intended viscosifying effects in water or other aqueous carriers of the compositions hereof.
  • a 1.0% solution of the polymer (on an actives basis) in deionized water will have a viscosity at 25 C of at least about 20,000 cP, preferably at least about 30,000 cP, when measured at 20 RPM by a Brookfield RVT (Brookfield Engineering Laboratories, Inc. Stoughton, MA, USA).
  • These cationic polymers can be made by polymerization of an aqueous solution containing from about 20% to about 60%, generally from about 25% to about 40%, by weight monomer, in the presence of an initiator (usually redox or thermal) until the polymerization terminates.
  • the crosslinking agent can also be added to the solution of the monomers to be polymerized, to incorporate it into the polymer.
  • the temperamre generally starts between about O and 95 C.
  • the polymerization can be conducted by forming a reverse phase dispersion of an aqueous phase of the monomers (and also any additional crosslinking agents) into a nonaqueous liquid, e.g. mineral oil, lanolin, isododecane, oleyl alcohol, and other volatile and nonvolatile esters, ethers, and alcohols, and the like.
  • a nonaqueous liquid e.g. mineral oil, lanolin, isododecane, oleyl alcohol, and other volatile and nonvolatile esters, ethers, and alcohols, and the like.
  • the molar proportion of (C) monomer based on the total molar amount of (A), (B), and (C), can be from 0% to about 99%.
  • the molar proportions of (A) and (B) can each be from 0% to 100% .
  • acrylamide is used as the (C) monomer, it will preferably be used at a level of from about 20% to about 99%, more preferably from about 50% to about 90%.
  • the ratio of monomer (A) to monomer (B) in the final polymer, on a molar basis, is preferably from about 99:5 to about 15:85, more preferably from about 80:20 to about 20:80.
  • the ratio is from about 5:95 to about 50:50, preferably from about 5:95 to about 25:75.
  • the ratio (A):(B) is from about 50:50 to about 85:15.
  • the ratio (A):(B) is about 60:40 to about 85:15, most preferably about 75:25 to about 85:15.
  • monomer (A) is not present and the ratio of monomer (B):monomer (C) is from about 30:70 to about 70:30, preferably from about 40:60 to about 60:40 and most preferably from about 45:55 to about 55:45.
  • Cationic polymers that are useful herein that are especially preferred are those conforming to the general strucmre (A) (B) (C) wherein 1 is zero, (B) is methyl quaternized dimethylaminoethyl methacrylate, the ratio of (B):(C) is from about 45:55 to about 55:45, and the crosslinking agent is methylenebisacrylamide.
  • a cationic polymer is one that is commercially available as a mineral oil dispersion (which can also include various dispersing aids such as PPG-1 trideceth-6) under the trademark Salcare SC92 from Allied Colloids Ltd. (Norfolk, Virginia).
  • This polymer has the proposed CTFA designation, "Polyquaternium 32 (and) Mineral Oil”.
  • cationic polymers useful herein are those not containing acrylamide or other (C) monomers, that is, n is zero.
  • the (A) and (B) monomer components are as described above.
  • An especially preferred group of these non-acrylamide containing polymers is one in which 1 is also zero.
  • the polymer is essentially a homopolymer of a dialkylaminoalkyl methacrlyate monomer or its quaternary ammonium or acid addition salt.
  • diaklylaminoalkyl methacrylate polymers preferably contain a crosslinking agent as described above.
  • a cationic polymer which is essentially a homopolymer, useful herein is one conforming to the general strucmre (A) (B) (C) wherein 1 is zero, (B) is methyl quaternized dimethylaminoethyl methacrylate, n is zero, and the crosslinking agent is methylenebisacrylamide.
  • An example of such a homopolymer is commercially available as a mixmre containing approximately 50% of the polymer, approximately 44% mineral oil, and approximately 6% PPG-1 trideceth-6 as a dispersing aid, from Allied Colloids Ltd, (Norfolk, VA) under the trademark Salcare SC95. This polymer has recently been given the CTFA designation "Polyquaternium 37 (and) Mineral Oil (and) PPG-1 Trideceth-6".
  • alkyl hydroxy alky lcellulose ethers polymers containing a cellulose backbone, i.e. a polysaccharaide backobone of repeating glucose units.
  • the hydroxy groups of the cellulose polymer are hydroyxalkylated (prefereably hydroxyethylated or hydropropylated) to form a hydroxyalkylated cellulose which is then further modified with a C10-C30 straight chain or branched chain alkyl group through an ether linkage.
