WO1997004742A1 - Compositions orales - Google Patents
Compositions orales Download PDFInfo
- Publication number
- WO1997004742A1 WO1997004742A1 PCT/US1996/011809 US9611809W WO9704742A1 WO 1997004742 A1 WO1997004742 A1 WO 1997004742A1 US 9611809 W US9611809 W US 9611809W WO 9704742 A1 WO9704742 A1 WO 9704742A1
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- Prior art keywords
- potassium
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- agents
- present
- composition
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
Definitions
- the present invention relates to oral compositions.
- it relates to oral compositions which exhibit improved desensitisation of teeth and more particularly to compositions containing both xylitol and potassium ions or strontium ions which exhibit improved desensitisation and help retard the de- mineralisation of teeth.
- teeth may be desensitised by apphcation of a paste containing lithium, sodium or potassium nitrate, potassium nitrate being preferred.
- EP-A-278,744 describes a tooth desensitising dentifrice composition
- Triclosan in combination with a water-soluble source of potassium ions selected from the group consisting of potassium nitrate, potassium citrate and potassium bicarbonate.
- the composition was found to produce a synergistic desensitising effect.
- EP-A-346,957 reports that a combination of potassium and / or strontium ions in combination with a hydroxyapatite abrasive is effective at desensitising teeth, each of the soluble and insoluble compounds having tooth desensitising activity.
- EP-A-529,212 claims a chewing gum comprising 0.01 to 5% of a water-soluble potassium salt, from 1 to 5% of a phosphate and at least 50% of xylitol or a mixture of xylitol and sorbitol.
- the chewing gum is for use in dental care.
- an oral composition in the form of a dentifrice, mouthwash, chewing gum or the like comprising: a) from about 1% to about 45% by weight of a sugar alcohol consisting essentially of xylitol; b) from about 0.1% to about 10% potassium ions or strontium ions or mixtures thereof; c) from about 45% to about 98.9% orally acceptable carrier materials.
- dentifrice compositions of the present invention may be in the form of pastes or gels.
- teethpaste as used herein, means paste and gel formulations unless otherwise specified.
- compositions comprise some essential components and several optional components. A detailed description of these components follows.
- An essential component of the present invention is a sugar alcohol consisting essentially of xylitol.
- Xylitol is also useful as a humectant and / or a bulk sweetener in the present compositions and may be used successfully at levels of up to about 45%, though as little as about 1% can be effective in enhancing the desensitising action of the potassium and / or strontium salts.
- xylitol will be used at levels of from about 3% to about 25%, more preferably from about 5% to about 10%.
- a further essential component ofthe present invention is a source of potassium and / or strontium ions, sufficient to provide at least 0.1% of the ions by weight.
- sources of the potassium and or strontium ions may be used, preferred sources are inorganic salts and the salts of orgamc acids.
- Suitable sources of strontium ions are the strontium fluoride, strontium chloride, strontium bromide, strontium nitrate and strontium acetate. Strontium nitrate is preferred. Potassium salts are preferred over strontium salts for reasons of weight efBciency, cost and greater compatibility with other formulation ingredients.
- Suitable potassium salts are potassium fluoride, potassium chloride, potassium bromide, potassium nitrate, potassium acetate, potassium carbonate, potassium bicarbonate, potassium citrate, potassium lactate, and the potassium or mixed sodium / potassium salts ofthe phosphates (particularly the oithophosphates, pyrophosphates, tripolyphosphates and monofluoro- phosphates) e.g. tetrapotassium pyrophosphate.
- Particularly preferred potassium sources are potassium nitrate, potassium citrate, potassium bicarbonate or mixtures thereof. Potassium nitrate is most preferred.
- the potassium and / or strontium ions are useful at levels of from about 0.1% to about 10%, preferably from about 0.5% to about 6%, more preferably from about 1% to about 4%.
- compositions of the present invention are in the form of a dentifrice, mouthwash, chewing gum or the like, and further comprise various carrier materials, acceptable to the oral cavity and appropriate to the form and function ofthe compositions, as would be appreciated by the man skilled in the art of their manufacture.
- carrier materials means any material safe and effective for use in the oral compositions prepared according to the present invention
- the carrier materials form the balance of the formulation, generally at a level of from about 50% to about 97% and will be described more fully below.
