WO1996017953A3 - Genetic basis of factor xiii activity - Google Patents

Genetic basis of factor xiii activity Download PDF

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Publication number
WO1996017953A3
WO1996017953A3 PCT/GB1995/002857 GB9502857W WO9617953A3 WO 1996017953 A3 WO1996017953 A3 WO 1996017953A3 GB 9502857 W GB9502857 W GB 9502857W WO 9617953 A3 WO9617953 A3 WO 9617953A3
Authority
WO
WIPO (PCT)
Prior art keywords
factor xiii
xiii activity
genetic basis
activity
changes
Prior art date
Application number
PCT/GB1995/002857
Other languages
French (fr)
Other versions
WO1996017953A2 (en
Inventor
Alexander Fred Markham
Original Assignee
Univ Leeds
Alexander Fred Markham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leeds, Alexander Fred Markham filed Critical Univ Leeds
Priority to JP8517415A priority Critical patent/JPH10510421A/en
Priority to EP95938560A priority patent/EP0796342A2/en
Publication of WO1996017953A2 publication Critical patent/WO1996017953A2/en
Publication of WO1996017953A3 publication Critical patent/WO1996017953A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a method for dianosing Factor XIII activity and in particular a genetic base method which identifies changes in the Factor XIII gene and correlates these changes with changes known to segretate with either an increase or decrease in Factor XIII activity.
PCT/GB1995/002857 1994-12-08 1995-12-07 Genetic basis of factor xiii activity WO1996017953A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP8517415A JPH10510421A (en) 1994-12-08 1995-12-07 Genetic basis of factor XIII activity
EP95938560A EP0796342A2 (en) 1994-12-08 1995-12-07 Genetic basis of factor xiii activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9424823.4 1994-12-08
GBGB9424823.4A GB9424823D0 (en) 1994-12-08 1994-12-08 Genetic basis of factor XIII activity

Publications (2)

Publication Number Publication Date
WO1996017953A2 WO1996017953A2 (en) 1996-06-13
WO1996017953A3 true WO1996017953A3 (en) 1996-10-24

Family

ID=10765640

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/002857 WO1996017953A2 (en) 1994-12-08 1995-12-07 Genetic basis of factor xiii activity

Country Status (4)

Country Link
EP (1) EP0796342A2 (en)
JP (1) JPH10510421A (en)
GB (1) GB9424823D0 (en)
WO (1) WO1996017953A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9625934D0 (en) * 1996-12-13 1997-01-29 Univ Leeds Atherothrombotic disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0250288A1 (en) * 1986-06-12 1987-12-23 Pasteur Merieux Serums Et Vaccins Process for preparing factor XIII from placenta
EP0411909A1 (en) * 1989-07-31 1991-02-06 Merck & Co. Inc. Imidazole compounds and their use as transglutaminase inhibitors
EP0494702A2 (en) * 1986-03-12 1992-07-15 BEHRINGWERKE Aktiengesellschaft Production of factor XIIIa by gene technology

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0494702A2 (en) * 1986-03-12 1992-07-15 BEHRINGWERKE Aktiengesellschaft Production of factor XIIIa by gene technology
EP0250288A1 (en) * 1986-06-12 1987-12-23 Pasteur Merieux Serums Et Vaccins Process for preparing factor XIII from placenta
EP0411909A1 (en) * 1989-07-31 1991-02-06 Merck & Co. Inc. Imidazole compounds and their use as transglutaminase inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
G.R. STANDEN ET AL,: "Factor XIII ABristol 1: detection of a nonsense mutation (Arg171-stop codon) in factor XIII A subunit deficiency", BRITISH JOURNAL OF HAEMATOLOGY, vol. 85, 1993 *
KOICHI SUZUKI ET AL: "Molecular basis for subtypic differences of the"a"subunit of coagulation factor XIII with descruption of the genesis of the subtypes", HUM GENETICS, vol. 94, 1994 *
M. BUTTERWEGGE, ET AL: "Faktor-XIII-Mangel: Gerinnungsdefekt in der Schwangerschaft", ZENT.BL.GYN#KOL, vol. 114, 1992 *
PHILIP BOARD ET AL.: "Identification of a Point Mutation in Factor XIII A Subunit Deficiency", BLOOD, vol. 80, no. 4, August 1992 (1992-08-01) *

Also Published As

Publication number Publication date
WO1996017953A2 (en) 1996-06-13
JPH10510421A (en) 1998-10-13
GB9424823D0 (en) 1995-02-08
EP0796342A2 (en) 1997-09-24

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