WO1997001493A1 - Recipient pour preparations liquides - Google Patents

Recipient pour preparations liquides Download PDF

Info

Publication number
WO1997001493A1
WO1997001493A1 PCT/JP1996/001702 JP9601702W WO9701493A1 WO 1997001493 A1 WO1997001493 A1 WO 1997001493A1 JP 9601702 W JP9601702 W JP 9601702W WO 9701493 A1 WO9701493 A1 WO 9701493A1
Authority
WO
WIPO (PCT)
Prior art keywords
cap
bottle
bottle mouth
container
shaped
Prior art date
Application number
PCT/JP1996/001702
Other languages
English (en)
Japanese (ja)
Inventor
Takuya Kukita
Junko Takada
Kouichi Okamoto
Tomohiro Ohtsuki
Takanori Kouchiwa
Muneyoshi Kato
Original Assignee
Taisho Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co., Ltd. filed Critical Taisho Pharmaceutical Co., Ltd.
Priority to AU61375/96A priority Critical patent/AU6137596A/en
Publication of WO1997001493A1 publication Critical patent/WO1997001493A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/023—Neck construction
    • B65D1/0238—Integral frangible closures

Definitions

  • the present invention generally relates to a liquid-filled container, and more specifically, a synthetic resin bottle filled with liquids (including viscous liquids) such as eye drops and other liquid drugs and health drinks.
  • liquids including viscous liquids
  • a so-called unit dose container wherein a cap is fusion-sealed at the mouth of the bottle, and when used, the cap is twisted or pressed toward the bottle-shaped body to break and open the fused portion. It relates to a liquid-filled container in the form of a liquid.
  • This type of liquid-filled container is generally used as a disposable container for eye drops in which a small amount (usually of one use or several uses) is enclosed.
  • a cylindrical parison is extruded using a synthetic resin compatible with the container, and the parison is cut to form a bottle-shaped main body by blow molding. It is manufactured by injecting and filling a liquid agent, then forming a cap, and simultaneously fusing the cap to the mouth of the bottle-shaped main body.
  • the conventional unit-dose type liquid agent-filled container has the following problems.
  • the first is that once the fused portion of the cap is ruptured and opened, it is difficult to re-close the cap in a sealed state, and even if re-capping, the cap is likely to come off the bottle mouth.
  • a preservative must be added to the liquid beforehand to prevent secondary contamination. That is what you have to do.
  • the use of the preservative is restricted depending on the type of the liquid to be filled in the container so that the combined preservative may irritate the eye mucous membrane.
  • preservatives are easily absorbed by contact lenses, regular users of contact lenses cannot use eye drops containing preservatives. Disclosure of the invention
  • An object of the present invention is to provide a liquid-filled container that can be completely re-cabinated even after the container is opened by breaking the fusion part between the cap and the bottle-shaped main body and that is convenient for multiple uses. Is to do.
  • Another object of the present invention is to provide a liquid material container capable of preventing contamination and secondary contamination of the liquid material after opening without blending a preservative into the liquid material.
  • a liquid-filled container according to the present invention has a synthetic-resin cap 2 fused and sealed to a synthetic-resin bottle-shaped main body 1 having a bottle opening 10.
  • the liquid-filled containers configured to break and open the fusion portion 40 between the shaped body 1 and the cap 2 are configured as follows.
  • the liquid agent-filled container according to the embodiment (2) of the present invention comprises: a bottle mouth portion 10 of the bottle-shaped body 1 and a body portion of the cap 2 (before the bottle is first opened; It is characterized in that one or both of the two parts (covering part) has a resealing means 3 in which the bottle mouth 10 is resealed by the cap 2.
  • the liquid medicine filling container according to the embodiment (2) of the invention is the liquid medicine filling container according to the embodiment (2), wherein the cap (2) and the bottle mouth (10) are mutually sealed in the resealed state when the cap (2) is resealed.
  • a locking means 4 that is lightly locked in the pull-out direction is formed.
  • the liquid filling container according to aspect (3) of the invention is a liquid filling container according to aspect (1) or (2), wherein the resealing means (3) covers the opened cap (2) over the bottle opening (10).
  • the small diameter portion 21 is formed inside the cap 2 so as to be in close contact with the outer peripheral surface of the bottle mouth portion 10 when pressed against the cap 2.
  • the refilling means 3 covers the opened bottle cap 10 with the bottle opening 10.
  • the tapered inner peripheral surface 23 formed on the inner peripheral portion of the cap 2 so as to be in close contact with the upper outer peripheral edge of the bottle mouth portion 10. as a feature , You.
  • the liquid filling container according to the embodiment (2) of the invention is the liquid filling container according to the embodiment (1) or (2).
  • the liquid medicine filling container according to the embodiment (2) of the invention is the liquid medicine filling container according to the embodiment (2), wherein the resealing means 3 comprises: a male screw 13 formed on an outer peripheral surface of the bottle mouth 10; And a female screw 25 formed on the inner peripheral surface of the cap 2 so as to conform to 13.
  • the resealing means 3 covers the opened cap (2) on the bottle mouth (10).
  • the inner plug 26 is formed on the inner upper surface of the cap 2 so as to be in close contact with at least the upper inner peripheral portion of the bottle mouth 10 when pressed.
  • the liquid filling container is the liquid filling container of the aspect of the invention, wherein the resealing means 3 presses the opened cap 2 so as to cover the bottle mouth 10.
  • a ring-shaped projection 27 is formed on the inner periphery of the cap 2 in close contact with the outer periphery of the bottle opening 10.
  • the liquid filling container according to the first aspect of the present invention is the liquid filling container according to the first or second aspect of the present invention, wherein the resealing means 3 presses the opened cap 2 so as to cover the bottle mouth 10. At this time, it is characterized in that it is a ring-shaped convex portion 17 formed on the outer peripheral surface of the bottle mouth 10 so as to be in close contact with the inner peripheral surface of the cap 2.
  • the resealing means 3 covers the opened cap (2) on the bottle mouth (10).
  • a bottle neck 18 having an outer diameter larger than the outer diameter of the bottle mouth 10 is formed on the base of the bottle mouth 10 so as to be in close contact with the inner peripheral surface of the skirt of the cap 2. It is characterized by that.
  • the liquid filling container according to the first aspect of the present invention is the liquid filling container according to the first or second aspect of the present invention, wherein the cap 2 after the resealing means 3 is opened is put on the bottle opening 10.
  • the tapered outer peripheral surface 15 a of the bottle shoulder 15 continuously formed on the base of the bottle mouth 10 in a state of being in close contact with the inner peripheral surface of the skirt of the cap 2.
  • the liquid medicine filling container according to the first aspect of the present invention is the liquid medicine filling container according to the second aspect of the present invention, wherein the resealing means 3 comprises a 'flange 19 formed on the outer periphery of an upper portion of the bottle mouth 10, When the cap 2 is pressed so as to cover the bottle mouth 10, the cap 2 is inwardly formed on the inner peripheral surface of the skirt of the cap 2 in a state in which the cap 2 is tightly locked to the lower part of the flange 19. And a flange 29.
  • the liquid filling container according to the embodiment (2) of the invention is the liquid filling container according to any of the embodiments (3), (4), (5), (6), (7), and (8) to (10), wherein the cap after opening the cap When the bottle 2 is pressed so as to cover the bottle mouth 10, a small and medium hole 28 is formed so as to close the opening edge 10 a of the bottle mouth 10.
  • a plate-shaped holding piece 14 is formed at the bottom of the bottle-shaped body 1 along the length direction of the bottle-shaped body 1, and the holding piece 1
  • a cap-shaped resealing means 5 is formed via a thin fusion portion 51, and the resealing means 5 moves the resealing means 5 to the bottle mouth 10 after opening. It is characterized in that at least a part of the inner peripheral surface is configured to be in close contact with the outer peripheral surface of the bottle mouth portion 10 when covered.
