WO1995021212A1 - Traitement de surface - Google Patents

Traitement de surface Download PDF

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Publication number
WO1995021212A1
WO1995021212A1 PCT/GB1995/000211 GB9500211W WO9521212A1 WO 1995021212 A1 WO1995021212 A1 WO 1995021212A1 GB 9500211 W GB9500211 W GB 9500211W WO 9521212 A1 WO9521212 A1 WO 9521212A1
Authority
WO
WIPO (PCT)
Prior art keywords
cross
wear
plasma treatment
prosthetic device
surface region
Prior art date
Application number
PCT/GB1995/000211
Other languages
English (en)
Inventor
David Franklin Farrar
Original Assignee
Smith & Nephew Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9402103A external-priority patent/GB9402103D0/en
Priority claimed from GB9402102A external-priority patent/GB9402102D0/en
Application filed by Smith & Nephew Plc filed Critical Smith & Nephew Plc
Priority to AU15428/95A priority Critical patent/AU1542895A/en
Publication of WO1995021212A1 publication Critical patent/WO1995021212A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification
    • C08J7/123—Treatment by wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/245—Differential crosslinking of one polymer with one crosslinking type, e.g. surface crosslinking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30922—Hardened surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Definitions

  • the present invention relates to medical devices which have improved properties due to surface treatment.
  • the present invention relates to jointed prosthetic devices and to implant devices and to a method for improving the wear surface of a prosthetic device.
  • Wear surfaces surfaces which are prone to wear
  • Such surfaces are found, for example, at articulating surfaces of jointed prostheses which bear against one another when a joint is articulated.
  • These surfaces can be surfaces of various hard materials.
  • different materials are used for two co-operating bearing surfaces e.g. one bearing surface may be a surface of a hard polished metal material such as a cobalt steel alloy and an opposing bearing surface may be a plastics material which has low frictional resistance properties.
  • Ultra high molecular weight polyethylene which has a molecular weight of about 4.5 x 10 6 or higher is conventionally used in these applications. It has been found that in this situation the plastics material is prone to wear. This is a particular problem for implanted prostheses since debris formed by wearing of UHMWPE may stimulate adverse cellular reactions leading to resorption of bone around the implant. This, and also the reduced thickness of the plastics material which can occur due to wear, may result in loosening of the fit of the prosthesis so that adjustment or replacement is necessary by revision surgery.
  • the present invention aims to overcome or at least to alleviate some of the above-mentioned disadvantages by providing a jointed prosthetic device in which at least one of the articulating surfaces of the joint comD ⁇ ses a surface modified UHMWPE having improved wear properties.
  • a method for improving the wear resistance of a wear surface of a medical prosthetic device wherein the wear surface comprises plastics material comprising subjecting a surface region of the wear surface to plasma treatment.
  • the present invention also provides a medical prosthetic device comprising a plastics material wherein at least a surface region of the plastics material has been plasma treated.
  • Plasma treated UHMWPE exhibits increased hardness compared to untreated UHMWPE.
  • plasma treatment can result in an increase in cross-linking at a surface region of the plastics material and that this cross-linking can result in increased hardness, and/or wear-resistance. Plasma treatment may also result in increased wettability and this can provide increased biocompatibility.
  • the surface region comprises a wear surface.
  • This surface may bear against another co-operating surface so that the surfaces are in sliding, pivoting or rotating relationships to one another.
  • the surface region can aptly be present at a joint of a prosthetic device.
  • the device may be an implantable prosthetic device e.g. an artificial knee or hip joint. Increased biocompatibility is advantageous since this can reduce the likelihood that the device will need to be replaced and also reduces the risk of adverse effects on the patient.
  • the implantable device be a jointed device or indeed that it have a wear surface since the increased biocompatibility and hardness achievable with the present invention can be advantageous for a large variety of implantable devices.
