CN111110346B - Device for laser interstitial thermotherapy system - Google Patents
Device for laser interstitial thermotherapy system Download PDFInfo
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- CN111110346B CN111110346B CN201911409241.0A CN201911409241A CN111110346B CN 111110346 B CN111110346 B CN 111110346B CN 201911409241 A CN201911409241 A CN 201911409241A CN 111110346 B CN111110346 B CN 111110346B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2205—Characteristics of fibres
- A61B2018/2222—Fibre material or composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2255—Optical elements at the distal end of probe tips
- A61B2018/2261—Optical elements at the distal end of probe tips with scattering, diffusion or dispersion of light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N2005/0612—Apparatus for use inside the body using probes penetrating tissue; interstitial probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
Abstract
The invention provides a device for a laser interstitial thermotherapy system and a manufacturing method thereof, wherein the device for the laser interstitial thermotherapy system comprises a light steering part, can realize steering and emitting of light, can be used for interstitial thermotherapy treatment, is high-temperature resistant, has stable finished product property and is easy to store; the invention also provides a manufacturing method of the device for the laser interstitial thermotherapy system.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a device for a laser interstitial thermotherapy system.
Background
The research on the laser interstitial thermotherapy system for treating diseases such as tumor and epilepsy has been advanced greatly since the 80 s of the 20 th century. In recent years, efforts are continuously made to achieve the purpose of enabling laser to radially emit, and a colloid containing different scattering particles is proposed to achieve the purpose, but in the actual use process, the colloid is complex to process, higher product consistency cannot be obtained, the colloid cannot bear too high temperature, so that a scattering head cannot be heated to higher temperature, and the colloid has the risk of thermal expansion and denaturation and even explosion, so that a light emitting device which has small or almost negligible volume change in the use temperature range and can bear higher temperature is required, and the safety risk of a device for a laser interstitial thermotherapy system is reduced.
Disclosure of Invention
In view of the above, the present invention provides a device for laser interstitial thermotherapy, which has a simple structural design, a strong structural strength, hardly deforms after being heated in a long-time working state, and has a relatively uniform strength of laser light scattered in an axial direction, and a method of manufacturing the device for laser interstitial thermotherapy.
In a first aspect, the present invention provides a device for laser interstitial thermotherapy, comprising a connector, an optical fiber, a sleeve, and a light-diverting portion, wherein the connector is connected to a proximal end of the optical fiber, a proximal end of the sleeve is connected to a distal end of the optical fiber, the light-diverting portion is connected to the distal end of the sleeve, and the light-diverting portion comprises a conical portion having a diameter gradually increasing from the proximal end to the distal end, such that light propagating along a long axial direction of the optical fiber is diverted to exit radially.
In the present invention, the sealed space surrounded by the optical fiber, the sleeve and the light diverting portion is vacuum, and the connection can be achieved by various connection methods, such as discharge welding. It will be understood by those skilled in the art that vacuum includes those that are relatively close to vacuum due to limitations of the prior art or cost constraints.
The connector may be any connector known in the art suitable for connecting a laser generator or other connector such that laser light may be transmitted through an optical fiber. The optical fiber may be any optical fiber, preferably a glass fiber that can be subjected to discharge fusion, most preferably a silica glass fiber.
The light steering part comprises a cone-like body consisting of a conical body part and a cylindrical body part, the diameter of the conical body part is gradually increased from the near end to the far end, and light rays propagating along the axial direction of the optical fiber are converted into radial outgoing light rays through a diffuse reflection surface formed on the surface of the conical body part and/or scattering particles inside the light steering part. The sleeve is made of a material that can be subjected to electric discharge welding, such as glass or quartz glass, and the proximal end thereof is connected to the distal end of the optical fiber.
The light-deflecting part and the sleeve have a thermal expansion coefficient of not more than 8 × 10 in the range of 0-300 deg.C-5/° c. Melting point higher than 300 deg.C and thermal expansion coefficient not more than 8 × 10-5The material of/° c ensures that the deformation of the light-diverting portion and the sleeve is very little when they are heated during treatment, avoiding the potential risk of expansion and bursting. The closed space is also hardly influenced by temperature due to vacuum or near vacuum, so that the use safety is ensured.