- a preferred embodiment of the present invention is a dentifrice.
- dentifrice carrier materials typically comprise from about 50% to about 94%, preferably from about 60% to about 80% by weight of the present compositions.
- the present dentifrice compositions typically comprise a soluble fluoride ion source.
- the soluble fluoride ion source when used, is present in amounts sufficient to provide from about 10 to about 3500 ppm of the fluoride ion.
- Preferred fluorides are sodium fluoride, stannous fluoride, indium fluoride, and sodium monofluorophosphate.
- Norris et al., U.S. Patent 2,946,1735, issued July 26, 1960 and Widder et al., U.S. Patent 3,678,154, issued July 18, 1972 disclose such salts as well as others. Both patents are inco ⁇ orated herein by reference in their entirety.
- the present compositions also typically contain a binder/thickening material to provide a desirable consistency.
- Preferred binder/thickening agents are carboxyvinyl polymers, carbomers, carrrageenan, hydroxyethyl cellulose and water soluble salts of cellulose ethers such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose.
- Natural gums such as gum karaya, xanthan gum, gum arabic, and gum tragacanth can also be used.
- Colloidal magnesium aluminium silicate or finely divided sihca can be used as part ofthe thickening agent to further improve texture.
- Thickening agents can be used in an amount from about 0.2% to about 5.0% by weight of the total composition.
- Preferred thickening sihca materials include those marketed by Rhone-Poulenc under the tradename, "Tixosil", particularly the sihca carrying the designation "Tixosil 43.”
- humectant material in a toothpaste to keep the composition from hardening upon exposure to air.
- Certain humectants can also impart a desirable sweetness or flavour to toothpaste compositions.
- the xylitol of the present invention is further useful for both humectancy and sweetening. Additional humectancy over and above that provided by the xylitol may be necessary however. Suitable additional humectants include glycerine, sorbitol, other edible polyhydric alcohols, and mixtures thereof, such that the total level of humectant is from about 15% to about 70% by weight ofthe composition.
- Titanium dioxide can also be added to the present compositions. Titanium dioxide is a white powder which adds pigment to the compositions. Titanium dioxide generally comprises from about 0.25% to about 1% by weight of composition.
- Water is also present in the dentifrice compositions of this invention.
- Water employed in the preparation of commercially suitable toothpastes should preferably be deionized and free of organic impurities.
- Water generally comprises from about 12% to about 50%, preferably from about 20% to about 45%, more preferably from about 25% to about 35% by weight of composition. These amounts of water include the free water which is added plus that which is introduced with other materials such as with sorbitol.
- Sodium bicarbonate also known as baking soda, is a household product with a variety of uses including use in dentifrices and mouthrinses, where it is often used to give a 'fresh' feeling to the teeth. It is a white powder that is soluble in water and unless stabilised, tends to release carbon dioxide in an aqueous system. If used in the present compositions, it will typically be at a level of from about 5% to about 50%, preferably from about 10% to about 30%.
- Buffering agents refer to agents that can be used to increase the pH of the compositions to a range of above about pH 8 as preferred for sodium bicarbonate and tetrasodium pyrophosphate containing toothpastes. These agents include monosodium orthophosphate, trisodium orthophosphate, sodium hydroxide and sodium carbonate. Sodium carbonate is preferred at a level of from about 0.5% to about 2% by weight of composition.
- the abrasive polishing material contemplated for use in the compositions of the present invention can be any material which does not excessively abrade dentine.
- silicas including gels and precipitates, calcium carbonate, dicalcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, insoluble sodium polymetaphosphate, hydrated alumina, and resinous abrasive materials such as particulate condensation products of urea and formaldehyde, and others such as disclosed by Cooley et al. in U.S. Patent 3,070,510, December 25, 1962, inco ⁇ orated herein by reference. Mixtures of abrasives can also be used.
- Silica dental abrasives of various types are preferred because of their unique benefits of exceptional dental cleaning and polishing performance without unduly abrading tooth enamel or dentine.
- the silica abrasive can be precipitated silica or sihca gels such as the sihca xerogels described in Pader et al., U.S. Patent 3,538,230, issued March 2, 1970 and DiGiulio, U.S. Patent 3,862,307, June 21, 1975, both inco ⁇ orated herein by reference.