  • the plastics material can be any plastics material which is cross-linkable by plasma-treatment. Suitable plastics materials include:-
  • the materials may be of low, medium or high density.
  • the UHMWPE may be present on a medical device in the form of a coating or may extend across the whole of the device or of a component thereof.
  • a preferred plastics material for use in the present invention is an ultra high molecular weight plastics material e.g. an ultra high molecular weight material polyalkylene which is preferably an ultra high molecular weight polyethylene:- referred to herein as UHMWPE.
  • the ultra high molecular weight plastics materials may comprise one or more substituent groups and may include one or more copolymers.
  • the term ultra high molecular weight is used herein to refer to a molecular weight of at least 10 6 and preferably of from 3 x 10 6 to 8 x 10 6
  • the surface region is cross-linked to a depth of at least 0.3 ⁇ m by the plasma treatment.
  • the surface region may be cross-linked to a depth of between 0.3 ⁇ m and 500 ⁇ m.
  • One way of determining the depth of cross-linking is provided in the example which is given later under the title "Estimation of Plasma Penetration Depth" wherein the presence of absorption bands at 2890 cm -1 is taken to indicate cross-linking occurring (due to the formation of tertiary -CH groups).
  • the surface region has a Vickers Hardness of at least 6.0.
  • the surface region may have a Vickers Hardness of from 6 to 25 (figures used herein for hardness are Vickers Hardness numbers). Hardness can be determined using the method described in the example under the heading "Micro- Hardness Testing".
  • surface region is used herein to include both the surface of a plastics material which has been cross-linked by plasma treatment and such material which underlies this surface.
  • a device having a surface region at least 0.3 ⁇ m deep comprised of ultra high molecular weight cross-linked polyethylene having a Vickers Hardness number of at least 6.0 and whose infra ⁇ red spectrum exhibits absorption bands at 2890 cm -1 .
  • the device of the present invention demonstrates a high degree of hardness, which correlates with a high wear resistance. It is thus useful in applications where surfaces bear against one another, e.g. in sliding, pivoting or rotating relationship to one another.
  • the surface region is part of a larger mass of ultra high molecular weight polyethylene.
  • the surface region may provide one of a pair of mutually co-operating bearing surfaces.
  • the other co-operating bearing surface may comprise a metal or a ceramic material.
  • the device is a medical prosthetic device or part of such a device and the surface region provides a wear surface for the device e.g. at a joint.
  • the present invention is particularly advantageous for use in prosthetic devices which are implanted in a patient's body. Increased biocompatibility results in a reduced likelihood that the implant will need to be replaced and also reduces the risk of adverse effects on the patient. Corresponding cost reductions can therefore be achieved.
  • Plasma treatment can increase the wettabiiity of a polymer surface and thus can increase biocompatibility by lowering surface tension. This is in addition to any improved hardness which can result from cross-linking.
  • the particular plasma-treatment used to achieve cross-linking can vary with the type of plastics material to be cross-linked but can be determined by the skilled man using no more than trial and error.
  • the present invention also provides a process for providing a cross-linked, UHMWPE surface region of a medical device which comprises cross-linking that region by subjecting it to plasma treatment.
  • UHMWPE material to be cross-linked may be plasma treated and then this may be formed into a device/part of a device after cross-linking.
  • cross-linking may be performed in situ on a pre-formed device/a preformed part of a device.
  • Plasma treatment is a process whereby a material is exposed to a gas composed of excited charged particles such as ions and electrons. These particles collide with the material surface causing modification due to gas particles chemically bonding to the surface or due to removal of material from the surface. As excited species fall to lower energy states photons are emitted and ultra violet (UV) cross-linking can occur.
  • excited charged particles such as ions and electrons.
  • Plasma may be generated by applying micro/radio waves to a gas at low pressure.
