WO1995014076A1

WO1995014076A1 - Concentrated surfactant compositions

Info

Publication number: WO1995014076A1
Application number: PCT/EP1994/003726
Authority: WO
Inventors: Neil Colin Bednall; Michael Blezard; Christopher Healy; Anthony Martin
Original assignee: Albright & Wilson Limited
Priority date: 1993-11-13
Filing date: 1994-11-11
Publication date: 1995-05-26
Also published as: CA2153900A1; GB9323449D0; EP0679180A1; NZ275820A; PL309892A1; HK1005778A1; JPH08505900A; AU8107494A; PL178957B1; CN1117741A; AU678312B2

Abstract

Aqueous, mobile, concentrated, amphoteric surfactant compositions consist substantially of: 5 % to 45 % by weight water, at least 36 % to 70 % by weight of amphoteric surfactant and 5 to 45 % of a water miscible, non-surfactant organic solvent, said compositions being in the 'G' or 'L1' phase.

Description

θDfK--eπtrated Surfactant ryrirositions

The present invention relates to novel, concentrated aqueous surfactant compositions, in particular to amphoteric surfactant compositions which are mobile or pumpable at high concentrations of active ingredient. Such compositions are prepared in the presence of a phase modifier, thus allowing the preparation of such compositions over a wider range of active concentrations than has hitherto been possible. More specifically, the present invention relates to a novel method for the production of particular concentrated amphoteric surfactant compositions, especially betaines and fatty imidazoline derivatives, wherein preparation of such surfactants or surfactant compositions utilises a non-surfactant organic solvent as a phase modifier.

The preferred betaines according to the present invention, are N-carboxymethylated derivatives of tertiary amine intermediates possessing at least one fatty alkyl chain e.g. cocoamido propyl betaine (CAPB) , sulphobetaines, phosphobetaines, and hydroxysulphobetaines, and N-carboxymethylated derivatives of amidoamines e.g. produced by the hydrolysis of imidazolines and especially of imidazolines having an alkyl and a hydroxyalkyl chain e.g. N-carboxymethylated lauric hydroxyethyl imidazoline (CL-HI) .

TECHNICAL BACKGROUND

Amphoteric surfactants incorporate electropositive and electronegative elements in the same molecule, allowing for the formation of salts in either acidic or alkaline conditions. Amphoteric surfactants are generally gentle on the skin and eyes, exhibit low toxicity, and are very effective as mild surfactants. Furthermore, developments in the detergent and personal hygiene product areas have become increasingly focused on derivatives of naturally- occurring raw materials, such as natural fats and oils, because of the environmental and toxicological advantages such derivatives offer over more conventional raw feedstocks.

Surfactant compositions are prepared and sold for a wide variety of industrial and domestic applications. They are often required in a fluid form, and it is therefore often desirable that they should contain as high a proportion of active material as possible, whilst retaining mobility in order to reduce the costs of storage and transport.

Where the surfactant composition has a melting point below, or only slightly above ambient temperature it is sometimes possible to supply the surfactants in the form of an anhydrous composition, or a composition containing up to about 5% of water, respectively. In the latter case the trace of water appears to act as a melting point depressor.

However, in the case of surfactant compositions which are solid at temperatures above about 25°C, it has often been impossible to obtain a fluid composition at concentrations above about 30 to 40% by weight of active ingredient, depending on the nature of the composition. Small amounts of water up to about 10% do not depress the melting point sufficiently, while larger amounts, sufficient to cause a phase change result in the formation of a rigid gel, rather than a fluid solution. It has generally been found that as the total concentration of active ingredient in a dilute solution approaches a critical level, which is usually about 30% by weight, or in the case of some mixtures may be somewhat higher, e.g. up to about 55% by weight, the viscosity of the solution begins to rise, causing difficulty in the preparation and handling of the compositions. At or around a critical concentration level the solution sets into an immobile gel, or phase separation occurs.

