WO1996039425A3 - Composes ayant une activite antagoniste de la bradykinine et une activite agoniste mu-opioïde - Google Patents
Composes ayant une activite antagoniste de la bradykinine et une activite agoniste mu-opioïde Download PDFInfo
- Publication number
- WO1996039425A3 WO1996039425A3 PCT/US1996/008923 US9608923W WO9639425A3 WO 1996039425 A3 WO1996039425 A3 WO 1996039425A3 US 9608923 W US9608923 W US 9608923W WO 9639425 A3 WO9639425 A3 WO 9639425A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- activity
- compounds
- bradykinin antagonistic
- opioid
- bradykinin
- Prior art date
Links
- 101800004538 Bradykinin Proteins 0.000 title 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 title 1
- 102100035792 Kininogen-1 Human genes 0.000 title 1
- 230000001270 agonistic effect Effects 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- UYRCOTSOPWOSJK-JXTBTVDRSA-N bradykinin antagonist Chemical compound C1C2=CC=CC=C2CC1[C@@H](NC(=O)C(CO)NC(=O)C(NC(=O)CNC(=O)[C@H]1N(C[C@H](O)C1)C(=O)C1N(CCC1)C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=N)CCCCCCC(=N)N[C@H](CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)N1C(CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)NC(C1CC2=CC=CC=C2C1)C(=O)NC(CO)C(=O)N[C@H](C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O)C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(=N)N)C(O)=O UYRCOTSOPWOSJK-JXTBTVDRSA-N 0.000 abstract 1
- 239000003152 bradykinin antagonist Substances 0.000 abstract 1
- 239000002756 mu opiate receptor agonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96918098A EP0832106A2 (fr) | 1995-06-05 | 1996-06-04 | Composes ayant une activite antagoniste de la bradykinine et une activite agoniste mu-opio de |
AU60444/96A AU6044496A (en) | 1995-06-05 | 1996-06-04 | Compounds having bradykinin antagonistic activity and mu-opi oid agonistic activity |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/465,672 US5843900A (en) | 1991-04-01 | 1995-06-05 | Bradykinin antagonists |
US08/465,672 | 1995-06-05 | ||
US64716096A | 1996-05-21 | 1996-05-21 | |
US08/647,160 | 1996-05-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996039425A2 WO1996039425A2 (fr) | 1996-12-12 |
WO1996039425A3 true WO1996039425A3 (fr) | 1997-01-30 |
Family
ID=27041368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/008923 WO1996039425A2 (fr) | 1995-06-05 | 1996-06-04 | Composes ayant une activite antagoniste de la bradykinine et une activite agoniste mu-opioïde |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0832106A2 (fr) |
AU (1) | AU6044496A (fr) |
TW (1) | TW407159B (fr) |
WO (1) | WO1996039425A2 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6262265B1 (en) * | 1999-06-18 | 2001-07-17 | Microgenics Corporation | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay |
EP1312923B1 (fr) * | 2001-11-16 | 2007-03-28 | Randox Laboratories Ltd. | Méthode et trousse pour détecter, ou quantifier, des métabolites de fentanyl et des métabolites de fentanyl analogues |
US7109310B2 (en) | 2001-11-16 | 2006-09-19 | Randox Laboratories, Ltd. | Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs |
WO2006055321A2 (fr) * | 2004-11-10 | 2006-05-26 | Boehringer Ingelheim Chemicals, Inc. | Procede de fabrication de produits intermediaires de fentanyle |
US7238791B1 (en) * | 2005-12-16 | 2007-07-03 | Roche Diagnostics Operations, Inc. | 6-monoacetylmorphine derivatives useful in immunoassay |
US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
MX2012000980A (es) * | 2009-07-21 | 2012-06-12 | Nektar Therapeutics | Conjugados de agonistas de oligómeros-opioides. |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0370453A2 (fr) * | 1988-11-24 | 1990-05-30 | Hoechst Aktiengesellschaft | Peptides avec action inhibitrice de la bradykinine |
WO1992017201A1 (fr) * | 1991-04-01 | 1992-10-15 | Cortech, Inc. | Antagonistes de la bradykinine |
WO1992018156A1 (fr) * | 1991-04-19 | 1992-10-29 | Nova Technology Limited Partnership | Peptides antagonistes de bradykinine |
WO1994011021A1 (fr) * | 1992-11-10 | 1994-05-26 | Cortech, Inc. | Antagoniste de bradykinine |
WO1995024422A1 (fr) * | 1994-03-09 | 1995-09-14 | Cortech, Inc. | Peptides antagonistes de la bradykinine contenant des glycines substituees en n |
WO1996016081A1 (fr) * | 1994-11-18 | 1996-05-30 | University Technology Corporation | Peptides antagonistes de la bradykinine contenant des acides amines a substituants indane |
-
1996
- 1996-06-04 AU AU60444/96A patent/AU6044496A/en not_active Abandoned
- 1996-06-04 WO PCT/US1996/008923 patent/WO1996039425A2/fr not_active Application Discontinuation
- 1996-06-04 EP EP96918098A patent/EP0832106A2/fr not_active Withdrawn
- 1996-06-05 TW TW85106740A patent/TW407159B/zh not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0370453A2 (fr) * | 1988-11-24 | 1990-05-30 | Hoechst Aktiengesellschaft | Peptides avec action inhibitrice de la bradykinine |
WO1992017201A1 (fr) * | 1991-04-01 | 1992-10-15 | Cortech, Inc. | Antagonistes de la bradykinine |
WO1992018156A1 (fr) * | 1991-04-19 | 1992-10-29 | Nova Technology Limited Partnership | Peptides antagonistes de bradykinine |
WO1994011021A1 (fr) * | 1992-11-10 | 1994-05-26 | Cortech, Inc. | Antagoniste de bradykinine |
WO1995024422A1 (fr) * | 1994-03-09 | 1995-09-14 | Cortech, Inc. | Peptides antagonistes de la bradykinine contenant des glycines substituees en n |
WO1996016081A1 (fr) * | 1994-11-18 | 1996-05-30 | University Technology Corporation | Peptides antagonistes de la bradykinine contenant des acides amines a substituants indane |
Also Published As
Publication number | Publication date |
---|---|
TW407159B (en) | 2000-10-01 |
EP0832106A2 (fr) | 1998-04-01 |
AU6044496A (en) | 1996-12-24 |
WO1996039425A2 (fr) | 1996-12-12 |
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