WO1997001493A1

WO1997001493A1 - Container for liquid preparations

Info

Publication number: WO1997001493A1
Application number: PCT/JP1996/001702
Authority: WO
Inventors: Takuya Kukita; Junko Takada; Kouichi Okamoto; Tomohiro Ohtsuki; Takanori Kouchiwa; Muneyoshi Kato
Original assignee: Taisho Pharmaceutical Co., Ltd.
Priority date: 1995-06-26
Filing date: 1996-06-20
Publication date: 1997-01-16
Also published as: AU6137596A

Abstract

A container for liquid preparations comprising a bottle-shaped synthetic resin container body (1) and a mouth (10), wherein the mouth (10) is sealed with a synthetic resin cap (2) fused thereto so as to be opened by breaking and means (3) for resealing the mouth (10) is formed at either or both of the body of the cap (2) and the mouth (10) or on the upper part of a holding piece (14) or the cap (2). The whole or necessary parts of the container contain antibacterial zeolite dispersed therein. As the container body (1) can be recapped in a hermetically sealed state even when the cap (2) is opened by breaking, the container is convenient for repeated use as required when carried after filling liquid preparations therein in such a quantity as to permit the administration thereof several times. As the container is always in a sterilized state, the filled preparations are protected from primary and secondary contaminations even when they do not contain any antiseptic, and the safety of the container itself is high.

Description

Specification

Liquid filling container

Technical field

The present invention generally relates to a liquid-filled container, and more specifically, a synthetic resin bottle filled with liquids (including viscous liquids) such as eye drops and other liquid drugs and health drinks. A so-called unit dose container, wherein a cap is fusion-sealed at the mouth of the bottle, and when used, the cap is twisted or pressed toward the bottle-shaped body to break and open the fused portion. It relates to a liquid-filled container in the form of a liquid. Background art

This type of liquid-filled container is generally used as a disposable container for eye drops in which a small amount (usually of one use or several uses) is enclosed.

In this type of container, a cylindrical parison is extruded using a synthetic resin compatible with the container, and the parison is cut to form a bottle-shaped main body by blow molding. It is manufactured by injecting and filling a liquid agent, then forming a cap, and simultaneously fusing the cap to the mouth of the bottle-shaped main body.

Therefore, it is suitable for mass production because molding, filling and sealing are performed continuously, and it has been awarded as a waste container and a waste container as described above.

However, the conventional unit-dose type liquid agent-filled container has the following problems.

The first is that once the fused portion of the cap is ruptured and opened, it is difficult to re-close the cap in a sealed state, and even if re-capping, the cap is likely to come off the bottle mouth.

Secondly, once opened, the liquid inside is easily contaminated by various bacteria, and when using or drinking the filled liquid several times, a preservative must be added to the liquid beforehand to prevent secondary contamination. That is what you have to do. However, for example, when the liquid is an eye drop, the use of the preservative is restricted depending on the type of the liquid to be filled in the container so that the combined preservative may irritate the eye mucous membrane. . In addition, since preservatives are easily absorbed by contact lenses, regular users of contact lenses cannot use eye drops containing preservatives. Disclosure of the invention

An object of the present invention is to provide a liquid-filled container that can be completely re-cabinated even after the container is opened by breaking the fusion part between the cap and the bottle-shaped main body and that is convenient for multiple uses. Is to do.

Another object of the present invention is to provide a liquid material container capable of preventing contamination and secondary contamination of the liquid material after opening without blending a preservative into the liquid material.

In order to solve the above-mentioned problems, a liquid-filled container according to the present invention has a synthetic-resin cap 2 fused and sealed to a synthetic-resin bottle-shaped main body 1 having a bottle opening 10. The liquid-filled containers configured to break and open the fusion portion 40 between the shaped body 1 and the cap 2 are configured as follows.

That is, the liquid agent-filled container according to the embodiment (2) of the present invention comprises: a bottle mouth portion 10 of the bottle-shaped body 1 and a body portion of the cap 2 (before the bottle is first opened; It is characterized in that one or both of the two parts (covering part) has a resealing means 3 in which the bottle mouth 10 is resealed by the cap 2.

The liquid medicine filling container according to the embodiment (2) of the invention is the liquid medicine filling container according to the embodiment (2), wherein the cap (2) and the bottle mouth (10) are mutually sealed in the resealed state when the cap (2) is resealed. In addition, a locking means 4 that is lightly locked in the pull-out direction is formed.

The liquid filling container according to aspect (3) of the invention is a liquid filling container according to aspect (1) or (2), wherein the resealing means (3) covers the opened cap (2) over the bottle opening (10). The small diameter portion 21 is formed inside the cap 2 so as to be in close contact with the outer peripheral surface of the bottle mouth portion 10 when pressed against the cap 2.

In the liquid medicine filling container according to the first aspect of the present invention, the refilling means 3 covers the opened bottle cap 10 with the bottle opening 10. When pressed into the state, the tapered inner peripheral surface 23 formed on the inner peripheral portion of the cap 2 so as to be in close contact with the upper outer peripheral edge of the bottle mouth portion 10. as a feature , You.

The liquid filling container according to the embodiment (2) of the invention is the liquid filling container according to the embodiment (1) or (2).

A state in which the resealing means 3 covers the conical taper surface 12 formed on the upper outer peripheral portion of the vial opening 10 and the cap 2 after opening on the vial opening 10. And a taper inner peripheral surface 24 formed on the inner peripheral portion of the cap 2 so as to be in close contact with the tapered surface 12 when pressed against the taper surface 12.

The liquid medicine filling container according to the embodiment (2) of the invention is the liquid medicine filling container according to the embodiment (2), wherein the resealing means 3 comprises: a male screw 13 formed on an outer peripheral surface of the bottle mouth 10; And a female screw 25 formed on the inner peripheral surface of the cap 2 so as to conform to 13.

In the liquid medicine filling container according to the embodiment (1) or (2) of the invention, the resealing means 3 covers the opened cap (2) on the bottle mouth (10). The inner plug 26 is formed on the inner upper surface of the cap 2 so as to be in close contact with at least the upper inner peripheral portion of the bottle mouth 10 when pressed. Aspect of the invention, the liquid filling container is the liquid filling container of the aspect of the invention, wherein the resealing means 3 presses the opened cap 2 so as to cover the bottle mouth 10. A ring-shaped projection 27 is formed on the inner periphery of the cap 2 in close contact with the outer periphery of the bottle opening 10.

The liquid filling container according to the first aspect of the present invention is the liquid filling container according to the first or second aspect of the present invention, wherein the resealing means 3 presses the opened cap 2 so as to cover the bottle mouth 10. At this time, it is characterized in that it is a ring-shaped convex portion 17 formed on the outer peripheral surface of the bottle mouth 10 so as to be in close contact with the inner peripheral surface of the cap 2.

In the liquid medicine filling container according to the embodiment (1) or (2) of the invention, the resealing means 3 covers the opened cap (2) on the bottle mouth (10). When pressed in such a manner, a bottle neck 18 having an outer diameter larger than the outer diameter of the bottle mouth 10 is formed on the base of the bottle mouth 10 so as to be in close contact with the inner peripheral surface of the skirt of the cap 2. It is characterized by that.

The liquid filling container according to the first aspect of the present invention is the liquid filling container according to the first or second aspect of the present invention, wherein the cap 2 after the resealing means 3 is opened is put on the bottle opening 10. When pressed against, the tapered outer peripheral surface 15 a of the bottle shoulder 15 continuously formed on the base of the bottle mouth 10 in a state of being in close contact with the inner peripheral surface of the skirt of the cap 2. Features.

The liquid medicine filling container according to the first aspect of the present invention is the liquid medicine filling container according to the second aspect of the present invention, wherein the resealing means 3 comprises a 'flange 19 formed on the outer periphery of an upper portion of the bottle mouth 10, When the cap 2 is pressed so as to cover the bottle mouth 10, the cap 2 is inwardly formed on the inner peripheral surface of the skirt of the cap 2 in a state in which the cap 2 is tightly locked to the lower part of the flange 19. And a flange 29.

The liquid filling container according to the embodiment (2) of the invention is the liquid filling container according to any of the embodiments (3), (4), (5), (6), (7), and (8) to (10), wherein the cap after opening the cap When the bottle 2 is pressed so as to cover the bottle mouth 10, a small and medium hole 28 is formed so as to close the opening edge 10 a of the bottle mouth 10.

