WO1996037623B1 - Vecteurs retroviraux - Google Patents

Vecteurs retroviraux

Info

Publication number
WO1996037623B1
WO1996037623B1 PCT/GB1996/001230 GB9601230W WO9637623B1 WO 1996037623 B1 WO1996037623 B1 WO 1996037623B1 GB 9601230 W GB9601230 W GB 9601230W WO 9637623 B1 WO9637623 B1 WO 9637623B1
Authority
WO
WIPO (PCT)
Prior art keywords
retroviral vector
promoter
gene
retrovirus
genes
Prior art date
Application number
PCT/GB1996/001230
Other languages
English (en)
Other versions
WO1996037623A1 (fr
Filing date
Publication date
Priority claimed from GBGB9510272.9A external-priority patent/GB9510272D0/en
Application filed filed Critical
Priority to DE69619514T priority Critical patent/DE69619514T2/de
Priority to EP96914342A priority patent/EP0827545B1/fr
Priority to AT96914342T priority patent/ATE213780T1/de
Priority to US08/952,948 priority patent/US6096538A/en
Priority to DK96914342T priority patent/DK0827545T3/da
Priority to JP53549496A priority patent/JP3886531B2/ja
Publication of WO1996037623A1 publication Critical patent/WO1996037623A1/fr
Publication of WO1996037623B1 publication Critical patent/WO1996037623B1/fr

Links

Abstract

L'invention porte sur des vecteurs rétroviraux qui sont utiles en thérapie génique. Un génome d'ARN encapsulable du vecteur constitue dans le provirus d'ADN un promoteur régulé qui est inductible par un facteur de régulation comme par exemple le transactivateur protéique Tat du VIH et par au moins un gène choisi dont la transcription est contrôlée par ce facteur. Dans le provirus d'ADN, le promoteur régulé est présent dans la répétition longue 5'-terminale à la place du promoteur de la répétition longue 5'-terminale du rétrovirus, et le gène choisi se trouve entre les répétitions longues terminales. Ainsi, lors de l'insertion dans la cellule hôte, le gène est exprimé uniquement quand le provirus d'ADN est exposé au facteur de régulation.
PCT/GB1996/001230 1995-05-22 1996-05-22 Vecteurs retroviraux WO1996037623A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE69619514T DE69619514T2 (de) 1995-05-22 1996-05-22 Retrovirale vektoren
EP96914342A EP0827545B1 (fr) 1995-05-22 1996-05-22 Vecteurs retroviraux
AT96914342T ATE213780T1 (de) 1995-05-22 1996-05-22 Retrovirale vektoren
US08/952,948 US6096538A (en) 1995-05-22 1996-05-22 Retroviral vectors
DK96914342T DK0827545T3 (da) 1995-05-22 1996-05-22 Retrovirale vektorer
JP53549496A JP3886531B2 (ja) 1995-05-22 1996-05-22 レトロウイルスベクター

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9510272.9A GB9510272D0 (en) 1995-05-22 1995-05-22 Retroviral vectors
GB9510272.9 1995-05-22

Publications (2)

Publication Number Publication Date
WO1996037623A1 WO1996037623A1 (fr) 1996-11-28
WO1996037623B1 true WO1996037623B1 (fr) 1997-01-30

Family

ID=10774804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/001230 WO1996037623A1 (fr) 1995-05-22 1996-05-22 Vecteurs retroviraux

Country Status (10)

Country Link
US (1) US6096538A (fr)
EP (2) EP0827545B1 (fr)
JP (1) JP3886531B2 (fr)
AT (2) ATE340864T1 (fr)
DE (2) DE69636581T2 (fr)
DK (1) DK0827545T3 (fr)
ES (1) ES2170856T3 (fr)
GB (1) GB9510272D0 (fr)
PT (1) PT827545E (fr)
WO (1) WO1996037623A1 (fr)

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AU5103996A (en) 1995-03-09 1996-10-02 Bavarian Nordic Research Institute A/S Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy
US5766945A (en) * 1996-02-13 1998-06-16 Fred Hutchinson Cancer Research Center 10A1 Retroviral packaging cells and uses thereof
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GB9621680D0 (en) * 1996-10-17 1996-12-11 Oxford Biomedica Ltd Lentiviral vectors
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ATE298371T1 (de) 1997-09-24 2005-07-15 Univ California Nicht-primaten lentivirale vektoren und verpackungssysteme
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US6790657B1 (en) 1999-01-07 2004-09-14 The United States Of America As Represented By The Department Of Health And Human Services Lentivirus vector system
EP1422298B1 (fr) * 1999-07-09 2010-01-27 Gen-Probe Incorporated Détection de l'HIV-1 par amplification des acides nucléiques
ATE391785T1 (de) 1999-11-16 2008-04-15 Geneart Ag Das genom des hiv-1 intersubtyps (c/b') und seine anwendungen
US7575924B2 (en) 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
WO2002087341A1 (fr) * 2001-05-01 2002-11-07 Genetix Pharmaceuticals, Inc. Nouveaux vecteurs lentiviraux a auto-inactivation (sin)
ATE527347T1 (de) 2001-08-02 2011-10-15 Inst Clayton De La Rech Verfahren und zusammensetzungen im zusammenhang mit verbesserten lentivirusvektor- produktionssystemen
US7195916B2 (en) * 2001-09-13 2007-03-27 California Institute Of Technology Method for expression of small antiviral RNA molecules within a cell
JP4344858B2 (ja) * 2001-09-13 2009-10-14 カリフォルニア インスティチュート オブ テクノロジー 細胞内で抗ウイルス性小ｒｎａ分子を発現させる方法
US7737124B2 (en) * 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
IL161229A0 (en) * 2001-10-02 2004-09-27 Inst Clayton De La Rech Methods and compositions relating to restricted expression lentiviral vectors and their applications.
US9738907B2 (en) 2002-02-01 2017-08-22 Oxford Biomedica (Uk) Limited Viral vector
PT1504108E (pt) 2002-02-01 2013-06-12 Oxford Biomedica Ltd Vetor lentiviral
US7135324B2 (en) 2002-09-04 2006-11-14 The University Of Connecticut Viral recombinases, related articles, and methods of use thereof
WO2004048583A2 (fr) * 2002-11-22 2004-06-10 Institut Clayton De La Recherche Compositions et systemes destines a la regulation genique
US7297536B2 (en) * 2003-01-23 2007-11-20 Wisconsin Alumni Research Foundation Inducible protein expression system
ES2221578B1 (es) * 2003-06-13 2006-03-01 Universidad De Jaen Vector diseñado para la destruccion de los virus latentes en el tratamiento de la infeccion por el virus de la inmunodeficiencia humana tipo 1 (vih-1) mediante terapia genica.
GB201318804D0 (en) 2013-10-24 2013-12-11 Adaptimmune Ltd Vectors for transgene expression
GB201322798D0 (en) 2013-12-20 2014-02-05 Oxford Biomedica Ltd Production system
WO2017180587A2 (fr) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Systèmes de biocircuits régulés
US20210347842A1 (en) 2018-06-19 2021-11-11 Eli Lilly And Company Compositions and methods of use of il-10 agents in conjunction with chimeric antigen receptor cell therapy
KR20220097492A (ko) 2019-11-12 2022-07-07 옥스포드 바이오메디카(유케이) 리미티드 생산 시스템

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