  • a plate-shaped holding piece 14 is formed at the bottom of the bottle-shaped body 1 along the length direction of the bottle-shaped body 1, and the holding piece 1
  • a plug-shaped resealing means 5a is formed via a thin-walled fusion portion 51, and the resealing means 5a is connected to the bottle mouth part after opening. It is characterized in that at least a part of the outer peripheral surface is in close contact with the inner peripheral surface of the bottle mouth portion 10 when pushed into the bottle 10.
  • a cap-shaped resealing means 5 is formed on the upper part of the cap 2, and the resealing means 5 is connected to the bottle mouth part after opening. It is characterized in that at least a part of the inner peripheral surface is in close contact with the outer peripheral surface of the bottle mouth portion 10 when it is put on the bottle 10.
  • a plug-shaped resealing A closing means 5a is formed, and when the resealing means 5a is pushed into the bottle mouth part 10 after opening, at least a part of the outer peripheral surface is the bottle mouth part 10a. Is characterized in that it is configured to be in intimate contact with the inner peripheral surface.
  • a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and a cap-shaped resealing means 5b is provided on the upper portion of the cap 2.
  • the resealing means 5b is formed such that when the resealing means 5b is placed on the bottle mouth 10 after opening, the inner periphery is locked so that the flange 19a is locked in a retaining shape.
  • the bottle is characterized in that it has an inward flange 54, and the inner upper surface 55 is in close contact with the opening edge 10a of the bottle mouth 10.
  • a flange 19 a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and the upper end of the bottle mouth portion 10 is formed above the cap 2.
  • a cap-shaped resealing means 5c having a groove portion 57 of a size into which the portion can be inserted is formed, and the upper end portion of the bottle mouth portion 10 is inserted into the groove portion 57 after opening.
  • the flange 19 a has an inward flange 54 on its inner peripheral portion in which the flange 19 a is locked in a retaining shape, and the inner upper surface 58 closely contacts the opening edge 10 a of the bottle mouth 10. It is characterized by being constituted so that it may be.
  • a flange 19 a is formed on the outer peripheral portion of the upper end of the bottle mouth 10, and the bottom of the bottle-shaped body 1 has a length of the bottle-shaped body 1.
  • a plate-like holding piece 14 is formed along the width direction, and a cap-shaped resealing means 5b is formed on a part of the holding piece 14 through a thin-walled fusion portion 51, and When the resealing means 5b is put on the bottle mouth 10 after opening, the sealing means 5b has an inward flange 54 in which the flange 19a is locked in a retaining shape.
  • the inner upper surface 55 is configured to be in close contact with the opening edge 10 a of the bottle opening 10.
  • a flange 19 a is formed on the outer peripheral portion of the upper end of the bottle mouth 10, and the length of the bottle-shaped body 1 is formed at the bottom of the bottle-shaped body 1.
  • a plate-like holding piece 14 is formed along the vertical direction, and a part of the holding piece 14 has a cap-like shape having a groove 57 having a size into which the upper end of the bottle mouth 10 can be inserted.
  • the resealing means 5 c is formed via the thin-walled fused portion 51, and the groove 57 is formed after opening.
  • the flange 19 a When the upper end of the bottle mouth 10 is inserted into the inside, the flange 19 a has an inward flange 54 on which the flange 19 a is locked in a retaining shape, and the inner upper surface 58 has the inner upper surface 58. It is characterized in that it is configured to be in close contact with the opening edge 10a of the bottle mouth 10.
  • the liquid-filled container according to the aspect of the invention is characterized in that the antimicrobial zeolite is dispersed and held on the entire surface or a required portion in any one of the liquid-filled containers according to aspects 1 to 6 of the invention.
  • the antibacterial zeolite may be an ion-exchangeable ion (eg, sodium ion, calcium ion, potassium ion, magnesium ion, and iron ion) in synthetic zeolite, natural zeolite, or a mixture thereof, such as silver, copper, and zinc. It has been replaced with a metal ion having other antibacterial properties.
  • an ion-exchangeable ion eg, sodium ion, calcium ion, potassium ion, magnesium ion, and iron ion
  • silver ions are preferably selected from the viewpoint of safety.
  • a mixed aqueous solution of salts containing antibacterial metal ions is adjusted to a pH of about 5 to 7, and the aqueous solution is brought into contact with the zeolite at a required temperature for a predetermined period of time, so that the zeolite has pores. It can be obtained industrially by substituting the above-mentioned ion-exchangeable ions described above with the above-mentioned metal ions having antibacterial properties.
  • a parison In a bottle-shaped container in which antibacterial zeolite is dispersed and held, a parison is manufactured by extruding heat-melted resin mixed with powdered, granular, or slurry-like antibacterial zeolite and kneading it into a cylinder of a predetermined size. Then, it can be manufactured by blow molding into a bottle shape that is cut into a predetermined length.
  • the zeolite preferably has an average particle size of 6 / m or less and a maximum particle size of 10 m or less.
  • the container When the container is formed to be relatively thick, it is preferable to disperse and hold the antibacterial zeolite only on the inner surface of the bottle-shaped main body 1 and other necessary surfaces in consideration of economy.
  • the liquid-filled container of this embodiment has an antibacterial action, its antibacterial activity naturally depends on the distribution density of antibacterial metal ions.
  • Antibacterial zeo to fully demonstrate antibacterial activity The necessary and sufficient mixing ratio of the light varies depending on the liquid agent to be filled and other conditions.However, when sterilizing Escherichia coli, Staphylococcus aureus, and other general bacteria and fungi that are present in a normal living environment, The purpose can be achieved by mixing 1 to 7 wt% of antibacterial zeolite containing 0.3 to 15 wt% of an antibacterial metal with an ion concentration of 0.3 to 15 wt% in synthetic resin, which is the material of the bottle-shaped body. .
  • the solution is an ophthalmic solution that has almost no viscosity
  • the liquid medicine filling container according to the aspect of the invention is characterized in that, in the liquid medicine filling container according to any one of the inventions 1 to 6, the container is a container for filling eye drops.
  • a suitable synthetic resin is selected according to the type of liquid and other conditions as the material of the container.
  • the steps of forming, filling, and fusing the cap of the liquid-filled container according to the present invention are almost the same as those of the conventional container of this type, but the cap 2 may be different depending on the specific structure of the resealing means. After molding, the cap 2 is filled with a liquid agent, and then cabbed and fused to the bottle-shaped main body 1.
  • the bottle mouth portion 10 and the main body portion of the cap 2 in the bottle-shaped main body 1 and / or the gap are provided with the resealing means 3, Even if the cap 2 is broken and opened once from the fused portion 40, the cap 2 can be re-cabled to the bottle mouth 10 in a sealed state.
  • the cap 2 and the bottle mouth 10 are resealed, the cap 2 and the bottle mouth portion 10 are lightly moved in the resealing state in the direction in which the cap 2 is resealed. Since the locking means 4 to be locked is provided, it is particularly effective when the cap 2 has a structure in which the cap 2 can be easily removed from the bottle opening 10 in the state where the cap 2 is re-cabbed by the resealing means 3 described above.
  • the locking means 4 is composed of a convex portion formed on the outer peripheral portion of the bottle mouth 10 and a convex portion formed on the inner peripheral portion of the cap 2, the cap When the seals are resealed, the protrusions are locked to each other in the direction in which the cap 2 is prevented from coming off, so that the existence of the locking means 4 and the operation procedure can be easily recognized.
  • the small diameter portion 21 formed on the inner peripheral portion of the cap 2 becomes the bottle mouth.
