Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/22—Peroxides; Oxygen; Ozone
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/24—Phosphorous; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
  • A61K8/66—Enzymes
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
  • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures

Definitions

• This invention relates to a system for whitening natural teeth and dental prostheses.
• the whitening is achieved through the use of an alkali metal tripolyphosphate at about between 5 to 25 percent by weight in a dentally acceptable carrier when used alone.
• the polyphosphate can be combined with a compound which provided active oxygen and/or an enzymatic hydrolytic agent; the polyphosphate may be present in 1 to 25 percent by weight when combined with one or both of these agents. Any orally acceptable presentation, or one suitable for dental prostheses, can be utilized in this invention.
• comestibles can stain or discolor tooth enamel, tea being one example of a beverage where the tannins in the tea deposit on the tooth enamel.
• Some medicinal agents may cause staining or discoloration via entrapment, though this is not a usual common cause of this type of staining.
• Proteolytic enzymes are the catalyst of choice, particularly papain.
• a second active such as a citric acid salt has been used by at least one manufacturer. These products are presented in a paste or gel. They claim to whiten teeth by removing the plaque which has entrapped the stain.
• This invention provides a unique alternative. It utilizes a alkali metal tripolyphosphate salt, optionally with a peroxide and/or a hydrolytic agent, to effect stain removal and whiten tooth enamel.
• a source of active oxygen means material containing an O-O bond which can break down to give an active oxygen specie(s).
• the peroxides and hydroperoxides are preferred for use in this invention.
• preferred peroxides are inorganic peroxides such as hydrogen peroxide, the alkali metal percarbonates such as sodium, potassium and calcium percarbonate; sodium, calcium, strontium, barium, zinc or magnesium peroxide, and the perborates.
• inorganic compounds which contain hydrogen peroxide of crystallization such as 2 Na2C ⁇ 3-3H2 ⁇ 2 and Na4P2 ⁇ 7./--H2 ⁇ 2 can be used.
• several organic peroxides can be used herein.
• certain enzymes may be combined with the active oxygen component to provide a dentifrice with three actives.
• Oxidizing agents such as peroxides degrade enzyme, inactivate them, rather rapidly. But it has been found that the rate of degradation for certain enzymes is not so rapid that they lose all hydrolytic effectiveness immediately, e.g. in less than a minute. And it has been found that this residual activity is sufficiently high to provide for protein and other stain hydrolysis over five to ten minutes. Since the methods of this invention will normally be carried out over one to ten minutes, the invention also contemplates a tripartite preparation combining the tripolyphosphate, a source of active oxygen and a hydrolytic agent which retains useful activity within this time frame. These relatively stable enzymes are termed peroxide-active enzymes herein.
• an effective amount of enzyme is to be used in the practice of this invention.
• the amount of enzyme required to make an effective dentifrice will depend on several factors, including the inherent activity of the enzyme, pH, salt concentration, and if combined with a peroxide, its susceptibility to attack by peroxides.
• the working formulation should contain sufficient enzyme to provide between about 0.001 to 5 Anson units of activity, preferably betweenabout 0.01 and 1 Anson units, per single treatment. Higher or lower amounts may be used.
• Tooth Whitening Toothpaste A toothpaste representative of what may be prepared for the practice of this invention was prepared as per the ingredient profile and percentages in Tables I and ⁇ .
• Tooth whitening was measured by the following process: Whitening was determined using a modification to a system normally employed in the dental arts for determining the abrasivity of dentifrices.
• Bovine jaws were obtained at a local abattoir and the teeth were extracted in their native state; no pre-cleaning was done. Teeth were mounted in a cap with dental acrylic so as to fit the format of a colorimeter and the brushing instrument; a detailed description is given below.
• An initial brushing was done with a slurry of Crest Regular toothpaste and an Oral B40, medium bristle, toothbrush. Then an initial L value was determined on a colorimeter (Hunter). This was designated as the initial whiteness value.
• the wear tester device was manufactured by Rame-Hart, of Mountain Lakes, New Jersey. This machine has often been used to test the abrasivity of dental preparations. Tooth brushes were mounted and the teeth and brushes aligned.
• a 1:3 slurry of paste and water was poured into the trays and brushing commenced for a total of six hours. The slurry was replaced hourly. At 3 and 6 hours L value determinations were made. This was done by first rinsing the teeth with deionized water, then placing them in a closed container at 100% humidity for 1 hours, then taking a reading on the colorimeter to obtain a 3 hour and 6 hour L value.

Landscapes

• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Veterinary Medicine (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Chemical & Material Sciences (AREA)
• Inorganic Chemistry (AREA)
• Emergency Medicine (AREA)
• Cosmetics (AREA)

Priority Applications (12)

Applications Claiming Priority (2)

Related Child Applications (1)

Publications (1)

Family

ID=22625182

Family Applications (1)

Country Status (18)

Cited By (16)

Families Citing this family (4)

Citations (7)

Family Cites Families (6)

• 1994
  • 1994-12-19 SG SG9603496A patent/SG83636A1/en unknown
  • 1994-12-19 WO PCT/US1994/014662 patent/WO1995017158A1/en not_active Application Discontinuation
  • 1994-12-19 CN CN94194840A patent/CN1145583A/zh active Pending
  • 1994-12-19 BR BR9408494A patent/BR9408494A/pt not_active Application Discontinuation
  • 1994-12-19 HU HU9601702A patent/HU219711B/hu not_active IP Right Cessation
  • 1994-12-19 EP EP95905431A patent/EP0735855A4/en not_active Withdrawn
  • 1994-12-19 AU AU14047/95A patent/AU697576B2/en not_active Ceased
  • 1994-12-19 UA UA96062413A patent/UA44720C2/uk unknown
  • 1994-12-19 CA CA002179317A patent/CA2179317A1/en not_active Abandoned
  • 1994-12-19 NZ NZ278531A patent/NZ278531A/xx unknown
  • 1994-12-19 SK SK790-96A patent/SK79096A3/sk unknown
  • 1994-12-19 RU RU96115202A patent/RU2139037C1/ru active
  • 1994-12-19 JP JP7517549A patent/JPH09507481A/ja active Pending
  • 1994-12-19 CZ CZ19961821A patent/CZ288821B6/cs not_active IP Right Cessation
  • 1994-12-22 EG EG81294A patent/EG20733A/xx active
  • 1994-12-22 ZA ZA9410247A patent/ZA9410247B/xx unknown
• 1996
  • 1996-06-18 NO NO962581A patent/NO962581L/no not_active Application Discontinuation
  • 1996-06-20 FI FI962588A patent/FI962588A/fi unknown

Patent Citations (7)

Non-Patent Citations (1)

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