According to the liquid-filled container of embodiment (1) of the invention, a plate-shaped holding piece 14 is formed at the bottom of the bottle-shaped body 1 along the length direction of the bottle-shaped body 1, and the holding piece 1 In part of 4, a cap-shaped resealing means 5 is formed via a thin fusion portion 51, and the resealing means 5 moves the resealing means 5 to the bottle mouth 10 after opening. It is characterized in that at least a part of the inner peripheral surface is configured to be in close contact with the outer peripheral surface of the bottle mouth portion 10 when covered.

According to the liquid-filled container of embodiment (1) of the invention, a plate-shaped holding piece 14 is formed at the bottom of the bottle-shaped body 1 along the length direction of the bottle-shaped body 1, and the holding piece 1 In part of 4, a plug-shaped resealing means 5a is formed via a thin-walled fusion portion 51, and the resealing means 5a is connected to the bottle mouth part after opening. It is characterized in that at least a part of the outer peripheral surface is in close contact with the inner peripheral surface of the bottle mouth portion 10 when pushed into the bottle 10.

According to the liquid filling container of the embodiment (2) of the invention, a cap-shaped resealing means 5 is formed on the upper part of the cap 2, and the resealing means 5 is connected to the bottle mouth part after opening. It is characterized in that at least a part of the inner peripheral surface is in close contact with the outer peripheral surface of the bottle mouth portion 10 when it is put on the bottle 10.

According to the liquid-filled container of the first aspect of the present invention, a plug-shaped resealing A closing means 5a is formed, and when the resealing means 5a is pushed into the bottle mouth part 10 after opening, at least a part of the outer peripheral surface is the bottle mouth part 10a. Is characterized in that it is configured to be in intimate contact with the inner peripheral surface.

According to the liquid agent filling container of Embodiment 1 of the invention, a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and a cap-shaped resealing means 5b is provided on the upper portion of the cap 2. The resealing means 5b is formed such that when the resealing means 5b is placed on the bottle mouth 10 after opening, the inner periphery is locked so that the flange 19a is locked in a retaining shape. The bottle is characterized in that it has an inward flange 54, and the inner upper surface 55 is in close contact with the opening edge 10a of the bottle mouth 10.

According to the liquid agent filling container of Embodiment 1 of the present invention, a flange 19 a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and the upper end of the bottle mouth portion 10 is formed above the cap 2. A cap-shaped resealing means 5c having a groove portion 57 of a size into which the portion can be inserted is formed, and the upper end portion of the bottle mouth portion 10 is inserted into the groove portion 57 after opening. In some cases, the flange 19 a has an inward flange 54 on its inner peripheral portion in which the flange 19 a is locked in a retaining shape, and the inner upper surface 58 closely contacts the opening edge 10 a of the bottle mouth 10. It is characterized by being constituted so that it may be.

According to the liquid agent filling container of Embodiment 1 of the present invention, a flange 19 a is formed on the outer peripheral portion of the upper end of the bottle mouth 10, and the bottom of the bottle-shaped body 1 has a length of the bottle-shaped body 1. A plate-like holding piece 14 is formed along the width direction, and a cap-shaped resealing means 5b is formed on a part of the holding piece 14 through a thin-walled fusion portion 51, and When the resealing means 5b is put on the bottle mouth 10 after opening, the sealing means 5b has an inward flange 54 in which the flange 19a is locked in a retaining shape. And the inner upper surface 55 is configured to be in close contact with the opening edge 10 a of the bottle opening 10.

According to the liquid-filled container of aspect (2) of the present invention, a flange 19 a is formed on the outer peripheral portion of the upper end of the bottle mouth 10, and the length of the bottle-shaped body 1 is formed at the bottom of the bottle-shaped body 1. A plate-like holding piece 14 is formed along the vertical direction, and a part of the holding piece 14 has a cap-like shape having a groove 57 having a size into which the upper end of the bottle mouth 10 can be inserted. The resealing means 5 c is formed via the thin-walled fused portion 51, and the groove 57 is formed after opening. When the upper end of the bottle mouth 10 is inserted into the inside, the flange 19 a has an inward flange 54 on which the flange 19 a is locked in a retaining shape, and the inner upper surface 58 has the inner upper surface 58. It is characterized in that it is configured to be in close contact with the opening edge 10a of the bottle mouth 10.

The liquid-filled container according to the aspect of the invention is characterized in that the antimicrobial zeolite is dispersed and held on the entire surface or a required portion in any one of the liquid-filled containers according to aspects 1 to 6 of the invention.

The antibacterial zeolite may be an ion-exchangeable ion (eg, sodium ion, calcium ion, potassium ion, magnesium ion, and iron ion) in synthetic zeolite, natural zeolite, or a mixture thereof, such as silver, copper, and zinc. It has been replaced with a metal ion having other antibacterial properties.

As these metal ions having antibacterial properties, silver ions are preferably selected from the viewpoint of safety.

For the above-mentioned antibacterial zeolite, for example, a mixed aqueous solution of salts containing antibacterial metal ions is adjusted to a pH of about 5 to 7, and the aqueous solution is brought into contact with the zeolite at a required temperature for a predetermined period of time, so that the zeolite has pores. It can be obtained industrially by substituting the above-mentioned ion-exchangeable ions described above with the above-mentioned metal ions having antibacterial properties.

In a bottle-shaped container in which antibacterial zeolite is dispersed and held, a parison is manufactured by extruding heat-melted resin mixed with powdered, granular, or slurry-like antibacterial zeolite and kneading it into a cylinder of a predetermined size. Then, it can be manufactured by blow molding into a bottle shape that is cut into a predetermined length.

Since this type of container is often thin-walled, the zeolite preferably has an average particle size of 6 / m or less and a maximum particle size of 10 m or less.

When the container is formed to be relatively thick, it is preferable to disperse and hold the antibacterial zeolite only on the inner surface of the bottle-shaped main body 1 and other necessary surfaces in consideration of economy.

Although the liquid-filled container of this embodiment has an antibacterial action, its antibacterial activity naturally depends on the distribution density of antibacterial metal ions. Antibacterial zeo to fully demonstrate antibacterial activity The necessary and sufficient mixing ratio of the light varies depending on the liquid agent to be filled and other conditions.However, when sterilizing Escherichia coli, Staphylococcus aureus, and other general bacteria and fungi that are present in a normal living environment, The purpose can be achieved by mixing 1 to 7 wt% of antibacterial zeolite containing 0.3 to 15 wt% of an antibacterial metal with an ion concentration of 0.3 to 15 wt% in synthetic resin, which is the material of the bottle-shaped body. .

In particular, when the solution is an ophthalmic solution that has almost no viscosity, mix 2-4 wt% of antibacterial zeolite containing 2.5-5 wt% ionic concentration of antibacterial metal with synthetic resin. Is preferred.

The liquid medicine filling container according to the aspect of the invention is characterized in that, in the liquid medicine filling container according to any one of the inventions 1 to 6, the container is a container for filling eye drops.

In the liquid-filled container according to the present invention, a suitable synthetic resin is selected according to the type of liquid and other conditions as the material of the container.

The steps of forming, filling, and fusing the cap of the liquid-filled container according to the present invention are almost the same as those of the conventional container of this type, but the cap 2 may be different depending on the specific structure of the resealing means. After molding, the cap 2 is filled with a liquid agent, and then cabbed and fused to the bottle-shaped main body 1.

According to the liquid-filled container of the embodiment (1) of the present invention, since the bottle mouth portion 10 and the main body portion of the cap 2 in the bottle-shaped main body 1 and / or the gap are provided with the resealing means 3, Even if the cap 2 is broken and opened once from the fused portion 40, the cap 2 can be re-cabled to the bottle mouth 10 in a sealed state.

Therefore, especially in a unit dose type container, it is very convenient to fill the liquid agent for several uses and carry it around repeatedly as needed, and at the same time, economic efficiency of the unit dose type container Can be increased.

According to the liquid agent-filled container of the embodiment (2) of the present invention, when the cap 2 and the bottle mouth 10 are resealed, the cap 2 and the bottle mouth portion 10 are lightly moved in the resealing state in the direction in which the cap 2 is resealed. Since the locking means 4 to be locked is provided, it is particularly effective when the cap 2 has a structure in which the cap 2 can be easily removed from the bottle opening 10 in the state where the cap 2 is re-cabbed by the resealing means 3 described above. When the locking means 4 is composed of a convex portion formed on the outer peripheral portion of the bottle mouth 10 and a convex portion formed on the inner peripheral portion of the cap 2, the cap When the seals are resealed, the protrusions are locked to each other in the direction in which the cap 2 is prevented from coming off, so that the existence of the locking means 4 and the operation procedure can be easily recognized.

