WO1995019795A1 - Wound dressing - Google Patents
Wound dressing Download PDFInfo
- Publication number
- WO1995019795A1 WO1995019795A1 PCT/GB1995/000114 GB9500114W WO9519795A1 WO 1995019795 A1 WO1995019795 A1 WO 1995019795A1 GB 9500114 W GB9500114 W GB 9500114W WO 9519795 A1 WO9519795 A1 WO 9519795A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fibres
- weight
- wound dressing
- gel forming
- wound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
Definitions
- This invention relates a would dressing and in particular a non-adherent wound dressing comprising fibrous material.
- the invention also relates to a method of treating a wound comprising applying the dressing to a wound.
- wound dressings comprise gauze, foams, sponges, cotton wads or other fibrous materials. Gauze and other fibrous materials absorb fluids by capillary action with the disadvantage that when new tissue is formed as part of the healing process, it engulfs the fibres and is torn when the material is removed causing wound injury.
- the present invention provides a wound dressing comprising in sheet form a mixture of textile fibres and gel forming fibres.
- the wound dressing according to the invention may have the advantages that it is non-adherent to wound tissue while being absorbent and relatively inexpensive and the added advantage that it may be retained on the wound for longer periods of time than conventional cotton gauze. This results in fewer changes of the dressing being needed which reduces material costs and health care personnel time. In addition a moist wound environment may be created which has been found to be beneficial to wound healing.
- the dressing preferably comprises from 50% to 95% by weight of textile fibres and from 5% to 50% by weight of gel forming fibres. More preferably the dressing comprises from 75% to 90% by weight of textile fibres and particularly 80% by weight and from 10% to 25% of gel forming fibres and more particularly 20% by weight.
- the textile fibres for use in the present invention can be natural or synthetic but are preferably cellulosic fibres for example viscose rayon, multi-limbed viscose, cotton, or regenerated cellulose or fibres having a higher absorbency than most textile fibres such as the multi-limbed cellulose fibres as described in EP-A-301874.
- cellulosic fibres for example viscose rayon, multi-limbed viscose, cotton, or regenerated cellulose or fibres having a higher absorbency than most textile fibres such as the multi-limbed cellulose fibres as described in EP-A-301874.
- textile fibres absorb liquids by capillary action and are not hygroscopic this means that their absorbancies as measured by the free swell absorbancy test are low such as less than 1 gram of liquid per gram of fibre.
- the gel forming fibres for use in the present invention are hygroscopic fibres which upon the uptake of wound exudate become moist and slippery or gelatinous and thus reduce the tendancy for the surrounding fibres to adhere to the wound.
- the gel forming fibres can be of the type which retain their structural integrity on absorbtion of exudate or can be of the type which lose their fibrous form and become a structureless gel or a solution on absorbtion of exudate.
- the gel forming fibres are preferably spun sodium carboxymethylcellulose fibres, chemically modified cellulosic fibres, in particular carboxymethylated cellulose fibres as described in PCT WO/9312275, pectin fibres, alginate fibres, chitosan fibres, hyaluronic acid fibres, or other polysaccharide fibres or fibres derived from gums.
- the cellulosic fibres preferably have a degree of substitution of at least 0.05 carboxymethyl groups per glucose unit.
- the gel forming fibres preferably have an absorbency of at least 2 grams 0.9% saline solution per gram of fibre (as measured by the free swell method) and a tenacity of at least lOcN/tex.
- the production of solvent- spun cellulose fibres is described for example in US-A- 4246221 and US-A-4196281 as well as in PCT WO/9312275 mentioned above.
- the alginate fibres are preferably of the highly absorbent type as described in WO 9417227 and WO 9400164.
- the gel forming fibres for use in the present invention have an absorbency of at least 15 g/g as measured in the free swell absorbency method, more preferably between 25 g/g and 50 g/g.
- the degree of substitution of the cellulosic gel forming fibre is preferably at least 0.2 carboxymethyl groups per glucose unit, more preferably between 0.3 and 0.5.
- the tenacity of the fibre is preferably in the range 25-15 cN/tex.
- the gel forming fibres suitable for use in the present invention can be processed using conventional textile machinery, for example by the staple route including cutting, carding and if desired crimping, drafting and spinning.
- the wound dressing of the present invention is in sheet form and may be made by intimately mixing the gel forming fibres with the textile fibres, for example by carding or air-laying the fibres together to form a web of mixed fibres.
- the wound dressing of the present invention may be made by spinning or twisting the gel forming fibres and the textile fibres together to form a yarn and then knitting or weaving the yarn to form a bandage or stocking.
- the wound dressing of the present invention may be in the form of swabs, wound pads, wadding ribbons, sponges, nets and bandages and may be used as a primary or secondary dressing especially in the treatment of leg ulcers.