- silica xerogels marketed under the tradename "Syloid” by W. R. Grace & Company, Davison Chemical Division.
- Preferred precipitated silica materials include those marketed by the J. M. Huber Co ⁇ oration under the tradename, "Zeodent", particularly the silicas carrying the designation "Zeodent 119", described in U.S. Patent 4,340,583, July 29, 1982, inco ⁇ orated herein by reference, and "Zeodent 128".
- the abrasive is preferably present at a level of from about 6% to 70%, more preferably from about 20% to about 40% by weight.
- the toothpaste compositions can also contain surfactants.
- Suitable surfactants are those which are reasonably stable and foam throughout a wide pH range, including non-soap anionic, nonionic, cationic, zwitterionic and amphoteric organic synthetic detergents. Many of these suitable agents are disclosed by Gieske et al. in U.S. Patent 4,051,234, September 27, 1977, inco ⁇ orated herein by reference.
- Preferred surfactants for use herein include sodium alkyl sulphate and polyethylene glycol, at levels of about 4% and about 3% by weight of compositions respectively.
- sodium and potassium salts of surfactants selected from the group consisting of sarcosinate surfactants, isethionate surfactants and taurate surfactants especially: lauroyl sarcosinate, myristoyl sarcosinate, palmitoyl sarcosinate, stearoyl sarcosinate and oleoyl sarcosinate.
- surfactants can be present in the compositions of the present invention from about 0.1% to about 2.5%, preferably from about 0.3% to about 2.5% and most preferably from about 0.5% to about 2.0% by weight of the total composition. They can optionally be used in conjunction with a chelating agent such as alkali metal citrates or, preferably, tartrates as described, for example, in WO 93 14183.
- Flavouring agents can also be added to the present compositions.
- Suitable flavouring agents include oil of wintergreen, oil of peppermint, oil of spear ⁇ mint, oil of sassafras, and oil of clove.
- Sweetening agents which can be used include aspartame, acesulphame, saccharin, dextrose, levulose and sodium cyclamate.
- Flavouring and sweetening agents are generally used in toothpastes at levels offrom about 0.005% to about 2% by weight of composition.
- compositions can also contain optional pharmaceutical agents (e.g. triclosan) and other tartar control agents.
- Optional tartar control agents include such known materials as synthetic anionic polymers (including polyacrylates and copolymers of maleic anhydride or acid and methyl vinyl ether (e.g., Gantrez), as described for example in U.S. Patent 4,627,977 to Gaffar et al., the disclosures of which are inco ⁇ orated herein by reference in their entirety; as well as, e.g., polyamino propane sulphonic acid (AMPS)), polyphosphates (e.g. tripolyphosphate; hexametaphosphate), diphosphonates (e.g. EHDP; AHP), polypeptides (such as polyaspartic and polyglutamic acids), and mixtures thereof.
- synthetic anionic polymers including polyacrylates and copolymers of maleic anhydride or acid and methyl vinyl ether (e.g., Gantrez), as described for
- compositions of the present invention are zinc, copper and stannous salts such as zinc lactate, zinc citrate, stannous pyro ⁇ phosphate, stannous gluconate and copper bisglycinate.
- Antimicrobial quaternary ammonium salts such as cetyl pyridinium chloride, tetradecylethyl pyridinium chloride, and bis-biguanide salts including chlorhexidine digluconate; nonionic antimicrobial salts and antimicrobial flavour oils such as thymol may also be used.
- Such agents are disclosed in U.S. Patent No. 2,946,725, July 26, 1960, to Norris et al. and U.S. Patent No. 4,051,234, September 27, 1977 to Gieske et al., inco ⁇ orated herein by reference. These agents, if present, are included at levels offrom about 0.01% to about 2%.
- Preferred tartar control agents are pyrophosphate salts as described, for example, in U.S. Patent 4,999,184, to Parran, Jr. et al., issued March 12, 1991, the disclosure of which is inco ⁇ orated herein by reference in its entirety. Most preferred is tetrasodium pyrophosphate, although tetra alkali metal pyrophosphate other than tetrasodium pyrophosphate, such as dialkah metal diacid pyrophosphates, trialkali metal monoacid pyrophosphate and mixtures thereof may also be used, including those where the alkali metal is potassium as already described above. (Pyrophosphate salts are described in more detail in Kirk & Othmer, Encyclopedia of Chemical Technology. Second Edition, Volume 15, Interscience Publishers (1958), inco ⁇ orated herein by reference in its entirety). These salts are useful in both their hydrated and unhydrated forms.
