WO1997012978A1 - AGONISTE DU RECEPTEUR DE c-mpl - Google Patents

AGONISTE DU RECEPTEUR DE c-mpl Download PDF

Info

Publication number
WO1997012978A1
WO1997012978A1 PCT/US1996/015938 US9615938W WO9712978A1 WO 1997012978 A1 WO1997012978 A1 WO 1997012978A1 US 9615938 W US9615938 W US 9615938W WO 9712978 A1 WO9712978 A1 WO 9712978A1
Authority
WO
WIPO (PCT)
Prior art keywords
leu
gly
ser
pro
val
Prior art date
Application number
PCT/US1996/015938
Other languages
English (en)
Inventor
Nicholas R. Staten
Lyle E. Pegg
Charles A. Mcwherter
Yiqing Feng
John P. Mckearn
Neena L. Summers
Judith G. Giri
Original Assignee
G.D. Searle & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G.D. Searle & Co. filed Critical G.D. Searle & Co.
Priority to EP96936192A priority Critical patent/EP0870027A1/fr
Priority to JP09514462A priority patent/JP2000513924A/ja
Priority to AU73901/96A priority patent/AU722759B2/en
Publication of WO1997012978A1 publication Critical patent/WO1997012978A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

On décrit des protéines agonistes du récepteur du ligand c-mpl, des ADN qui codent ces protéines, des procédés permettant d'obtenir ces protéines agonistes du récepteur de c-mpl, et des procédés d'utilisation de ces protéines.
PCT/US1996/015938 1995-10-05 1996-10-04 AGONISTE DU RECEPTEUR DE c-mpl WO1997012978A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP96936192A EP0870027A1 (fr) 1995-10-05 1996-10-04 Agoniste du recepteur de c-mpl
JP09514462A JP2000513924A (ja) 1995-10-05 1996-10-04 新規ｃ−ｍｐｌ受容体アゴニスト
AU73901/96A AU722759B2 (en) 1995-10-05 1996-10-04 Novel C-MPL receptor agonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US482495P 1995-10-05 1995-10-05
US60/004,824 1995-10-05

Publications (1)

Publication Number Publication Date
WO1997012978A1 true WO1997012978A1 (fr) 1997-04-10

Family

ID=21712708

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/015938 WO1997012978A1 (fr) 1995-10-05 1996-10-04 AGONISTE DU RECEPTEUR DE c-mpl

Country Status (5)

Country Link
EP (1) EP0870027A1 (fr)
JP (1) JP2000513924A (fr)
AU (1) AU722759B2 (fr)
CA (1) CA2234059A1 (fr)
WO (1) WO1997012978A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632426B2 (en) 1993-01-28 2003-10-14 Amgen Inc. G-CSF analog compositions and methods
US7655766B2 (en) 2005-06-01 2010-02-02 Carsten Germansen Compositions comprising positional isomers of PEGylated G-CSF
US7696153B2 (en) 2000-01-10 2010-04-13 Maxygen, Inc. G-CSF conjugates
CN101889007A (zh) * 2007-12-06 2010-11-17 日产化学工业株式会社 采用杂环化合物的造血干细胞的扩增方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0675201A1 (fr) * 1994-03-31 1995-10-04 Amgen Inc. Compositions et procédés pour la stimulation de la croissance et la différenciation des mégacaryocytes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0675201A1 (fr) * 1994-03-31 1995-10-04 Amgen Inc. Compositions et procédés pour la stimulation de la croissance et la différenciation des mégacaryocytes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FREDERIC J. DE SAUVAGE ET AL.: "Stimulation of megakaryocytopoiesis and thrombopoiesis by the cMpl ligand", NATURE, vol. 369, no. 6481, 16 June 1994 (1994-06-16), LONDON GB, pages 533 - 538, XP002024318 *
LEISHA S. MULLINS ET AL.: "Transposition of protein sequences: circular permutation of ribonuclease T1", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 116, no. 13, 29 June 1994 (1994-06-29), DC US, pages 5529 - 5533, XP002024319 *
ROBERT J. KREITMAN ET AL.: "Increased antitumor activity of a circularly permuted Interleukin 4-Toxin in mice with Interleukin 4 receptor-bearing human carcinoma", CANCER RESEARCH, vol. 55, no. 15, 1 August 1995 (1995-08-01), MD US, pages 3357 - 3363, XP002024320 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632426B2 (en) 1993-01-28 2003-10-14 Amgen Inc. G-CSF analog compositions and methods
US7381804B2 (en) 1993-01-28 2008-06-03 Amgen Inc. G-CSF analog compositions and methods
US8058398B2 (en) 1993-01-28 2011-11-15 Amgen Inc. Modified G-CSF polypeptide
US7696153B2 (en) 2000-01-10 2010-04-13 Maxygen, Inc. G-CSF conjugates
US7655766B2 (en) 2005-06-01 2010-02-02 Carsten Germansen Compositions comprising positional isomers of PEGylated G-CSF
CN101889007A (zh) * 2007-12-06 2010-11-17 日产化学工业株式会社 采用杂环化合物的造血干细胞的扩增方法
US9527828B2 (en) 2007-12-06 2016-12-27 Nissan Chemical Industries, Ltd. Method for expanding hematopoietic stem cells using heterocyclic compound

Also Published As

Publication number Publication date
AU722759B2 (en) 2000-08-10
CA2234059A1 (fr) 1997-04-10
AU7390196A (en) 1997-04-28
EP0870027A1 (fr) 1998-10-14
JP2000513924A (ja) 2000-10-24

Similar Documents

Publication Publication Date Title
AU734594B2 (en) Circularly permuted polypeptides as novel stem cell factor receptor agonists
US6254870B1 (en) Thrombopoietin: IL-3 fusion protein
US6660257B1 (en) Circular permuteins of flt3 ligand
US6730303B1 (en) Fused G-CSF and IL-3 proteins and uses thereof
KR100497423B1 (ko) 다기능 키메라 조혈 수용체 아고니스트
AU705083B2 (en) Multi-functional hematopoietic receptor agonists
WO1997012985A9 (fr) Agonistes multifonctionnels des recepteurs hematopoietiques
US6358505B1 (en) G-CSF receptor agonists
CA2234042A1 (fr) Nouveaux agonistes du recepteur du g-csf
US20070081979A1 (en) Multi-functional chimeric hematopoietic receptor agonists
AU722759B2 (en) Novel C-MPL receptor agonists
AU703627B2 (en) Interleuken-3 (IL-3) receptor agonists
MXPA99003875A (en) NOVEL flt-3 RECEPTOR AGONISTS

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1996936192

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2234059

Country of ref document: CA

Ref country code: CA

Ref document number: 2234059

Kind code of ref document: A

Format of ref document f/p: F

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1996936192

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1996936192

Country of ref document: EP