WO1996016684A1 - Pompe centrifuge integree a faible volume d'amorçage et oxygenateur a membrane - Google Patents
Pompe centrifuge integree a faible volume d'amorçage et oxygenateur a membrane Download PDFInfo
- Publication number
- WO1996016684A1 WO1996016684A1 PCT/US1994/013763 US9413763W WO9616684A1 WO 1996016684 A1 WO1996016684 A1 WO 1996016684A1 US 9413763 W US9413763 W US 9413763W WO 9616684 A1 WO9616684 A1 WO 9616684A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fibers
- ring
- mass transfer
- fluid
- transfer bed
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 46
- 230000037452 priming Effects 0.000 title claims abstract description 16
- 239000000835 fiber Substances 0.000 claims abstract description 126
- 238000012546 transfer Methods 0.000 claims abstract description 77
- 239000012530 fluid Substances 0.000 claims description 71
- 239000008280 blood Substances 0.000 claims description 26
- 210000004369 blood Anatomy 0.000 claims description 26
- 230000001706 oxygenating effect Effects 0.000 claims description 23
- 238000005086 pumping Methods 0.000 claims description 11
- 239000012510 hollow fiber Substances 0.000 claims description 10
- 239000000853 adhesive Substances 0.000 claims description 9
- 230000001070 adhesive effect Effects 0.000 claims description 9
- 239000004593 Epoxy Substances 0.000 claims description 6
- 229920002635 polyurethane Polymers 0.000 claims description 6
- 239000004814 polyurethane Substances 0.000 claims description 6
- 239000004831 Hot glue Substances 0.000 claims description 5
- 238000005192 partition Methods 0.000 claims description 4
- 238000004382 potting Methods 0.000 claims description 4
- 238000001356 surgical procedure Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims 6
- 239000007767 bonding agent Substances 0.000 claims 3
- 239000011324 bead Substances 0.000 claims 1
- 239000007789 gas Substances 0.000 description 41
- 239000010410 layer Substances 0.000 description 17
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 12
- 238000006213 oxygenation reaction Methods 0.000 description 12
- 239000000463 material Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 229910002092 carbon dioxide Inorganic materials 0.000 description 6
- 239000001569 carbon dioxide Substances 0.000 description 6
- 230000002612 cardiopulmonary effect Effects 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011982 device technology Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000009325 pulmonary function Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000003673 urethanes Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
- A61M1/1625—Dialyser of the outside perfusion type, i.e. blood flow outside hollow membrane fibres or tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
- A61M1/262—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
- A61M1/267—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving used for pumping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3623—Means for actively controlling temperature of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
- A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
- A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
- A61M60/232—Centrifugal pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
- A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
- A61M60/38—Blood oxygenation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
- A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
- A61M60/416—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted directly by the motor rotor drive shaft
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/021—Manufacturing thereof
- B01D63/0232—Manufacturing thereof using hollow fibers mats as precursor, e.g. wound or pleated mats
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/025—Bobbin units
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/034—Lumen open in more than two directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/24—Specific pressurizing or depressurizing means
Definitions
- U.S. Patent No. 3,841,837 discloses a blood oxygenator or dialyzer that achieves enhanced transfer through rotation of a cylindrically mounted membrane placed eccentrically inside a stator housing. Blood flows in the annular space between the rotor and the stator. Rotation causes a pumping action, thus causing pumping and oxygenation to occur simultaneously. All of these prior art devices have required relatively large amounts of fluid to prime the pump and oxygenator. There have also been difficulties with the safety and ease of use by the perfusionist. Furthermore, these devices can be quite costly to manufacture.
- the low priming volume integrated centrifugal pump and membrane oxygenator of the present invention comprises housing 10 containing impeller 30 surrounded by mass transfer bed 40.
- the top and bottom of the mass transfer bed 40 are sealed to the upper and lower internal faces of housing 10.
- Fluid entering housing 10 through fluid inlet 12 is pumped by impeller 30 through mass transfer bed 40.
- mass transfer bed 40 the fluid is oxygenated and the carbon dioxide is removed.
- the fluid is then collected and discharged through a tapered exit manifold 14 located around the outer diameter of mass transfer bed 40.
- impeller 30 has flow channels 32 that act to force the fluid through the mass transfer bed 40.
- flow channels 32 deliver uniform radial flow to the mass transfer bed 40 in the course of its 360 degree rotation. This uniform radial flow enhances oxygenation by insuring that the mass transfer bed 40 is uniformly perfused with blood to be oxygenated.