It is sometimes possible to increase the concentration of active ingredient stably incorporated into a solution by the addition of viscosity modifiers or cosolvents. These additives act as thinners, both lowering the viscosity of the solution and inhibiting the formation of gels, so that higher concentrations may be attained. However such cosolvents, for example alcohols, may be effective in producing substantial increases in the attainable concentration of the surfactant composition having an acceptable viscosity, only when they are present in such large amounts that may adversely affect the properties of the product for many of its desired end uses and/or increase the cost of the product.

It is known (see for example "Advances in Colloid Interface Science" 1 (1967) 79-110 pp. 82-83) that many surfactant compounds or mixtures are capable of forming highly viscous, non-pumpable liquid crystal phases. Some of these compounds or mixtures form a phase of relatively low viscosity compared with other liquid crystal phases, which is usually referred to as the "G" or "lamellar phase" and which forms only within a specific concentration range. The "G" phase is a pumpable fluid which is formed over a narrow range of concentrations which range usually lies between 40% and 85% by weight of active ingredient and is characterised by a lamellar structure in which the surfactant molecules are associated to form plates of indefinite size separated by planes of water molecules. However, in the few cases of the amphoteric surfactants where the existence of a "G" phase has been reported, it can only be formed at elevated temperatures, or over a concentration range so narrow as to be of no practical use. - A -

It is known in the art that certain surfactants of commercial value e.g. some ammonium alkyl sulphates and some olefin sulphonates form "G" phases at ambient temperature, and are now prepared in a fluid form at very much higher concentrations than could previously have been achieved. (See for example GB Patent No. 1,488,352.)

Mixtures of surfactants tend to form fluid "G" phases at relatively low temperatures compared with the typical minimum temperatures at which aqueous solutions of most individual surfactants (which are capable of forming "G" phases) can exist in such a phase. Usually mixtures can be obtained as a fluid "G" phase at ambient temperatures or by slight warming, whereas individual surfactants are typically much more difficult to obtain as "G" phases.

Typically, when a composition of the surfactants according to the present invention is prepared in aqueous solutions of increasing concentration, the molecules are first found to associate in spherical clusters (micelles) , which with increasing concentrations become rod-like. With increasing concentration, the micelles become more crowded, resulting in a rise in the viscosity of the solution and, with the great majority of cases, said micelles eventually lengthening to form a regular hexagonal array of cylindrical surfactant micelles in an aqueous medium, usually referred to as the rigid "M₁" liquid crystal phase. If the concentration of a surfactant in the "M " phase is progressively increased, a phase change occurs to produce either a hydrated solid phase, or, in the case of certain surfactant mixtures containing one or more surfactants of this invention, to convert the M phase progressively to a fluid "G" phase until a viscosity minimum is reached. Further increasing the concentration of the "G" phase results in an increase in viscosity, and ultimately to a further phase change, producing either an hydrated solid or a second immobile liquid crystal phase (the M phase) which resembles the M phase in structure, but wherein the structure is inverted - i.e. with water as the internal phase and the surfactant as the continuous phase.

The foregoing description is however somewhat simplified. The term "hydrated solid phase" has been used broadly to include those systems which comprise suspensions of solid or immobile gel phases in one or more viscous or gel phase to provide a more or less rigid material usually having a granular appearance under a polarising microscope. No one surfactant has been found which will form all of the various liquid crystal phases.

The following terms may require explanation or definition in relation to the different phases discussed in this specification: "Optically isotropic" phases do not tend to rotate the plane of polarisation of plane polarised light. If a drop of sample is placed between two sheets of optically plane polarising material whose planes of polarisation are at right angles, and light is shone on one sheet, optically isotropic samples do not appear substantially brighter than their surroundings when viewed through the other sheet. Optically anisotropic materials however appear substantially brighter. Optically anistropic esophases typically show characteristic textures when viewed through a microscope between crossed polarisers, whereas optically isotropic phases usually show a dark, essentially featureless continuum.

Newtonian liquids have a viscosity which is independent of shear. For the purposes of this specification, liquids are considered Newtonian if the viscosity does not vary substantially at shear rates up to 1000 -1 L -phases are mobile, optically isotropic, and typically Newtonian liquids which show no texture under the polarising microscope. Electron microscopy is capable of resolving texture only at very high magnifications. The viscosity of an L -phase is usually low, but may rise significantly as the concentration approaches the upper phase boundary. This is believed to reflect a change in the shape of the micelles from spherical to prolate.