  • these polymers are ethers of C10-C30 straight or branched chain alcohols with hydroxyalkylcelluloses.
  • alkyl groups useful herein include those selected from the group consisting of stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl (i.e. alkyl groups derived from the alcohols of coconut oil), palmityl, oleyl, linoleyl, linolenyl, rincioleyl, behenyl, and mixmres thereof.
  • alkyl hydroxyalkyl cellulose ethers Preferred among the alkyl hydroxyalkyl cellulose ethers is the material given the CTFA designation cetyl hydroxyethylcellulose, which is the ether of cetyl alcohol and hydroxyethylcellulose. This material is sold under the tradename Natrosol CS Plus from Aqualon Corporation.
  • quaternary ammonium hydroyxalkylcellulose polymer polymers containing a cellulose backbone, i.e. a polysaccharaide backbone of repeating glucose units.
  • the hydroxy groups of the cellulose polymer are hydroxyalkylated (preferably hydroxyethylated or hydroxypropylated) to form a hydroxyalkylated cellulose which is then further modified with a cationic quaternary ammonium or protonated ammonium group.
  • Preferred cationic modifying groups are those having at least one C 10-20 alkyl chain and two shorter alkyl chains (i.e. Cl or C2) on the nitrogen.
  • the substituent on the cellulose polymer can thus be depicted as - (X)NRR'R" wherein X is hydroxyalkyl (preferably -OCH CH - or - OCH CHOHCH -), R and R' are methyl or ethyl, and R * s C10-20 alkyl [preferably lauryH stearyl, or cocoyl (i.e. a mixmre of alkyl groups derived from coconut oil)]. It has alternatively been found that when R, R', and R" are all methyl (i.e. the trimonium group) that useful cellulose polymers are also obtained.
  • the substituent on the cellulose polymer can be depicted as -(X)-OCH CH -NRR'R" wherein X is hydroxyalkyl (preferably -OCH ⁇ CH - or -OCH CHOHCH -), R and R' are methyl or ethyl, and R" is ClO-20 alkyl [preferably lauryl, stearyl, or cocoyl (i.e. a mixmre of alkyl groups derived from coconut oil)] . It has alternatively been found that when R, R', and R" are all methyl (i.e. the trimonium group) that useful cellulose polymers are also obtained.
  • the cationic substituent on the cellulose contains both a hydroxyethyl and a hydroxypropyl group such that the moiety can be depicted as -(OCH CH O)-CH CHOHCH NRR'R" wherein R, R', and R" are methyl or ethyl, and R" is C1CP20 alkyl [preferably lauryl, stearyl, or cocoyl (i.e. a mixmre of alkyl groups derived from coconut oil)], or alternatively wherein R, R ⁇ and R" are all methyl (i.e. the trimonium group).
  • CTFA designated polyquaternium-24, which is the quaternary ammonium salt of hydroxyethyl cellulose reacted with a lauryl dimethyl ammonium substimted epoxide (wherein in the above formula -(X)-OCH CH - NRR'R", X is -OCH CH -, R and R' are methyl, and R" is stearyl).
  • This material is sold under the tradename Quatrisoft Polymer LM-200 and is available from Amerchol Corporation.
  • laurdimonium hydroxethyl cellulose (wherein in the above formula - (X)NRR'R", X is -OCH ⁇ CH -, R and R' are methyl, and R" is lauryl), steardimonium hydroxyethyl cellulose (wherein in the above formula - (X)NRR'R", X is -OCH CH -, R and R' are methyl, and R" is stearyl), and cocodimonium hydroxyethyl cellulose (wherein in the above formula
  • (X)NRR'R X is -OCH CH -, R and R' are methyl, and R" is cocoyl).
  • Crodacel QL Crodacel QS
  • Crodacel QM Crodacel QM
  • Another highly useful cationic cellulose is laurdimmonium hydroxypropyl oxyethyl cellulose (wherein the modifying group on the cellulose is -(OCH CH 0)-CH CHOHCH NRR'R", wherein R R' are methyl and R is lauryl), which is commercially available as Crodacel QL Special, from Croda Co ⁇ .
  • compositions of the present invention comprise from about 25 % to about 99.7%, more preferably from about 65% to about 95%, and most preferably from about 70% to about 90% water.
  • An optional component of the present invention is a fatty acid.
  • These fatty acids can be used to increase emulsion viscosity and to provide a smooth feel to the finished emulsion.
  • these fatty acids can comprise from about 0.1 % to about 10%, more preferably from about 0.1 % to about 7.5 % , and most preferably from about 0.1 % to about 5 % of the compositions.