  • Plasma treatment can be used to provide a device according to the present invention by plasma treating a region of high molecular weight polyethylene so that the region becomes cross-linked to a depth of at least 0.3 ⁇ m and a Vickers Hardness of at least 6.0 is achieved.
  • the cross-linking is detected by the presence of infra-red absorption bands at 2890cm- 1
  • the depth of cross-linking and the hardness of the cross- linked region can be assayed using the method described later in this specification in the example.
  • the plasma treatment improves wettabiiity of a polymer surface, which can increase biocompatibility by lowering interfacial tension.
  • plasma treatment is carried out for up to 60 mins (e.g. from 1 to 30 mins) and at a power level of from 10-300 watts (e.g. from 60 to 200 watts). At high power levels it is generally the case that treatment can be performed for shorter periods of time than for lower power levels in order to achieve the same degree of cross- linking.
  • the temperature of the UHMWPE should not exceed 100°C during plasma treatment in order to avoid problems of thermal degradation. The temperature of the UHMWPE can be monitored during treatment and if it gets close to 100°C the treatment can be stopped or the power level can be reduced accordingly.
  • a chamber in which the treatment is carried out is maintained at a pressure within the range of 0.1 to 1 m. bar preferably within the range of 0.1 to 0.3 m.bar.
  • UHMWPE plaques measuring approx. 2.5 x 3.5 x 0.1 cm were cut from polyethylene sheets supplied by Goodfellows, Cambridge, UK. These plaques were then polished with silicon carbide paper using a Buchler Metasem Polisher, the final finish being achieved with 1200 grade paper.
  • plaques Two adjacent corners of the plaques were trimmed to mark a handling area and they were washed in IMS (which is an abbreviation for Industrial Methylated Spirit) and dried overnight. Forceps were used to handle the samples. For each treatment, five plaques were mounted on a microscope slide using "BLUE TACK" (Trade Mark).
  • the slide was placed inside the plasma barrel of a plasma barrel etcher sold under the Trade Mark of "PT7300 VG Microtech” (obtainable from Fisons Instruments of Bishopmeadow Road, Loughborough), after which the chamber was evacuated twice and flushed with argon before the plasma was initiated. The pressure inside the chamber and the plasma power were held constant. After treatment the plaques were kept in an argon atmosphere for a few minutes before exposure to air. Samples were treated as indicated in Table 1. Plasma treatment was carried out with the chamber pressure at 0.2 m. bar.
  • plaques were then sterilised using gamma ray irradiation treatments.
  • Control samples include plasma treatment without gamma sterilisation (J1210X), gamma sterilisation without plasma treatment (LOO) and no plasma treatment or gamma sterilisation.
  • the treated samples were then tested for micro-hardness using the method described below.
  • the specimens were tested in a Schimadzu microhardness tester with a pyramidal shaped indentor. The diagonals were measured at 400 x magnifications and the Vickers Hardness number calculated. At least 10 indents were measured for each sample.
  • Penetration depth of the plasma was investigated using a variable angle ATR device obtainable from Graseby Specac.
  • the refractive index of the sample permitted the use of angles between 42 deg. and 60 deg. Both sides of sample 12030 were examined at each angle. Spectra were recorded as follows:- IR Number Angle of Infrared penetration 2890 cm -1 incidence depth of 2890 cm -1 present/absent
  • the advancing angle is the angle measured as the sample is being immersed into the liquid.
  • the receding angle is that measured as the sample is withdrawn from the liquid.
  • plasma treatment improves wettabiiity of the polymer surface. It may therefore improve biocompatibility of jointed devices implanted in a patient by reducing inter-facial tension.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Procédé d'amélioration de la résistance de surfaces soumises à l'usure de prothèses médicales dont lesdites surfaces sont en matière plastique, et qui consiste à les soumettre à un traitement par plasma. Le matériau peut être du UHMWPE; la surface se trouve réticulée jusqu'à une profondeur d'au moins 0,3 νm comme l'atteste la présence de bandes d'absorption de l'IR à 2890 cm-1.
PCT/GB1995/000211 1994-02-03 1995-02-02 Traitement de surface WO1995021212A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU15428/95A AU1542895A (en) 1994-02-03 1995-02-02 Surface treatment