  • the bottle-shaped main body 1 is resealed by closely contacting the outer peripheral surface of the part 10.
  • the bottle-shaped main body 1 is resealed. Therefore, the resealing and resealing operations are very simple.
  • Embodiment 1 of the present invention when the opened cap 2 is pressed so as to cover the bottle mouth 10, a conical tapered inner peripheral surface formed on the inner peripheral portion of the cap 2 is formed. 23 comes into close contact with the upper peripheral edge of the bottle mouth 10, and the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out of the cap 2, the bottle-shaped main body 1 is resealed. Therefore, the operation of resealing and resealing is very simple.
  • Embodiment 1 of the present invention when the opened cap 2 is pressed so as to cover the bottle mouth 10, a conical surface-shaped tape formed on the upper outer peripheral portion of the bottle mouth 10 is pressed.
  • the inner surface 12 and the tapered inner peripheral surface 24 formed on the inner peripheral portion of the cap 2 are in close contact with each other, and the bottle-shaped main body 1 is resealed.
  • the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.
  • the cap 2 when the cap 2 is screwed to the bottle mouth 10 after opening, the bottle-shaped main body 1 is resealed, and when the screw is returned in the loosening direction, the bottle is resealed. Therefore, resealing and resealing is very easy.
  • the cap 2 does not easily come off from the bottle mouth 10 in the resealed state even without the locking means 4.
  • the inner stopper 26 formed on the inner upper surface of the cap 2 becomes the bottle mouth 10 10.
  • the bottle-shaped main body 1 is re-closed to the upper inner peripheral edge of the container.
  • the cap 2 is pulled out from the mouth of the bottle, the bottle-shaped body 1 is resealed. Therefore, resealing and resealing Always easy.
  • the ring-shaped convex portion 27 of the inner peripheral portion of the cap 2 becomes the bottle mouth 1.
  • the bottle is in close contact with the outer peripheral surface of 0 and the bottle-shaped body 1 is resealed.
  • the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.
  • the ring-shaped convex portion formed on the outer peripheral surface of the bottle mouth 10 is pressed. 17 closely adheres to the inner peripheral surface of the cap, and the bottle-shaped main body 1 is resealed.
  • the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, resealing and reopening are very easy.
  • the tapered outer peripheral surface 15 a of the bottle shoulder 15 and the hem of the cap 2 are pressed.
  • the inner peripheral surface is in close contact, and the bottle-shaped main body 1 is resealed.
  • the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.
  • the cap 2 after opening is pressed so as to cover the bottle mouth 10
  • the inward flange 29 formed on the inner peripheral surface of the skirt of the cap 2 is tightly locked, and the bottle-shaped main body 1 is resealed.
  • the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.
  • the inner surface of the cap 2 is provided with the cap 2
  • the small inner plug 28 is formed so as to close the opening of the bottle mouth 10, so that the bottle-shaped body 1 is more completely resealed.
  • the cap-shaped resealing means 5 before opening the bottle-shaped main body 1, the cap-shaped resealing means 5 is separated from the holding piece 14 by the thin-walled fusion portion 51 in advance.
  • the inner peripheral surface of the cap-shaped resealing means 5 comes into close contact with the outer peripheral surface of the bottle mouth 10 and the bottle-shaped main body 1 Is resealed.
  • the bottle mouth 10 is pulled out from the resealing means 5
  • the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.
  • the tubular resealing means 5 a is cut off from the holding piece 14 in advance by the thin-walled fusion portion 51, When the resealing means is pushed into the bottle mouth 10, the bottle-shaped main body is resealed. When the resealing means is pulled away from the mouth of the bottle, it is reopened. Therefore, resealing and resealing are very simple.
  • the cap-shaped resealing means 5 or 5b formed on the upper portion of the cap 2 is pressed against the bottle opening 10 after opening. Then, the bottle-shaped body 1 is resealed.
  • the resealing means 5 or 5b is pulled away from the bottle mouth 10 force, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.
  • the plug-shaped resealing means 5 a formed at the upper part of the cap 2 is pushed into the opened mouth 10 of the bottle, the bottle-shaped main body 1 is resealed. Is performed.
  • the resealing means 5a is pulled out from the bottle mouth 10, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very simple.
  • the bottle-shaped main body 1 is resealed. Is done.
  • the bottle mouth 10 is slid out of the groove 57, the bottle 1 is resealed. Therefore, resealing and resealing are very simple.
  • the cap-shaped resealing means 5b before opening the bottle-shaped main body 1, the cap-shaped resealing means 5b is cut off from the holding piece 14 by the thin fusion portion 51 in advance. After opening the container, cover it so that the resealing means 5b is pressed against the bottle opening 10 after opening. Then, the bottle-shaped body 1 is resealed. When the bottle mouth 10 is pulled out from the resealing means 5b, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very easy.
  • the cap-shaped resealing means 5c before opening the bottle-shaped main body 1, the cap-shaped resealing means 5c is previously cut off from the holding piece 14 by the thin fusion portion 51.
  • the bottle-shaped main body 1 When the opened bottle opening 10 is slid and inserted into the groove 57 of the resealing means 5c, the bottle-shaped main body 1 is resealed.
  • the bottle mouth 10 is slid out of the groove 57, the bottle body 1 is resealed. Therefore, resealing and resealing are very simple.
  • the liquid agent filling container of the aspect (2) of the present invention since the antibacterial zeolite is dispersed and held on the entire surface or a required portion, for example, as shown in Test Example-1, the liquid agent filled inside is It is sterilized by antibacterial metal ions held in the antibacterial zeolite.
  • Test Example 12 since the container itself is completely safe, it can be used repeatedly without containing a preservative, and provides a highly safe liquid-filled container. Is done.
  • FIG. 1 is a partial sectional view showing a first embodiment of a liquid agent filling container according to the present invention.
  • FIG. 2 is a perspective view showing the entire container of FIG.
  • FIG. 3 is a partial cross-sectional view of the container of FIG.
  • FIG. 4 is a partial sectional view showing a second embodiment of the liquid agent container according to the present invention.
  • FIG. 5 is a partial cross-sectional view of the container of FIG.
  • FIG. 6 is a partial sectional view showing a third embodiment of the liquid agent filling container according to the present invention.
  • FIG. 7 is a partial cross-sectional view showing a state in which the bottle mouth of the container of FIG. 6 is resealed.
  • FIG. 8 is a partial sectional view showing a fourth embodiment of the liquid material container according to the present invention.
  • FIG. 9 is a partial sectional view showing a fifth embodiment of the liquid agent filling container according to the present invention.
  • FIG. 10 is a partial sectional view showing a sixth embodiment of the liquid-filled container according to the present invention.
  • FIG. 11 is a perspective view showing the entire container of FIG.
  • FIG. 12 is a partial cross-sectional view of the container of FIG. 10 in a state where the bottle mouth is resealed.
  • FIG. 13 is a partial sectional view showing a modification of the container of FIG.
  • FIG. 14 is a partial sectional view of the container of FIG. 13 in a state where the bottle mouth is resealed.
  • FIG. 15 is a partial sectional view showing a seventh embodiment of the liquid agent filling container according to the present invention.
  • FIG. 16 is a partial cross-sectional view showing a state in which the bottle mouth of the container of FIG. 15 is resealed.
  • FIG. 17 is a partial sectional view showing an eighth embodiment of the liquid material container according to the present invention.
  • FIG. 18 is a partial cross-sectional view showing a state in which the bottle mouth of the container of FIG. 17 is resealed.
  • FIG. 19 is a partial cross-sectional view showing a ninth embodiment of the liquid medicine filling container according to the present invention.
  • FIG. 20 is a partial sectional view of the container of FIG. 19 in a state where the bottle mouth is resealed.