G-phases are pourable, thixotropic, anisotropic products. They are typically viscous-looking, opalescent materials with a characteristic "smeary" appearance on flowing. They form characteristic textures under the polarising microscope.

M-phases are typically immobile, anisotropic products resembling waxes. They give characteristic textures under the polarising microscope.

The "G" phase or "L " phase can be located very rapidly and easily, using standard laboratory equipment, by placing a sample of the test composition (at the active concentration estimated to produce a "G" or "L " phase) on a slide on the block of a heated stage microscope. Examination between crossed polarisers will reveal in which phase the sample is present. The various phases each have a characteristic appearance which is easily identified by comparison, for example with the photographs of typical liquid crystal phases in the classic paper by Rosevear, JAOCS Vol 31 P 628 (1954) or in J. Colloid and Interfacial Science, Vol 30 No 4 P 500.

If the mixture is in a M phase, water may be allowed to evaporate from the edges of the sample under the cover disk and any phase resulting changes observed. If an M„ phase or hydrated solid is present water may be added around the edge of the cover disks and allowed to diffuse into the composition, both of which may alter the active concentration of the sample under investigation, by an amount sufficient to produce a "G" phase. If no "G" phase is located in this way samples may be heated progressively on the block and the operation repeated.

The term "active concentration" as used herein refers to the total concentration of surface active material in the total aqueous surfactant composition.

THE PROBLEM

A particular requirement exists for mobile, pumpable concentrated aqueous amphoteric surfactant compositions, in order to reduce transport and storage costs. This need is increased by the growing trend towards the use of amphoteric surfactant compositions in applications where mildness is considered an important feature of the surfactant.

A further requirement exists for the production of amphoteric surfactants "in situ" to produce a mobile, pumpable, concentrated surfactant composition at high concentrations of active ingredient that hitherto were unattainable.

Previously at the levels of active ingredients described according to the present invention, such compositions would typically have been an immobile gel (M-^phase) with poor dilution characteristics, causing significant problems in preparation and handling.

PRIOR ART

Aπphoteric surfactant coirpositions, for example CAPB and CL-HI, have hitherto only been obtainable as liquid compositions at concentrations of less than approximately 30% w/w active ingredient, based on the total weight of the composition. At more commercially desirable concentrations (eg. up to about 50% w/w active ingredient) the coirpositions are typically sticky, very viscous or immobile, and difficult to handle, requiring where possible expensive spray-drying in order to achieve a commercially acceptable powdered product. However, because of the finely divided nature of the powder, this also presents handling difficulties and, moreover may entail health risks.

THE INVE.NTIQN

We have discovered that by preparing solutions of individual surfactants in the presence of small amounts of water soluble non-surface active solvent at the particular active concentration corresponding to the formation of the "G" phase or "L " phase we have been able to obtain puπpable, mobile surfactant compositions at active concentrations which are in excess of those that have hitherto been attainable. This gives rise to substantial savings in the cost of transporting and storing the products.

Generally, and unexpectedly, dilution of the concentrated compositions back to conventional concentrations in many instances presents no particular technical difficulties with the coirpositions exhibiting little or no tendency to form an intermediate gel phase on addition of sufficient water to effect such dilution.

We have further discovered that by controlling the non-surfactant organic solvent:water ratio in the reaction medium it is possible to produce concentrated aqueous surfactant compositions in either an "L " phase or "G" phase, both phases being mobile and puπpable, at concentrations of active ingredients that hitherto in the absence of the aforementioned solvent, typically produced 'M ' phase coirpositions. Although the ratio of solvent:water required to obtain either an "L " or

"G" phase composition will vary according to the particular active ingredients in question "L " phase composition is more likely to be formed in a reaction medium having an excess of water, and a "G" phase composition is more likely to be formed in a reaction medium having an excess of solvent. However, this is only a generalisation, the exact ratio for the reaction medium being dependent upon the active ingredients cσπprising said surfactant system.