  • fatty acid any organic acid from natural or synthetic sources having from about 10 to about 40 carbon atoms, more preferably from about 10 to about 30 carbon atoms, and most preferably from about 12 to about 22 carbon atoms. Also included within this definition of fatty acid are the corresponding branched carbon chain materials.
  • Noniimiting examples of fatty alcohols include those selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, ricinoleic acid, behenic acid, isostearic acid, and mixmres thereof.
  • Examples of fatty alcohols are described in CTFA International Cosmetic Ingredient Dictionary Fourth Edition, which is inco ⁇ orated herein by reference in its entirety.
  • hydroxy substimted derivatives of the fatty acids described herein are also useful.
  • Noniimiting examples of these materials include hydroxystearic acid, hydroxypalmitic acid, hydroxylauric acid, and mixmres thereof.
  • An optional component of the present invention is a fatty alcohol.
  • These fatty alochols can be used to increase emulsion viscosity and to provide a smooth feel to the finished emulsion.
  • these fatty alcohols can comprise from about 0.1 % to about 10%, more preferably from about 0.1 % to about 7.5 % , and most preferably from about 0.1 % to about 5% of the compositions.
  • fatty alcohol any organic alcohol from natural or synthetic sources having from about 10 to about 40 carbon atoms, more preferably from about 10 to about 30 carbon atoms, and most preferably from about 12 to about 22 carbon atoms. Also included within this definition of fatty alcohol are the corresponding branched carbon chain materials.
  • Noniimiting examples of fatty alcohols include those selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, linoleyl alcohol, linolenyl alcohol, ricinoleyl alcohol, behenyl alcohol, and mixmres thereof.
  • fatty alcohols are described in CTFA International Cosmetic Ingredient Dictionary Fourth Edition, which is inco ⁇ orated herein by reference in its entirety.
  • humectant can comprise from about 0.1 % to about 20%, more preferably from about 0.5% to about 10%, and most preferably from about 1 % to about 5% of the compositions. Even though these materials are defined herein as humectants, they can also possess moisturizing, skin conditioning, and other related properties.
  • humectants useful herein include materials such as urea; guanidine; glycolic acid and glycolate salts (e.g. ammonium and quaternary alkyl ammonium); lactic acid and lactate salts (e.g.
  • aloe vera in any of its variety of forms (e.g., aloe vera gel); polyhydroxy alcohols such as sorbitol, glycerol, low molecular weight polypropylene glycols (e.g., dipropylene glycol and tripropylene glycol), hexanetriol, propylene glycol, butylene glycol, hexylene glycol, and the like; polyethylene glycol; sugars and starches; sugar and starch derivatives (e.g., alkoxylated glucose); hyaluronic acid; chitin, starch-grafted sodium polyacrylates such as Sanwet (RTM) IM- 1000, IM-1500, and IM-2500 (available from Celanese Superabsorbent Materials, Portsmouth, VA); lactamide monoethanolamine; acetamide monoethanolamine; propoxylated glycerol (as described in U.S. Patent No. 4,976,
  • Preferred humectants useful in the compositions of the present invention are urea, C3-C6 diols and triols, low molecular weight polypropylene glycols, and propoxylated glycerin.
  • Preferred humectants include those materials selected from the group consisting of urea, propylene glycol, 1,3-dihydroxy ⁇ ropane, glycerin, butylene glycol, hexylene glycol, 1,4- dihydroxyhexane, 1,2,6-hexanetriol, dipropylene glycol, tripropylene glycol, and mixmres thereof.
  • urea glycerin
  • butylene glycol hexylene glycol
  • glycerin dipropylene glycol
  • tripropylene glycol and mixmres thereof.
  • urea glycerin, and mixmres thereof.
  • compositions of the present invention can also include an emollient.
  • suitable emollients include, but are not limited to, volatile and non-volatile silicone oils (e.g., dimethicone, cyclomethicone, dimethiconol, and the like), highly branched hydrocarbons, and non-polar carboxylic acid and alcohol esters, and mixmres thereof.
  • Emollients useful in the instant invention are further described in U.S. Patent No. 4,919,934, to Deckner et al., issued April 24 1990, which is inco ⁇ orated herein by reference in its entirety.
  • the emollients can typically comprise in total from about 0.5% to about 50%, more preferably from about 0.5% to about 25%, and most preferably from about 0.5% to about 15% by weight of the compositions of the present invention.
