WO1995014377A3 - Modele pour maladies infectieuses - Google Patents

Modele pour maladies infectieuses Download PDF

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Publication number
WO1995014377A3
WO1995014377A3 PCT/IB1994/000417 IB9400417W WO9514377A3 WO 1995014377 A3 WO1995014377 A3 WO 1995014377A3 IB 9400417 W IB9400417 W IB 9400417W WO 9514377 A3 WO9514377 A3 WO 9514377A3
Authority
WO
WIPO (PCT)
Prior art keywords
sepsis model
model
mammal
sepsis
double
Prior art date
Application number
PCT/IB1994/000417
Other languages
English (en)
Other versions
WO1995014377A2 (fr
Inventor
Suk-Man Yeung Rae
W Mak Tak
Original Assignee
Amgen Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Canada Inc filed Critical Amgen Canada Inc
Priority to EP95901576A priority Critical patent/EP0734201A1/fr
Priority to JP7514946A priority patent/JPH09500025A/ja
Priority to AU10758/95A priority patent/AU1075895A/en
Publication of WO1995014377A2 publication Critical patent/WO1995014377A2/fr
Publication of WO1995014377A3 publication Critical patent/WO1995014377A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Mammifère non humain doublement transgénique, et à double expulsion de gène endogène, qui sert de modèle pour évaluer des traitements thérapeutiques ou préventifs de maladies infectieuses.
PCT/IB1994/000417 1993-11-29 1994-11-28 Modele pour maladies infectieuses WO1995014377A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP95901576A EP0734201A1 (fr) 1993-11-29 1994-11-28 Modele pour maladies infectieuses
JP7514946A JPH09500025A (ja) 1993-11-29 1994-11-28 敗血症モデル
AU10758/95A AU1075895A (en) 1993-11-29 1994-11-28 Sepsis model

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15867793A 1993-11-29 1993-11-29
US08/158,677 1993-11-29

Publications (2)

Publication Number Publication Date
WO1995014377A2 WO1995014377A2 (fr) 1995-06-01
WO1995014377A3 true WO1995014377A3 (fr) 1995-08-31

Family

ID=22569210

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1994/000417 WO1995014377A2 (fr) 1993-11-29 1994-11-28 Modele pour maladies infectieuses

Country Status (5)

Country Link
EP (1) EP0734201A1 (fr)
JP (1) JPH09500025A (fr)
AU (1) AU1075895A (fr)
CA (1) CA2175250A1 (fr)
WO (1) WO1995014377A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827302B1 (fr) * 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
F. P. GILLESPIE ET AL.: "Tissue-specific expression of human CD4 in transgenic mice", MOLECULAR CELLULAR BIOL., vol. 13, no. 5, pages 2952 - 2958 *
MARCO W. SCHILHAM ET AL.: "Alloreactive cytotoxic T cells can develop and fumction in mice lacking both CD4 and CD8", EUROP. J. IMMUNOLOGY, vol. 23, pages 1299 - 1304 *
MARCO W. SCHILHAM ET AL.: "CD8 is needed for development of cytotoxic T cells but not helper T cells", CELL, vol. 65, 3 May 1991 (1991-05-03), CAMBRIDGE, pages 443 - 449 *
NIGEL KILLEEN: "Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4", EMBO JOURNAL, vol. 12, no. 4, OXFORD, pages 1547 - 1553 *

Also Published As

Publication number Publication date
WO1995014377A2 (fr) 1995-06-01
CA2175250A1 (fr) 1995-06-01
AU1075895A (en) 1995-06-13
EP0734201A1 (fr) 1996-10-02
JPH09500025A (ja) 1997-01-07

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