STKΓEMEWΓ OF PJ E-NIT-ON

The present invention provides aqueous, mobile, concentrated, amphoteric surfactant compositions, consisting substantially of at least 5% and not more than 45% by weight of water, preferably not more than 40%; at least 30% by weight of amphoteric surfactant, preferably 35 to 70%; and 5 to 45% of a water-miscible, non-surfactant organic solvent, wherein said composition is a "G" phase and the concentration of surfactant in said composition corresponds to that at which the composition can exist, at least predominantly, in the "G" phase.

The present invention further provides aqueous, mobile, concentrated amphoteric surfactant coirpositions, consisting essentially of at least 5% and not greater than 65% by weight of water, preferably 10% to 60%; at least 25% by weight of amphoteric surfactant, preferably 30% to 70%; 5% to 45% of a water miscible, non-surfactant organic solvent, wherein said composition is an "L " phase.

The amphoteric surfactants may for example comprise a compound of the formula:-

R [C0NH(CH₂)_χ]_y[0(CH₂)_χ]_z

Wherein R is an alkyl, alkenyl, alkyla idoalkyl, al-kenylamidoalkyl, alk(en)yl polyoxyalkylene or alkaryl group having in each case a C„_ C₂₂

Straight or branched chain aJ-k(en)yl group or may be combined with R. to

1 . form a cyclic group, , x = 0 to 8, y = 0 or 1, z = 0 to 20, R is H or a

C.-Cr. straight or branched chain alkyl, alkenyl or hydroxyalkyl group or may be combined with R or R- to form a cyclic group, R- is H or a C, C, straight or branched chain alkyl, alkenyl or hydroxyl group, or may be absent or may be combined with R to form a cyclic group, X is nitrogen or phosphorus n is from 1 to 3 and A is 000 , SO or PO H .

The composition of the present invention may be prepared by reacting a secondary or tertiary amine:-

R[O0NH(CH₂)_χ]_y[O(CH₂)_χ]₂

*2

wherein R, R. and R^ are as hereinabove defined, with a carboxymethylating agent in the presence of the appropriate proportions of the non-surfactant water-miscible solvent and water.

Typically the amphoteric surfactant may be a derivative of a fatty imidazoline such as (for example) an N-hydroxyethyl fatty alkyl imidazoline.

Compositions of our invention may be prepared by:

(i) adding a chloroacetate ester to a secondary or tertiary amine to produce an ester of formula: R[OONH(CH₂)_χ]_y[0(CH₂)_χ]₂

CH₂000R₄

*2 CI

Wherein R, R- , R_ are as hereinabove defined and R is a C- to C alkyl group, and

(ii) said quaternised amine is subsequently saponified with an aqueous base e.g. sodium hydroxide, to produce the betaine.

The coirpositions of the present invention preferably contain at least 30% by weight of the amphoteric surfactant, preferably at least 33%, e.g. at least 35%, such as 45%, all percentages being based upon the total weight of said composition.

It is an especially preferred feature of the present invention that said betaine aπphoteric surfactants are prepared from alkylamido dimethyl amines, alkyldimethylamines or fatty acid hydroxethyl imidazoline.

It is a preferred feature that any fatty imidazolines used comprise a ^C8~^C22 ^al}Y¹ group' especially a C₁₀- ₁₈ alkyl group, and a C to C hydroxyalkyl group, especially a C -0. hydroxyalkyl group. For example the fatty imidazoline derivatives may be derived from lauryl hydroxyethyl imidazoline. KE-ACTION MEDHW

The organic solvents used to produce the reaction medium according to the present invention are non-surface active and miscible with water in some or all proportions.

Organic solvents suitable for use according to the present invention include water soluble onohydric alcohols e.g. C -C monohydric alcohols; water soluble diols e.g. C -C glycols such as ethylene glycol, propylene glycol, and hexylene glycol; water soluble polyglycols e.g. polyethylene glycol and polypropylene glycol; water soluble polyhydric alcohols e.g. glycerol, polyglycerols, and pentaerythritol; water soluble ethoxylated C alcohols, e.g. dipropylene glycol monomethylether.

Especially preferred organic solvents, according to the present invention, are propylene glycol, polyethylene glycol, dipropylene glycol monomethy1 ether and/or glycerol.