  • compositions of the present invention can be incorporated into the compositions of the present invention.
  • additional ingredients include vitamins and derivatives thereof (e.g tocopherol, tocopherol acetate, and the like); other thickening agents (e.g., poly acrylamide and C isoparaffin and laureth-7, available as Sepigel
  • guar gum, xanthan gum and the like waxes (both naturally occurring and synthetic); polymers for aiding the film-forming properties and substantivity of the composition (such as a copolymer of eicosene and vinyl pyrrolidone, an example of which is available from GAF Chemical Co ⁇ oration as Ganex V-220 ); abrasive scrub particles for cleansing and exfoliating the skin [e.g., ACuscrub Mild Abrasives (e.g., ACuscrub 30, 31, 32, 40, 41, 42, 43, 44, 50, 51, and 52) available from Allied Signal, Inc., Morristown, NJ; and 3M Brand PMU Capsules microecapsulated mineral oil available from 3M Co ⁇ oration, St.
  • ACuscrub Mild Abrasives e.g., ACuscrub 30, 31, 32, 40, 41, 42, 43, 44, 50, 51, and 52
  • ethyl panthenol ethyl panthenol
  • aloe vera pantothenic acid and its derivatives
  • clove oil menthol
  • camphor eucalyptus oil
  • eugenol menthyl lactate
  • witch hazel distillate allantoin, bisabalol, dipotassium glycyrrhizinate and the like.
  • compositions of the present invention are useful for cleansing the skin and also for depositing an antimicrobial agent onto the skin.
  • a suitable amount of the cleansing composition is applied to the skin to be cleansed. It is preferred to premoisten the skin with water.
  • a suitable amount of the cleansing composition can be applied to the skin via intermediate application to a washcloth, a sponge, or other application device. It has been found that the compositions of the present invention provide their optimal cleansing performance when combined with water during the cleansing process.
  • the composition is thoroughly rinsed from the skin with water, leaving the antimicrobial agent on the skin surface.
  • an effective amount of the emulsion composition is utilized, for example, from about 0.5 mg/cm to about 5.0 mg/cm of skin area to be cleansed.
  • compositions of the examples can be prepared as follows:
  • the glycerin, disodium EDTA and water are mixed in a first vessel.
  • the mixmre is heated to 75-80 0C.
  • the PPG- 15 stearyl ether, salicylic acid and the PPG-30 are mixed together in a second vessel and the resulting mixmre is heated to 75-80 OC.
  • the oil phase has reached 55 0c the stearyl alcohol, cetyl alcohol, behenyl alcohol, distearyldimonium chloride, steareth-21 and steareth-2 are added to the oil phase. Mixing of the oil phase is continued whilst heating to 75-800C.
  • both phases have reached 75-800C, the oil phase is transferred from the second vessel to the first vessel with mixing.
  • the main batch is then emulsified whilst maintaining a temperamre of 75-80 Oc.
  • the mixmre is then cooled to 45 0C, and the perfume and menthol are added.
  • the mixmre is cooled further.
  • the cetyl betaine and the polyethylene beads are mixed until the beads are dispersed.
  • the sodium lauryl sulphate is then added to the third vessel and mixing is continued for 30 minutes.
  • the surfactant premix is transferred from the third vessel to the main batch.
  • the JMAC TD is then added to the main batch.
  • the resulting batch is mixed for at least an hour while cooling to 29-31 0c.
  • the batch is then ready for packing.
  • the resulting emulsions are useful for application to the skin for cleansing and antibacterial purposes and for treating acne.

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Abstract

L'invention porte sur une composition nettoyante comportant, a), de 0,1 à 30 % environ en poids d'un agent émulsifiant choisi parmi un agent émulsifiant amphotère, un agent émulsifiant zwittérionique, un agent émulsifiant non ionique, un agent émulsifiant anionique, un agent émulsifiant cationique et leurs mélanges, b), de 0,00001 à 5 % environ en poids d'un agent anti-microbien, cet agent comprenant un composé à base d'argent déposé sur un support particulaire inerte et, c), de l'eau. La composition selon l'invention offre de nouvelles propriétés nettoyantes et un pouvoir anti-microbien renforcé.
