WO1995035086A1 - Composition and treatment for baldness - Google Patents
Composition and treatment for baldness Download PDFInfo
- Publication number
- WO1995035086A1 WO1995035086A1 PCT/US1995/008847 US9508847W WO9535086A1 WO 1995035086 A1 WO1995035086 A1 WO 1995035086A1 US 9508847 W US9508847 W US 9508847W WO 9535086 A1 WO9535086 A1 WO 9535086A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- weight
- pharmaceutical composition
- zinc
- starch
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 73
- 238000011282 treatment Methods 0.000 title claims abstract description 60
- 201000004384 Alopecia Diseases 0.000 title claims abstract description 21
- 230000003676 hair loss Effects 0.000 title description 7
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 140
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 95
- 229920002472 Starch Polymers 0.000 claims abstract description 75
- 239000008107 starch Substances 0.000 claims abstract description 75
- 235000019698 starch Nutrition 0.000 claims abstract description 75
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 75
- 229910001868 water Inorganic materials 0.000 claims abstract description 75
- 239000011787 zinc oxide Substances 0.000 claims abstract description 70
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 68
- 239000004327 boric acid Substances 0.000 claims abstract description 67
- 238000000034 method Methods 0.000 claims abstract description 40
- 208000004631 alopecia areata Diseases 0.000 claims abstract description 21
- 206010068168 androgenetic alopecia Diseases 0.000 claims abstract description 13
- 239000004615 ingredient Substances 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 150000001875 compounds Chemical class 0.000 claims description 114
- 229910052796 boron Inorganic materials 0.000 claims description 54
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 53
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 53
- 239000011701 zinc Substances 0.000 claims description 53
- 229910052725 zinc Inorganic materials 0.000 claims description 53
- 239000002453 shampoo Substances 0.000 claims description 38
- 230000000699 topical effect Effects 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 4
- 210000004209 hair Anatomy 0.000 abstract description 48
- 210000004761 scalp Anatomy 0.000 abstract description 16
- 239000011148 porous material Substances 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 3
- 210000002268 wool Anatomy 0.000 abstract description 3
- 235000019687 Lamb Nutrition 0.000 abstract description 2
- 208000001840 Dandruff Diseases 0.000 description 10
- 206010013786 Dry skin Diseases 0.000 description 8
- 206010039792 Seborrhoea Diseases 0.000 description 8
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 6
- 229940107889 rogaine Drugs 0.000 description 6
- 208000024963 hair loss Diseases 0.000 description 5
- 238000012423 maintenance Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000003779 hair growth Effects 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 2
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 229940099112 cornstarch Drugs 0.000 description 2
- 229960004544 cortisone Drugs 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 150000001639 boron compounds Chemical class 0.000 description 1
- -1 boron ions Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- ORXJMBXYSGGCHG-UHFFFAOYSA-N dimethyl 2-methoxypropanedioate Chemical compound COC(=O)C(OC)C(=O)OC ORXJMBXYSGGCHG-UHFFFAOYSA-N 0.000 description 1
- HCIBTBXNLVOFER-UHFFFAOYSA-N diphenylcyclopropenone Chemical compound O=C1C(C=2C=CC=CC=2)=C1C1=CC=CC=C1 HCIBTBXNLVOFER-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical group [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 230000003660 hair regeneration Effects 0.000 description 1
- 230000003659 hair regrowth Effects 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000000820 nonprescription drug Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- GAAKLDANOSASAM-UHFFFAOYSA-N undec-10-enoic acid;zinc Chemical compound [Zn].OC(=O)CCCCCCCCC=C GAAKLDANOSASAM-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- 229940118257 zinc undecylenate Drugs 0.000 description 1
- IPCXNCATNBAPKW-UHFFFAOYSA-N zinc;hydrate Chemical compound O.[Zn] IPCXNCATNBAPKW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95927167A EP0835092A4 (en) | 1994-06-21 | 1995-06-20 | Composition and treatment for baldness |
AU31277/95A AU3127795A (en) | 1994-06-21 | 1995-06-20 | Composition and treatment for baldness |