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9402103.7 1994-02-03
GB9402103A GB9402103D0 (en) 1994-02-03 1994-02-03 Surface treatment
GB9402102A GB9402102D0 (en) 1994-02-03 1994-02-03 Plastics materials
GB9402102.9 1994-02-03

Publications (1)

Publication Number Publication Date
WO1995021212A1 true WO1995021212A1 (fr) 1995-08-10

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PCT/GB1995/000211 WO1995021212A1 (fr) 1994-02-03 1995-02-02 Traitement de surface

Country Status (2)

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AU (1) AU1542895A (fr)
WO (1) WO1995021212A1 (fr)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19736449A1 (de) * 1997-08-21 1999-02-25 Gfe Met & Mat Gmbh Verbundwerkstoff
US5922161A (en) * 1995-06-30 1999-07-13 Commonwealth Scientific And Industrial Research Organisation Surface treatment of polymers
WO1999052474A1 (fr) 1996-10-15 1999-10-21 The Orthopaedic Hospital Polyethylene resistant a l'usure a gradient de surface de reticulation
US6228900B1 (en) 1996-07-09 2001-05-08 The Orthopaedic Hospital And University Of Southern California Crosslinking of polyethylene for low wear using radiation and thermal treatments
US6245276B1 (en) 1999-06-08 2001-06-12 Depuy Orthopaedics, Inc. Method for molding a cross-linked preform
US6281264B1 (en) 1995-01-20 2001-08-28 The Orthopaedic Hospital Chemically crosslinked ultrahigh molecular weight polyethylene for artificial human joints
US6379741B1 (en) 1998-11-30 2002-04-30 The Regents Of The University Of California Plasma-assisted surface modification of polymers for medical device applications
US6395799B1 (en) 2000-02-21 2002-05-28 Smith & Nephew, Inc. Electromagnetic and mechanical wave energy treatments of UHMWPE
US6547828B2 (en) 2001-02-23 2003-04-15 Smith & Nephew, Inc. Cross-linked ultra-high molecular weight polyethylene for medical implant use
US6562540B2 (en) 1996-10-02 2003-05-13 Depuy Orthopaedics, Inc. Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance
US6627141B2 (en) 1999-06-08 2003-09-30 Depuy Orthopaedics, Inc. Method for molding a cross-linked preform
US6692679B1 (en) 1998-06-10 2004-02-17 Depuy Orthopaedics, Inc. Cross-linked molded plastic bearings
US6818172B2 (en) 2000-09-29 2004-11-16 Depuy Products, Inc. Oriented, cross-linked UHMWPE molding for orthopaedic applications
US7550555B2 (en) 2002-01-29 2009-06-23 Smith & Nephew Orthopaedics Ag Sintering ultrahigh molecular weight polyethylene
US7819925B2 (en) 2002-01-28 2010-10-26 Depuy Products, Inc. Composite prosthetic bearing having a crosslinked articulating surface and method for making the same
US7938861B2 (en) 2003-04-15 2011-05-10 Depuy Products, Inc. Implantable orthopaedic device and method for making the same
US8083802B2 (en) 2001-06-30 2011-12-27 Deput Products, Inc. Prosthetic bearing with encapsulated reinforcement
US8871131B2 (en) 2006-10-30 2014-10-28 Smith And Nephew Orthopaedics Ag Processes comprising crosslinking polyethylene or using crosslinked polyethylene
US9132209B2 (en) 2010-05-07 2015-09-15 Howmedia Osteonics Corp. Surface crosslinked polyethylene
CN110497624A (zh) * 2019-07-30 2019-11-26 华南理工大学 一种利用放电等离子烧结加工超高分子量聚乙烯的方法
CN111763364A (zh) * 2020-07-08 2020-10-13 中国科学院长春应用化学研究所 一种抗氧化超高分子量聚乙烯粉末及其制备方法和抗氧化超高分子量聚乙烯辐照交联板材

Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0348252A1 (fr) * 1988-05-24 1989-12-27 Nitruvid Procédé pour réduire le coefficient de frottement et l'usure entre une piéce métallique et une pièce à base d'un polymère ou copolymère organique et son application à des prothèses articulaires et des emboîtements travaillant dans des milieux marins
US5223309A (en) * 1991-07-10 1993-06-29 Spire Corporation Ion implantation of silicone rubber
US5236563A (en) * 1990-06-18 1993-08-17 Advanced Surface Technology Inc. Surface-modified bioabsorbables

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0348252A1 (fr) * 1988-05-24 1989-12-27 Nitruvid Procédé pour réduire le coefficient de frottement et l'usure entre une piéce métallique et une pièce à base d'un polymère ou copolymère organique et son application à des prothèses articulaires et des emboîtements travaillant dans des milieux marins
US5236563A (en) * 1990-06-18 1993-08-17 Advanced Surface Technology Inc. Surface-modified bioabsorbables
US5223309A (en) * 1991-07-10 1993-06-29 Spire Corporation Ion implantation of silicone rubber