  • FIG. 21 is a partial sectional view showing a tenth embodiment of the liquid agent-filled container according to the present invention.
  • FIG. 22 is a partial sectional view of the container of FIG. 21 in a state where the bottle mouth is resealed.
  • FIG. 23 is a partial cross-sectional view showing a first embodiment of the liquid medicine filling container according to the present invention.
  • FIG. 24 is a cross-sectional view of the container of FIG. 23 taken along the arrow AA.
  • FIG. 25 is a cross-sectional view of the container of FIG. 23 taken along arrows B-B.
  • FIG. 26 is a partial cross-sectional view of the container of FIG. 23 in a state where the bottle mouth is resealed.
  • FIG. 27 is a partial sectional view showing a 12th embodiment of the liquid agent filled container according to the present invention.
  • FIG. 28 is a cross-sectional view of the container of FIG. 27 taken along arrows C-C.
  • FIG. 29 is a partial cross-sectional view of the container of FIG.
  • FIG. 30 is a partial cross-sectional view showing a thirteenth embodiment of the liquid-filled container according to the present invention.
  • FIG. 31 is a partial cross-sectional view of the container of FIG. 30 in a state where the bottle mouth is resealed.
  • FIG. 32 is a partial cross-sectional view showing a fourteenth embodiment of the liquid medicine container according to the present invention. You.
  • FIG. 33 is a partial cross-sectional view of the container of FIG.
  • FIG. 34 is a partial sectional view showing a fifteenth embodiment of the liquid agent-filled container according to the present invention.
  • FIG. 35 is a partial sectional view of the container of FIG.
  • FIG. 36 is a partial cross-sectional view showing a 16th embodiment of the liquid agent-filled container according to the present invention.
  • FIG. 37 is a partial cross-sectional view of the container of FIG.
  • FIG. 38 is a partial sectional view showing a seventeenth embodiment of the liquid material container according to the present invention.
  • FIG. 39 is a partial sectional view showing an eighteenth embodiment of the liquid agent-filled container according to the present invention.
  • FIG. 40 is a graph showing changes in body weight of male mice after extracting the liquid-filled container manufactured according to the example of FIG. 1 with physiological saline and cottonseed oil, and administering the extracts. .
  • FIGS. 1 to 3 show examples corresponding to aspects 1 to 3 of the invention and aspect 2 of the invention.
  • the bottle-shaped body 1 made of a relatively soft and transparent synthetic resin (eg, polyethylene) filled with the liquid a, which is an eye drop, has a hollow plate-shaped holding piece 14 at the bottom and a shoulder 15 at the top.
  • the bottle mouths 10 are formed integrally with each other via the through hole.
  • a hollow knob 20 is integrally formed on the upper part of the cap 2 made of the same material as the bottle-shaped main body 1. Inside the hem of the cap 2 is a bottle mouth 10 (for example, an inner diameter of 1.5 to 1.5 mm). 2 mm).
  • the inner periphery of the skirt of cap 2 is fused to bottle mouth 10 In the state where the bottle opening 10 is covered, the inner periphery of the opening 10 is slightly smaller than the outer diameter of the bottle opening 10 and The resealing means 3 is formed by the small-diameter portion 21 so as to be able to be brought into close contact with the outer peripheral portion in a press-fit manner.
  • An antibacterial zeolite (not shown) is dispersed and held on the entire surface of the bottle-shaped body 1 and the cap 2.
  • the holding piece 14 is grasped with one hand, the grasping portion 20 of the cap 2 is grasped with the other hand, and the cap 2 is bottled at the time of use.
  • the fused portion 40 is broken and the bottle-shaped main body 1 is opened.
  • the bottle-shaped main body 1 is tilted upside down so that the bottle mouth 10 is brought close to the eyes, the main body 1 is pinched, and the liquid material a inside is used to be pushed out.
  • a convex portion 11 is formed on the outer peripheral portion of the bottle mouth portion 10 so as to be continuous or intermittent in the circumferential direction below the fused portion 40.
  • a fracture mark remains on the inner periphery of the skirt of the cap 2 and, as shown in FIG. Is formed.
  • the protrusion 22 and the protrusion 11 constitute a locking means 4 that is lightly locked in the direction in which the cap 2 is released in the resealed state. .
  • the molding of the bottle-shaped main body 1, the filling of the liquid material a, and the capping are performed in a series of lines as follows.
  • antibacterial zeolite containing an antibacterial metal (silver ion in this example) with an ion concentration of 2.5 to 5 wt% is kneaded into the heated and melted polyethylene at a ratio of 2 to 4 wt%, and this is extruded. It extrudes between two sets of blow mold sets to produce a cylindrical parison of a given size.
  • the lower end of the parison is fusion-sealed by aligning the main body forming mold of the mold set with a unitary shape, and the parison is sealed. Cut at a predetermined length position.
  • the mold set is moved to another place, compressed air filtered and filtered by a nozzle is supplied to the inside of the parison, and the parison is expanded toward the inner wall side of the surrounding body forming mold, and the bottle is opened.
  • the bottle-shaped main body 1 excluding the mouth 10 is formed.
  • the inside is filled with the liquid agent a by a nozzle, for example, from 0.6 to
  • the antibacterial zeolite is dispersed and held on the entire surface, and has the resealing means 3 (small-diameter portion 22) and the locking means 4 as described above, and a bottle filled with eye drops inside.
  • a shaped container is manufactured.
  • a single container is illustrated in this embodiment, usually, a plurality of bottle-shaped bodies 1 are integrally manufactured so that the bottle-shaped bodies 1 are arranged side by side through thin connecting portions 16 on the sides of the bottle-shaped body 1. Then, it is configured such that it is separated one by one from the connecting portion 16 at the time of use.
  • the cap 2 is still bottled.
  • the bottle 10 is pressed against the bottle mouth 10 in a manner to cover the mouth 10
  • the upper portion of the bottle mouth 10 is lightly pressed into the small diameter portion 21 of the cap 2 constituting the resealing means 3.
  • the small-diameter portion 21 adheres tightly to the upper outer peripheral surface of the bottle mouth portion 10, and the bottle mouth portion 10 is re-cabled in a sealed state, and the fusion portion is formed.
  • the convex part 22 of the cap 2 which is the trace of the break of 40, goes over the convex part 11 formed in the bottle mouth part 10, and the cap 2 and the bottle mouth part 10 are locked in a locked state. Is done.
  • the cap 2 does not come off from the bottle mouth 10 during normal storage and handling.
  • eye drops were prepared according to the following formulation by a conventional method.
  • the test method was as follows: a container was finely chopped and poured out with physiological saline and cottonseed oil at 70 ° C for 24 hours, and the physiological saline extract was injected into the vein of a mouse, and the extract in cottonseed oil was extracted male. Each of the mice was intraperitoneally administered once, and the mice were observed for general condition and weighed over time.
  • the liquid-filled container of the first embodiment has high safety, and zeolite carrying antibacterial metal ions is dispersed and held on the entire surface. Sterilized by the antibacterial metal ions in the zeolite. During use, the periphery of the opening 10a of the bottle mouth 10 that is easily contaminated by various bacteria is always in a sterilized state.
  • liquid material filling container of the first embodiment is very convenient for carrying the liquid material container and repeatedly using the filled liquid material a several times.
  • the filling amount of the liquid a which is an eye drop, is equivalent to the usage of about 2 to 6 times, so that users of eye drops do not need to carry a large capacity bottle-shaped container and use it once. It is cheaper and more economical than conventional unit-dose containers.
  • the resealing means 3 is constituted by a conical tapered inner peripheral surface 23 formed on the inner peripheral portion of the cap 2. .
  • the taper inner peripheral surface 23 as shown in FIG.
  • the locking means 4 consisting of the convex part 1 1 on the outer peripheral part of the bottle mouth part 10 and the convex part 22 on the inner peripheral part of the skirt part of the cap 2 is lightly locked in a stopper-like manner while firmly sticking to the outer periphery of the upper part of the bottle. Is done.
