WO1997023467A1 - Nouveaux composes a effet analgesique - Google Patents

Nouveaux composes a effet analgesique Download PDF

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Publication number
WO1997023467A1
WO1997023467A1 PCT/SE1996/001636 SE9601636W WO9723467A1 WO 1997023467 A1 WO1997023467 A1 WO 1997023467A1 SE 9601636 W SE9601636 W SE 9601636W WO 9723467 A1 WO9723467 A1 WO 9723467A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
compound according
conr
cor
hydrogen
Prior art date
Application number
PCT/SE1996/001636
Other languages
English (en)
Inventor
Edward Roberts
Claes Wahlestedt
Original Assignee
Astra Pharma Inc.
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL12499796A priority Critical patent/IL124997A0/xx
Application filed by Astra Pharma Inc., Astra Aktiebolag filed Critical Astra Pharma Inc.
Priority to AU12163/97A priority patent/AU706436B2/en
Priority to JP09523558A priority patent/JP2000502680A/ja
Priority to PL96327538A priority patent/PL327538A1/xx
Priority to SK819-98A priority patent/SK81998A3/sk
Priority to EE9800195A priority patent/EE9800195A/xx
Priority to KR1019980704758A priority patent/KR19990076649A/ko
Priority to BR9612206A priority patent/BR9612206A/pt
Priority to NZ324888A priority patent/NZ324888A/xx
Priority to EP96943427A priority patent/EP0873322A1/fr
Publication of WO1997023467A1 publication Critical patent/WO1997023467A1/fr
Priority to IS4768A priority patent/IS4768A/is
Priority to NO982863A priority patent/NO982863L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composés de la formule (I) et leurs sels pharmaceutiquement acceptables, et compositions pharmaceutiques renfermant ces nouveaux composés. Les nouveaux composés de la formule (I) sont utiles pour le traitement de la douleur.
PCT/SE1996/001636 1995-12-22 1996-12-11 Nouveaux composes a effet analgesique WO1997023467A1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EE9800195A EE9800195A (et) 1995-12-22 1996-12-11 Uudsed analgeetilise toimega ühendid
AU12163/97A AU706436B2 (en) 1995-12-22 1996-12-11 Novel compounds with analgesic effect
JP09523558A JP2000502680A (ja) 1995-12-22 1996-12-11 鎮痛作用を有する新規化合物
PL96327538A PL327538A1 (en) 1995-12-22 1996-12-11 Novel compounds of analgesic activity
SK819-98A SK81998A3 (en) 1995-12-22 1996-12-11 Compounds having analgesic effects
IL12499796A IL124997A0 (en) 1995-12-22 1996-12-11 Compounds with analgesic effect
KR1019980704758A KR19990076649A (ko) 1995-12-22 1996-12-11 진통 효과가 있는 신규 화합물
EP96943427A EP0873322A1 (fr) 1995-12-22 1996-12-11 Nouveaux composes a effet analgesique
NZ324888A NZ324888A (en) 1995-12-22 1996-12-11 Substituted 7-membered nitrogen ring (homopiperazinyl) containing compounds with analgesic effect
BR9612206A BR9612206A (pt) 1995-12-22 1996-12-11 Composto uso do composto composição farmacêutica processo para preparação do composto e para o tratamento da dor
IS4768A IS4768A (is) 1995-12-22 1998-06-10 Ný efnasambönd sem hafa verkjastillandi áhrif
NO982863A NO982863L (no) 1995-12-22 1998-06-19 Nye forbindelser med analgetisk effekt

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9504662-9 1995-12-22
SE9504662A SE9504662D0 (sv) 1995-12-22 1995-12-22 New compounds

Publications (1)

Publication Number Publication Date
WO1997023467A1 true WO1997023467A1 (fr) 1997-07-03

Family

ID=20400740

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1996/001636 WO1997023467A1 (fr) 1995-12-22 1996-12-11 Nouveaux composes a effet analgesique

Country Status (21)

Country Link
EP (1) EP0873322A1 (fr)
JP (1) JP2000502680A (fr)
KR (1) KR19990076649A (fr)
CN (1) CN1209126A (fr)
AU (1) AU706436B2 (fr)
BR (1) BR9612206A (fr)
CA (1) CA2239162A1 (fr)
CZ (1) CZ176798A3 (fr)
EE (1) EE9800195A (fr)
HU (1) HUP9900105A3 (fr)
IL (1) IL124997A0 (fr)
IS (1) IS4768A (fr)
NO (1) NO982863L (fr)
NZ (1) NZ324888A (fr)
PL (1) PL327538A1 (fr)
SE (1) SE9504662D0 (fr)
SK (1) SK81998A3 (fr)
TR (1) TR199801184T2 (fr)
TW (1) TW360641B (fr)
WO (1) WO1997023467A1 (fr)
ZA (1) ZA9610355B (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200978B1 (en) * 1998-03-05 2001-03-13 Pfizer Inc. Compounds as delta opioid agonists
EP1181279A1 (fr) * 1999-05-12 2002-02-27 Torrey Pines Institute For Molecular Studies Composes dicetodiazacycliques, composes diazacycliques, et leurs bibliotheques combinatoires
EP1408037A1 (fr) * 1995-12-22 2004-04-14 AstraZeneca AB Nouveaux dérivés de diarylméthylpiperazine et diarylméthylphényle ayant un effet analgésique
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE9900336A (et) 1999-10-27 2000-10-16 Bellakem OÜ Tsükkeltegevuse seade polümeerühendeid sisaldavate jäätmete utiliseerimiseks
RU2186295C2 (ru) 1999-10-27 2002-07-27 Беллакем Ою Установка циклического действия для утилизации отходов, содержащих полимерные соединения