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281264B1 (en) 1995-01-20 2001-08-28 The Orthopaedic Hospital Chemically crosslinked ultrahigh molecular weight polyethylene for artificial human joints
US5922161A (en) * 1995-06-30 1999-07-13 Commonwealth Scientific And Industrial Research Organisation Surface treatment of polymers
US6228900B1 (en) 1996-07-09 2001-05-08 The Orthopaedic Hospital And University Of Southern California Crosslinking of polyethylene for low wear using radiation and thermal treatments
US6562540B2 (en) 1996-10-02 2003-05-13 Depuy Orthopaedics, Inc. Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance
EP1028760A4 (fr) * 1996-10-15 2001-04-11 Orthopaedic Hospital Polyethylene reticule a gradient de surface, resistant a l'usure
US6165220A (en) * 1996-10-15 2000-12-26 The Orthopaedic Hospital Wear resistant surface-gradient crosslinked polyethylene
EP1028760A1 (fr) * 1996-10-15 2000-08-23 Orthopaedic Hospital Polyethylene reticule a gradient de surface, resistant a l'usure
WO1999052474A1 (fr) 1996-10-15 1999-10-21 The Orthopaedic Hospital Polyethylene resistant a l'usure a gradient de surface de reticulation
US6494917B1 (en) 1996-10-15 2002-12-17 Orthopaedic Hospital Wear resistant surface-gradient crosslinked polyethylene
US6057031A (en) * 1997-08-21 2000-05-02 Gfe Metalle Und Materialien Gmbh. Plastic substrate with thin metal-containing layer
DE19736449A1 (de) * 1997-08-21 1999-02-25 Gfe Met & Mat Gmbh Verbundwerkstoff
US6692679B1 (en) 1998-06-10 2004-02-17 Depuy Orthopaedics, Inc. Cross-linked molded plastic bearings
US6379741B1 (en) 1998-11-30 2002-04-30 The Regents Of The University Of California Plasma-assisted surface modification of polymers for medical device applications
US6685743B2 (en) 1998-11-30 2004-02-03 The Regents Of The University Of California Plasma-assisted surface modification of polymers for medical device applications
US6245276B1 (en) 1999-06-08 2001-06-12 Depuy Orthopaedics, Inc. Method for molding a cross-linked preform
US6627141B2 (en) 1999-06-08 2003-09-30 Depuy Orthopaedics, Inc. Method for molding a cross-linked preform
US6395799B1 (en) 2000-02-21 2002-05-28 Smith & Nephew, Inc. Electromagnetic and mechanical wave energy treatments of UHMWPE
US6818172B2 (en) 2000-09-29 2004-11-16 Depuy Products, Inc. Oriented, cross-linked UHMWPE molding for orthopaedic applications
EP2272542A2 (fr) 2001-02-23 2011-01-12 Smith and Nephew, Inc. Polyéthylène à poids moléculaire ultra élevé pour l'utilisation dans un implant médical
US6547828B2 (en) 2001-02-23 2003-04-15 Smith & Nephew, Inc. Cross-linked ultra-high molecular weight polyethylene for medical implant use
US6709464B2 (en) 2001-02-23 2004-03-23 Smith & Nephew, Inc., Research Cross-linked ultra-high molecular weight polyethylene for medical implant use
US6726727B2 (en) 2001-02-23 2004-04-27 Smith & Nephew, Inc. Cross-linked ultra-high molecular weight polyethylene for medical implant use
US8083802B2 (en) 2001-06-30 2011-12-27 Deput Products, Inc. Prosthetic bearing with encapsulated reinforcement
US7819925B2 (en) 2002-01-28 2010-10-26 Depuy Products, Inc. Composite prosthetic bearing having a crosslinked articulating surface and method for making the same
US7863410B2 (en) 2002-01-29 2011-01-04 Smith & Nephew Orthopaedics Ag Sintering ultrahigh molecular weight polyethylene
US7550555B2 (en) 2002-01-29 2009-06-23 Smith & Nephew Orthopaedics Ag Sintering ultrahigh molecular weight polyethylene
US7938861B2 (en) 2003-04-15 2011-05-10 Depuy Products, Inc. Implantable orthopaedic device and method for making the same
US8871131B2 (en) 2006-10-30 2014-10-28 Smith And Nephew Orthopaedics Ag Processes comprising crosslinking polyethylene or using crosslinked polyethylene
US9132209B2 (en) 2010-05-07 2015-09-15 Howmedia Osteonics Corp. Surface crosslinked polyethylene
US9828474B2 (en) 2010-05-07 2017-11-28 Howmedica Osteonics Corp. Surface crosslinked polyethylene
US9951190B2 (en) 2010-05-07 2018-04-24 Howmedica Osteonics Corp. Surface crosslinked polyethylene
CN110497624A (zh) * 2019-07-30 2019-11-26 华南理工大学 一种利用放电等离子烧结加工超高分子量聚乙烯的方法
CN111763364A (zh) * 2020-07-08 2020-10-13 中国科学院长春应用化学研究所 一种抗氧化超高分子量聚乙烯粉末及其制备方法和抗氧化超高分子量聚乙烯辐照交联板材
CN111763364B (zh) * 2020-07-08 2021-09-21 中国科学院长春应用化学研究所 一种抗氧化超高分子量聚乙烯粉末及其制备方法和抗氧化超高分子量聚乙烯辐照交联板材

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