WO1996007451A2 - Phototherapeutic apparatus - Google Patents
Phototherapeutic apparatus Download PDFInfo
- Publication number
- WO1996007451A2 WO1996007451A2 PCT/US1995/011246 US9511246W WO9607451A2 WO 1996007451 A2 WO1996007451 A2 WO 1996007451A2 US 9511246 W US9511246 W US 9511246W WO 9607451 A2 WO9607451 A2 WO 9607451A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- radiation
- housing
- fiber
- tip
- light
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2255—Optical elements at the distal end of probe tips
- A61B2018/2261—Optical elements at the distal end of probe tips with scattering, diffusion or dispersion of light
Definitions
- phototherapeutic instruments can be employed to treat electrical arrhythmia of the heart.
- a catheter having a fiber optic component is fed via a major artery into a patient's heart. Once inside the heart, a catheter senses electrical impulses with electrical contacts on its outer sheath or other catheter elements in order to locate the source of arrhythmia . Once located, the phototherapeutic component is activated to "ablate" a portion of the inner heart wall. By coagulating the tissue in the vicinity of the a ⁇ hythmia source, the likelihood that the patent's heart will continue to experience arrhythmia is thus reduced.
- the outer sheath surrounds the entire optical transmission apparatus and ensures that the radiation-generating components do not come into direct contact with the patient's body structures. This permits reuse of the instrument. Only the sheath surrounding the apparatus needs to be disposed after each use. Phototherapeutic instruments are also disclosed having integral stopper devices which limit the penetration of an optical fiber tip.
- a fluted outer sheath is disposed about an internal optical fiber. The fluted sheath is configured to fold into an expanded form during penetration into a patient's tissue. As the sheath is forced back and expands, the optically-transmissive assembly presents a much larger cross-sectional area which prevents penetration of the instrument beyond a pre-determined desirable distance.
- FIG. 17 is a schematic view of the use of present invention as part of an endoscopic system
- Light propagating through optical fiber core 14 is transmitted into the scatterer medium 22 A and scattered in a cylindrical pattern along the length of the assembly 10. Each time the light encounters a scatterer particles, it is deflected and, at some point, the net deflection exceeds the critical angle for internal reflection at the interface between the housing 20 and medium 21. When this happens, the light will exit. Similarly, light which passes through this first chamber is transmitted to the second chamber 23 where it encounters the scatterers 22B, causing more of the light to be reflected. Light which does not exit during this initial pass through the tip is reflected by the mirror 28 and returned through the tip assembly. During the second pass, the remaining radiation (or at least a major portion of this returning radiation) again encounters the scatterers 22 A and 22B which provide further circumferential diffusion of the light.
- FIG. 15B is a graph of intensity vs. radial distance for two fibers as shown in FIG. 15A.
- the curve 121 A illustrates the intensity of diffused radiation vs. axial length of one fiber while curve 121B represents a similar intensity distribution for a second fiber which has been deployed in an opposite configuration.
- the cumulative intensity distribution of these two fibers are shown by curve 123.
- Fig 20 is a more detailed cross-sectional view of the distal end of the apparatus of Fig. 19.
- the optically-transmissive element is shown having an optical fiber 220 with an optically transmissive core 222 surrounded by a cladding, and buffer coating.
- the end face of fiber core 222 is inserted into a housing 228 which contains a scattering medium 224 with optional individual scatterer particles 225.
- the medium 224 has a greater refractive index than the housing 228.
- the end cap 226 can be disposed at the distal end of the housing 228, and end cap 226 can be disposed.
- the end cap may also be fitted with a reflective mirror 240.
- the end cap 226 can further be ground or polished to a point 230 to facilitate penetration of body tissue.
- a diffusive tip assembly 314 is shown in more detail proving the optical fiber 312 having a light transmissive core 320 and a buffer coating or cladding 321.
- the end face of fiber core 320 is inserted into a housing 328 which contains a scattering medium 324 with optional individual scattering particles 325.
- the medium 324 again has a greater refractive index than the housing 328.
- an end plug 326 is disposed with a mirror reflector 340.