  • Other configurations, operations, and effects of this embodiment are substantially the same as those of the liquid-filled container of the first embodiment, and therefore, description thereof will be omitted.
  • the resealing means 3 includes a conical tapered inner peripheral surface 24 formed on an inner peripheral portion of the cap 2, It is constituted by a conical tapered surface 12 formed on the outer peripheral portion of the bottle mouth 10.
  • the cap 2 when the cap 2 is pressed so as to cover the bottle mouth 10 after opening, as shown in FIG. While being pressed against the paper surface 1 2, and the locking means 4 comprising the convex portion 1 1 on the outer periphery of the bottle mouth 10 and the convex portion 2 2 on the inner periphery of the skirt of the cap 2 comes off. Lightly locked in a stop.
  • FIG. 8 shows an embodiment corresponding to the liquid agent-filled container of the embodiment (4) of the present invention.
  • the resealing means 3 includes a male screw 13 formed on the outer peripheral portion of the bottle mouth 10 and the male screw 13 And a female screw 25 formed on the inner peripheral portion of the cap 2 so as to conform to the above.
  • the cap 2 after opening is screwed in the tightening direction with the cap 2 placed on the bottle mouth 10
  • the upper end of the bottle mouth 10 and the inner top surface of the cap 2 are pushed.
  • the cap 2 is tightly adhered in the state of being attached, and at the same time as the cap 2 is cabbaged in a sealed state, it does not come off from the bottle mouth 10.
  • FIG. 9 shows an embodiment corresponding to the liquid filling container according to the embodiment (4) of the present invention.
  • still another embodiment of the resealing means 3 is shown, and the resealing means 3 is constituted by an inner plug 26 formed at the center of the upper inside of the cap 2.
  • the inner plug 26 is pressed against the inner edge of the opening 10 a and adheres tightly.
  • the mouth 10 is resealed, and the protrusion 11 on the outer periphery of the bottle mouth 10
  • the locking means 4 comprising the convex portion 22 on the inner periphery of the skirt of the cap 2 is lightly locked in a retaining shape.
  • FIGS. 10 to 14 show examples corresponding to the liquid agent-filled containers according to the embodiments 1 and 2 of the invention.
  • the resealing means 3 is constituted by a ring-shaped convex portion 27 formed on the inner peripheral portion of the cap 2, and as a supplementary resealing means, a small-medium plug is provided on the inner upper surface of the cap 2. 2 8 are formed.
  • the ring-shaped convex portion 27 becomes the outer periphery of the bottle mouth 10.
  • the bottle is tightly pressed against the surface, and the bottle mouth 10 is resealed.
  • the small / medium plug 28 is pressed against the inner edge of the opening 10a, the bottle mouth 10 is more completely sealed.
  • the cap 2 must be pulled out with some force to come out of the bottle mouth 10.
  • the ring-shaped protrusions 27 shown in FIGS. 10 to 12 are formed such that the thickness of the cap 2 is entirely depressed inward, and the cap 2 is soft during the re-cabbing. Since it is pressed against the outer periphery of the bottle mouth 10 by elasticity, a more preferable resealing state is obtained.
  • the convex portion 27 can be implemented in a shape in which only the inner wall surface of the cap 2 projects in the inner circumferential direction as shown in FIGS. 13 and 14. Even if it is formed, it can be carried out.
  • Seventh Embodiment-Figs. 15 and 16 show an embodiment corresponding to the liquid material container according to the embodiment of the present invention.
  • still another embodiment of the resealing means 3 is shown, and the resealing means 3 is constituted by a ring-shaped convex portion 17 formed on the outer peripheral portion of the bottle mouth 10.
  • a small / medium square 28 is formed on the inner upper surface of the cap 2.
  • the ring-shaped convex portion formed on the outer periphery of the bottle mouth 10 is pressed. 17 is pressed against the inner peripheral surface of the cap 2 so that the bottle mouth 10 is resealed.
  • the ring-shaped convex portion 17 is formed such that the thickness of the bottle mouth portion 10 is entirely bulged outward, and the bottle mouth portion 10 is formed by soft elasticity at the time of the re-cabbing. Since it is pressed against the outer periphery, a more preferable resealing state is obtained.
  • the convex portion 17 can be implemented in a shape in which only the outer wall surface of the bottle mouth portion 10 protrudes in the outer peripheral direction, or can be implemented even if a plurality of convex portions are formed. .
  • FIGS. 17 and 18 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.
  • the resealing means 3 is formed at the base of the bottle mouth 10 and is larger than the outer diameter of the bottle mouth 10. It is constituted by a bottle neck 18 which is large and has an outer diameter slightly larger than the inner diameter of the cap 2. According to the container of this embodiment, as shown in FIG. 18, when the opened cap 2 is pressed to cover the bottle mouth 10, the bottle neck 18 formed at the base of the bottle mouth 10 is pressed. The outer peripheral surface of the bottle 10 is pressed against the inner peripheral surface of the hem of the cap 2 so that the bottle mouth 10 is resealed.
  • FIGS. 19 and 20 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.
  • the resealing means 3 is configured such that when the cap 2 after opening is pressed to cover the bottle mouth 10,
  • the bottle shoulder portion 15 is formed by a tapered outer peripheral surface 15a formed continuously with the base of the bottle mouth portion 10 so as to be in close contact with the inner peripheral surface of the skirt portion 2.
  • the inner peripheral surface of the skirt of the cap 2 becomes the tape of the bottle shoulder 15.
  • the bottle mouth 10 is resealed because it is tightly pressed against the tape-shaped outer peripheral surface 15a.
  • FIGS. 21 and 22 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.
  • the resealing means 3 includes a flange 19 formed on the outer periphery of the upper portion of the bottle mouth 10 and a skirt of the cap 2. And an inward flange 29 formed on the peripheral surface.
  • the inward flange 29 is formed so as to be slightly upwardly inclined in the cross section, and the fusion portion 40 between the cap 2 and the bottle mouth 10 is formed by the tip of the inward flange 29 and the flange 1. 9 is formed at the interface with the lower surface.
  • the cap 2 when the cap 2 is slightly pushed in the direction of the bottle mouth 10 and twisted slightly, the fused portion 40 is broken, and when the cap 2 is pulled away from the bottle mouth 10, Since the inward flange 29 passes over the flange 19, the bottle-shaped main body 1 is opened.
  • the inward flange 29 crosses over the flange 19 and is tightly locked to the lower portion of the flange 19, so that the bottle is closed.
  • the mouth 10 is resealed.
  • FIG. 23 and below show an embodiment in which the resealing means is provided in a portion other than the main body of the cap 2 and the bottle mouth 10.
  • a cap-shaped reed having a ring-shaped convex portion 50 on the inner peripheral surface is formed on a part of a hollow plate-shaped holding piece 14 integrally formed on the bottom of the bottle-shaped main body 1. It is formed through five sealing means and a thin-walled fusion part 51.
  • the cap-like resealing means 5 is formed on the both sides of the holding piece 14 so as to be located on both sides of the resealing means 5 as described above.
  • Groove-shaped concave portions 52, 52 are formed in a state to be continuous with the fused portion 51, and the concave portions 52, 52 on both surfaces of the holding piece 14 are separated from each other by a partition wall 52a. . Since the fused portion 51 is thin, when a part of the holding piece 14 and the other part on which the resealing means 5 are formed are separated with a certain force, the fused portion 5 is formed. 1 and the partition wall 5 2a are broken, and the resealing means 5 is separated from the holding piece 14 by force.
  • the resealing means 5 is cut off from the holding piece 14 in advance, and after being opened, the resealing means 5 is pressed so as to cover the bottle mouth 10, whereby the resealing means 5
  • the ring-shaped convex portion 50 comes into close contact with the outer peripheral surface of the bottle mouth portion 10 in a compressed state, and the bottle-shaped main body 1 is resealed.
  • the ring-shaped convex portion 50 comes into close contact with the outer peripheral surface of the bottle mouth portion 10 while being pressed against it. Therefore, the cap-closed resealing means 5 is pulled out from the bottle mouth portion 10. I can't come off.