- the amount of pyrophosphate salt useful in these compositions is any tartar control effective amount, and is generally enough to provide at least about 1.0%, preferably from about 1.5% to about 10%, more preferably from about 3.0% to about 6% P2 ⁇ "4, by weight of the compositions. It is to be appreciated that the level of P2O7-4 is that amoimt capable of being provided to the composition (i.e., the theoretical amount at an appropriate pH) and that other pyrophosphate forms (e.g., ⁇ P O ⁇ ) may be present when a final product pH is estabhshed.
- the level of tetrasodium pyrophosphate salt preferably used in the present methods and compositions is therefore from about 1.5% to about 15%, and more preferably from about 2% to about 10%, by weight ofthe dentifrice composition.
- the dentifrice compositions are prepared by mixing together the components described above according to methods known in the art.
- Mouthwashes generally comprise from about 20:1 to about 2:1 of a water/ethyl alcohol solution and preferably other ingredients such as flavour, sweeteners, antimicrobials and humectants, as described above.
- the mouthwash carrier materials of the invention comprise 5% to 60% (preferably 10% to 20%) ethyl alcohol, 0% to 20% (preferably 5% to 20%) of a humectant, 0% to 2% (preferably 0.01% to 0.15%) emulsifying agent, 0% to 0.5% (preferably 0.005% to 0.06%) sweetening agent such as saccharin, 0% to 0.3% (preferably 0.03% to 0.3%) flavouring agent, and the balance water.
- the amount of antimicrobial agent in mouthwashes is typically from about 0.01% to about 1.5% by weight.
- Chewing gums generally comprise an essentially tasteless, predominantly water-insoluble masticatory portion (the gum base) and one or more additives, which may be water-soluble or water-extractable whose piupose is usually to improve the organoleptic properties of the gum.
- Gum bases useful in the present invention generally comprise various ingredients well known in the art including; an elastomer, an elastomer solvent, a resin, a plasticiser, various fats and waxes, a filler, sweeteners, flavourants, colorants, pigments and anti ⁇ oxidants. Finished gum bases are available commercially from e.g. Cafosa SPA.
- a variety of gum base additives are typically added to the pre-prepared gum base to form the final consumer-acceptable chewing gum composition. These include bulk and high intensity sweeteners, flavourants, softeners, and fillers. Xyhtol itself is a suitable bulk sweetener and is useful in the chewing gum compositions of the present invention in amounts of from about 1% to about 45% by weight and most preferably about 10% to about 35% by weight.
- the potassium or strontium ions of the present invention are most readily inco ⁇ orated in the form of salts, as described above, with the other gum base additives.
- Examples I, II and HI are suitable paste dentifrices, IV is a suitable gel dentifrice.
- the paste compositions are prepared as follows.
- the jacket temperature of a mixing tank is set to about 150°F (65°C) to about 160°F (71°C).
- the humectants, xyhtol and water are added to the mixing tank and agitation is started.
- the temperature reaches approximately 120°F (50°C) fluoride, potassium nitrate, sweetening agents, buffering agents, chelant, coloring agents and titanium dioxide are added.
- Thickening agents are added to the abrasive and the resulting mixture is added to the mixing tank with high agitation.
- the surfactant is added to the combination and mixing is continued.
- the tank is cooled to 120°F (50°C) and the flavoring agents are added. Mixing is continued for approximately 5 minutes.
- Examples V and VI are mouthwash compositions within the scope of the present invention.
- Examples VI and Vu are suitable chewing gum compositions within the scope ofthe present invention.
- compositions of the invention are effective in desensitisation of the teeth.