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166302A2 (fr) * 1984-06-19 1986-01-02 POLI INDUSTRIA CHIMICA S.p.A. 1-[Bis-(4-fluorophényl)méthyl]-4-(3-phényl-2-propényl)-hexahydro-1H-1,4-diazépine, sa préparation et composition la contenant
EP0283310A1 (fr) * 1987-03-18 1988-09-21 Sankyo Company Limited Dérivés hétérocycliques N-substitués par le groupe benzhydryle, leur préparation et leur application
EP0289227A1 (fr) * 1987-04-24 1988-11-02 Syntex Pharmaceuticals Ltd. Dérivés substitués d'imidazolyl-alkyl-pipérazines et -diazépines
GB2210366A (en) * 1987-09-30 1989-06-07 American Home Prod Substituted cycloalkanols
WO1993015062A1 (fr) * 1992-02-03 1993-08-05 The Wellcome Foundation Limited Piperidines et piperazines de diarylmethyle opioides
WO1995004051A1 (fr) * 1993-07-30 1995-02-09 The Wellcome Foundation Limited Composes a base de piperazine, a usage therapeutique

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166302A2 (fr) * 1984-06-19 1986-01-02 POLI INDUSTRIA CHIMICA S.p.A. 1-[Bis-(4-fluorophényl)méthyl]-4-(3-phényl-2-propényl)-hexahydro-1H-1,4-diazépine, sa préparation et composition la contenant
EP0283310A1 (fr) * 1987-03-18 1988-09-21 Sankyo Company Limited Dérivés hétérocycliques N-substitués par le groupe benzhydryle, leur préparation et leur application
EP0289227A1 (fr) * 1987-04-24 1988-11-02 Syntex Pharmaceuticals Ltd. Dérivés substitués d'imidazolyl-alkyl-pipérazines et -diazépines
GB2210366A (en) * 1987-09-30 1989-06-07 American Home Prod Substituted cycloalkanols
WO1993015062A1 (fr) * 1992-02-03 1993-08-05 The Wellcome Foundation Limited Piperidines et piperazines de diarylmethyle opioides
WO1995004051A1 (fr) * 1993-07-30 1995-02-09 The Wellcome Foundation Limited Composes a base de piperazine, a usage therapeutique

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1408037A1 (fr) * 1995-12-22 2004-04-14 AstraZeneca AB Nouveaux dérivés de diarylméthylpiperazine et diarylméthylphényle ayant un effet analgésique
US6809202B2 (en) 1996-11-07 2004-10-26 Torrey Pines Institute For Molecular Studies Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
US9302096B2 (en) 1997-07-21 2016-04-05 Bruce H. Levin Apparatus for treating cerebral neurovascular disorders including headaches by neural stimulation
US8224438B2 (en) 1997-07-21 2012-07-17 Levin Bruce H Method for directed intranasal administration of a composition
US9381349B2 (en) 1997-07-21 2016-07-05 Bhl Patent Holdings Llc Apparatus for treating cerebral neurovascular disorders including headaches by neural stimulation
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US6200978B1 (en) * 1998-03-05 2001-03-13 Pfizer Inc. Compounds as delta opioid agonists
EP1181279A4 (fr) * 1999-05-12 2002-09-25 Torrey Pines Inst Composes dicetodiazacycliques, composes diazacycliques, et leurs bibliotheques combinatoires
EP1181279A1 (fr) * 1999-05-12 2002-02-27 Torrey Pines Institute For Molecular Studies Composes dicetodiazacycliques, composes diazacycliques, et leurs bibliotheques combinatoires
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8781574B2 (en) 2008-12-29 2014-07-15 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US9554694B2 (en) 2008-12-29 2017-01-31 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US8886325B2 (en) 2009-04-22 2014-11-11 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism

Also Published As

Publication number Publication date
CZ176798A3 (cs) 1998-09-16
NO982863D0 (no) 1998-06-19
MX9804797A (es) 1998-10-31
NO982863L (no) 1998-06-19
SE9504662D0 (sv) 1995-12-22
NZ324888A (en) 1999-01-28
SK81998A3 (en) 1998-11-04
HUP9900105A2 (hu) 1999-04-28
ZA9610355B (en) 1997-06-23
EE9800195A (et) 1998-12-15
IS4768A (is) 1998-06-10
PL327538A1 (en) 1998-12-21
EP0873322A1 (fr) 1998-10-28
KR19990076649A (ko) 1999-10-15
JP2000502680A (ja) 2000-03-07
AU1216397A (en) 1997-07-17
IL124997A0 (en) 1999-01-26
TW360641B (en) 1999-06-11
CN1209126A (zh) 1999-02-24
HUP9900105A3 (en) 2000-05-29
TR199801184T2 (xx) 1998-09-21
CA2239162A1 (fr) 1997-07-03
BR9612206A (pt) 1999-07-13
AU706436B2 (en) 1999-06-17

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