According to the liquid filling container of the embodiment (3) of the invention, when the opened cap 2 is pressed so as to cover the bottle mouth 10, the small diameter portion 21 formed on the inner peripheral portion of the cap 2 becomes the bottle mouth. The bottle-shaped main body 1 is resealed by closely contacting the outer peripheral surface of the part 10. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, the resealing and resealing operations are very simple.

According to the liquid agent filling container of Embodiment 1 of the present invention, when the opened cap 2 is pressed so as to cover the bottle mouth 10, a conical tapered inner peripheral surface formed on the inner peripheral portion of the cap 2 is formed. 23 comes into close contact with the upper peripheral edge of the bottle mouth 10, and the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out of the cap 2, the bottle-shaped main body 1 is resealed. Therefore, the operation of resealing and resealing is very simple.

According to the liquid-filled container of Embodiment 1 of the present invention, when the opened cap 2 is pressed so as to cover the bottle mouth 10, a conical surface-shaped tape formed on the upper outer peripheral portion of the bottle mouth 10 is pressed. The inner surface 12 and the tapered inner peripheral surface 24 formed on the inner peripheral portion of the cap 2 are in close contact with each other, and the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.

According to the liquid agent filling container of Embodiment 1 of the present invention, when the cap 2 is screwed to the bottle mouth 10 after opening, the bottle-shaped main body 1 is resealed, and when the screw is returned in the loosening direction, the bottle is resealed. Therefore, resealing and resealing is very easy. In addition, in the liquid-filled container of this embodiment, the cap 2 does not easily come off from the bottle mouth 10 in the resealed state even without the locking means 4.

According to the liquid agent-filled container of the embodiment (1) of the present invention, when the cap 2 is pressed so as to cover the bottle mouth 10 after opening, the inner stopper 26 formed on the inner upper surface of the cap 2 becomes the bottle mouth 10 10. The bottle-shaped main body 1 is re-closed to the upper inner peripheral edge of the container. When the cap 2 is pulled out from the mouth of the bottle, the bottle-shaped body 1 is resealed. Therefore, resealing and resealing Always easy.

According to the liquid agent filling container of Embodiment 1 of the present invention, when the cap 2 is pressed so as to cover the bottle mouth 10 after opening, the ring-shaped convex portion 27 of the inner peripheral portion of the cap 2 becomes the bottle mouth 1. The bottle is in close contact with the outer peripheral surface of 0 and the bottle-shaped body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.

According to the liquid agent-filled container of the embodiment (1) of the invention, when the opened cap 2 is pressed to cover the bottle mouth 10, the ring-shaped convex portion formed on the outer peripheral surface of the bottle mouth 10 is pressed. 17 closely adheres to the inner peripheral surface of the cap, and the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, resealing and reopening are very easy.

According to the liquid agent-filled container of embodiment (1) of the invention, when the opened cap 2 is pressed to cover the bottle mouth 10, the outer periphery of the large-diameter bottle neck formed at the base of the bottle mouth 10 is pressed. The surface comes into close contact with the inner peripheral surface of the bottom of the cap 2, and the bottle-shaped main body 1 is resealed. When the bottle 10 is pulled out from the cap 2, the bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very simple.

According to the liquid filling container of the embodiment (1) of the invention, when the opened cap 2 is pressed so as to cover the bottle mouth 10, the tapered outer peripheral surface 15 a of the bottle shoulder 15 and the hem of the cap 2 are pressed. The inner peripheral surface is in close contact, and the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.

According to the liquid filling container of the embodiment (1) of the invention, when the cap 2 after opening is pressed so as to cover the bottle mouth 10, the lower part of the flange 19 formed on the upper outer periphery of the bottle mouth 10. Inward, the inward flange 29 formed on the inner peripheral surface of the skirt of the cap 2 is tightly locked, and the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.

According to the liquid filling container of the embodiment (2), in the container of any of the embodiments (3), (4), (5), (6), (7), (8) to (9), the inner surface of the cap 2 is provided with the cap 2 When the bottle body 10 is pressed so as to cover the bottle mouth 10, the small inner plug 28 is formed so as to close the opening of the bottle mouth 10, so that the bottle-shaped body 1 is more completely resealed.

According to the liquid agent-filled container of the embodiment (1) of the present invention, before opening the bottle-shaped main body 1, the cap-shaped resealing means 5 is separated from the holding piece 14 by the thin-walled fusion portion 51 in advance. When the resealing means 5 is placed so as to be pressed against the bottle mouth 10 after opening, the inner peripheral surface of the cap-shaped resealing means 5 comes into close contact with the outer peripheral surface of the bottle mouth 10 and the bottle-shaped main body 1 Is resealed. When the bottle mouth 10 is pulled out from the resealing means 5, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.

According to the liquid agent-filled container of the embodiment (1) of the present invention, before opening the bottle-shaped main body 1, the tubular resealing means 5 a is cut off from the holding piece 14 in advance by the thin-walled fusion portion 51, When the resealing means is pushed into the bottle mouth 10, the bottle-shaped main body is resealed. When the resealing means is pulled away from the mouth of the bottle, it is reopened. Therefore, resealing and resealing are very simple.

According to the liquid agent filling container of the embodiment (2) and the liquid container of the embodiment (2), the cap-shaped resealing means 5 or 5b formed on the upper portion of the cap 2 is pressed against the bottle opening 10 after opening. Then, the bottle-shaped body 1 is resealed. When the resealing means 5 or 5b is pulled away from the bottle mouth 10 force, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.

According to the liquid-filled container of the embodiment (2) of the invention, when the plug-shaped resealing means 5 a formed at the upper part of the cap 2 is pushed into the opened mouth 10 of the bottle, the bottle-shaped main body 1 is resealed. Is performed. When the resealing means 5a is pulled out from the bottle mouth 10, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.

According to the liquid filling container of the embodiment (2) of the invention, when the upper end of the opened bottle mouth 10 is slid and inserted into the groove 57 of the cap-shaped resealing means 5c, the bottle-shaped main body 1 is resealed. Is done. When the bottle mouth 10 is slid out of the groove 57, the bottle 1 is resealed. Therefore, resealing and resealing are very simple.

According to the liquid-filled container of the embodiment (1) of the present invention, before opening the bottle-shaped main body 1, the cap-shaped resealing means 5b is cut off from the holding piece 14 by the thin fusion portion 51 in advance. After opening the container, cover it so that the resealing means 5b is pressed against the bottle opening 10 after opening. Then, the bottle-shaped body 1 is resealed. When the bottle mouth 10 is pulled out from the resealing means 5b, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid filling container of the aspect (1) of the present invention, before opening the bottle-shaped main body 1, the cap-shaped resealing means 5c is previously cut off from the holding piece 14 by the thin fusion portion 51. When the opened bottle opening 10 is slid and inserted into the groove 57 of the resealing means 5c, the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is slid out of the groove 57, the bottle body 1 is resealed. Therefore, resealing and resealing are very simple.

According to the liquid agent filling container of the aspect (2) of the present invention, since the antibacterial zeolite is dispersed and held on the entire surface or a required portion, for example, as shown in Test Example-1, the liquid agent filled inside is It is sterilized by antibacterial metal ions held in the antibacterial zeolite.

Therefore, it is not necessary to add a preservative to the liquid in advance in order to prevent contamination and secondary contamination of the liquid by germs.

Also, as shown in Test Example 12, since the container itself is completely safe, it can be used repeatedly without containing a preservative, and provides a highly safe liquid-filled container. Is done.

According to the liquid medicine filling container of the embodiment (4) of the present invention, there is no need to carry a large-capacity container filled with eye drops and carry it around, which is very convenient. BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a partial sectional view showing a first embodiment of a liquid agent filling container according to the present invention. FIG. 2 is a perspective view showing the entire container of FIG.

FIG. 3 is a partial cross-sectional view of the container of FIG.

FIG. 4 is a partial sectional view showing a second embodiment of the liquid agent container according to the present invention. FIG. 5 is a partial cross-sectional view of the container of FIG.