- Various optional ingredients can also be included in the final composition such as preservatives and small amounts of pharmacologically active ingredients.
- an antibiotic or antimicrobial agent such as metronidazole, silver sulphadiazine, neomycin or penicillin and antiseptic agent such as povidone iodine and antiinflammatory agent such as hydrocortisone or triamcinolone acteonide or a skin protective agent such as a zinc oxide can be included.
- an antibiotic or antimicrobial agent such as metronidazole, silver sulphadiazine, neomycin or penicillin and antiseptic agent such as povidone iodine and antiinflammatory agent such as hydrocortisone or triamcinolone acteonide or a skin protective agent such as a zinc oxide
- the invention is illustrated by the following examples : -
- Example 1 Gel forming fibres were made as follows:
- a tow of 1.7 decitex solvent-spun cellulosic fibres, the fibres having a substantially uniform structure across their cross-section, as sold under the Trade Mark "Tencel” was obtained in a never-dried state.
- the tow was passed through a hand mangle.
- the amount of water left on the tow after mangling was 62%.
- This wet tow was placed in a solution containing 7.5% sodium hydroxide and 22.1% sodium onochloroacetate at room temperature for 2 minutes.
- the padded tow was mangled again and reacted in a conditioning cabinet set at 23% RH and 90°C for five minutes.
- the tow was washed in a solution containing 55% industrial alcohol, 42% water and 3% acetic acid.
- the washed tow was then treated with a finish containing 99% industrial alcohol and 1% Atlas 61086 emulsifier.
- the tow was dried at low temperature, leaving some residual moisture on the fibres.
- the finished tow was cut into fibres.
- the fibres had a degree of substitution above 0.1, a tenacity of 22.5 cN/tex and an extensibility of 12%.
- the free swell absorbency of the fibres was measured by the free swell absobancy method by dispersing 0.5g fibre in 30ml of 0.9% saline solution and leaving for 5 minutes. The dispersion was then filtered through a sintered Mark 1 funnel of pore size 100-160 microns and was left for 5 minutes, or until it stopped dripping. The water filtered through the funnel was weighed and the weight of water absorbed by the fibres calculated by subtraction. The absorbency was 30g/g.
- the wound dressing when in contact with a wound will absorb exudate causing the gel forming fibres to swell and form a gel.
- the gel will render the wound dressing sufficiently slippery to prevent adherence of the dressing to the newly forming tissue.
- Gel forming fibres were produced as follows: A tow of never-dried Tencel fibres of filament decitex 1.7 was padded with a solution of sodium hydroxide and sodium monochloroacetate. The concentrations of the reagents differed as shown in the table below. The tow was lightly mangled to stop dripping and dried at 90°C to a moisture level of 13%
- the resulting tow was washed in a solution containing 55% ethanol, 42% water, 2.5% acetic acid and 0.5% citric acid.
- the washed tow was treated with a finish and dried as described in Example 1.
- the tow of filaments produced in each example above was cut into 50 mm lengths and 50% by weight of the gel-forming fibres was carded in a blend with 50% viscose rayon fibre (Galaxy) to form a non-woven fabric. The fabric was then sealed in a foil envelope and sterilized to form a wound dressing.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Nonwoven Fabrics (AREA)
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69530180T DE69530180T2 (en) | 1994-01-20 | 1995-01-20 | WOUND DRESSING |
EP95908310A EP0740554B1 (en) | 1994-01-20 | 1995-01-20 | Wound dressing |
AU16673/95A AU691245B2 (en) | 1994-01-20 | 1995-01-20 | Wound dressing |
DK95908310T DK0740554T3 (en) | 1994-01-20 | 1995-01-20 | Wound dressing |
CA002179415A CA2179415C (en) | 1994-01-20 | 1995-01-20 | Non-adherent wound dressing of gel-forming and textile fibres |
AT95908310T ATE235925T1 (en) | 1994-01-20 | 1995-01-20 | WOUND DRESSING |
NZ279516A NZ279516A (en) | 1994-01-20 | 1995-01-20 | Wound dressing, which is non-adherent and absorbent, comprising textile fibres and gel forming fibres |
US08/663,131 US6471982B1 (en) | 1994-01-20 | 1995-01-20 | Wound dressing |
MX9602543A MX9602543A (en) | 1994-01-20 | 1995-01-20 | Wound dressing. |
JP7519419A JPH09509590A (en) | 1994-01-20 | 1995-01-20 | Wound dressing |
NO19962316A NO310059B1 (en) | 1994-01-20 | 1996-06-05 | Non-adhesive wound dressings containing textile fibers and gelled fibers, as well as the use of the same |
FI962916A FI115608B (en) | 1994-01-20 | 1996-07-19 | wound dressing |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9400994A GB9400994D0 (en) | 1994-01-20 | 1994-01-20 | Wound dressing |
GB9400994.1 | 1994-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995019795A1 true WO1995019795A1 (en) | 1995-07-27 |
Family
ID=10749032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1995/000114 WO1995019795A1 (en) | 1994-01-20 | 1995-01-20 | Wound dressing |
Country Status (16)
Country | Link |
---|---|
US (1) | US6471982B1 (en) |
EP (1) | EP0740554B1 (en) |
JP (1) | JPH09509590A (en) |
AT (1) | ATE235925T1 (en) |
AU (1) | AU691245B2 (en) |
CA (1) | CA2179415C (en) |
DE (1) | DE69530180T2 (en) |
DK (1) | DK0740554T3 (en) |
ES (1) | ES2193190T3 (en) |
FI (1) | FI115608B (en) |
GB (1) | GB9400994D0 (en) |
MX (1) | MX9602543A (en) |
NO (1) | NO310059B1 (en) |
NZ (1) | NZ279516A (en) |
PT (1) | PT740554E (en) |
WO (1) | WO1995019795A1 (en) |
Cited By (23)
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WO1997039170A1 (en) * | 1996-04-12 | 1997-10-23 | Bristol-Myers Squibb Company | Composite fibres, wound dressings incorporating such fibres and a method for making same |
WO1997041900A1 (en) * | 1996-05-08 | 1997-11-13 | Innovative Technologies Limited | Hydrogels |
WO1998009664A1 (en) * | 1996-09-05 | 1998-03-12 | Acordis Fibres (Holdings) Limited | Wood dressings and manufacture thereof |
WO1998031402A2 (en) * | 1997-01-21 | 1998-07-23 | Smith & Nephew Plc | Dressings |
WO1998046818A1 (en) * | 1997-04-11 | 1998-10-22 | Bristol-Myers Squibb Company | Knitted wound dressings and method for making same |
US5941840A (en) * | 1997-08-16 | 1999-08-24 | Bristol-Myers Squibb Company | Multi-layered wound dressing |
WO1999064080A1 (en) * | 1998-06-08 | 1999-12-16 | Akzo Nobel Uk Limited | Yarns and wound dressings containing the same |
WO2002003898A1 (en) * | 2000-07-12 | 2002-01-17 | Bristol-Myers Squibb Company | Multi layered wound dressing |
US6548730B1 (en) | 1998-07-01 | 2003-04-15 | Acordis Speciality Fibres Limited | Wound dressings and materials suitable for use therein |
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WO1997039170A1 (en) * | 1996-04-12 | 1997-10-23 | Bristol-Myers Squibb Company | Composite fibres, wound dressings incorporating such fibres and a method for making same |
WO1997041900A1 (en) * | 1996-05-08 | 1997-11-13 | Innovative Technologies Limited | Hydrogels |
WO1998009664A1 (en) * | 1996-09-05 | 1998-03-12 | Acordis Fibres (Holdings) Limited | Wood dressings and manufacture thereof |
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WO1998031402A2 (en) * | 1997-01-21 | 1998-07-23 | Smith & Nephew Plc | Dressings |
WO1998031402A3 (en) * | 1997-01-21 | 1998-09-17 | Smith & Nephew | Dressings |
US6191335B1 (en) * | 1997-01-21 | 2001-02-20 | Smith & Nephew Plc | Dressings |
AU735211B2 (en) * | 1997-01-21 | 2001-07-05 | Smith & Nephew Plc | Dressings |
WO1998046818A1 (en) * | 1997-04-11 | 1998-10-22 | Bristol-Myers Squibb Company | Knitted wound dressings and method for making same |
AU719928B2 (en) * | 1997-04-11 | 2000-05-18 | Convatec Technologies Inc. | Knitted wound dressings and method for making same |
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WO1999064080A1 (en) * | 1998-06-08 | 1999-12-16 | Akzo Nobel Uk Limited | Yarns and wound dressings containing the same |
US6548730B1 (en) | 1998-07-01 | 2003-04-15 | Acordis Speciality Fibres Limited | Wound dressings and materials suitable for use therein |
US7799048B2 (en) | 2000-05-09 | 2010-09-21 | Arthrocare Corporation | Nasal packing device |
GB2370781A (en) * | 2000-07-12 | 2002-07-10 | Bristol Myers Squibb Co | Multi layered wound dressing |
GB2370781B (en) * | 2000-07-12 | 2004-05-12 | Bristol Myers Squibb Co | Multi layered wound dressing |
US6793645B2 (en) | 2000-07-12 | 2004-09-21 | Bristol-Myers Squibb Company | Multi-layered wound dressing |
WO2002003898A1 (en) * | 2000-07-12 | 2002-01-17 | Bristol-Myers Squibb Company | Multi layered wound dressing |
US7803980B2 (en) | 2000-07-12 | 2010-09-28 | Convatec Technologies Inc. | Multi-layered wound dressing |
US10391197B2 (en) | 2000-09-21 | 2019-08-27 | Convatec Technologies Inc. | Silver containing wound dressing |
US8728513B2 (en) | 2000-09-21 | 2014-05-20 | Convatec Technologies Inc. | Silver containing wound dressing |
US10010647B2 (en) | 2000-09-21 | 2018-07-03 | Convatec Technologies Inc. | Silver containing wound dressing |
US9345805B2 (en) | 2000-09-21 | 2016-05-24 | Convatec Technologies Inc. | Silver containing wound dressing |
US9066989B2 (en) | 2000-09-21 | 2015-06-30 | Convatec Technologies Inc. | Silver containing wound dressing |
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WO2007085391A1 (en) * | 2006-01-30 | 2007-08-02 | Carl Freudenberg Kg | Layer and use of a layer as a dressing for direct wound contact |
WO2012007363A1 (en) | 2010-07-12 | 2012-01-19 | Akzo Nobel Chemicals International B.V. | Cellulosic fibre composition |
GB2496310A (en) * | 2011-11-01 | 2013-05-08 | Brightwake Ltd | Yarn and textile material for wound dressings |
EP3351665A1 (en) * | 2011-11-01 | 2018-07-25 | Brightwake Limited | Gelling wound dressings |
WO2013064831A1 (en) * | 2011-11-01 | 2013-05-10 | Brightwake Limited | Wound dressings, and yarn useful therein |
GB2504873A (en) * | 2011-11-01 | 2014-02-12 | Brightwake Ltd | Three-dimensional textile material for wound dressings |
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EP3296436A1 (en) * | 2011-11-01 | 2018-03-21 | Brightwake Limited | Wound dressings, and fabric useful therein |
US9562305B2 (en) | 2011-12-01 | 2017-02-07 | Convatec Technologies Inc. | Yarn comprising gel-forming filaments or fibres |
AU2012343583B2 (en) * | 2011-12-01 | 2017-08-24 | Convatec Technologies Inc. | A yarn comprising gel-forming filaments or fibres |
WO2013079949A1 (en) * | 2011-12-01 | 2013-06-06 | Convatec Technologies Inc. | A yarn comprising gel-forming filaments or fibres |
US10968543B2 (en) | 2011-12-01 | 2021-04-06 | Convatec Technologies Inc. | Wound dressing for use in vacuum therapy |
WO2014009488A2 (en) | 2012-07-13 | 2014-01-16 | Laboratoires Urgo | Dressing having the controlled release of active agents |
US10172972B2 (en) | 2012-07-13 | 2019-01-08 | Laboratoires Urgo | Dressing having sustained release of active agents |
WO2014147339A1 (en) | 2013-03-20 | 2014-09-25 | Laboratoires Urgo | Dressing having an adhesive peripheral edge with an undulating circumference |
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WO2017153289A1 (en) | 2016-03-08 | 2017-09-14 | Urgo Recherche Innovation Et Developpement | Dressing suitable for sensitive skin |
WO2018011520A1 (en) | 2016-07-12 | 2018-01-18 | Urgo Recherche Innovation Et Developpement | Dressing enabling the controlled and prolonged release of metformin |
US20200141031A1 (en) * | 2017-06-27 | 2020-05-07 | Carl Freudenberg Kg | Hydrogel-forming multicomponent fiber |
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Also Published As
Publication number | Publication date |
---|---|
NO310059B1 (en) | 2001-05-14 |
GB9400994D0 (en) | 1994-03-16 |
EP0740554B1 (en) | 2003-04-02 |
DE69530180T2 (en) | 2004-01-08 |
NO962316L (en) | 1996-07-03 |
CA2179415A1 (en) | 1995-07-27 |
NZ279516A (en) | 1998-07-28 |
MX9602543A (en) | 1997-02-28 |
NO962316D0 (en) | 1996-06-05 |
DK0740554T3 (en) | 2003-07-07 |
FI115608B (en) | 2005-06-15 |
JPH09509590A (en) | 1997-09-30 |
CA2179415C (en) | 2006-08-08 |
ES2193190T3 (en) | 2003-11-01 |
US6471982B1 (en) | 2002-10-29 |
PT740554E (en) | 2003-06-30 |
FI962916A (en) | 1996-07-19 |
AU691245B2 (en) | 1998-05-14 |
DE69530180D1 (en) | 2003-05-08 |
ATE235925T1 (en) | 2003-04-15 |
EP0740554A1 (en) | 1996-11-06 |
AU1667395A (en) | 1995-08-08 |
FI962916A0 (en) | 1996-07-19 |
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