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
Composition orale se présentant sous la forme d'un dentifrice, bain de bouche, chewing-gum ou autre et comprenant: a) d'environ 1 % à environ 45 % en poids d'un alcool de sucre composé principalement de xylitol; b) d'environ 0,1 % à environ 10 % d'ions potassium ou d'ions strontium ou des mélanges de ceux-ci; c) d'environ 45 % à environ 98,9 % de substances porteuses acceptables par voie orale. Ces compositions ont une meilleure efficacité dans la désensibilisation des dents.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9507628A JPH11510161A (ja) | 1995-07-29 | 1996-07-17 | 口腔組成物 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9515597.4 | 1995-07-29 | ||
GBGB9515597.4A GB9515597D0 (en) | 1995-07-29 | 1995-07-29 | Oral compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997004742A1 true WO1997004742A1 (fr) | 1997-02-13 |
Family
ID=10778483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/011809 WO1997004742A1 (fr) | 1995-07-29 | 1996-07-17 | Compositions orales |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPH11510161A (fr) |
GB (1) | GB9515597D0 (fr) |
WO (1) | WO1997004742A1 (fr) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998052524A1 (fr) * | 1997-05-19 | 1998-11-26 | Colgate-Palmolive Company | Remineralisation dentaire sans fluorure |
WO1999003445A2 (fr) * | 1997-07-17 | 1999-01-28 | Henkel Kommanditgesellschaft Auf Aktien | Agents de soin a usage buccal et dentaire pour dents sensibles |
WO1999005987A1 (fr) * | 1997-07-31 | 1999-02-11 | Anderson Michael R | Dispositif permettant de blanchir les dents |
WO1999048467A1 (fr) * | 1998-03-20 | 1999-09-30 | Biocosmetics, S.L. | Composition de blanchiment des dents |
WO2002078663A1 (fr) * | 2001-03-29 | 2002-10-10 | Curozone Ireland Limited | Rinçage contenant un reducteur pour traitement a l'ozone de caries dentaires |
WO2002080872A1 (fr) * | 2001-03-29 | 2002-10-17 | Curozone Ireland Limited | Preparations pour remineralisation des dents |
EP1745823A1 (fr) * | 2005-07-12 | 2007-01-24 | Henkel Kommanditgesellschaft auf Aktien | Composition eau dentifrice prêt-à-usage et son utilisation |
US8263143B2 (en) | 2005-08-22 | 2012-09-11 | Kraft Foods Global Brands Llc | Degradable chewing gum |
US8282971B2 (en) | 2005-08-22 | 2012-10-09 | Kraft Foods Global Brands Llc | Degradable chewing gum |
US8287928B2 (en) | 2005-08-22 | 2012-10-16 | Kraft Foods Global Brands Llc | Degradable chewing gum |
WO2023187028A1 (fr) * | 2022-03-31 | 2023-10-05 | Nadavia Holding Aps | Composition de bain de bouche comprenant un ou plusieurs sels de strontium |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4656293B2 (ja) * | 2004-09-29 | 2011-03-23 | ライオン株式会社 | 口腔用組成物 |
WO2006126657A1 (fr) * | 2005-05-23 | 2006-11-30 | Ajinomoto Co., Inc. | Chewing-gum sans sucre |
BRPI0618667A2 (pt) * | 2005-11-18 | 2011-09-06 | Cadbury Adams Usa Llc | goma de mascar degradante |
US7919107B2 (en) * | 2008-07-28 | 2011-04-05 | Sudzucker Aktiengesellschaft Mannhein/Ochsenfurt | Method for treating hypersensitive teeth |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4645662A (en) * | 1984-07-26 | 1987-02-24 | Lion Corporation | Oral composition |
US5182099A (en) * | 1989-03-13 | 1993-01-26 | Swedima, Inc. | Preparation for prevention of emission of mercury from amalgam fillings and method |
US5256402A (en) * | 1991-09-13 | 1993-10-26 | Colgate-Palmolive Company | Abrasive tooth whitening dentifrice of improved stability |
US5270031A (en) * | 1991-12-20 | 1993-12-14 | Block Drug Company Inc. | Dentinal desensitizing compositions |
US5284648A (en) * | 1989-03-17 | 1994-02-08 | White Robert D | Alcohol-free, oral rinse and pre-rinse emulsions method of prepration and method of use |
