WO1996012438A1 - Blood vessel graft quality evaluation - Google Patents
Blood vessel graft quality evaluation Download PDFInfo
- Publication number
- WO1996012438A1 WO1996012438A1 PCT/EP1995/004095 EP9504095W WO9612438A1 WO 1996012438 A1 WO1996012438 A1 WO 1996012438A1 EP 9504095 W EP9504095 W EP 9504095W WO 9612438 A1 WO9612438 A1 WO 9612438A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- graft
- pressure
- syringe
- blood vessel
- blood
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
Definitions
- the invention relates to the evaluation of Coronary Artery Bypass Graft (CABG) surgery and other medical procedures, which involve blood vessel surgery.
- CABG Coronary Artery Bypass Graft
- the invention enables to evaluate grafts and anastomotic site occlusions, leakage and proper location.
- CABG coronary artery bypass grafts
- the invention relates to the determination of flow rates through blood vessels involved in surgery Means and methods for effecting such measurements are provided which are exceedingly simple, yet highly efficient and which provide real time data for the surgeon performing surgery
- Coronary bypass surgery of the type referred to in the present invention generally involves the attachment (anastomosis) of a graft blood vessel to an existing blood vessel of the patient, which is of the order of diameter of a few millimeters, carrying out the control and evaluation according to the invention, and after ascertaining that such attachment is in order, attaching the second end of the graft to the aorta
- the device of the invention and the method of evaluation is also applicable to other types of blood vessel surgery, such as that of blood vessels of the feet etc.
- the device comprises a liquid container provided at one end with means for applying a predetermined pressure, and at another end with exit means, means for applying controlled pressure (continuous or in pulsed form) to a liquid (saline, blood) in said container, where the pressure is applied to the free end (proximal end) of the blood vessel used as graft, after the anastomosis to the coronary artery is made to the other end (distal end) of the graft, means being provided for the accurate measurement of the parameters involved such as pressure curve, pressure inside the vessel, liquid volume, time and flow rate calculation.
- a syringe or syringe-like container is used, to the piston of which there is applied the desired pressure, which can be essentially constant or which can be pulsed, with a pulse rate and form similar to that provided by the human heart.
- a closed servo loop which monitors and adjusts the pressure applied to the liquid in said container (syringe).
- the flow rate measurement through the blood vessel intended to be used for the graft is made before connecting the proximal end of the graft to the aorta; it is not required to reactivate the heart to produce pressure and establish the flow through the vessel.
- the surgeon is able to determine in real time the graft patency whether the attachment to the artery does not leak or get blocked, and if this is not entirely satisfactory, to repair it or replace it by another graft This determination is made right after the anastomosis to the coronary artery
- a device of the invention which comprises a syringe 11 , having a piston area of about 10 cm2 which is held in holding means 12, which grasp the flange 13 of syringe 11
- the syringe piston 14 is attached to a movable pushing plate 15
- a linear motor 16 that moves the pushing plate 15, which is used for pushing piston 14 into the body of the syringe 1 1
- a 3- way stopcock 18 to which there are attached tubes 20 and 21 , tube 20 being connected with pressure transducer 19, the other tube, 21 being attached to the blood vessel to be used as graft 22
- a 60 ml syringe was connected as part of a device shown in Fig 1 and filled with saline solution
- a pulsative pressure of 100 mm Hg (mean value) was applied for 10 seconds
- saline as test liquid, and after measuring the flow rate through a blood vessel intended as graft, the surgeon can decide in real time whether the graft can serve as by-pass
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95935946A EP0786957A1 (en) | 1994-10-23 | 1995-10-18 | Blood vessel graft quality evaluation |
AU38059/95A AU3805995A (en) | 1994-10-23 | 1995-10-18 | Blood vessel graft quality evaluation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11136694A IL111366A0 (en) | 1994-10-23 | 1994-10-23 | Blood vessel graft quality evaluation |
IL111366 | 1994-10-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996012438A1 true WO1996012438A1 (en) | 1996-05-02 |
Family
ID=11066678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1995/004095 WO1996012438A1 (en) | 1994-10-23 | 1995-10-18 | Blood vessel graft quality evaluation |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0786957A1 (en) |
AU (1) | AU3805995A (en) |
CA (1) | CA2205229A1 (en) |
IL (1) | IL111366A0 (en) |
WO (1) | WO1996012438A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007024193A3 (en) * | 2005-08-25 | 2007-04-19 | Millicore Ab | Vascular resistance gauge |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4392847A (en) * | 1979-01-08 | 1983-07-12 | Whitney Douglass G | Injection and monitoring system |
US4551133A (en) * | 1984-04-16 | 1985-11-05 | American Hospital Supply Corporation | Patient controlled medication infusion system |
EP0439018A1 (en) * | 1990-01-08 | 1991-07-31 | Ernest Feiler, M.D. | Diagnostic method for checking the blood flow |
-
1994
- 1994-10-23 IL IL11136694A patent/IL111366A0/en unknown
-
1995
- 1995-10-18 WO PCT/EP1995/004095 patent/WO1996012438A1/en not_active Application Discontinuation
- 1995-10-18 EP EP95935946A patent/EP0786957A1/en not_active Withdrawn
- 1995-10-18 AU AU38059/95A patent/AU3805995A/en not_active Abandoned
- 1995-10-18 CA CA002205229A patent/CA2205229A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4392847A (en) * | 1979-01-08 | 1983-07-12 | Whitney Douglass G | Injection and monitoring system |
US4551133A (en) * | 1984-04-16 | 1985-11-05 | American Hospital Supply Corporation | Patient controlled medication infusion system |
EP0439018A1 (en) * | 1990-01-08 | 1991-07-31 | Ernest Feiler, M.D. | Diagnostic method for checking the blood flow |
Non-Patent Citations (1)
Title |
---|
S.E. LOGAN: "On the Fluid Mechanics of Human Coronary Artery Stenosis", IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, vol. BME-22, no. 4, NEW YORK US, pages 327 - 334 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007024193A3 (en) * | 2005-08-25 | 2007-04-19 | Millicore Ab | Vascular resistance gauge |
US8075490B2 (en) | 2005-08-25 | 2011-12-13 | Assut Europe S.P.A. | Vascular resistance gauge |
Also Published As
Publication number | Publication date |
---|---|
EP0786957A1 (en) | 1997-08-06 |
AU3805995A (en) | 1996-05-15 |
IL111366A0 (en) | 1994-12-29 |
CA2205229A1 (en) | 1996-05-02 |
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