The ratio of water-soluble, non-surface active organic solvent:water in said reaction medium is from 1:10 to 10:1, dependent upon the desired phase and viscosity of the resultant surfactant composition.

Said solvents may be present in the composition in a ratio of solvent: water such that the surfactant is present in an "L " phase or in a "G" phase. Typically an excess of solvent e.g. 60/40 w/w ratio of propylene glycol:water is required in the preparation of amphoteric surfactants, e.g. betaines, to produce a "G" phase, and an excess of water e.g. a 15/85 w/w ratio of propylene glycol:water is required in the preparation of amphoteric surfactants, e.g. imidazoline derivatives, to produce an "L " phase, where in the absence of solvent an immobile or high viscosity coirposition would result.

Typically, said solvent is present in said coirposition at levels not exceeding 75%, usually between 5% and 65% based on the total weight of the composition, preferably 7%-40%. The percentage of said solvent, and its ratio to water, is adjusted according to the phase behaviour of the particular amphoteric surfactant, to provide a composition comprising essentially amphoteric surfactant, organic solvent and water, said composition being an "L " phase or a "G" phase at ambient temperature.

The level of reaction medium in the composition is typically greater than 35% by weight and less than 70% by weight of the composition, e.g. 40-65% dependent upon the nature of the active ingredients.

HttPA-AT-EON OF OCMPOSTTIONS

The coirpositions according to the present invention may be prepared by mixing an appropriate quantity of an amphoteric surfactant, which in the absence of the reaction medium according to the present invention would typically produce an immobile or high viscosity gel, with the correct proportion of water, and water miscible, non-surface active organic solvent, in order to obtain a surfactant composition in the "L " phase, or the "G" phase.

It is also possible to prepare the composition containing the active ingredients in a phase other than the "G" phase or "L " phase and adjust the water content of said coirposition by evaporation from, or diffusion into the mixture. The last method is not, however, usually practicable on an industrial scale. Alternatively, the coirposition of the present invention may be prepared by the production of the amphoteric surfactant directly in the solvent/water medium, i.e. in situ. In such cases the proportions of solvent:water in said medium are sufficient to be capable of producing a composition in the "G" phase or "L " phase.

cart-c-xyπiet-hylat-ion of amines to produce amphoteric surfactants

Frequently used carboxymethylation agents include those agents such a methyl acrylate, ethyl acrylate, acrylic acid, 2-hydroxy-l,3-propane sultone, 3-chloro-2-hydroxypropane sulphonic acid, 1,3-propane sultone, alkyl chloroacetate, and especially sodium chloroacetate. With the last, preferred carboxymethylating agent, alkylations may be carried out either neat, in inert solvents or, in aqueous solution.

Sufficient water should be present in the solvent medium to avoid the risk of substantially carboxymethylating the solvent.

Any suitable amount of-carboxymethylating agent may be added to the reaction medium, typically being the minimum amount required to substantially carboxylate the amine.

The carboxylate may be neutralised to produce the amphoteric surfactant by treatment with any suitable neutralising agent, for example alkali or alkaline earth metal hydroxides e.g. NaOH.

The temperature of the carboxymethylation reaction may be between ambient and 120°C such that degradation of the amine or the amphoteric surfactant does not occur e.g. 35°C-90°C, especially 50°C-80°C. The carboxymethylation reaction may be carried out over a period of 0.5 to 24 hours dependent upon the temperature of the reaction mixture and the degree of carboxymethylation required e.g. 5 to 20 hours, such as 12 to 18 hours.

Typically the reaction mixture may have a 10% aqueous solution pH of 7 to 14, e.g. 9 to 12.5, such as 10 to 12.

At the completion of the carboxymethylation reaction to produce an amphoteric surfactant composition, said composition typically has a solids content of 30-60% w/w, e.g. 35-55% and is either an "L " phase or "G" phase dependent upon the reaction medium employed and the active ingredients in question.

VISCOSITY CHΆRAC ERΓSΓΓCS

It is preferred that the compositions of the present invention, whilst being mobile, have a viscosity at ambient temperature such that they may be pumped at a rate sufficient to facilitate easy handling of the coirpositions.