FIG. 6 is a partial sectional view showing a third embodiment of the liquid agent filling container according to the present invention. FIG. 7 is a partial cross-sectional view showing a state in which the bottle mouth of the container of FIG. 6 is resealed. FIG. 8 is a partial sectional view showing a fourth embodiment of the liquid material container according to the present invention. FIG. 9 is a partial sectional view showing a fifth embodiment of the liquid agent filling container according to the present invention. FIG. 10 is a partial sectional view showing a sixth embodiment of the liquid-filled container according to the present invention. FIG. 11 is a perspective view showing the entire container of FIG.

FIG. 12 is a partial cross-sectional view of the container of FIG. 10 in a state where the bottle mouth is resealed.

FIG. 13 is a partial sectional view showing a modification of the container of FIG.

FIG. 14 is a partial sectional view of the container of FIG. 13 in a state where the bottle mouth is resealed.

FIG. 15 is a partial sectional view showing a seventh embodiment of the liquid agent filling container according to the present invention. FIG. 16 is a partial cross-sectional view showing a state in which the bottle mouth of the container of FIG. 15 is resealed.

FIG. 17 is a partial sectional view showing an eighth embodiment of the liquid material container according to the present invention. FIG. 18 is a partial cross-sectional view showing a state in which the bottle mouth of the container of FIG. 17 is resealed.

FIG. 19 is a partial cross-sectional view showing a ninth embodiment of the liquid medicine filling container according to the present invention. FIG. 20 is a partial sectional view of the container of FIG. 19 in a state where the bottle mouth is resealed.

FIG. 21 is a partial sectional view showing a tenth embodiment of the liquid agent-filled container according to the present invention.

FIG. 22 is a partial sectional view of the container of FIG. 21 in a state where the bottle mouth is resealed.

FIG. 23 is a partial cross-sectional view showing a first embodiment of the liquid medicine filling container according to the present invention.

FIG. 24 is a cross-sectional view of the container of FIG. 23 taken along the arrow AA.

FIG. 25 is a cross-sectional view of the container of FIG. 23 taken along arrows B-B.

FIG. 26 is a partial cross-sectional view of the container of FIG. 23 in a state where the bottle mouth is resealed.

FIG. 27 is a partial sectional view showing a 12th embodiment of the liquid agent filled container according to the present invention.

FIG. 28 is a cross-sectional view of the container of FIG. 27 taken along arrows C-C.

FIG. 29 is a partial cross-sectional view of the container of FIG.

FIG. 30 is a partial cross-sectional view showing a thirteenth embodiment of the liquid-filled container according to the present invention.

FIG. 31 is a partial cross-sectional view of the container of FIG. 30 in a state where the bottle mouth is resealed.

FIG. 32 is a partial cross-sectional view showing a fourteenth embodiment of the liquid medicine container according to the present invention. You.

FIG. 33 is a partial cross-sectional view of the container of FIG.

FIG. 34 is a partial sectional view showing a fifteenth embodiment of the liquid agent-filled container according to the present invention. FIG. 35 is a partial sectional view of the container of FIG.

FIG. 36 is a partial cross-sectional view showing a 16th embodiment of the liquid agent-filled container according to the present invention. FIG. 37 is a partial cross-sectional view of the container of FIG.

FIG. 38 is a partial sectional view showing a seventeenth embodiment of the liquid material container according to the present invention.

FIG. 39 is a partial sectional view showing an eighteenth embodiment of the liquid agent-filled container according to the present invention.

FIG. 40 is a graph showing changes in body weight of male mice after extracting the liquid-filled container manufactured according to the example of FIG. 1 with physiological saline and cottonseed oil, and administering the extracts. . BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, preferred embodiments of a liquid agent-filled container according to the present invention will be described in detail with reference to the drawings.

First embodiment

FIGS. 1 to 3 show examples corresponding to aspects 1 to 3 of the invention and aspect 2 of the invention.

The bottle-shaped body 1 made of a relatively soft and transparent synthetic resin (eg, polyethylene) filled with the liquid a, which is an eye drop, has a hollow plate-shaped holding piece 14 at the bottom and a shoulder 15 at the top. The bottle mouths 10 are formed integrally with each other via the through hole.

A hollow knob 20 is integrally formed on the upper part of the cap 2 made of the same material as the bottle-shaped main body 1. Inside the hem of the cap 2 is a bottle mouth 10 (for example, an inner diameter of 1.5 to 1.5 mm). 2 mm).

Body part of cap 2 (The inner periphery of the skirt of cap 2 is fused to bottle mouth 10 In the state where the bottle opening 10 is covered, the inner periphery of the opening 10 is slightly smaller than the outer diameter of the bottle opening 10 and The resealing means 3 is formed by the small-diameter portion 21 so as to be able to be brought into close contact with the outer peripheral portion in a press-fit manner. An antibacterial zeolite (not shown) is dispersed and held on the entire surface of the bottle-shaped body 1 and the cap 2.

According to the filled container of the eye drops of this embodiment, at the time of use, the holding piece 14 is grasped with one hand, the grasping portion 20 of the cap 2 is grasped with the other hand, and the cap 2 is bottled at the time of use. By slightly twisting in the direction of, the fused portion 40 is broken and the bottle-shaped main body 1 is opened.

After opening the container in this manner, the bottle-shaped main body 1 is tilted upside down so that the bottle mouth 10 is brought close to the eyes, the main body 1 is pinched, and the liquid material a inside is used to be pushed out.

In the filling container of this embodiment, a convex portion 11 is formed on the outer peripheral portion of the bottle mouth portion 10 so as to be continuous or intermittent in the circumferential direction below the fused portion 40. On the other hand, when the fused portion 40 is broken as described above, a fracture mark remains on the inner periphery of the skirt of the cap 2 and, as shown in FIG. Is formed.

When the cap 2 is resealed, the protrusion 22 and the protrusion 11 constitute a locking means 4 that is lightly locked in the direction in which the cap 2 is released in the resealed state. .

In this liquid material filling container, the molding of the bottle-shaped main body 1, the filling of the liquid material a, and the capping are performed in a series of lines as follows.

In the following description, neither the manufacturing equipment nor the molded product in the manufacturing process is shown.

First, antibacterial zeolite containing an antibacterial metal (silver ion in this example) with an ion concentration of 2.5 to 5 wt% is kneaded into the heated and melted polyethylene at a ratio of 2 to 4 wt%, and this is extruded. It extrudes between two sets of blow mold sets to produce a cylindrical parison of a given size.

When the parison has been extruded for a predetermined length, the lower end of the parison is fusion-sealed by aligning the main body forming mold of the mold set with a unitary shape, and the parison is sealed. Cut at a predetermined length position.

Then, the mold set is moved to another place, compressed air filtered and filtered by a nozzle is supplied to the inside of the parison, and the parison is expanded toward the inner wall side of the surrounding body forming mold, and the bottle is opened. The bottle-shaped main body 1 excluding the mouth 10 is formed.

After the molding of the bottle-shaped main body 1, the inside is filled with the liquid agent a by a nozzle, for example, from 0.6 to

Fill about 1.8 ml, move the mold set to another place, and combine the other molds placed on the upper part of the main body forming mold to form the bottle opening 10.

While the bottle mouth 10 is in a heated state, a separately molded cap 2 is put on the bottle mouth 10 and its hem is fused to a required portion of the outer periphery of the bottle mouth 10, and then Let the whole cool down.

By the above manufacturing process, the antibacterial zeolite is dispersed and held on the entire surface, and has the resealing means 3 (small-diameter portion 22) and the locking means 4 as described above, and a bottle filled with eye drops inside. A shaped container is manufactured.

Although a single container is illustrated in this embodiment, usually, a plurality of bottle-shaped bodies 1 are integrally manufactured so that the bottle-shaped bodies 1 are arranged side by side through thin connecting portions 16 on the sides of the bottle-shaped body 1. Then, it is configured such that it is separated one by one from the connecting portion 16 at the time of use. According to the liquid-filled container of this embodiment, even if the fused portion 40 between the cap 2 and the bottle mouth 10 is broken as described above and the bottle mouth 10 is opened, the cap 2 is still bottled. When the bottle 10 is pressed against the bottle mouth 10 in a manner to cover the mouth 10, the upper portion of the bottle mouth 10 is lightly pressed into the small diameter portion 21 of the cap 2 constituting the resealing means 3.

