WO1996022117A3 - On-line drug delivery system in extracorporeal therapy - Google Patents

On-line drug delivery system in extracorporeal therapy Download PDF

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Publication number
WO1996022117A3
WO1996022117A3 PCT/US1996/000458 US9600458W WO9622117A3 WO 1996022117 A3 WO1996022117 A3 WO 1996022117A3 US 9600458 W US9600458 W US 9600458W WO 9622117 A3 WO9622117 A3 WO 9622117A3
Authority
WO
WIPO (PCT)
Prior art keywords
extracorporeal therapy
drug delivery
delivery system
reaction chamber
line drug
Prior art date
Application number
PCT/US1996/000458
Other languages
French (fr)
Other versions
WO1996022117A2 (en
Inventor
Dennis A Briggs
Kyu H Lee
Joseph Garro Jr
Original Assignee
Johnson & Johnson Corp
Dennis A Briggs
Kyu H Lee
Joseph Garro Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson Corp, Dennis A Briggs, Kyu H Lee, Joseph Garro Jr filed Critical Johnson & Johnson Corp
Priority to EP96902672A priority Critical patent/EP0814854A1/en
Priority to SK968-97A priority patent/SK96897A3/en
Priority to CA002210477A priority patent/CA2210477C/en
Priority to AU46989/96A priority patent/AU4698996A/en
Publication of WO1996022117A2 publication Critical patent/WO1996022117A2/en
Publication of WO1996022117A3 publication Critical patent/WO1996022117A3/en
Priority to MXPA/A/1997/005405A priority patent/MXPA97005405A/en
Priority to NO973292A priority patent/NO973292L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1692—Detection of blood traces in dialysate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/302—Details having a reservoir for withdrawn untreated blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/303—Details having a reservoir for treated blood to be returned
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/304—Treatment chamber used as reservoir, e.g. centrifuge bowl or filter with movable membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/305—Control of inversion point between collection and re-infusion phase
    • A61M1/308—Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3626—Gas bubble detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4523—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through sieves, screens or meshes which obstruct the whole diameter of the tube
    • B01F25/45231—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through sieves, screens or meshes which obstruct the whole diameter of the tube the sieves, screens or meshes being cylinders or cones which obstruct the whole diameter of the tube, the flow changing from axial in radial and again in axial
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M3/00—Investigating fluid-tightness of structures
    • G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
    • G01M3/04—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point
    • G01M3/16—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means
    • G01M3/18—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators
    • G01M3/186—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators for containers, e.g. radiators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/70—Gravity drainage systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A61M2205/3386—Low level detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • External Artificial Organs (AREA)

Abstract

A preferred patient blood treatment system and method for the photoactivation of reagents in contact with a patient's blood achieves a well-mixed and accurate drug concentration in extracorporeal therapy. The preferred drug delivery system of the present invention comprises specially designed components and a microprocessor control system including a syringe pump, drug mixer and a reaction chamber, whereby the microprocessor control system monitors patient blood flow and regulates the system components to deliver the desired drug concentration to the reaction chamber maximizing the effectiveness of extracorporeal therapy.
PCT/US1996/000458 1995-01-17 1996-01-16 On-line drug delivery system in extracorporeal therapy WO1996022117A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP96902672A EP0814854A1 (en) 1995-01-17 1996-01-16 On-line drug delivery system in extracorporeal therapy
SK968-97A SK96897A3 (en) 1995-01-17 1996-01-16 On-line drug delivery system in extracorporeal therapy
CA002210477A CA2210477C (en) 1995-01-17 1996-01-16 On-line drug delivery system in extracorporeal therapy
AU46989/96A AU4698996A (en) 1995-01-17 1996-01-16 On-line drug delivery system in extracorporeal therapy
MXPA/A/1997/005405A MXPA97005405A (en) 1995-01-17 1997-07-15 Assay system in the line of farmaco in therapy out of the cue
NO973292A NO973292L (en) 1995-01-17 1997-07-16 On-line drug delivery system in extracorporeal therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37370395A 1995-01-17 1995-01-17
US08/373,703 1995-01-17

Publications (2)

Publication Number Publication Date
WO1996022117A2 WO1996022117A2 (en) 1996-07-25
WO1996022117A3 true WO1996022117A3 (en) 1996-11-07

Family

ID=23473514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/000458 WO1996022117A2 (en) 1995-01-17 1996-01-16 On-line drug delivery system in extracorporeal therapy

Country Status (12)