  • a ring-shaped convex portion 50 is formed on the outer periphery of the cap-shaped resealing means 5 as described above in order to make the structure rich in elasticity.
  • the entire inner peripheral surface of the cap-shaped resealing means 5 can be configured to be in close contact with the outer peripheral surface of the bottle opening 10.
  • FIGS. 27 to 29 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.
  • a stopper-shaped resealing means 5a is formed integrally with a part of the holding piece 14 integrally formed on the bottle-shaped main body 1 through a thin-walled fusion part 51.
  • the resealing means 5 a is configured such that, when the resealing means 5 a is opened and then pushed into the bottle mouth 10, its outer peripheral surface is in close contact with the inner circumferential surface of the bottle mouth 10.
  • the holding piece 14 is in the form of a hollow plate, in order to form a plug-shaped resealing means 5a, the above-mentioned fused portions 51 are continuously formed on both surfaces around the base except for the base of the resealing means 5. Forming and gluing.
  • the fusion part 51 is thin, when a part of the holding piece 14 is separated from the other part on which the resealing means 5a is formed, the fusion part 51 is broken, and The part where the sealing means 5 a is formed can be easily separated from the holding piece 14.
  • the resealing means 5a when opening the bottle-shaped main body 1, the resealing means 5a is separated from a part of the holding piece 14 in advance, and after opening, the resealing means 5a is connected to the bottle mouth as shown in FIG. When it is pushed into 10, the outer peripheral surface of the resealing means 5a comes into close contact with the inner peripheral surface of the bottle mouth 10 in a compressed state, and the bottle-shaped main body 1 is resealed.
  • the resealing means 5a Since the resealing means 5a is in close contact with the inner peripheral surface of the bottle mouth 10 in a state of being pressed, the bottle mouth 10 force must be pulled out from the bottle mouth 10 with some force. No, it won't be.
  • the entire outer peripheral surface of the portion of the resealing means 5a inserted into the bottle mouth portion 10 is configured to be in close contact with the inner circumferential surface of the bottle mouth portion 10;
  • the present invention can also be implemented by forming a part of the outer peripheral surface of 5a so as to be in close contact with the inner peripheral surface of the bottle mouth part 10.
  • FIGS. 30 and 31 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.
  • the upper knob 20 of the cap 2 has a cap-shaped resealing having a ring-shaped protrusion 50 on its inner peripheral surface which can be in close contact with the outer peripheral surface of the bottle mouth 10.
  • Means 5 are formed in the body.
  • the liquid-filled container of this embodiment is different from the container of the first embodiment in that the cap-shaped resealing means 5 is formed not on the holding piece 14 but on the knob 20 of the cap 2. Only the differences.
  • the resealing means 5 can be formed on the knob portion 20 via a thin fusion bonding portion (not shown).
  • FIGS. 32 to 33 show an embodiment corresponding to the liquid agent-filled container according to the embodiment (4) of the present invention.
  • the upper knob 20 of the cap 2 has a plug-like shape whose outer peripheral surface is in close contact with the inner peripheral surface of the bottle opening 10 when pushed into the opened bottle opening 10.
  • the reclosing means 5a is formed in the body.
  • the liquid-filled container of this embodiment is different from the container of the first embodiment in that the plug-shaped resealing means 5a is formed not on the holding piece 14 but on the knob portion 20 of the cap 2. Only the differences.
  • the resealing means 5a can be formed on the knob portion 20 via a thin-walled fused portion.
  • FIGS. 34 and 35 show an embodiment corresponding to the liquid-filled container of the present invention. Have been.
  • a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and the inner peripheral portion of the skirt portion of the cap 2 is fused to the lower surface of the flange 19a.
  • a hole 5 3 having a size capable of pushing the upper end of the bottle mouth 10 is formed on one surface of the hollow plate-shaped knob 20 formed at the upper part of the cap 2.
  • An inward flange 54 is formed on the inner peripheral edge.
  • the knob portion 20 constitutes a cap-shaped resealing means 5b as a whole, and the inner upper surface 55 (FIG. 35) of the hole 53 is smooth, and the inside of the hole 53 A concave portion 56 similar to a groove is formed around the periphery.
  • the resealing means 5 b is pressed against the bottle mouth 10. Then, the bottle mouth 10 is pushed into the hole 53.
  • the flange 19a is locked to the inward flange 54 so as not to come off, and the opening edge 10a of the bottle mouth 10 is Since it adheres to 5 5, the bottle-shaped body 1 is resealed.
  • FIGS. 36 and 37 show an embodiment corresponding to the liquid agent-filled container of the embodiment (4) of the present invention.
  • a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and the inner peripheral portion of the skirt portion of the cap 2 is fused to the lower surface of the flange 19a.
  • a groove portion 57 having a size capable of inserting the upper end portion of the bottle mouth portion 10 is formed on one surface of the hollow plate-shaped knob portion 20 formed at the upper portion of the cap 2.
  • An inward flange 54 is formed on the periphery.
  • the knob 20 as a whole constitutes a cap-shaped resealing means 5 c, the inner upper surface 58 (FIG. 37) of the groove 57 is smooth, and the inner periphery of the groove 57 is Has a recess similar to a dovetail A part 56 is formed.
  • the bottle mouth 10 When the bottle mouth 10 is slid with respect to the groove 57 to remove the cap-shaped resealing means 5c from the bottle mouth 10, the bottle mouth 10 is resealed.
  • FIG. 38 shows an embodiment corresponding to the liquid agent-filled container of the embodiment (4) of the present invention.
  • a flange 19a is formed on the outer periphery of the upper end of the bottle mouth 10 and is integrally formed on the bottom of the bottle-shaped main body 1.
  • a cap-like resealing means 5 b substantially similar to the container of the fifteenth embodiment is formed on a part of the holding piece 14 via a thin-walled fusion part 51.
  • the fusion part 40 when the fusion part 40 is broken and the bottle mouth part 10 is opened, the fusion part 51 is broken in advance and the resealing means 5 b is held by the holding piece 1. 4, and after opening, the bottle opening 10 can be reclosed in the same manner as in the container of the fifteenth embodiment.
  • FIG. 39 shows an embodiment corresponding to the liquid agent-filled container according to the embodiment of the present invention.
  • a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth 10 and is integrally formed on the bottom of the bottle-shaped main body 1.
  • a part of the holding piece 14 is formed via a thin fusion-bonded portion 51 with a cap-like resealing means 5 c ⁇ similar to the container of the 16th embodiment.
  • the fusion port 40 is broken and the bottle opening 10 is opened. Therefore, the fusion part 51 is broken in advance, the resealing means 5b is separated from the holding piece 14, and after opening, the bottle mouth part 10 is resealed in the same manner as the container of the 16th embodiment. Can be closed.
  • a small and middle stopper 28 is formed on the inner upper surface of the cap 2 in substantially the same manner as the containers of the sixth to ninth embodiments. be able to.
  • the liquid-filled container according to the present invention is provided with resealing means in one or both of the main body portion of the cap 2 and the bottle mouth portion 10, or the holding piece 14 or the grip portion 20 of the cap 2. Therefore, even if the cap 2 is once broken open from the bottle mouth 10, the cap 2 can be re-cabled to the bottle mouth 10 in a sealed state. Therefore, especially in a unit dose type container, it is very convenient to fill the liquid agent for several uses and carry it repeatedly as needed, and it is also economical to use the unit dose type container economically. Usage efficiency can be improved.
  • the antimicrobial zeolite is dispersed and held on the entire surface or a required portion of the liquid-filled container of the embodiment (2), the entire surface or the required portion of the container is always sterilized and extremely sanitary, and Even if a preservative is not added to the liquid filled in the container, contamination and secondary contamination of the liquid can be prevented, and the safety of the container is high.