In some embodiments, the material of the light redirecting portion and the sleeve is glass or sapphire, and the glass can be quartz glass containing no more than 20% by mass of sodium oxide or potassium oxide, wherein the mass fraction of sodium oxide or potassium oxide can be any value not more than 20% and greater than 1%, such as 2%, 3%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, etc. The glass may also be fired primarily from boron oxide to provide more toughness.
In one embodiment, in the device for laser interstitial thermotherapy system of the present invention, the surface of the cone portion of the light diverting portion is a diffuse reflection surface, and the light direction is switched by diffuse reflection.
In other embodiments, the device for laser interstitial thermotherapy system of the present invention, the light diverting part is made of a material containing scattering particles, and the direction conversion of the light is realized by the scattering particles. Further, the scattering particles may be metal particles, oxide particles, bubbles, and the particle size and distribution density thereof may be adjusted as needed.
In yet another embodiment, the light turning part can have both the diffuse reflection surface and the scattering particles, thereby enhancing the ability to emit light radially, i.e. part of the light transmission direction can be changed by the surface of the cone part, while the other part of the light transmission direction can be changed by the scattering particles of the cone part and the cylinder part.
In some embodiments of the invention, the sleeve of the device for laser interstitial hyperthermia system comprises a reflective layer capable of limiting the emergence of light rays to a desired range; the desired range may be varied and the light exit area defined by the reflective layer may be sector shaped to correspond in cross-section to a range of 0-270 degrees, e.g., 30 degrees, 60 degrees, etc., centered about the long axis of the fiber.
In the invention, the light beam steering part enables the light beam propagating along the long axial direction of the optical fiber to be converted into radial emergent light, and the light intensity of the radial emergent light at different positions of the long axis of the light beam steering part is relatively close; the light intensity is relatively close, that is, the ratio of the minimum light intensity to the maximum light intensity in the range of at least 80% of the length of the cone portion of the light diverting portion in the long axis direction of the optical fiber is not less than 0.2, such as 0.5, 0.6, 0.7, 0.8, 0.9, 0.95 and 0.98.
In a second aspect, the invention also provides a corresponding method of manufacturing a device for laser interstitial hyperthermia, in one embodiment, the method of manufacturing comprises:
processing the base material to obtain a cone-like body containing a conical body part and a cylindrical body part, wherein the diameter of the cylindrical body part is less than or equal to the inner diameter of the sleeve;
coating or polishing the surface of the cone to obtain a diffuse reflection surface which becomes a light turning part;
stripping off the part of the far end of the optical fiber outside a section of the cladding to expose the cladding, wherein the outer diameter of the cladding is less than or equal to the inner diameter of the sleeve;
under the vacuum condition, the cylinder, the sleeve and the optical fiber are connected together through discharge welding to form a closed space.
In another embodiment, the method of making includes:
using a cylindrical material containing scattering particles, enabling a part of the material to be in a tractable and denatured state at high temperature, obtaining a conical part through traction, and then cutting the conical part from a base material to obtain a cone-like body containing the conical part and the cylindrical part, wherein the diameter of the cylindrical part is less than or equal to the inner diameter of the sleeve;
stripping off the part of the far end of the optical fiber outside a section of the cladding to expose the cladding, wherein the outer diameter of the cladding is less than or equal to the inner diameter of the sleeve;
under the vacuum condition, the cylinder part of the cone-like body, the sleeve and the optical fiber are connected together through discharge welding to form a closed space.
In another embodiment, the method may further comprise the step of obtaining a diffuse reflective surface on the surface of the cone-like body.