Country Link
EP (1) EP0814854A1 (en)
AR (1) AR000901A1 (en)
AU (1) AU4698996A (en)
CA (1) CA2210477C (en)
CO (1) CO4700313A1 (en)
CZ (3) CZ9900756A3 (en)
HU (1) HUP9800776A2 (en)
IL (1) IL116765A0 (en)
NO (1) NO973292L (en)
SK (1) SK96897A3 (en)
TW (1) TW338722B (en)
WO (1) WO1996022117A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20072397A1 (en) 2007-12-20 2009-06-21 Gambro Lundia Ab MEDICAL EQUIPMENT FOR EXTRA-REPAIR TREATMENT
DE202009000053U1 (en) 2009-01-23 2009-09-03 Jing Xiang Kai Industry Co., Ltd. Foot ring spanner
US9399093B2 (en) 2012-01-27 2016-07-26 Fenwal, Inc. Systems and methods for performing online extracorporeal photopheresis
US9814824B2 (en) 2015-06-01 2017-11-14 Asia Pacific Medical Technology Development Company, Ltd Systems and methods for extracorporeal support
US10434240B2 (en) 2015-08-17 2019-10-08 Fenwal, Inc. Methods and systems for processing and washing a photopheresis mononuclear cell product
US10213542B2 (en) 2015-11-04 2019-02-26 Asia Pacific Medical Technology Development Company, Ltd Systems and methods for flow stagnation control
EP3370798B1 (en) * 2015-11-04 2020-09-23 Asia Pacific Medical Technology Development Company, Ltd Systems and methods for flow stagnation control
US10265460B2 (en) 2015-11-04 2019-04-23 Asia Pacific Medical Technology Development Company, Ltd. Systems and methods for providing zones of selective thermal therapy
US12048793B2 (en) * 2018-06-11 2024-07-30 Epicentrx, Inc. Medication infusion devices, systems, and methods
CN115243741A (en) * 2019-12-11 2022-10-25 埃皮辛特瑞柯斯公司 Drug infusion device, system and method
IT202000003407A1 (en) * 2020-02-19 2021-08-19 Pelham Crescent S R L MACHINE FOR THE EXTRA-BODY PHOTOPHERESIS OF A BIOLOGICAL FLUID
US20220347368A1 (en) * 2021-04-13 2022-11-03 Fenwal, Inc. Systems and methods for performing extracorporeal photopheresis

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1168263A (en) * 1966-03-04 1969-10-22 James C Ii Hobbs Apparatus for Injecting Radio Opaque Liquid into a Vascular System
GB2100143A (en) * 1981-06-12 1982-12-22 Edelson Richard Leslie Treatment of blood to reduce lymphocyte population
EP0246158A1 (en) * 1986-05-14 1987-11-19 Buffet, Jacques External device for medical injection
US5015226A (en) * 1988-11-03 1991-05-14 Fresenius Ag Apparatus for infusion of medicaments
US5254096A (en) * 1992-09-23 1993-10-19 Becton, Dickinson And Company Syringe pump with graphical display or error conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3861652A (en) * 1972-11-15 1975-01-21 Du Pont Mixing device
US5104526A (en) * 1987-01-30 1992-04-14 Baxter International Inc. Centrifugation system having an interface detection system
US5191795A (en) * 1987-05-01 1993-03-09 Abbott Laboratories Ultrasonic detector
US4789853A (en) * 1987-06-15 1988-12-06 Gentiluomo Joseph A Detection device for electrically conductive fluids
US4764166A (en) * 1987-08-17 1988-08-16 Fisher Scientific Company Ultrasonic air-in-line detector
US5205153A (en) * 1992-01-23 1993-04-27 Cobe Laboratories, Inc. Method and apparatus for detection of air bubbles in tubing

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1168263A (en) * 1966-03-04 1969-10-22 James C Ii Hobbs Apparatus for Injecting Radio Opaque Liquid into a Vascular System
GB2100143A (en) * 1981-06-12 1982-12-22 Edelson Richard Leslie Treatment of blood to reduce lymphocyte population
EP0246158A1 (en) * 1986-05-14 1987-11-19 Buffet, Jacques External device for medical injection
US5015226A (en) * 1988-11-03 1991-05-14 Fresenius Ag Apparatus for infusion of medicaments
US5254096A (en) * 1992-09-23 1993-10-19 Becton, Dickinson And Company Syringe pump with graphical display or error conditions

Also Published As

Publication number Publication date
TW338722B (en) 1998-08-21
WO1996022117A2 (en) 1996-07-25
IL116765A0 (en) 1996-05-14
MX9705405A (en) 1997-10-31
CZ9900758A3 (en) 2002-11-13
NO973292D0 (en) 1997-07-16
SK96897A3 (en) 1998-07-08
NO973292L (en) 1997-08-29
EP0814854A1 (en) 1998-01-07
AU4698996A (en) 1996-08-07
CA2210477C (en) 2005-03-29
CZ9900756A3 (en) 2002-11-13
AR000901A1 (en) 1997-08-06
CO4700313A1 (en) 1998-12-29
CZ9900757A3 (en) 2002-11-13
HUP9800776A2 (en) 1998-07-28
CA2210477A1 (en) 1996-07-25

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