Landscapes

  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)

Abstract

La présente invention concerne un récipient pour préparations liquides, qui comprend un corps (1) en résine synthétique ayant la forme d'une bouteille et une embouchure (10), celle-ci étant scellée par un bouchon (2) en résine synthétique appliqué dessus par fusion, de manière à être ouvert par rupture, et un moyen (3) de rescellement de l'embouchure (10) est formé soit sur le corps du bouchon (2) et l'embouchure (10), soit sur la partie supérieure d'une pièce de maintien (14) ou du bouchon (2), soit les deux. La totalité du récipient, ou les parties nécessaires, contiennent de la zéolithe antimicrobienne qui y est dispersée. Etant donné que le corps (1) du récipient peut être rebouché et rendu de nouveau étanche même quand le bouchon (2) a été ouvert par rupture, le récipient convient pour un emploi répété tel qu'il est nécessaire quand il est transporté après qu'on y a versé des préparations liquides en quantité telle qu'elle permet de les administrer plusieurs fois. Comme le récipient est toujours à l'état stérilisé, les préparations qui y sont mises sont protégées des contaminations primaires et secondaires même si elles ne contiennent aucun antiseptique, et la sécurité du récipient lui-même est élevée.
PCT/JP1996/001702 1995-06-26 1996-06-20 Recipient pour preparations liquides WO1997001493A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU61375/96A AU6137596A (en) 1995-06-26 1996-06-20 Container for liquid preparations