US08/844,707 US6033653A (en) | 1990-07-03 | 1997-04-18 | Shampoo products comprising starch, a compound comprising boron, a compound comprising zinc, and water |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/262,953 US6103273A (en) | 1990-07-03 | 1994-06-21 | Pharmaceutical composition comprising starch, a compound comprising boron, a compound comprising zinc, and water, and a method of using same to encourage hair growth |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/262,953 Continuation-In-Part US6103273A (en) | 1990-07-03 | 1994-06-21 | Pharmaceutical composition comprising starch, a compound comprising boron, a compound comprising zinc, and water, and a method of using same to encourage hair growth |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/844,707 Continuation-In-Part US6033653A (en) | 1990-07-03 | 1997-04-18 | Shampoo products comprising starch, a compound comprising boron, a compound comprising zinc, and water |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995035086A1 true WO1995035086A1 (en) | 1995-12-28 |
Family
ID=22999774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/008847 WO1995035086A1 (en) | 1990-07-03 | 1995-06-20 | Composition and treatment for baldness |
Country Status (4)
Country | Link |
---|---|
US (1) | US6103273A (en) |
EP (1) | EP0835092A4 (en) |
AU (1) | AU3127795A (en) |
WO (1) | WO1995035086A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432077B1 (en) * | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
US7687650B2 (en) | 2006-02-03 | 2010-03-30 | Jr Chem, Llc | Chemical compositions and methods of making them |
CA2641420C (en) | 2006-02-03 | 2013-06-25 | Jr Chem, Llc | Anti-aging treatment using copper and zinc compositions |
US7897800B2 (en) | 2006-02-03 | 2011-03-01 | Jr Chem, Llc | Chemical compositions and methods of making them |
US7867522B2 (en) | 2006-09-28 | 2011-01-11 | Jr Chem, Llc | Method of wound/burn healing using copper-zinc compositions |
US8273791B2 (en) | 2008-01-04 | 2012-09-25 | Jr Chem, Llc | Compositions, kits and regimens for the treatment of skin, especially décolletage |
WO2010085753A1 (en) | 2009-01-23 | 2010-07-29 | Jr Chem, Llc | Rosacea treatments and kits for performing them |
US8952057B2 (en) | 2011-01-11 | 2015-02-10 | Jr Chem, Llc | Compositions for anorectal use and methods for treating anorectal disorders |
US20170172869A1 (en) * | 2015-12-17 | 2017-06-22 | Sidiram S. Ragoonath | Hair Growth Product |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US992937A (en) * | 1911-05-23 | Brodbeck Company | Nursery-powder compound. | |
US2652355A (en) * | 1950-01-31 | 1953-09-15 | Warner Hudnut Inc | Fungicides |
FR2653996A1 (en) * | 1989-11-09 | 1991-05-10 | Lourenco Armando | Hair restorer composition and aqueous solution |
US5015470A (en) * | 1986-12-23 | 1991-05-14 | Gibson Walter T | Cosmetic composition |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US143133A (en) * | 1873-09-23 | Improvement in medical compounds or powders for infants | ||
US415208A (en) * | 1889-11-19 | Ointment | ||
US124751A (en) * | 1872-03-19 | Improvement in medical compounds or salves | ||
US2289125A (en) * | 1938-04-18 | 1942-07-07 | Wilfred B Kell | Therapeutic agent for the treatment of fungus infection |
NZ210840A (en) * | 1984-01-18 | 1987-05-29 | Johnson & Johnson Baby Prod | Composition comprising synergistic combination of miconazole nitrate and zinc oxide |
US4816254A (en) * | 1987-07-29 | 1989-03-28 | Moss Thomas D | Ointment for treating skin irritations |
GB8806892D0 (en) * | 1988-03-23 | 1988-04-27 | Unilever Plc | Lactams their synthesis & use in cosmetic compositions |
GB9210756D0 (en) * | 1992-05-20 | 1992-07-08 | Unilever Plc | Cosmetic composition |
-
1994
- 1994-06-21 US US08/262,953 patent/US6103273A/en not_active Expired - Fee Related
-
1995
- 1995-06-20 WO PCT/US1995/008847 patent/WO1995035086A1/en not_active Application Discontinuation
- 1995-06-20 EP EP95927167A patent/EP0835092A4/en not_active Withdrawn
- 1995-06-20 AU AU31277/95A patent/AU3127795A/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US992937A (en) * | 1911-05-23 | Brodbeck Company | Nursery-powder compound. | |
US2652355A (en) * | 1950-01-31 | 1953-09-15 | Warner Hudnut Inc | Fungicides |
US5015470A (en) * | 1986-12-23 | 1991-05-14 | Gibson Walter T | Cosmetic composition |
FR2653996A1 (en) * | 1989-11-09 | 1991-05-10 | Lourenco Armando | Hair restorer composition and aqueous solution |
Non-Patent Citations (1)
Title |
---|
See also references of EP0835092A4 * |
Also Published As
Publication number | Publication date |
---|---|
EP0835092A1 (en) | 1998-04-15 |
US6103273A (en) | 2000-08-15 |
EP0835092A4 (en) | 2000-05-10 |
AU3127795A (en) | 1996-01-15 |
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