In the process of treating the focus by the laser interstitial thermotherapy system, in order to prevent the tissue from carbonizing and prevent the laser from penetrating the tissue, the invention adopts a cooling circulation mode to limit the temperature of the target tissue below the carbonization temperature. Further, the device for laser interstitial thermotherapy system provided by the invention further comprises a sleeve. In some embodiments, the cannula is a double-walled cannula; the material of the sleeve is selected from any one of the following materials: polycarbonate (polycarbonate), polyurethane (polyurethane), polyethylene, polypropylene, silicone, nylon, polyvinyl chloride, polyethylene terephthalate (PET), Polytetrafluoroethylene (PTFE), ABS plastic (Acrylonitrile Butadiene Styrene), polyethylene succinate (PES), polyether ether ketone (PEEK), fluorinated ethylene propylene copolymer (FEP).
According to a preferred embodiment, in the device for laser interstitial thermotherapy system provided by the present invention, the coolant in the cooling jacket may be liquid or gas, preferably using physiological saline as coolant.
The device for laser interstitial hyperthermia system as described hereinbefore is particularly suitable for operations performed on the brain. The optical fiber is particularly suitable for transmitting infrared light and is compatible with magnetic resonance imaging. In certain embodiments, the structure of the optical fiber may have a protective layer, such as a plastic protective layer, in addition to the described core, cladding, coating, etc., also as part of the device for laser interstitial hyperthermia system of the present invention.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts. The structures in the drawings are merely exemplary and not true to scale, which may vary from true to true for ease of understanding. Some non-essential parts of some of the figures are omitted, for example, in some optical fibres there may also be a protective layer, which is not shown in the figures.
Fig. 1 is a schematic view of a device for laser interstitial thermotherapy according to the present invention, an exemplary device 10 for laser interstitial thermotherapy system comprises a connector 11, a silica glass fiber 12, a sleeve 13, a light diverting part 14;
FIG. 2 is a partial schematic view of a device for laser interstitial thermotherapy provided according to an embodiment of the present invention, an exemplary section I showing a fiber core 121, a cladding layer 122, a coating layer 123, a sleeve 13, a light turning section 14, sleeve-to-cladding connections 13-122, an enclosed space 15, and two cross-sections indicated at dashed lines A-A and B-B;
FIG. 3 is a partial schematic view of a device for laser interstitial thermotherapy according to another embodiment of the present invention, an exemplary portion I of the device for laser interstitial thermotherapy showing the fiber core 121, the cladding 122, the coating 123, the sleeve 13, the light redirecting portion 14, the conical portion 141, the enclosed space 15, and cross-sectional views at points A-A, B-B, C-C and D-D, the junctions being shown with bold lines;
FIG. 4 is a partial schematic view of a device for laser interstitial thermotherapy according to yet another embodiment of the present invention, an exemplary portion I of the device for laser interstitial thermotherapy showing the fiber core 121, the cladding 122, the coating 123, the sleeve 13, the light redirecting portion 14, the conical portion 141, the enclosed space 15, and further showing cross-sectional views at four locations A-A, B-B, C-C and D-D, the junctions being shown with bold lines;
FIG. 5 is a partial schematic view of a device for laser interstitial thermotherapy provided according to an embodiment of the present invention, an exemplary portion I of the device for laser interstitial thermotherapy showing the fiber core 121, the cladding 122, the coating 123, the sleeve 13, the light redirecting portion 14, the conical portion 141, the enclosed space 15, and further showing cross-sectional views at four locations A-A, B-B, C-C and D-D, the junctions being shown with bold lines;
fig. 6 is a partial schematic view of a device for laser interstitial thermotherapy provided according to an embodiment of the present invention, a portion I of an exemplary device for laser interstitial thermotherapy, showing a fiber core 121, a cladding 122, a coating 123, a cannula 13, a light redirecting portion 14, a conical portion 141, a closed space 15, and a blunt end 16;
fig. 7 is a partial schematic view of a device for laser interstitial thermotherapy according to another embodiment of the present invention, a portion I of an exemplary device for laser interstitial thermotherapy, showing a fiber core 121, a cladding 122, a coating 123, a sleeve 13, a light redirecting portion 14, a conical portion 141, an enclosed space 15, and a sharp end 16;
fig. 8 is a partial schematic view of a device for laser interstitial thermotherapy provided according to yet another embodiment of the present invention, a portion I of an exemplary device for laser interstitial thermotherapy, showing a fiber core 121, a cladding 122, a coating layer 123, a sleeve 13, a light diverting part 14, a conical part 141, a closed space 15, and a light absorbing part 16;
FIG. 9 shows a schematic view of an example of a sleeve containing a reflective layer, showing sleeve 13, reflective layer 131 on the outer wall of the sleeve, and a cross-section showing the angle at which light rays exit at 90 degrees;
FIG. 10 shows a schematic view of another example of a sleeve containing a reflective layer, showing the sleeve 13, the reflective layer 131 on the inner wall of the sleeve, and a cross-section showing the angle at which the light rays exit at 60 degrees;
fig. 11 is a partial schematic view of a device for laser interstitial thermotherapy provided according to yet another embodiment of the present invention, showing an optical fiber 12, a cannula 13, and a cooling assembly 80, which includes an inlet assembly 82, an outlet assembly 83, a cooling cannula inner tube 84, a cooling cannula outer tube 86, an outlet 87, and an inlet 88.
Figure 12 is a photograph of an exit light from one embodiment of the device for laser interstitial thermotherapy of the present invention.
FIG. 13 is a graph of the results of monitoring the illumination intensity at different angles along the long axis for the embodiment shown in FIG. 12.
Detailed Description
To make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Defining:
the terms used herein have scientific meanings commonly understood by those of ordinary skill in the art, but in order to more clearly describe the present invention, the meanings of some words are defined below, and if conflicting with definitions outside the present text, the definitions herein shall control.
Proximal end: the proximal end refers to the end of the device used in the laser interstitial thermotherapy system, the whole device, the quartz glass optical fiber, the sleeve, the optical fiber steering part and the like, which is relatively close to the laser generator after being connected with the laser generator in the working state.
A far end: the far end is the end of the device used in the laser interstitial thermotherapy system, wherein the whole device, the quartz glass optical fiber, the sleeve, the optical fiber steering part and the like are in the context of being connected with the laser generator in the working state and then are relatively far away from the laser generator.
Silica glass fiber: the core and cladding portions are composed primarily of silica, are suitable for transmitting light (particularly infrared), are suitable for electrical discharge welding, and are compatible with magnetic resonance optical fibers.
Quartz glass: glasses, which are composed primarily of silica, may be doped with scattering particles and are compatible with magnetic resonance imaging.
Example 1:
referring to fig. 1, there is shown a schematic view of a device for laser interstitial thermal treatment system according to one embodiment of the present invention, the device 10 for laser interstitial thermal treatment system comprises a connector 11, an optical fiber 12, a cannula 13, a light diverting part 14. The shape of the connector 11 is merely exemplary and any shape or type of connector that can be used to connect to a laser generator or other connector is contemplated. The length of the optical fiber 12 can be adjusted as required, and the optical fiber can be any suitable optical fiber type as long as the sealed connection with the sleeve 13 can be realized, and preferably, the optical fiber is a quartz glass optical fiber, and the connection can be realized by discharge welding. The sleeve 13 is made of a suitable light-transmitting material and is sealingly connected to the optical fibre and the light redirecting portion 14, preferably by means of electrical discharge welding. The light turning portion 14 is composed of a cone portion and a cylinder portion, the cone portion is mainly used for changing the light propagation direction, so that light can be emitted in the radial direction perpendicular to the long axis of the optical fiber, and the cylinder mainly plays a role in connection, but also can have a role in changing the light propagation direction. The optical fiber 12, the ferrule 13 and the light redirecting portion 14 form an enclosed space 15.
Fig. 2 is a sectional view of a specific example of the portion I in the axial direction, in which the outer surface of the conical portion of the light-ray turning portion 14 is a diffuse reflection surface so that the transmission direction of the light ray is changed. The optical fiber includes a core 121, a cladding 122, and a protective layer 123. The sleeve 13 is connected to the cladding 122, the interfaces 13-122 of the connection are shown by the bold lines, the light redirecting portion 14 is connected to the sleeve 13, and the interfaces of the connection are shown by the bold lines. While two cross-sections a-A, B-B are shown, it will be understood by those skilled in the art that, for ease of illustration, they are not shown to scale.
The device may further comprise a cooling jacket, referring to fig. 11, showing a cooling assembly 80 of the device for laser interstitial thermotherapy system of the invention according to one embodiment, showing the optical fiber 12, the jacket 13 (containing a light turning part, not shown), an inlet assembly 82, an outlet assembly 83, a cooling jacket inner tube 84, a cooling jacket outer tube 86, an outlet 87, an inlet 88. When the laser interstitial thermotherapy system is used for a long time, the temperature of the light steering part and the sleeve is too high due to laser irradiation, so that the carbonization of surrounding tissues and other adverse conditions can be caused, and the temperature of the light steering part and the sleeve is reduced by using a cooling agent through the cooling sleeve, so that the laser interstitial thermotherapy system can perform large-volume ablation. The coolant may be a gas or a liquid, preferably physiological saline. The arrows in the figure show one direction of flow of the coolant. It will be understood by those skilled in the art that the inlet and outlet may be used interchangeably, i.e., inlet 88 is the outlet, while outlet 87 is the inlet.
Any suitable material may be used for the material of the sleeve, for example, polycarbonate, polyurethane, polyethylene, polypropylene, silicone, nylon, polyvinyl chloride, polyethylene terephthalate, polytetrafluoroethylene, ABS plastic, polyethylene succinate, polyetheretherketone, fluorinated ethylene propylene copolymer.
Example 2:
fig. 3 is a cross-sectional view of another specific example of the portion I in the axial direction, in which the light-redirecting portion 14 contains scattering particles, which may be metal particles, oxide particles, bubbles, or the like. The optical fiber includes a core 121, a cladding 122, and a protective layer 123. The sleeve 13 is connected to the cladding 122, the interface of the connection is shown by the bold lines, the light diverting portion 14 is connected to the sleeve 13, and the interface of the connection is shown by the bold lines. While the four sections A-A, B-B, C-C and D-D are shown, it will be understood by those skilled in the art that, for ease of illustration, they are not shown to scale. The angle of the conical portion of the light redirecting portion 14 is a, which can be selected as desired, preferably in the range of 15 ° to 150 °, for example 30 °, 45 °, 60 °, so that the conical portion can have different lengths.
The volume size and distribution density of the scattering particles can be adjusted as desired. When the scattering particles are bubbles, due to the refractive index n of the quartz glass1Refractive index n greater than air2When the incident angle on the interface is large sin-1(n2/n1) When the optical fiber emits all emission, less than sin-1(n2/n1) At this time, the light continues to propagate forward, forming an axially extending radial light exit scatter. The gas in the bubbles may be selected from a variety of gases, such as air, nitrogen, helium, etc., depending on the process environment in which the material is being fabricated.
The light-deflecting part and the sleeve have a thermal expansion coefficient of not more than 8 × 10 in the range of 0-300 deg.C-5/° c. The thermal expansion coefficient is not more than 8 x 10 in the range of 0 to 300 DEG C-5The material of/° c ensures that the deformation of the light-diverting portion and the sleeve is very little when they are heated during treatment, avoiding the potential risk of expansion and bursting.
The material for making the light-deflecting part and the sleeve is glass or sapphire, and the glass can be quartz glass containing no more than 20% of sodium oxide or potassium oxide, wherein the mass fraction of the sodium oxide or potassium oxide can be any value of no more than 20% and more than 1%, such as 2%, 3%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, etc. The glass may also be fired primarily from boron oxide for better toughness.
Example 3:
referring to FIG. 4, FIG. 4 is a cross-sectional view of a portion I of another embodiment in the axial direction, showing a core 121, a cladding 122, and a protective layer 123 of an optical fiber. The sleeve 13 is connected with the cladding 122, the connected interface is displayed by a thickened line, the light steering part 14 is connected with the sleeve 13, and the connected interface is displayed by a thickened line; the difference from fig. 3 is that the angle b of the conical portion of the light diverting portion 14 is different from the angle a in embodiment 2, and the surface of the conical portion is a diffuse reflection surface, and the change of the light outgoing direction can be realized by the interaction of the diffuse reflection surface of the conical portion and the scattering particles included in the light diverting portion.
Example 4:
referring to fig. 5, fig. 5 is a sectional view of a portion I of a further embodiment in the axial direction, and the structure and reference numerals are substantially the same as those described in embodiment 3, except that the apex of the conical portion 141 of the light redirecting portion 14 is in direct contact with the fiber core 121, so that the distance between the light redirecting portion 14 and the fiber core 121 is minimized, thereby minimizing the length of the jacket 13.
In all the above embodiments, the distal end of the portion I may also have additional structures 16 as needed, such as a blunt end 16 as shown in fig. 6 for protection, such as a sharp end 16 as shown in fig. 7 for puncture, or a light absorbing portion 16 as shown in fig. 8, to avoid the ablation laser from irradiating unintended portions and causing accidental injury.
Example 5:
referring to fig. 9, there is shown a schematic diagram of an example of a ferrule having a reflective layer, the rest of which is substantially the same as the previous embodiment and will not be repeated for the sake of simplicity, only showing a side view of the ferrule 13, with the slashed portion representing the reflective layer 131 of the ferrule. The cross-sectional view shows the range occupied by the outgoing light, the thick solid lines indicate the reflective layer 131, which is located on the outer wall of the sleeve 13, and the hatched portions represent the main body of the sleeve 13.
Example 6:
verification of the direction and intensity of light emission was performed using an example of the present invention, fig. 12 shows the result of the end portion of the device for laser interstitial thermotherapy system converting the direction of the optical fiber transmitted by the optical fiber (side view), the transverse direction is the long axis direction of the optical fiber, the light turning portion turns the light propagating along the long axis direction of the optical fiber to be emitted radially, and the light intensity of the radial emission is relatively close at different positions of the long axis of the light turning portion; the light intensity is relatively close, which means that the ratio of the minimum light intensity to the maximum light intensity in the range of at least 80% of the length of the long axis of the conical portion of the light diverting portion in the long axis direction of the optical fiber is not less than 0.2, and further preferably 0.5, 0.6, 0.7, 0.9, 0.95, 0.98, etc. Along the long axis of the light steering part, calculation is started by taking the near end of the light steering part as a starting point 0, the length unit is millimeter (mm), the distance length from the far end to 101mm is a horizontal axis, on the cross section, the long axis is taken as a center of a circle on the cross section, any radial direction is 0 degree, 45 degrees are sequentially increased clockwise, the distribution of light intensity (brightness) along the long axis is measured at the outer wall of the sleeve in 8 directions of 0 degree, 45 degrees, 90 degrees, 135 degrees, 180 degrees, 225 degrees, 270 degrees and 315 degrees (represented by lines with different colors), the result is shown in fig. 13, it can be seen that the consistency of the light intensity measured in different directions at different positions of the long axis is very good, in the length range of 5mm-85mm, the difference of the light intensity at different positions is very small, the maximum difference is not more than 5%, namely the ratio of the minimum value to the maximum. It was confirmed that the system for laser interstitial thermotherapy of the present invention has excellent radial light-emitting uniformity in the light-diverting part and uniformity in different positions of the long axis in all radial directions.
Example 7:
referring to fig. 10, there is shown a schematic view of another example of a ferrule having a reflective layer, the rest of which is substantially the same as the previous embodiment and will not be repeated for the sake of brevity, only showing a side view of the ferrule 13, with the slashed portion representing the reflective layer 131 of the ferrule. The cross-sectional view shows the range occupied by the outgoing light rays, the thick solid lines indicate the reflective layer 131, which is located on the inner wall of the sleeve 13, and the hatched portions represent the main body of the sleeve 13.
Example 8:
method for manufacturing a device for laser interstitial hyperthermia system, comprising the steps of:
processing the glass substrate to obtain a cone-like body with a part of a cylinder and a part of a cone, wherein the diameter of the cylinder part is less than or equal to the inner diameter of the sleeve, the cone can be formed by polishing, can be obtained by stretching the cylindrical substrate in a high-temperature deformable state, and can also be obtained by etching;
coating or polishing the surface of the cone part of the cone-like body to obtain a diffuse reflection surface to form a light steering part;
stripping off the part of the far end of the optical fiber outside a section of cladding to expose the cladding, wherein the outer diameter of the cladding is less than or equal to the inner diameter of the sleeve;
connecting the cylindrical part of the light ray steering part with the far end of the sleeve, and connecting the near end of the sleeve with the far end of the optical fiber;
and connecting the near end of the optical fiber with the optical fiber connector.
The glass may preferably be more ductile to enhance safety; for example, quartz glass containing sodium oxide or potassium oxide, or glass containing boron oxide as a main component is selected. In the silica glass containing sodium oxide or potassium oxide, the mass fraction of sodium oxide or potassium oxide is more than 20% and the mass fraction of sodium oxide or potassium oxide is more than 1%, and the mass fraction of sodium oxide or potassium oxide may be any value not more than 20% and more than 1%, for example, 2%, 3%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, or the like.
Example 9:
another method of making a device for laser interstitial hyperthermia system, comprising the steps of:
processing a glass substrate containing scattering particles to obtain a light steering part with a part of a cylinder and a part of a cone, wherein the diameter of the cylinder part is less than or equal to the inner diameter of the sleeve, the cone can be formed by polishing, can be obtained by stretching the cylindrical substrate in a high-temperature deformable state, and can also be obtained by etching;
stripping off the part of the far end of the optical fiber outside a section of cladding to expose the cladding, wherein the outer diameter of the cladding is less than or equal to the inner diameter of the sleeve;
connecting the cylindrical part of the light ray steering part with the far end of the sleeve, and connecting the near end of the sleeve with the far end of the optical fiber;
and connecting the near end of the optical fiber with the optical fiber connector.
The glass substrate contains scattering particles, which may be metal particles, oxide particles, bubbles, or the like, and the particle size and distribution density of the scattering particles may need to be adjusted. Other properties of the glass substrate are similar to those described in example 5 and may be a glass with better toughness.
The cone portion described herein may be a right circular cone, or may be other circular cones as long as it can realize the desired conversion of the light emitting direction.
Example 10:
a further method of making a device for laser interstitial hyperthermia system comprising the steps of:
processing a glass substrate containing scattering particles to obtain a cone-like body with a part of a cylinder and a part of a cone, wherein the diameter of the cylinder part is less than or equal to the inner diameter of the sleeve, the cone can be formed by polishing, can be obtained by stretching the cylindrical substrate in a high-temperature deformable state, and can also be obtained by etching;
coating or polishing the surface of the cone part of the cone-like body to obtain a diffuse reflection surface which becomes a light turning part;
stripping off the part of the far end of the optical fiber outside a section of cladding to expose the cladding, wherein the outer diameter of the cladding is less than or equal to the inner diameter of the sleeve;
connecting the cylindrical part of the light ray steering part with the far end of the sleeve, and connecting the near end of the sleeve with the far end of the optical fiber;
and connecting the near end of the optical fiber with the optical fiber connector.
The glass substrate may contain scattering particles that may be metal particles, oxide particles, bubbles, or the like, and the particle size and distribution density of the scattering particles may need to be adjusted. Other properties of the glass substrate are similar to those described in example 5 and may be a glass with better toughness.
The cone portion described herein may be a right circular cone, or may be other circular cones as long as it can realize the desired conversion of the light emitting direction.
The connection steps described herein have no precedence, so long as all connections are made, and the best connection order can be selected according to actual processing conditions.