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP7/159050 1995-06-26
JP15905095 1995-06-26
JP7/312274 1995-11-30
JP31227495 1995-11-30

Publications (1)

Publication Number Publication Date
WO1997001493A1 true WO1997001493A1 (fr) 1997-01-16

Family

ID=26485969

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1996/001702 WO1997001493A1 (fr) 1995-06-26 1996-06-20 Recipient pour preparations liquides

Country Status (2)

Country Link
AU (1) AU6137596A (fr)
WO (1) WO1997001493A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049611A1 (fr) * 1996-06-27 1997-12-31 Lameplast S.R.L. Recipient pouvant etre referme et procede de fabrication
WO2001096186A1 (fr) * 2000-06-15 2001-12-20 Lameplast S.P.A. Receptacle refermable adapte notamment pour des produits fluides
WO2003057583A1 (fr) * 2001-12-28 2003-07-17 Toyo Seikan Kaisha, Ltd. Structure de fermeture d'un recipient, recipient comprenant cette structure de fermeture et procede de fabrication de cette structure de fermeture
FR2852295A1 (fr) * 2003-03-14 2004-09-17 Seaquist General Plastics Dispositif de fermeture de reservoir de produit fluide
JP2005035675A (ja) * 2003-06-27 2005-02-10 Toyo Seikan Kaisha Ltd 容器の開封構造及びその開封構造を備えた容器、その開封構造の製造方法
US7552652B2 (en) 2004-05-07 2009-06-30 Endress + Hauser Flowtec Ag Device for determining and/or monitoring the volume-and/or mass-flow of a medium
CN111991229A (zh) * 2020-09-02 2020-11-27 山东新华医疗器械股份有限公司 一种瓶口无毛边的滴眼剂瓶及成型方法
GR20200100346A (el) * 2020-06-18 2022-01-13 Μαριανα Στεφαν Oanta Καινοτομος συσκευη για ασφαλη και ευκολη ενσταλαξη στους οφθαλμους φαρμακευτικων διαλυματων

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61141230U (fr) * 1985-02-25 1986-09-01
JPH0252751U (fr) * 1988-09-30 1990-04-16
JPH0353454U (fr) * 1989-09-28 1991-05-23
JPH0565856U (ja) * 1992-02-14 1993-08-31 株式会社吉野工業所 チュ−ブ容器

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61141230U (fr) * 1985-02-25 1986-09-01
JPH0252751U (fr) * 1988-09-30 1990-04-16
JPH0353454U (fr) * 1989-09-28 1991-05-23
JPH0565856U (ja) * 1992-02-14 1993-08-31 株式会社吉野工業所 チュ−ブ容器

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049611A1 (fr) * 1996-06-27 1997-12-31 Lameplast S.R.L. Recipient pouvant etre referme et procede de fabrication
US6234333B1 (en) * 1996-06-27 2001-05-22 Lameplast S.R.L. Reclosable container
WO2001096186A1 (fr) * 2000-06-15 2001-12-20 Lameplast S.P.A. Receptacle refermable adapte notamment pour des produits fluides
US6827227B2 (en) 2000-06-15 2004-12-07 Lameplast S.P.A Reclosable container particularly for fluid products
WO2003057583A1 (fr) * 2001-12-28 2003-07-17 Toyo Seikan Kaisha, Ltd. Structure de fermeture d'un recipient, recipient comprenant cette structure de fermeture et procede de fabrication de cette structure de fermeture
WO2004083044A3 (fr) * 2003-03-14 2004-10-28 Seaquist General Plastics Dispositif de fermeture de reservoir de produit fluide
WO2004083044A2 (fr) * 2003-03-14 2004-09-30 Seaquist General Plastics Dispositif de fermeture de reservoir de produit fluide
FR2852295A1 (fr) * 2003-03-14 2004-09-17 Seaquist General Plastics Dispositif de fermeture de reservoir de produit fluide
US7762414B2 (en) 2003-03-14 2010-07-27 Seaquist General Plastics Closure device for a fluid product reservoir
JP2005035675A (ja) * 2003-06-27 2005-02-10 Toyo Seikan Kaisha Ltd 容器の開封構造及びその開封構造を備えた容器、その開封構造の製造方法
JP4548583B2 (ja) * 2003-06-27 2010-09-22 東洋製罐株式会社 容器の開封構造及びその開封構造を備えた容器、その開封構造の製造方法
US7552652B2 (en) 2004-05-07 2009-06-30 Endress + Hauser Flowtec Ag Device for determining and/or monitoring the volume-and/or mass-flow of a medium
GR20200100346A (el) * 2020-06-18 2022-01-13 Μαριανα Στεφαν Oanta Καινοτομος συσκευη για ασφαλη και ευκολη ενσταλαξη στους οφθαλμους φαρμακευτικων διαλυματων
CN111991229A (zh) * 2020-09-02 2020-11-27 山东新华医疗器械股份有限公司 一种瓶口无毛边的滴眼剂瓶及成型方法

Also Published As

Publication number Publication date
AU6137596A (en) 1997-01-30

Similar Documents

Publication Publication Date Title
US3993223A (en) Dispensing container
US3777949A (en) Improved single dose disposable container and accessories
US7188750B2 (en) Blow fill sealed container with twist off top operated by overcap and method of forming the same
US10518930B2 (en) Dispenser and process
CA2398919C (fr) Pipettes jetables prechargees
US4566613A (en) Multiple opening structure receptacle
US3917120A (en) Single use container for liquid pharmaceutical compositions
CN201002786Y (zh) 镀膜瓶塞
US6387073B1 (en) Hermetically sealed container with medicament storing and dispensing insert
JPH09507404A (ja) 眼科用パッケージおよび滴下装置
JPH0580910B2 (fr)
WO1997001493A1 (fr) Recipient pour preparations liquides
US4547900A (en) Flexible container with integral ports and diaphragm
US20190046744A1 (en) Fluid Delivery Apparatus
JP4171529B2 (ja) 点眼剤の充填容器
EP0150751B1 (fr) Emballage pour distribuer une préparation liquide ou en pâte sur une partie du corps humain ou animal
US20110147333A1 (en) Device for packaging two products to be mixed and for dispensing the mixture of these products
EP2753549B1 (fr) Contenants à bouchons séparables par rupture
CN219790848U (zh) 一种次抛型重组胶原蛋白精华液包装瓶
CN208963570U (zh) 一种油性液体敷料避光和防伪内包装装置
Winfield Oral unit dosage forms
CN219049510U (zh) 一种双腔室药液分离试剂瓶
JPH092517A (ja) 液状薬剤の包装用材料
CN101721307B (zh) 塑料安瓿药瓶
WO2024168960A1 (fr) Structure d'emballage isolante et son processus de formation

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA CN KR US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA