WO1995017508A3 - Glutamate receptor (or eaa receptor) polynucleotides and their uses - Google Patents

Glutamate receptor (or eaa receptor) polynucleotides and their uses Download PDF

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Publication number
WO1995017508A3
WO1995017508A3 PCT/CA1994/000705 CA9400705W WO9517508A3 WO 1995017508 A3 WO1995017508 A3 WO 1995017508A3 CA 9400705 W CA9400705 W CA 9400705W WO 9517508 A3 WO9517508 A3 WO 9517508A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
polynucleotides
eaa
unedited
edited
Prior art date
Application number
PCT/CA1994/000705
Other languages
French (fr)
Other versions
WO1995017508A2 (en
Inventor
Rajender Kamboj
Stephen Nutt
Original Assignee
Allelix Biopharma
Rajender Kamboj
Stephen Nutt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allelix Biopharma, Rajender Kamboj, Stephen Nutt filed Critical Allelix Biopharma
Priority to DE69434333T priority Critical patent/DE69434333T2/en
Priority to AT95904979T priority patent/ATE293162T1/en
Priority to JP7517070A priority patent/JPH09511901A/en
Priority to AU13770/95A priority patent/AU1377095A/en
Priority to EP95904979A priority patent/EP0741782B1/en
Priority to CA002179208A priority patent/CA2179208C/en
Publication of WO1995017508A2 publication Critical patent/WO1995017508A2/en
Publication of WO1995017508A3 publication Critical patent/WO1995017508A3/en
Priority to US08/666,221 priority patent/US6136544A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Dental Preparations (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Human CNS receptor-encoding DNA is provided from which more than one form of the receptor protein, an edited form and an unedited form, is expressed in vivo. The edited and unedited receptor forms are functionally distinct, and appear to be selectively expressed. Thus, a CNS receptor-encoding gene that is subject to such editing has value in screening compounds for potential therapeutic utility.
PCT/CA1994/000705 1993-12-23 1994-12-21 Glutamate receptor (or eaa receptor) polynucleotides and their uses WO1995017508A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE69434333T DE69434333T2 (en) 1993-12-23 1994-12-21 METHODS USING EAA3 OR EAA4 RECEPTORS
AT95904979T ATE293162T1 (en) 1993-12-23 1994-12-21 METHODS USING EAA3 OR EAA4 RECEPTORS
JP7517070A JPH09511901A (en) 1993-12-23 1994-12-21 Glutamate receptor (or EAA receptor) polynucleotides and uses thereof
AU13770/95A AU1377095A (en) 1993-12-23 1994-12-21 Glutamate receptor (or eaa receptor) polynucleotides and their uses
EP95904979A EP0741782B1 (en) 1993-12-23 1994-12-21 Methods using eaa3 or eaa4 receptors
CA002179208A CA2179208C (en) 1993-12-23 1994-12-21 Human cns receptor polynucleotides
US08/666,221 US6136544A (en) 1993-12-23 1996-06-20 Glutamate receptor (or EAA receptor) polynucleotides and their uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17218893A 1993-12-23 1993-12-23
US08/172,188 1993-12-23

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US17218893A Continuation-In-Part 1993-12-23 1993-12-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US08/666,221 Continuation-In-Part US6136544A (en) 1993-12-23 1996-06-20 Glutamate receptor (or EAA receptor) polynucleotides and their uses

Publications (2)

Publication Number Publication Date
WO1995017508A2 WO1995017508A2 (en) 1995-06-29
WO1995017508A3 true WO1995017508A3 (en) 1995-08-03

Family

ID=22626704

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1994/000705 WO1995017508A2 (en) 1993-12-23 1994-12-21 Glutamate receptor (or eaa receptor) polynucleotides and their uses

Country Status (8)

Country Link
US (1) US6136544A (en)
EP (1) EP0741782B1 (en)
JP (1) JPH09511901A (en)
AT (1) ATE293162T1 (en)
AU (1) AU1377095A (en)
CA (1) CA2179208C (en)
DE (1) DE69434333T2 (en)
WO (1) WO1995017508A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030185815A1 (en) * 2001-04-03 2003-10-02 Muralidhara Padigaru Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use
US20030134314A1 (en) * 2001-12-17 2003-07-17 Millennium Pharmaceuticals, Inc. Methods and compositions for treating hematological disorders using 252, 304, 1980, 14717, 9941, 19310 and 17832

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0568384A1 (en) * 1992-05-01 1993-11-03 Eli Lilly And Company Human glutamate receptor proteins and associated DNA compounds
EP0574257A2 (en) * 1992-06-10 1993-12-15 Biopharmaceuticals Inc. Allelix Amino-hydroxy-methyl-isoxazole-propionate binding human glutamate receptors
EP0578409A2 (en) * 1992-06-24 1994-01-12 Allelix Biopharmaceuticals Inc. Kainate-binding, human CNS (central nervous system) receptors of the EAA4 (excitatory amino acid) family
EP0617123A1 (en) * 1992-12-11 1994-09-28 Allelix Biopharmaceuticals Inc. Kainate-binding, human CNS receptors of the EAA3 family

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56128919A (en) * 1980-03-14 1981-10-08 Matsushita Electric Ind Co Ltd Manufacture of picture display panel
JPS6355529A (en) * 1986-08-25 1988-03-10 Nec Corp Active matrix liquid crystal display device and its production
JPS63101831A (en) * 1986-10-17 1988-05-06 Nec Corp Active matrix liquid crystal display device and its manufacture
JP2580617B2 (en) * 1987-09-09 1997-02-12 セイコーエプソン株式会社 Liquid crystal device
JP2979196B2 (en) * 1990-09-05 1999-11-15 セイコーインスツルメンツ株式会社 Semiconductor substrate device for light valve and method of manufacturing the same
JP3062698B2 (en) * 1990-09-25 2000-07-12 セイコーインスツルメンツ株式会社 Single crystal thin film semiconductor device for light valve substrate
JPH04133034A (en) * 1990-09-25 1992-05-07 Seiko Instr Inc Single crystal thin film semiconductor device for optical valve substrate
JP3103981B2 (en) * 1990-09-07 2000-10-30 セイコーインスツルメンツ株式会社 Semiconductor single crystal substrate liquid crystal panel device
JP3124303B2 (en) * 1991-02-16 2001-01-15 セイコーインスツルメンツ株式会社 Semiconductor device and manufacturing method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0568384A1 (en) * 1992-05-01 1993-11-03 Eli Lilly And Company Human glutamate receptor proteins and associated DNA compounds
EP0574257A2 (en) * 1992-06-10 1993-12-15 Biopharmaceuticals Inc. Allelix Amino-hydroxy-methyl-isoxazole-propionate binding human glutamate receptors
EP0578409A2 (en) * 1992-06-24 1994-01-12 Allelix Biopharmaceuticals Inc. Kainate-binding, human CNS (central nervous system) receptors of the EAA4 (excitatory amino acid) family
EP0617123A1 (en) * 1992-12-11 1994-09-28 Allelix Biopharmaceuticals Inc. Kainate-binding, human CNS receptors of the EAA3 family

Also Published As

Publication number Publication date
ATE293162T1 (en) 2005-04-15
DE69434333T2 (en) 2006-03-09
JPH09511901A (en) 1997-12-02
DE69434333D1 (en) 2005-05-19
EP0741782A1 (en) 1996-11-13
CA2179208C (en) 2003-05-27
CA2179208A1 (en) 1995-06-29
AU1377095A (en) 1995-07-10
US6136544A (en) 2000-10-24
EP0741782B1 (en) 2005-04-13
WO1995017508A2 (en) 1995-06-29

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