As a result, as shown in FIG. 3, the small-diameter portion 21 adheres tightly to the upper outer peripheral surface of the bottle mouth portion 10, and the bottle mouth portion 10 is re-cabled in a sealed state, and the fusion portion is formed. The convex part 22 of the cap 2, which is the trace of the break of 40, goes over the convex part 11 formed in the bottle mouth part 10, and the cap 2 and the bottle mouth part 10 are locked in a locked state. Is done.

Therefore, the cap 2 does not come off from the bottle mouth 10 during normal storage and handling.

When the cap 2 is pulled to a certain extent from the bottle mouth 10: in the pulling direction, the protrusion 22 comes off the other protrusion 11, and the bottle mouth 10 comes out of the cap 2. Therefore, the bottle-shaped body 1 is reopened. Test Example 1

First, eye drops were prepared according to the following formulation by a conventional method.

Prescription sodium chloride 750mg

Potassium chloride 90mg

Boric acid 250mg

Sterile purified water Total 100 m 1

Next, 0 wt%, 2 wt and 3 wt% of antibacterial zeolite powder having an average particle size of 6 m containing silver at an ion concentration of 2.5% were added to the heated and melted polyethylene, and kneaded uniformly. Ophthalmic solution prepared as described above by using polyethylene. 1. Each sample having the same structure as the container of the first example filled with Oml was produced.

These samples were opened, and the required bacteria were inoculated into the eye drops filled therein, and an antibacterial activity test was performed according to the United States Pharmacopeia. The results are as shown in Table 1, and it was confirmed that each specimen in which the antibacterial zeolite was dispersed and held had a sufficient antibacterial activity.

Table 1

Test Example 1 2

Average particle size containing 2.5% silver ion concentration in heat-melted polyethylene An antibacterial zeolite powder having a thickness of 3 m was uniformly kneaded at 3 wt%, and a sample of an empty container not filled with a liquid agent was formed using this polyethylene with the same configuration as the container of the first embodiment. The safety of these containers was evaluated in accordance with “Standards and Test Methods for Plastic Containers for Ophthalmic Solutions” in Ministry of Health and Welfare Notification No. 958. The test method was as follows: a container was finely chopped and poured out with physiological saline and cottonseed oil at 70 ° C for 24 hours, and the physiological saline extract was injected into the vein of a mouse, and the extract in cottonseed oil was extracted male. Each of the mice was intraperitoneally administered once, and the mice were observed for general condition and weighed over time.

The same test was also performed for each of the blank test solutions (saline solution itself and cottonseed oil itself).

As a result, as shown in FIG. 40, no decrease in the body weight of the mouse over time was observed, and no change was observed in observation of the general state.

Further, for each of the three rabbits, apply the extract of the container strips to the right eye once and the blank test solution 0.2 m each to the left eye once each. evaluated.

The results are as shown in Table 1-2. No eye irritation was observed for any of the extracts, confirming that the safety of the empty container sample was high.

Table 1 2

抽出 Extract with liquid

: Extract As described above, the liquid-filled container of the first embodiment has high safety, and zeolite carrying antibacterial metal ions is dispersed and held on the entire surface. Sterilized by the antibacterial metal ions in the zeolite. During use, the periphery of the opening 10a of the bottle mouth 10 that is easily contaminated by various bacteria is always in a sterilized state.

Therefore, it is not necessary to add a preservative to liquid a to prevent contamination by bacteria and secondary contamination.

Further, the liquid material filling container of the first embodiment is very convenient for carrying the liquid material container and repeatedly using the filled liquid material a several times.

The filling amount of the liquid a, which is an eye drop, is equivalent to the usage of about 2 to 6 times, so that users of eye drops do not need to carry a large capacity bottle-shaped container and use it once. It is cheaper and more economical than conventional unit-dose containers.

Second embodiment

4 and 5 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.

In this embodiment, another mode of the resealing means 3 is shown, and the resealing means 3 is constituted by a conical tapered inner peripheral surface 23 formed on the inner peripheral portion of the cap 2. .

According to the container of this embodiment, when the opened cap 2 is pressed so as to cover the bottle mouth 10, the taper inner peripheral surface 23 as shown in FIG. The locking means 4 consisting of the convex part 1 1 on the outer peripheral part of the bottle mouth part 10 and the convex part 22 on the inner peripheral part of the skirt part of the cap 2 is lightly locked in a stopper-like manner while firmly sticking to the outer periphery of the upper part of the bottle. Is done. Other configurations, operations, and effects of this embodiment are substantially the same as those of the liquid-filled container of the first embodiment, and therefore, description thereof will be omitted.

Third embodiment

6 and 7 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (2) of the invention. :

In this embodiment, still another embodiment of the resealing means 3 is shown. The resealing means 3 includes a conical tapered inner peripheral surface 24 formed on an inner peripheral portion of the cap 2, It is constituted by a conical tapered surface 12 formed on the outer peripheral portion of the bottle mouth 10.

According to the container of this embodiment, when the cap 2 is pressed so as to cover the bottle mouth 10 after opening, as shown in FIG. While being pressed against the paper surface 1 2, and the locking means 4 comprising the convex portion 1 1 on the outer periphery of the bottle mouth 10 and the convex portion 2 2 on the inner periphery of the skirt of the cap 2 comes off. Lightly locked in a stop.

Other configurations, operations, and effects of the container of this embodiment are almost the same as those of the liquid agent-filled container of the first embodiment, and therefore description thereof is omitted.

Fourth embodiment

FIG. 8 shows an embodiment corresponding to the liquid agent-filled container of the embodiment (4) of the present invention. In this embodiment, still another embodiment of the resealing means 3 is shown. The resealing means 3 includes a male screw 13 formed on the outer peripheral portion of the bottle mouth 10 and the male screw 13 And a female screw 25 formed on the inner peripheral portion of the cap 2 so as to conform to the above.

According to the container of this embodiment, when the cap 2 after opening is screwed in the tightening direction with the cap 2 placed on the bottle mouth 10, the upper end of the bottle mouth 10 and the inner top surface of the cap 2 are pushed. The cap 2 is tightly adhered in the state of being attached, and at the same time as the cap 2 is cabbaged in a sealed state, it does not come off from the bottle mouth 10.

Other configurations, operations, and effects of the container of this embodiment are almost the same as those of the container of the first embodiment, and therefore, description thereof will be omitted.

Fifth embodiment

FIG. 9 shows an embodiment corresponding to the liquid filling container according to the embodiment (4) of the present invention. In this embodiment, still another embodiment of the resealing means 3 is shown, and the resealing means 3 is constituted by an inner plug 26 formed at the center of the upper inside of the cap 2.

According to the container of this embodiment, when the opened cap 2 is pressed to cover the bottle mouth 10, the inner plug 26 is pressed against the inner edge of the opening 10 a and adheres tightly. The mouth 10 is resealed, and the protrusion 11 on the outer periphery of the bottle mouth 10 The locking means 4 comprising the convex portion 22 on the inner periphery of the skirt of the cap 2 is lightly locked in a retaining shape.

Other configurations, operations, and effects of the container of this embodiment are almost the same as those of the container of the first embodiment, and thus description thereof will be omitted.

Sixth embodiment

FIGS. 10 to 14 show examples corresponding to the liquid agent-filled containers according to the embodiments 1 and 2 of the invention.

In this embodiment, still another embodiment of the resealing means 3 is shown. The resealing means 3 is constituted by a ring-shaped convex portion 27 formed on the inner peripheral portion of the cap 2, and as a supplementary resealing means, a small-medium plug is provided on the inner upper surface of the cap 2. 2 8 are formed.

According to the container of this embodiment, as shown in FIG. 12, when the opened cap 2 is pressed so as to cover the bottle mouth 10, the ring-shaped convex portion 27 becomes the outer periphery of the bottle mouth 10. The bottle is tightly pressed against the surface, and the bottle mouth 10 is resealed. At this time, since the small / medium plug 28 is pressed against the inner edge of the opening 10a, the bottle mouth 10 is more completely sealed. In addition, the cap 2 must be pulled out with some force to come out of the bottle mouth 10.

The ring-shaped protrusions 27 shown in FIGS. 10 to 12 are formed such that the thickness of the cap 2 is entirely depressed inward, and the cap 2 is soft during the re-cabbing. Since it is pressed against the outer periphery of the bottle mouth 10 by elasticity, a more preferable resealing state is obtained.