- the rotation of the impeller 30 insures true and uniform radial flow over the entire circumference and height of the mass transfer bed 40.
- a local flow pulse is created followed by a quiescent period until the next flow channel 32 arrives. This pulse enhances mass transfer, in particular, oxygenation and carbon dioxide removal.
- the flow channel volume of flow channels 32 is relatively small compared with the envelope of the impeller 30. This is in direct contrast to conventional radial impellers for centrifugal pumps. Conventional centrifugal pumps generally operate in a region of higher flow rates for a given required delivery pressure. Typical impellers have thin vanes with wide flow channels between the vanes to keep the flow channel volume as close to the maximum volume available as possible to create high flow rates. However, in extracorporeal cardiopulmonary support, relatively low flow and high pressure is required. Thus the impeller diameter and RPM requirements are dictated more by delivery pressure than flow demands.
- the small flow channel volume of the present invention results in high fluid delivery pressures at adequate flow rates, and thus allows the priming volume to be reduced. Another effect of the small flow channel volume is reduced turbulence in the pumping portion of the integrated pump and oxygenator.
- the volume of flow channels 32 should be of a size to permit relatively laminar flow of the fluid in the impeller 8
- the flow channel volume is from about 5% to about 60% of the total envelope volume. More preferably the flow channel volume is less than 50% of the total envelope volume. Most preferably the flow channel volume is from about 5% to about 30% of the total envelope volume.
- the flow channel volume can be altered by any means such as adjusting the size, shape and number of the flow channels.
- Impeller 30 should be of a size sufficient to force the fluid through the mass transfer bed 40 and to return it to the patient without the need for an external pump. Preferably, the impeller 30 has a diameter of from about 2 inches to about 6 inches.
- the pump, including impeller and housing can be made from any inert material that will not react with the blood or the oxygen.
- the pump, impeller and housing may be molded from plastic materials such as polycarbonate and the like.
- the mass transfer bed 40 has a gas inlet header 60 and gas inlet manifold 62 to allow the passage of a second fluid, the oxygen gas, into the lumens 46 of the fibers 38.
- the second fluid exits the lumens 46 by means of gas outlet manifold 64 and gas outlet header 66, while maintaining separation of the second fluid from the first fluid.
- Manifold partition 68 separates the gas inlet header 60 and gas inlet manifold 62 from gas outlet header 66 and gas outlet manifold 64.
- the headers 60 and 66 are aligned at an angle to the fibers 38 of the mass transfer bed 40.
- the mass transfer bed 40 is of a sufficient size to permit it to be sealed to the upper and lower internal faces of housing 10.
- the mass transfer bed 40 has a radial thickness ranging from about 1/10 inch to about 1.5 inches.
- the mass transfer bed 40 may be bonded 11
- An engineering model of the integrated pump and membrane oxygenator of the present invention was constructed to test the fluid dynamics.
- the inside of the housing was 6 inches in diameter and 1 1/2 inches high.
- the impeller had 4 grooved flow channels and was powered by means of a drillpress motor.
- the engineering model had a ring 17
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Manufacturing & Machinery (AREA)
- External Artificial Organs (AREA)
Abstract
Pompe centrifuge intégrée à faible volume d'amorçage et oxygénateur à membrane comprenant un boîtier (10) qui contient un lit (40) à transfert de matière constitué de fibres creuses (38) de membrane perméables au gaz placées circonférentiellement en anneau autor d'une roue hélice (30). Le lit (40) à transfert de matière est formé d'un enroulement d'un ruban (42) de fibres comprenant au moins deux couches de fibres (38) collées ensemble suivant une orientation précise telle que les fibres des couches alternées soient positionnées en ligne, les ouvertures entre les fibres étant situées dans les couches supérieure et inférieure. Des dispositifs de fixation assurent l'orientation précise des fibres (38). Le volume d'amorçage est encore réduit par un volume de canal d'écoulement déterminé par une petite roue hélice.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1994/013763 WO1996016684A1 (fr) | 1994-11-28 | 1994-11-28 | Pompe centrifuge integree a faible volume d'amorçage et oxygenateur a membrane |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1994/013763 WO1996016684A1 (fr) | 1994-11-28 | 1994-11-28 | Pompe centrifuge integree a faible volume d'amorçage et oxygenateur a membrane |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996016684A1 true WO1996016684A1 (fr) | 1996-06-06 |
Family
ID=22243339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/013763 WO1996016684A1 (fr) | 1994-11-28 | 1994-11-28 | Pompe centrifuge integree a faible volume d'amorçage et oxygenateur a membrane |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1996016684A1 (fr) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003018088A1 (fr) * | 2001-08-23 | 2003-03-06 | Michigan Critical Care Consultants, Inc. | Appareil assurant un echange de gaz dans un liquide |
WO2006118817A1 (fr) | 2005-04-21 | 2006-11-09 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Poumon-para-corporel d'assistance respiratoire |
US8585968B2 (en) | 2006-04-21 | 2013-11-19 | Scott W. Morley | Method and system for purging moisture from an oxygenator |
US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US11185677B2 (en) | 2017-06-07 | 2021-11-30 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
US11964145B2 (en) | 2019-07-12 | 2024-04-23 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
US12102815B2 (en) | 2019-09-25 | 2024-10-01 | Shifamed Holdings, Llc | Catheter blood pumps and collapsible pump housings |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4031012A (en) * | 1975-09-17 | 1977-06-21 | Gics Pharmaceuticals, Inc. | Separatory apparatus |
EP0187708A2 (fr) * | 1985-01-08 | 1986-07-16 | Medtronic, Inc. | Appareil de transfert de masse à membrane microporeuse sous forme de fibre creuse enroulée en spirale |
US4906581A (en) * | 1988-10-20 | 1990-03-06 | Minntech Corporation | Method of quality control for hollow fiber gas transfer cells |
US5043140A (en) * | 1989-05-26 | 1991-08-27 | A. Jorrdan Medical, Inc. | Blood oxygenator |
WO1993005828A2 (fr) * | 1991-09-25 | 1993-04-01 | Baxter International Inc. | Pompe centrifuge integree et oxygenateur a membrane |
WO1994002187A1 (fr) * | 1992-07-21 | 1994-02-03 | Baxter International Inc. | Pompe a sang du type centrifuge |
-
1994
- 1994-11-28 WO PCT/US1994/013763 patent/WO1996016684A1/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4031012A (en) * | 1975-09-17 | 1977-06-21 | Gics Pharmaceuticals, Inc. | Separatory apparatus |
EP0187708A2 (fr) * | 1985-01-08 | 1986-07-16 | Medtronic, Inc. | Appareil de transfert de masse à membrane microporeuse sous forme de fibre creuse enroulée en spirale |
US4906581A (en) * | 1988-10-20 | 1990-03-06 | Minntech Corporation | Method of quality control for hollow fiber gas transfer cells |
US5043140A (en) * | 1989-05-26 | 1991-08-27 | A. Jorrdan Medical, Inc. | Blood oxygenator |
WO1993005828A2 (fr) * | 1991-09-25 | 1993-04-01 | Baxter International Inc. | Pompe centrifuge integree et oxygenateur a membrane |
WO1994002187A1 (fr) * | 1992-07-21 | 1994-02-03 | Baxter International Inc. | Pompe a sang du type centrifuge |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003018088A1 (fr) * | 2001-08-23 | 2003-03-06 | Michigan Critical Care Consultants, Inc. | Appareil assurant un echange de gaz dans un liquide |
WO2006118817A1 (fr) | 2005-04-21 | 2006-11-09 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Poumon-para-corporel d'assistance respiratoire |
EP2295133A1 (fr) * | 2005-04-21 | 2011-03-16 | University of Pittsburgh of the Commonwealth System of Higher Education | Poumon d'assistance respiratoire extracorporel |
US7927544B2 (en) | 2005-04-21 | 2011-04-19 | Alung Technologies, Inc. | Paracorporeal respiratory assist lung |
AU2006242663B2 (en) * | 2005-04-21 | 2012-01-19 | Alung Technologies, Inc. | Paracorporeal respiratory assist lung |
US8585968B2 (en) | 2006-04-21 | 2013-11-19 | Scott W. Morley | Method and system for purging moisture from an oxygenator |
US11717670B2 (en) | 2017-06-07 | 2023-08-08 | Shifamed Holdings, LLP | Intravascular fluid movement devices, systems, and methods of use |
US11185677B2 (en) | 2017-06-07 | 2021-11-30 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11229784B2 (en) | 2018-02-01 | 2022-01-25 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US12076545B2 (en) | 2018-02-01 | 2024-09-03 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US11964145B2 (en) | 2019-07-12 | 2024-04-23 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
US12102815B2 (en) | 2019-09-25 | 2024-10-01 | Shifamed Holdings, Llc | Catheter blood pumps and collapsible pump housings |
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