PCT/US1996/020067 1995-12-22 1996-12-09 Compositions nettoyantes WO1997023594A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9526395.0 1995-12-22
GB9526395A GB9526395D0 (en) 1995-12-22 1995-12-22 Cleansing compositions

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WO1997023594A1 true WO1997023594A1 (fr) 1997-07-03

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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998059026A1 (fr) * 1997-06-20 1998-12-30 Reckitt & Colman Products Limited Ameliorations apportees au nettoyage de surfaces
WO1999039749A2 (fr) * 1998-02-10 1999-08-12 Vladimir Emelyanovich Oganesov Solution aqueuse desinfectante
WO2000010513A1 (fr) * 1998-08-18 2000-03-02 The Procter & Gamble Company Compositions cosmetiques contenant de l'oxyde de titane de rutile et d'anatase et des emollients
EP1129703A2 (fr) * 2000-03-04 2001-09-05 Clariant GmbH Compositions personnelles nettoyantes aqueuses ou hydroalcooliques comprenant des esters du sorbitol
WO2002083830A1 (fr) * 2001-04-12 2002-10-24 Dieter Meissner Mousse, procede de production de mousse et utilisation de mousse
US6630016B2 (en) * 2002-01-31 2003-10-07 Koslow Technologies Corp. Microporous filter media, filtration systems containing same, and methods of making and using
US6835311B2 (en) 2002-01-31 2004-12-28 Koslow Technologies Corporation Microporous filter media, filtration systems containing same, and methods of making and using
US6866704B2 (en) * 2002-01-31 2005-03-15 Koslow Technologies Corporation Microporous filter media with intrinsic safety feature
WO2006083980A1 (fr) * 2005-02-01 2006-08-10 The Procter & Gamble Company Composition d'emulsion pour lingettes humides contenant un ingredient benefique pour la peau non irritant, et procede de fabrication associe
US7105691B2 (en) 2003-06-26 2006-09-12 Colgate-Palmolive Company Aluminum / zirconium / glycine antiperspirant actives stabilized with Betaine
EP1703955A2 (fr) * 2003-08-14 2006-09-27 Koslow Technologies Corporation Structures inhibant la croissance microbienne
US7204976B2 (en) 2003-05-30 2007-04-17 Colgate-Palmolive Company High efficacy gel with low glycol content
WO2013142474A1 (fr) * 2012-03-23 2013-09-26 The Procter & Gamble Company Compositions liquides de nettoyage et de désinfection
EP2688411A2 (fr) * 2011-03-24 2014-01-29 Silver Anti-Bac, LLC Compositions de chlorure d'argent pour la désodorisation et la désinfection
US9133417B2 (en) 2012-03-23 2015-09-15 The Procter & Gamble Company Liquid cleaning and disinfecting compositions comprising an assymetrically branched amine oxide
US9289702B2 (en) 2010-02-26 2016-03-22 Kx Technologies, Llc Method of making a filter media with an enriched binder
US10144908B2 (en) 2013-04-16 2018-12-04 Conopco, Inc. Liquid soap having enhanced antibacterial activity
US10370622B2 (en) 2013-04-16 2019-08-06 Conopco, Inc. Soap bar having enhanced antibacterial activity
WO2021191413A1 (fr) * 2020-03-26 2021-09-30 Arch Uk Biocides Ltd Compositions désinfectantes

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US5334588A (en) * 1987-02-25 1994-08-02 The Trustees Of Columbia University In The City Of New York Composition for inhibiting transmission of hepatitis B virus
US5413788A (en) * 1986-07-03 1995-05-09 Johnson Matthey Public Limited Company Antimicrobial compositions

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US4906466A (en) * 1986-07-03 1990-03-06 Johnson Matthey Public Limited Company Silver compound antimicrobial compositions
US5413788A (en) * 1986-07-03 1995-05-09 Johnson Matthey Public Limited Company Antimicrobial compositions
US4952411A (en) * 1987-02-25 1990-08-28 Trustees Of Columbia University In The City Of New York Method of inhibiting the transmission of AIDS virus
US5334588A (en) * 1987-02-25 1994-08-02 The Trustees Of Columbia University In The City Of New York Composition for inhibiting transmission of hepatitis B virus
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Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2341394A (en) * 1997-06-20 2000-03-15 Reckitt & Colmann Prod Ltd Improvements in or relating to the cleansing of surfaces
GB2341394B (en) * 1997-06-20 2001-08-08 Reckitt & Colmann Prod Ltd Antimicrobial cleaning agent