Landscapes
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Radiation-Therapy Devices (AREA)
- Laser Surgery Devices (AREA)
- Polarising Elements (AREA)
- Surgical Instruments (AREA)
- Harvester Elements (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU36269/95A AU725320B2 (en) | 1994-09-09 | 1995-09-08 | Phototherapeutic apparatus |
JP50963496A JP3675482B2 (en) | 1994-09-09 | 1995-09-08 | Phototherapy equipment |
EP95933733A EP0781154A2 (en) | 1994-09-09 | 1995-09-08 | Phototherapeutic apparatus |
CA002199384A CA2199384C (en) | 1994-09-09 | 1995-09-08 | Phototherapeutic apparatus |
KR1019970701608A KR970706039A (en) | 1994-09-09 | 1995-09-08 | PHOTOTHERAPEUTIC APPARATUS |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30360594A | 1994-09-09 | 1994-09-09 | |
US08/471,744 US5637877A (en) | 1995-06-06 | 1995-06-06 | Ultraviolet sterilization of instrument lumens |
US08/467,414 US5632767A (en) | 1994-09-09 | 1995-06-06 | Loop diffusers for diffusion of optical radiation |
US08/468,568 US5643253A (en) | 1995-06-06 | 1995-06-06 | Phototherapy apparatus with integral stopper device |
US08/468,568 | 1995-06-06 | ||
US08/303,605 | 1995-06-06 | ||
US08/467,414 | 1995-06-06 | ||
US08/471,744 | 1995-06-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996007451A2 true WO1996007451A2 (en) | 1996-03-14 |
WO1996007451A3 WO1996007451A3 (en) | 1996-05-23 |
Family
ID=27501834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/011246 WO1996007451A2 (en) | 1994-09-09 | 1995-09-08 | Phototherapeutic apparatus |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0781154A2 (en) |
JP (1) | JP3675482B2 (en) |
KR (1) | KR970706039A (en) |
CN (1) | CN1072971C (en) |
AU (1) | AU725320B2 (en) |
CA (1) | CA2199384C (en) |
WO (1) | WO1996007451A2 (en) |
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5754717A (en) * | 1995-10-31 | 1998-05-19 | Indigo Medical, Incorporated | Light-diffusing device for an optical fiber, methods of producing and using same, and apparatus for diffusing light from an optical fiber |
WO1998022184A1 (en) * | 1996-11-21 | 1998-05-28 | Boston Scientific Corporation | Mucosal ablation using light |
US5773835A (en) * | 1996-06-07 | 1998-06-30 | Rare Earth Medical, Inc. | Fiber optic spectroscopy |
FR2767704A1 (en) * | 1997-09-04 | 1999-02-26 | Medlight Sa | LIGHT DIFFUSER DEVICE FOR PHOTODYNAMIC TREATMENT OF ORGANS |
US5947959A (en) * | 1994-09-09 | 1999-09-07 | Rare Earth Medical, Inc. | Phototherapeutic apparatus with diffusive tip assembly |
US6071302A (en) * | 1997-12-31 | 2000-06-06 | Cardiofocus, Inc. | Phototherapeutic apparatus for wide-angle diffusion |
US6096030A (en) * | 1997-09-23 | 2000-08-01 | Pharmacyclics, Inc. | Light delivery catheter and PDT treatment method |
US6102905A (en) * | 1994-09-09 | 2000-08-15 | Cardiofocus, Inc. | Phototherapy device including housing for an optical element and method of making |
WO2001008576A2 (en) | 1999-07-30 | 2001-02-08 | Cardiofocus, Inc. | Laser method and apparatus for treatment of tissue |
US6200307B1 (en) | 1997-05-22 | 2001-03-13 | Illumenex Corporation | Treatment of in-stent restenosis using cytotoxic radiation |
US6270492B1 (en) | 1994-09-09 | 2001-08-07 | Cardiofocus, Inc. | Phototherapeutic apparatus with diffusive tip assembly |
DE10008557A1 (en) * | 2000-02-24 | 2001-10-25 | Huettinger Medtech Gmbh | Device for thermal obliteration of biological tissue using intense laser radiation, where the device is split into a handpiece and a puncture shaft, the latter being easily removable to facilitate cleaning |
WO2001087416A1 (en) * | 2000-05-17 | 2001-11-22 | Kent Crossley | Method and apparatus to prevent infections |
WO2002005722A1 (en) * | 2000-07-14 | 2002-01-24 | Cardiofocus, Inc. | Cardiac photoablation instruments |
EP1210146A1 (en) * | 1999-06-23 | 2002-06-05 | Robert A. Ganz | Apparatus and method for debilitating or killing microorganisms within the body |
WO2003013653A1 (en) | 2001-08-10 | 2003-02-20 | Kemeny Lajos | Phototherapeutical apparatus |
US6579285B2 (en) | 1994-09-09 | 2003-06-17 | Cardiofocus, Inc. | Photoablation with infrared radiation |
WO2003065880A2 (en) | 2002-02-05 | 2003-08-14 | Pharmacyclics, Inc. | Conical light diffuser and method of making |
US6676656B2 (en) | 1994-09-09 | 2004-01-13 | Cardiofocus, Inc. | Surgical ablation with radiant energy |
WO2004012805A2 (en) * | 2002-08-05 | 2004-02-12 | Miravant Medical Technologies | Light delivery catheter |
WO2004012589A2 (en) * | 2002-08-05 | 2004-02-12 | Miravant Medical Technologies, Inc. | Catheter for diagnosis and treatment of diseased vessels |
WO2007118745A1 (en) * | 2006-04-11 | 2007-10-25 | Vimecon Gmbh | Laser applicator |
WO2010062769A1 (en) * | 2008-11-03 | 2010-06-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Device for irradiating an internal body surface |
US8140148B2 (en) | 1998-01-20 | 2012-03-20 | Boston Scientific Scimed Ltd. | Readable probe array for in vivo use |
US8961580B2 (en) | 2006-11-30 | 2015-02-24 | Keio University | Abnormal electrical conduction blocking apparatus using photodynamic therapy (PDT) |
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US9861437B2 (en) | 1999-07-14 | 2018-01-09 | Cardiofocus, Inc. | Guided cardiac ablation catheters |
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Also Published As
Publication number | Publication date |
---|---|
WO1996007451A3 (en) | 1996-05-23 |
CA2199384C (en) | 2006-06-06 |
AU725320B2 (en) | 2000-10-12 |
KR970706039A (en) | 1997-11-03 |
CN1165485A (en) | 1997-11-19 |
CA2199384A1 (en) | 1996-03-14 |
CN1072971C (en) | 2001-10-17 |
JPH10504989A (en) | 1998-05-19 |
EP0781154A2 (en) | 1997-07-02 |
JP3675482B2 (en) | 2005-07-27 |
AU3626995A (en) | 1996-03-27 |
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