In the container of this embodiment, the convex portion 27 can be implemented in a shape in which only the inner wall surface of the cap 2 projects in the inner circumferential direction as shown in FIGS. 13 and 14. Even if it is formed, it can be carried out.

Seventh Embodiment-Figs. 15 and 16 show an embodiment corresponding to the liquid material container according to the embodiment of the present invention. In this embodiment, still another embodiment of the resealing means 3 is shown, and the resealing means 3 is constituted by a ring-shaped convex portion 17 formed on the outer peripheral portion of the bottle mouth 10. Further, as an auxiliary resealing means, a small / medium square 28 is formed on the inner upper surface of the cap 2.

According to the container of this embodiment, as shown in FIG. 16, when the opened cap 2 is pressed to cover the bottle mouth 10, the ring-shaped convex portion formed on the outer periphery of the bottle mouth 10 is pressed. 17 is pressed against the inner peripheral surface of the cap 2 so that the bottle mouth 10 is resealed.

The ring-shaped convex portion 17 is formed such that the thickness of the bottle mouth portion 10 is entirely bulged outward, and the bottle mouth portion 10 is formed by soft elasticity at the time of the re-cabbing. Since it is pressed against the outer periphery, a more preferable resealing state is obtained.

In the container of this embodiment, the convex portion 17 can be implemented in a shape in which only the outer wall surface of the bottle mouth portion 10 protrudes in the outer peripheral direction, or can be implemented even if a plurality of convex portions are formed. .

Other configurations, operations, and effects of the container of this embodiment are substantially the same as those of the container of the sixth embodiment, and therefore, description thereof will be omitted.

Eighth embodiment

FIGS. 17 and 18 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.

In this embodiment, still another embodiment of the resealing means 3 is shown, and the resealing means 3 is formed at the base of the bottle mouth 10 and is larger than the outer diameter of the bottle mouth 10. It is constituted by a bottle neck 18 which is large and has an outer diameter slightly larger than the inner diameter of the cap 2. According to the container of this embodiment, as shown in FIG. 18, when the opened cap 2 is pressed to cover the bottle mouth 10, the bottle neck 18 formed at the base of the bottle mouth 10 is pressed. The outer peripheral surface of the bottle 10 is pressed against the inner peripheral surface of the hem of the cap 2 so that the bottle mouth 10 is resealed.

Other configurations, operations, and effects of the container of this embodiment are almost the same as those of the container of the sixth embodiment, and therefore description thereof will be omitted.

Ninth embodiment FIGS. 19 and 20 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.

In this embodiment, still another embodiment of the resealing means 3 is shown, and the resealing means 3 is configured such that when the cap 2 after opening is pressed to cover the bottle mouth 10, The bottle shoulder portion 15 is formed by a tapered outer peripheral surface 15a formed continuously with the base of the bottle mouth portion 10 so as to be in close contact with the inner peripheral surface of the skirt portion 2. According to the container of this embodiment, as shown in FIG. 20, when the opened cap 2 is pressed so as to cover the bottle mouth 10, the inner peripheral surface of the skirt of the cap 2 becomes the tape of the bottle shoulder 15. The bottle mouth 10 is resealed because it is tightly pressed against the tape-shaped outer peripheral surface 15a.

10th embodiment

FIGS. 21 and 22 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.

In this embodiment, still another embodiment of the resealing means 3 is shown. The resealing means 3 includes a flange 19 formed on the outer periphery of the upper portion of the bottle mouth 10 and a skirt of the cap 2. And an inward flange 29 formed on the peripheral surface.

The inward flange 29 is formed so as to be slightly upwardly inclined in the cross section, and the fusion portion 40 between the cap 2 and the bottle mouth 10 is formed by the tip of the inward flange 29 and the flange 1. 9 is formed at the interface with the lower surface.

According to the container of this embodiment, when the cap 2 is slightly pushed in the direction of the bottle mouth 10 and twisted slightly, the fused portion 40 is broken, and when the cap 2 is pulled away from the bottle mouth 10, Since the inward flange 29 passes over the flange 19, the bottle-shaped main body 1 is opened.

Then, when the opened cap 2 is pressed so as to cover the bottle mouth portion 10, the inward flange 29 crosses over the flange 19 and is tightly locked to the lower portion of the flange 19, so that the bottle is closed. The mouth 10 is resealed.

Other configurations, operations and effects of the container in this embodiment are the same as those of the container of the first embodiment. The description is omitted because they are almost the same.

FIG. 23 and below show an embodiment in which the resealing means is provided in a portion other than the main body of the cap 2 and the bottle mouth 10.

1st embodiment

23 to 26 show an embodiment corresponding to the liquid agent-filled container of the embodiment (4) of the present invention.

In this embodiment, a cap-shaped reed having a ring-shaped convex portion 50 on the inner peripheral surface is formed on a part of a hollow plate-shaped holding piece 14 integrally formed on the bottom of the bottle-shaped main body 1. It is formed through five sealing means and a thin-walled fusion part 51.

Since the holding piece 14 is a hollow plate, the cap-like resealing means 5 is formed on the both sides of the holding piece 14 so as to be located on both sides of the resealing means 5 as described above. Groove-shaped concave portions 52, 52 are formed in a state to be continuous with the fused portion 51, and the concave portions 52, 52 on both surfaces of the holding piece 14 are separated from each other by a partition wall 52a. . Since the fused portion 51 is thin, when a part of the holding piece 14 and the other part on which the resealing means 5 are formed are separated with a certain force, the fused portion 5 is formed. 1 and the partition wall 5 2a are broken, and the resealing means 5 is separated from the holding piece 14 by force.

Therefore, when the bottle-shaped main body 1 is opened, the resealing means 5 is cut off from the holding piece 14 in advance, and after being opened, the resealing means 5 is pressed so as to cover the bottle mouth 10, whereby the resealing means 5 The ring-shaped convex portion 50 comes into close contact with the outer peripheral surface of the bottle mouth portion 10 in a compressed state, and the bottle-shaped main body 1 is resealed.

As described above, the ring-shaped convex portion 50 comes into close contact with the outer peripheral surface of the bottle mouth portion 10 while being pressed against it. Therefore, the cap-closed resealing means 5 is pulled out from the bottle mouth portion 10. I can't come off.

In this embodiment, a ring-shaped convex portion 50 is formed on the outer periphery of the cap-shaped resealing means 5 as described above in order to make the structure rich in elasticity. In addition, the entire inner peripheral surface of the cap-shaped resealing means 5 can be configured to be in close contact with the outer peripheral surface of the bottle opening 10.

Other configurations, operations, and effects of the container in this embodiment are almost the same as those of the container of the first embodiment, and thus description thereof will be omitted. 12th embodiment

FIGS. 27 to 29 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.

In this embodiment, a stopper-shaped resealing means 5a is formed integrally with a part of the holding piece 14 integrally formed on the bottle-shaped main body 1 through a thin-walled fusion part 51. The resealing means 5 a is configured such that, when the resealing means 5 a is opened and then pushed into the bottle mouth 10, its outer peripheral surface is in close contact with the inner circumferential surface of the bottle mouth 10.

Since the holding piece 14 is in the form of a hollow plate, in order to form a plug-shaped resealing means 5a, the above-mentioned fused portions 51 are continuously formed on both surfaces around the base except for the base of the resealing means 5. Forming and gluing.

Since the fusion part 51 is thin, when a part of the holding piece 14 is separated from the other part on which the resealing means 5a is formed, the fusion part 51 is broken, and The part where the sealing means 5 a is formed can be easily separated from the holding piece 14.

Therefore, when opening the bottle-shaped main body 1, the resealing means 5a is separated from a part of the holding piece 14 in advance, and after opening, the resealing means 5a is connected to the bottle mouth as shown in FIG. When it is pushed into 10, the outer peripheral surface of the resealing means 5a comes into close contact with the inner peripheral surface of the bottle mouth 10 in a compressed state, and the bottle-shaped main body 1 is resealed.

Since the resealing means 5a is in close contact with the inner peripheral surface of the bottle mouth 10 in a state of being pressed, the bottle mouth 10 force must be pulled out from the bottle mouth 10 with some force. No, it won't be.

In the container of this embodiment, the entire outer peripheral surface of the portion of the resealing means 5a inserted into the bottle mouth portion 10 is configured to be in close contact with the inner circumferential surface of the bottle mouth portion 10; The present invention can also be implemented by forming a part of the outer peripheral surface of 5a so as to be in close contact with the inner peripheral surface of the bottle mouth part 10.