US5296215A (en) * | 1993-06-16 | 1994-03-22 | Colgate-Palmolive Company | High foaming rheologically stable non-irritating oral composition |
US5380530A (en) * | 1992-12-29 | 1995-01-10 | Whitehill Oral Technologies | Oral care composition coated gum |
-
1995
- 1995-07-29 GB GBGB9515597.4A patent/GB9515597D0/en active Pending
-
1996
- 1996-07-17 WO PCT/US1996/011809 patent/WO1997004742A1/fr active Application Filing
- 1996-07-17 JP JP9507628A patent/JPH11510161A/ja active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4645662A (en) * | 1984-07-26 | 1987-02-24 | Lion Corporation | Oral composition |
US5182099A (en) * | 1989-03-13 | 1993-01-26 | Swedima, Inc. | Preparation for prevention of emission of mercury from amalgam fillings and method |
US5284648A (en) * | 1989-03-17 | 1994-02-08 | White Robert D | Alcohol-free, oral rinse and pre-rinse emulsions method of prepration and method of use |
US5256402A (en) * | 1991-09-13 | 1993-10-26 | Colgate-Palmolive Company | Abrasive tooth whitening dentifrice of improved stability |
US5270031A (en) * | 1991-12-20 | 1993-12-14 | Block Drug Company Inc. | Dentinal desensitizing compositions |
US5380530A (en) * | 1992-12-29 | 1995-01-10 | Whitehill Oral Technologies | Oral care composition coated gum |
US5296215A (en) * | 1993-06-16 | 1994-03-22 | Colgate-Palmolive Company | High foaming rheologically stable non-irritating oral composition |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998052524A1 (fr) * | 1997-05-19 | 1998-11-26 | Colgate-Palmolive Company | Remineralisation dentaire sans fluorure |
AU732775B2 (en) * | 1997-05-19 | 2001-04-26 | Colgate-Palmolive Company, The | Fluoride free dental remineralization |
WO1999003445A2 (fr) * | 1997-07-17 | 1999-01-28 | Henkel Kommanditgesellschaft Auf Aktien | Agents de soin a usage buccal et dentaire pour dents sensibles |
WO1999003445A3 (fr) * | 1997-07-17 | 1999-04-08 | Henkel Kgaa | Agents de soin a usage buccal et dentaire pour dents sensibles |
WO1999005987A1 (fr) * | 1997-07-31 | 1999-02-11 | Anderson Michael R | Dispositif permettant de blanchir les dents |
WO1999048467A1 (fr) * | 1998-03-20 | 1999-09-30 | Biocosmetics, S.L. | Composition de blanchiment des dents |
ES2141050A1 (es) * | 1998-03-20 | 2000-03-01 | Biocosmetics Sl | Composicion blanqueadora dental. |
US6419905B1 (en) | 1998-03-20 | 2002-07-16 | Biocosmetics, S.L. | Tooth whitening composition |
WO2002078663A1 (fr) * | 2001-03-29 | 2002-10-10 | Curozone Ireland Limited | Rinçage contenant un reducteur pour traitement a l'ozone de caries dentaires |
WO2002080872A1 (fr) * | 2001-03-29 | 2002-10-17 | Curozone Ireland Limited | Preparations pour remineralisation des dents |
US6649148B2 (en) | 2001-03-29 | 2003-11-18 | Curozone Ireland Limited | Reductant rinse for use with ozone treatment of dental caries |
US6669931B2 (en) | 2001-03-29 | 2003-12-30 | Curozone Ireland Limited | Formulation for the remineralization of teeth |
EP1745823A1 (fr) * | 2005-07-12 | 2007-01-24 | Henkel Kommanditgesellschaft auf Aktien | Composition eau dentifrice prêt-à-usage et son utilisation |
US8263143B2 (en) | 2005-08-22 | 2012-09-11 | Kraft Foods Global Brands Llc | Degradable chewing gum |
US8282971B2 (en) | 2005-08-22 | 2012-10-09 | Kraft Foods Global Brands Llc | Degradable chewing gum |
US8287928B2 (en) | 2005-08-22 | 2012-10-16 | Kraft Foods Global Brands Llc | Degradable chewing gum |
WO2023187028A1 (fr) * | 2022-03-31 | 2023-10-05 | Nadavia Holding Aps | Composition de bain de bouche comprenant un ou plusieurs sels de strontium |
Also Published As
Publication number | Publication date |
---|---|
JPH11510161A (ja) | 1999-09-07 |
GB9515597D0 (en) | 1995-09-27 |
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