Finally, it should be noted that: the above-mentioned embodiments are only specific embodiments of the present invention, which are used for illustrating the technical solutions of the present invention and not for limiting the same, and the protection scope of the present invention is not limited thereto, although the present invention is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: any person skilled in the art can modify or easily conceive the technical solutions described in the foregoing embodiments or equivalent substitutes for some technical features within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the embodiments of the present invention, and they should be construed as being included therein. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (12)
1. A device for laser interstitial thermotherapy system, characterized by, contain connector, optic fibre, sleeve pipe, and light turn to the portion, wherein, the connector with the near-end of optic fibre is connected, the near-end of sleeve pipe with the distal end of optic fibre is connected, light turn to the portion and the distal end of sleeve pipe are connected, light turn to the portion and contain the cone portion that increases from near-end to distal end diameter gradually, light turn to the portion and contain the scattering granule, realize the conversion of light direction through the scattering granule, and the cone portion surface of light turn to the portion is the diffuse reflection surface, makes the light that propagates along the long axial of optic fibre turn to radial outgoing and at light long axial's cone portion surfaceThe light intensity of radial emergent light at different positions of the long shaft of the steering part is relatively close, and the thermal expansion coefficient of the light steering part and the sleeve in the range of 0-300 ℃ is not more than 8 multiplied by 10-5Per deg.C glass or sapphire.
2. The device for laser interstitial thermotherapy system according to claim 1, wherein the space enclosed by the connection of the optical fiber, the sleeve and the light diverting part is vacuum.
3. Device for laser interstitial hyperthermia system according to claim 1, wherein the glass is quartz glass containing not more than 20% mass fraction of sodium oxide or potassium oxide.
4. The device for laser interstitial thermotherapy system according to claim 1, wherein the glass has a main component of boron oxide.
5. The device for laser interstitial thermotherapy system according to claim 1, wherein the sleeve comprises a reflective layer capable of limiting the emergence of light to a desired range.
6. The apparatus for laser interstitial thermotherapy according to claim 5, wherein the light exit area defined by the reflective layer is formed to have an angle ranging from 0 to 270 degrees in cross-section with respect to a long axis of the optical fiber as a center.
7. The device for laser interstitial thermotherapy system according to claim 6, wherein a reflective layer is located on the inner or outer wall of the casing.
8. The device for laser interstitial hyperthermia system according to any of the claims 1 to 7, further comprising a cooling jacket.
9. Method for manufacturing a device for laser interstitial hyperthermia system, comprising:
processing the material containing the scattering particles to obtain a cone-like body containing a cone part and a cylinder part;
coating or polishing the surface of the cone part of the cone-like body to obtain a diffuse reflection surface and form a light turning part;
stripping off the part of the far end of the optical fiber outside a section of cladding to expose the cladding, wherein the outer diameter of the cladding is less than or equal to the inner diameter of the sleeve;
connecting the cylindrical part of the light ray steering part with the far end of the sleeve, and connecting the near end of the sleeve with the far end of the optical fiber;
and connecting the near end of the optical fiber with the optical fiber connector.
10. The method of claim 9, wherein the joining may be achieved by electric discharge welding.
11. The method of claim 10, wherein the connecting is performed under vacuum.
12. A laser interstitial thermotherapy instrument, wherein the device for a laser interstitial thermotherapy system according to any one of claims 1 to 8 is used.
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| CN201911409241.0A CN111110346B (en) | 2019-12-31 | 2019-12-31 | Device for laser interstitial thermotherapy system |
| CN202110232124.2A CN113017825A (en) | 2019-12-31 | 2019-12-31 | Device for laser interstitial thermotherapy system |
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| CN113855228B (en) * | 2021-09-30 | 2023-12-01 | 杭州佳量医疗科技有限公司 | Sheath structure for ablation operation optical fiber |
| EP4268754A1 (en) * | 2022-04-28 | 2023-11-01 | Oberon GmbH | Waveguide for treating inner walls of inner pathways of a human body |
| WO2024060314A1 (en) * | 2022-09-21 | 2024-03-28 | 上海超光微医疗科技有限公司 | Medical treatment device and treatment probe |
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| CN111110346A (en) | 2020-05-08 |
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