Other configurations, operations, and effects of the container in this embodiment are almost the same as those of the container of the first embodiment, and thus description thereof will be omitted.

13th embodiment

FIGS. 30 and 31 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention. In this embodiment, the upper knob 20 of the cap 2 has a cap-shaped resealing having a ring-shaped protrusion 50 on its inner peripheral surface which can be in close contact with the outer peripheral surface of the bottle mouth 10. Means 5 are formed in the body.

The liquid-filled container of this embodiment is different from the container of the first embodiment in that the cap-shaped resealing means 5 is formed not on the holding piece 14 but on the knob 20 of the cap 2. Only the differences.

Therefore, the resealing procedure (FIG. 31), the operation, the effect, and the fact that the entire inner surface of the resealing means 5 can be in close contact with the outer surface of the bottle mouth 10 can be implemented. Is almost the same as that of the container of the eleventh embodiment, and the description thereof is omitted.

Also in this embodiment, the resealing means 5 can be formed on the knob portion 20 via a thin fusion bonding portion (not shown).

14th embodiment

FIGS. 32 to 33 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.

In this embodiment, the upper knob 20 of the cap 2 has a plug-like shape whose outer peripheral surface is in close contact with the inner peripheral surface of the bottle opening 10 when pushed into the opened bottle opening 10. The reclosing means 5a is formed in the body.

The liquid-filled container of this embodiment is different from the container of the first embodiment in that the plug-shaped resealing means 5a is formed not on the holding piece 14 but on the knob portion 20 of the cap 2. Only the differences.

Therefore, the resealing procedure (Fig. 33), the function and effect, and whether to implement even if a part of the outer circumferential surface of the resealing means 5a is in close contact with the inner circumferential surface of the bottle mouth 10 are performed. Since what can be done and other configurations are almost the same as those of the container of the 12th embodiment, their description is omitted.

Also in this embodiment, the resealing means 5a can be formed on the knob portion 20 via a thin-walled fused portion.

15th embodiment

FIGS. 34 and 35 show an embodiment corresponding to the liquid-filled container of the present invention. Have been.

In this embodiment, a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and the inner peripheral portion of the skirt portion of the cap 2 is fused to the lower surface of the flange 19a.

On one surface of the hollow plate-shaped knob 20 formed at the upper part of the cap 2, a hole 5 3 having a size capable of pushing the upper end of the bottle mouth 10 is formed. An inward flange 54 is formed on the inner peripheral edge. The knob portion 20 constitutes a cap-shaped resealing means 5b as a whole, and the inner upper surface 55 (FIG. 35) of the hole 53 is smooth, and the inside of the hole 53 A concave portion 56 similar to a groove is formed around the periphery.

According to the liquid-filled container of this embodiment, after the fused portion 40 between the cap 2 and the bottle mouth 10 is broken and opened, the resealing means 5 b is pressed against the bottle mouth 10. Then, the bottle mouth 10 is pushed into the hole 53.

At this time, as shown in Fig. 35, the flange 19a is locked to the inward flange 54 so as not to come off, and the opening edge 10a of the bottle mouth 10 is Since it adheres to 5 5, the bottle-shaped body 1 is resealed.

When the bottle mouth 10 is pulled out from the cap-shaped resealing means 5b, the flange 19a escapes from the hole 53 over the inward flange 54, and the bottle mouth 10 is resealed. Other configurations, operations, and effects of the container in this embodiment are almost the same as those of the container of the first embodiment, and thus description thereof will be omitted.

16th embodiment

FIGS. 36 and 37 show an embodiment corresponding to the liquid agent-filled container of the embodiment (4) of the present invention.

On one surface of the hollow plate-shaped knob portion 20 formed at the upper portion of the cap 2, a groove portion 57 having a size capable of inserting the upper end portion of the bottle mouth portion 10 is formed. An inward flange 54 is formed on the periphery. The knob 20 as a whole constitutes a cap-shaped resealing means 5 c, the inner upper surface 58 (FIG. 37) of the groove 57 is smooth, and the inner periphery of the groove 57 is Has a recess similar to a dovetail A part 56 is formed.

After breaking and opening the fused portion 40 between the cap 2 and the bottle mouth 10, slide the upper end of the bottle mouth 10 into the groove 57 and insert it as shown in FIG. 37. Since the flange 19 a is locked to the inward flange 54 in a retaining manner, and the opening edge 10 a of the bottle mouth 10 is in close contact with the inner upper surface 58 of the groove 57, the bottle-shaped body is formed. 1 is reclosed.

When the bottle mouth 10 is slid with respect to the groove 57 to remove the cap-shaped resealing means 5c from the bottle mouth 10, the bottle mouth 10 is resealed.

Other configurations, operations, and effects of the container in this embodiment are almost the same as those of the container of the fifteenth embodiment, and thus description thereof will be omitted.

17th embodiment

FIG. 38 shows an embodiment corresponding to the liquid agent-filled container of the embodiment (4) of the present invention. In the container of this embodiment, similarly to the container of the fifteenth embodiment, a flange 19a is formed on the outer periphery of the upper end of the bottle mouth 10 and is integrally formed on the bottom of the bottle-shaped main body 1. A cap-like resealing means 5 b substantially similar to the container of the fifteenth embodiment is formed on a part of the holding piece 14 via a thin-walled fusion part 51.

According to the container of this embodiment, when the fusion part 40 is broken and the bottle mouth part 10 is opened, the fusion part 51 is broken in advance and the resealing means 5 b is held by the holding piece 1. 4, and after opening, the bottle opening 10 can be reclosed in the same manner as in the container of the fifteenth embodiment.

18th embodiment

FIG. 39 shows an embodiment corresponding to the liquid agent-filled container according to the embodiment of the present invention. In the container of this embodiment, similarly to the container of the 16th embodiment, a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth 10 and is integrally formed on the bottom of the bottle-shaped main body 1. A part of the holding piece 14 is formed via a thin fusion-bonded portion 51 with a cap-like resealing means 5 c <similar to the container of the 16th embodiment.

According to the container of this embodiment, the fusion port 40 is broken and the bottle opening 10 is opened. Therefore, the fusion part 51 is broken in advance, the resealing means 5b is separated from the holding piece 14, and after opening, the bottle mouth part 10 is resealed in the same manner as the container of the 16th embodiment. Can be closed.

Other configurations, operations, and effects of the container in this embodiment are almost the same as those of the container of the 16th embodiment, and therefore, description thereof will be omitted.

In the liquid-filled containers of the first to fourth embodiments and the tenth embodiment, a small and middle stopper 28 is formed on the inner upper surface of the cap 2 in substantially the same manner as the containers of the sixth to ninth embodiments. be able to. Industrial applicability

The liquid-filled container according to the present invention is provided with resealing means in one or both of the main body portion of the cap 2 and the bottle mouth portion 10, or the holding piece 14 or the grip portion 20 of the cap 2. Therefore, even if the cap 2 is once broken open from the bottle mouth 10, the cap 2 can be re-cabled to the bottle mouth 10 in a sealed state. Therefore, especially in a unit dose type container, it is very convenient to fill the liquid agent for several uses and carry it repeatedly as needed, and it is also economical to use the unit dose type container economically. Usage efficiency can be improved.

In addition, since the antimicrobial zeolite is dispersed and held on the entire surface or a required portion of the liquid-filled container of the embodiment (2), the entire surface or the required portion of the container is always sterilized and extremely sanitary, and Even if a preservative is not added to the liquid filled in the container, contamination and secondary contamination of the liquid can be prevented, and the safety of the container is high.

Claims

The scope of the claims

1. A synthetic resin cap 2 is fusion-sealed to a synthetic resin bottle-shaped main body 1 having a bottle mouth 10.

It is configured such that the fused portion 40 between the bottle-shaped main body 1 and the cap 2 is broken and opened.

One or both of the bottle mouth 10 and the main body portion of the cap 2 are resealing means for closing the bottle mouth 10 when the cap 2 is put on the bottle mouth 10. 3 is formed,

Liquid filling container.

2. The cap 2 and the bottle mouth 10 have a locking means 4 that is lightly locked in the pull-out direction when the cap 2 is resealed. 2. The liquid agent-filled container according to claim 1, wherein:

3. The resealing means 3 is formed inside the cap 2 so as to be in close contact with the outer peripheral surface of the bottle mouth 10 when the cap 2 is pressed to cover the bottle mouth 10 after opening. 3. The liquid-filled container according to claim 1, wherein the liquid-filled container has a small diameter portion 21.