AU739120B2 (en) * 1997-06-20 2001-10-04 Reckitt Benckiser (Uk) Limited Improvements in or relating to the cleansing of surfaces
US6375964B1 (en) 1997-06-20 2002-04-23 Reckitt Benckiser (Uk) Limited Hard surface cleaners comprising a polyurethane foam matrix and a composite of a source of silver ions and porous support material
WO1998059026A1 (fr) * 1997-06-20 1998-12-30 Reckitt & Colman Products Limited Ameliorations apportees au nettoyage de surfaces
WO1999039749A2 (fr) * 1998-02-10 1999-08-12 Vladimir Emelyanovich Oganesov Solution aqueuse desinfectante
WO1999039749A3 (fr) * 1998-02-10 1999-11-04 Vladimir Emelyanovich Oganesov Solution aqueuse desinfectante
WO2000010513A1 (fr) * 1998-08-18 2000-03-02 The Procter & Gamble Company Compositions cosmetiques contenant de l'oxyde de titane de rutile et d'anatase et des emollients
EP1129703A3 (fr) * 2000-03-04 2003-11-05 Clariant GmbH Compositions personnelles nettoyantes aqueuses ou hydroalcooliques comprenant des esters du sorbitol
EP1129703A2 (fr) * 2000-03-04 2001-09-05 Clariant GmbH Compositions personnelles nettoyantes aqueuses ou hydroalcooliques comprenant des esters du sorbitol
WO2002083830A1 (fr) * 2001-04-12 2002-10-24 Dieter Meissner Mousse, procede de production de mousse et utilisation de mousse
US7008537B2 (en) * 2002-01-31 2006-03-07 Koslow Technologies Corporation Microporous filter media, filtration systems containing same, and methods of making and using
US6866704B2 (en) * 2002-01-31 2005-03-15 Koslow Technologies Corporation Microporous filter media with intrinsic safety feature
US6959820B2 (en) * 2002-01-31 2005-11-01 Koslow Evan E Microporous filter media, filtration systems containing same, and methods of making and using
US6998058B2 (en) * 2002-01-31 2006-02-14 Koslow Evan E Microporous filter media, filtration systems containing same, and methods of making and using
US6630016B2 (en) * 2002-01-31 2003-10-07 Koslow Technologies Corp. Microporous filter media, filtration systems containing same, and methods of making and using
US7011753B2 (en) * 2002-01-31 2006-03-14 Koslow Evan E Microporous filter media, filtration systems containing same, and methods of making and using
US6835311B2 (en) 2002-01-31 2004-12-28 Koslow Technologies Corporation Microporous filter media, filtration systems containing same, and methods of making and using
US7204976B2 (en) 2003-05-30 2007-04-17 Colgate-Palmolive Company High efficacy gel with low glycol content
US7105691B2 (en) 2003-06-26 2006-09-12 Colgate-Palmolive Company Aluminum / zirconium / glycine antiperspirant actives stabilized with Betaine
EP1703955A4 (fr) * 2003-08-14 2008-03-19 Kx Technologies Llc Structures inhibant la croissance microbienne
EP1703955A2 (fr) * 2003-08-14 2006-09-27 Koslow Technologies Corporation Structures inhibant la croissance microbienne
WO2006083980A1 (fr) * 2005-02-01 2006-08-10 The Procter & Gamble Company Composition d'emulsion pour lingettes humides contenant un ingredient benefique pour la peau non irritant, et procede de fabrication associe
US9289702B2 (en) 2010-02-26 2016-03-22 Kx Technologies, Llc Method of making a filter media with an enriched binder
EP2688411A2 (fr) * 2011-03-24 2014-01-29 Silver Anti-Bac, LLC Compositions de chlorure d'argent pour la désodorisation et la désinfection
EP2688411A4 (fr) * 2011-03-24 2014-08-27 Silver Anti Bac Llc Compositions de chlorure d'argent pour la désodorisation et la désinfection
WO2013142474A1 (fr) * 2012-03-23 2013-09-26 The Procter & Gamble Company Compositions liquides de nettoyage et de désinfection
US8871700B2 (en) 2012-03-23 2014-10-28 The Procter & Gamble Company Liquid cleaning and disinfecting compositions comprising a zinc salt and amine oxide
US9133417B2 (en) 2012-03-23 2015-09-15 The Procter & Gamble Company Liquid cleaning and disinfecting compositions comprising an assymetrically branched amine oxide
US10144908B2 (en) 2013-04-16 2018-12-04 Conopco, Inc. Liquid soap having enhanced antibacterial activity
US10370622B2 (en) 2013-04-16 2019-08-06 Conopco, Inc. Soap bar having enhanced antibacterial activity
WO2021191413A1 (fr) * 2020-03-26 2021-09-30 Arch Uk Biocides Ltd Compositions désinfectantes

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