4. When the cap 2 is pressed to cover the bottle mouth 10 after opening, the resealing means 3 closes the cap 2 so as to be in close contact with the upper peripheral edge of the bottle mouth 10. 3. The liquid agent-filled container according to claim 1, wherein the liquid agent-filled container is a conical tapered inner peripheral surface 23 formed on an inner peripheral portion.

5. The resealing means 3 is pressed against the conical tapered surface 12 formed on the outer peripheral portion of the upper portion of the bottle mouth portion 10 so as to cover the bottle mouth portion 10 with the cap 2 after opening. The tapered inner peripheral surface 24 formed on the inner peripheral portion of the cap 2 in a state of being in close contact with the tapered surface 12. Liquid filling container.

6. The resealing means 3 includes a male screw 13 formed on the outer peripheral surface of the bottle mouth 10 and a female screw formed on the inner peripheral surface of the cap 2 so as to fit the male screw 13. 25. The liquid material-filled container according to claim 1, comprising: 25.

7. The resealing means 3 covers the bottle mouth 10 with the cap 2 after opening. The inner plug 26 formed on the inner upper surface of the cap 2 in a state of being in close contact with at least the upper inner peripheral edge of the bottle mouth 10 when pressed in such a manner as to be described in claim 1 or 2. Item 6. The liquid-filled container according to Item 1.

8. When the cap 2 is pressed to cover the bottle mouth 10 after opening, the resealing means 3 closes the inside of the cap 2 so as to be in close contact with the outer peripheral surface of the bottle mouth 10. 3. The liquid agent-filled container according to claim 1, wherein the container is a ring-shaped convex portion 27 formed on a peripheral portion.

9. When the cap 2 is pressed so as to cover the bottle mouth 10 after opening, the resealing means 3 causes the outer periphery of the bottle mouth 10 to be in close contact with the inner peripheral surface of the cap 2. 3. The liquid agent-filled container according to claim 1, wherein the container is a ring-shaped convex portion 17 formed on the surface.

10. When the cap 2 is pressed to cover the bottle mouth 10 after opening, the resealing means 3 closes the bottle mouth 10 to the inner peripheral surface of the skirt of the cap 2. 3. The bottle neck portion 18 formed on the base of the bottle and having an outer diameter larger than the outer diameter of the bottle mouth 10 and slightly smaller than the inner diameter of the cap 2. Liquid filling container.

1 1. When the cap 2 is pressed to cover the bottle mouth 10 after opening the bottle, the resealing means 3 is brought into close contact with the inner peripheral surface of the skirt of the cap 2. 3. The liquid agent-filled container according to claim 1, wherein the container is a tapered outer peripheral surface 15a of a bottle shoulder portion 15 formed continuously to a base portion of the liquid agent-filled container.

1 2. The resealing means 3, when pressed so as to cover the flange 19 formed on the upper periphery of the bottle mouth 10 and the cap 2 after opening the bottle mouth 10, The liquid filler according to claim 1, further comprising an inward flange (29) formed on an inner peripheral surface of a skirt portion of the cap (2) in a state of being tightly locked to a lower portion of the flange (19).塡 Container.

1 3. When the cap 2 is pressed to cover the bottle mouth 10 after opening, a small amount is formed on the inner upper surface of the cap 2 so as to close the opening edge 10 a of the bottle mouth 10. The liquid agent-filled container according to any one of claims 3, 4, 5, 6, and 8 to 12, wherein a center 28 is formed.

14. A synthetic resin cap 2 is fusion-sealed to a synthetic resin bottle body 1 having a bottle mouth 10.

At the bottom of the bottle-shaped body 1, a plate-shaped holding piece 14 is formed along the length direction of the bottle-shaped body 1,

On a part of the holding piece 14, a cap-shaped resealing means 5 is formed via a thin fused portion 51,

The resealing means 5 is configured such that when the resealing means 5 is put on the bottle mouth 10 after opening, at least a part of the inner peripheral surface is in close contact with the outer circumferential surface of the bottle mouth 10. Characterized by being

Liquid filling container.

15. A synthetic resin cap 2 is fusion-sealed to a synthetic resin bottle body 1 having a bottle mouth 10.

A plug-shaped resealing means 5 a is formed on a part of the holding piece 14 via a thin-walled fusion part 51,

When the resealing means 5 a is pushed into the bottle mouth 10 after opening, at least a part of the outer peripheral surface is in close contact with the inner circumferential surface of the bottle mouth 10. Characterized in that:

Liquid filling container.

16. A synthetic resin cap 2 is fusion-sealed to a synthetic resin bottle body 1 having a bottle mouth 10.

A cap-shaped resealing means 5 is formed on the upper part of the cap 2, The resealing means 5 is configured such that when the resealing means 5 is put on the bottle mouth 10 after opening, at least a part of the inner peripheral surface is in close contact with the outer circumferential surface of the bottle mouth 10. It is characterized that

Liquid filling container.

17. Synthetic resin with a bottle mouth 10. A synthetic resin cap 2 is fusion-sealed to a fat-made bottle-shaped body 1,

A plug-shaped resealing means 5a is formed on the upper part of the cap 2,

The resealing means 5 a is configured such that when the resealing means is pushed into the bottle mouth 10 after opening, at least a part of the outer peripheral surface is in close contact with the inner circumferential surface of the bottle mouth 10. Characterized by being

Liquid filling container.

18. A synthetic resin cap 2 is fusion-sealed to a synthetic resin bottle-shaped body 1 having a bottle mouth 10.

A flange 19 a is formed on the outer periphery of the upper end of the bottle mouth 10,

At the upper part of the cap 2, a cap-closed resealing means 5b is formed, and when the resealing means 5b is put on the bottle mouth 10 after opening, the flange The inner peripheral portion 55 has an inward flange 54, and the inner upper surface 55 is in close contact with the opening edge 10a of the bottle mouth portion 10 so that 19a is locked in a retaining shape. Characterized in that it is composed of

Liquid filling container.

19. Synthetic resin cap 2 is fusion-sealed to synthetic resin bottle body 1 having bottle mouth 10

A flange 19 a is formed on the outer periphery of the upper end of the bottle mouth 10 of the bottle-shaped main body 1, On the upper part of the cap 2, a cap-shaped resealing means 5c having a groove 57 having a size into which the upper end of the bottle mouth 10 can be inserted is formed,

When the upper end of the bottle mouth 10 is inserted into the groove 57 after opening, the groove 57 has an inward flange 54 in which the flange 19 a is locked in a retaining shape. It has an inner peripheral portion, and the inner upper surface 58 is configured to be in close contact with the opening edge 1 Oa of the bottle mouth 10,

Liquid filling container.

20. A synthetic resin cap 2 is fusion-sealed to a synthetic resin bottle body 1 having a bottle mouth 10.

A cap-shaped resealing means 5b is formed on a part of the holding piece 14 via a thin-walled fused portion 51,

The resealing means 5b includes an inward flange 54 in which the flange 19a is locked in a retaining shape when the resealing means 5b is put on the bottle mouth 10 after opening. A peripheral portion, and the inner upper surface 55 is configured to be in close contact with an opening edge 10a of the bottle mouth portion 10;

Liquid filling container.

2 1. A synthetic resin cap 2 is fusion-sealed to a synthetic resin bottle body 1 having a bottle mouth 10.

At the bottom of the bottle-shaped main body 1, a plate-shaped holding piece is provided along the length of the bottle-shaped main body 1. 1 4 is formed,

A part of the holding piece 14 is provided with a cap-shaped resealing means 5 c having a groove portion 57 having a size into which the upper end of the bottle mouth portion 10 can be inserted via a thin-walled fusion portion 51. Formed

When the upper end of the bottle mouth 10 is inserted into the groove 57 after opening, the groove 57 has an inward flange 54 in which the flange 19 a is locked in a retaining shape. It has an inner peripheral portion, and the inner upper surface 58 is configured so as to be in close contact with the opening edge 1 O a of the bottle mouth 10.

Liquid filling container.

22. The liquid agent-filled container according to any one of claims 1 to 21, wherein the antibacterial zeolite is dispersed and held on the entire surface or a required portion.

23. The liquid medicine filling container according to any one of claims 1 to 22, wherein the container is a container for filling eye drops.