Typically, the compositions of the present invention have viscosities in the range 400 to 15,000 centipose (cps), preferably 600 to 7000 cps, most preferably 700 to 6000 cps at ambient temperature.

Usually the coirposition is puπpable at concentrations within a range of + 10%, active ingredient preferably + 5% e.g. + 2.5% of the minimum viscosity concentration. This range tends to be broader at more elevated temperatures. The viscosity of compositions of the present invention may be determined by any suitable method e.g. Brookfield Viscometer or controlled shear/stress rheσmeter.

OPTIONAL IWGRE IE-WrS

The compositions of the present invention may contain minor amounts of non-colloidal electrolytes such as sodium chloride or sodium sulphate. Such inclusions may be present as impurities from the feedstocks used during the manufacture of the component, or may be generated as by-products if the surfactant is manufactured in-situ. However, the presence of organic salts or similar non-colloidal electrolyte is undesirable, often resulting in an increase in the viscosity of the fluid "G" phase, and in the case of chloride salts may ultimately lead to problems of corrosion. We therefore prefer that the proportion of non-surface active electrolyte present in the coirpositions of the present invention is below 10% and more preferably below 5% by weight of the active mixture, preferably below 5% by weight of the total compositions. However, there are certain circumstances in which the presence of some electrolyte may be useful, e.g. when the melting point of the "G" phase is slightly above ambient temperature, and an increase in the electrolyte content of the coirposition may depress the melting point sufficiently to obtain a pumpable "G" phase without heating.

In such circumstances it may sometimes be desirable to deliberately add up to about 6% by weight of a non-colloidal electrolyte, e.g. sodium chloride, sodium sulphate, sodium acetate or sodium citrate.

The coirpositions of our invention may further optionally contain minor amounts, e.g. up to 5% by weight of the active mixture, of surface active material other than those specified herein. USES OF THE AMPHOTE-RIC SURFACTANT α.-MFOSrπClNS

Typically, the amphoteric surfactants of the present invention, may be formulated into surfactant compositions which may additionally comprise, for example, other surfactants or synergists, antiperspirants, deodorants, lanolin or other skin softening or moisturising preparation, analgesics, antiseptics, emulsifiers, dispersants, soaps, polymeric thickening agents, wetting agents, foam controlling agents, perfumes and colouring.

The amphoteric surfactants of the present invention are especially suitable for inclusion into the personal care products, where the mild nature of such surfactants is especially desirable.

EXAMPLES

The invention will be further illustrated by way of the following examples:-

Example 1 : The preparation of cocoamido propyl betaine (CAPB) in propylene glycol:water 60/40 w/w reaction medium

CAPB was prepared in-situ in a 60/40 w/w mixture of propylene glycol:water. Water (581.6g), propylene glycol (1556.4g), 80% aqueous monochloroacetic acid solution (781.2g) , 47% aqueous NaOH solution (394.0g) and coco amidopropyl dimethylamine (2000.Og) were mixed and heated to 80°C. After the initial charging of the reactants, the pH of the reaction mixture was adjusted to 9.0 using NaOH solution (I72.0g), with the reaction mixture being a clear, pale yellow liquid. No viscosity 'hump' characteristic of such preparations not using the reaction medium of the present invention was noted over this initial stage. The mixture was further heated at 80°C whilst maintaining the pH between 9.0-9.5 by addition of NaOH solution (100.Og in total) As the reaction progressed, the mixture became increasingly turbid, especially at room temperature, with the mixture eventually becoming properly turbid at 50°C. The total reaction time was approximately 20 hours, with one addition of 80% monochloroacetic acid solution (7.5g) being made to lower the free amidoamine content. The pH of the final product was lowered to 5.1 by addition of CH SO .

Analysis:

% W/W

CAPB Active matter 40.2

Sodium chloride 7.0

Propylene glycol 30.7

Water 22.8

Free amidoamine 0.43

Sodium monochloroacetate <25ppm

Free fatty acid 0.45

Sodium sulphate 0.30

Formaldehyde 0.03

Total active level (including salt) 47.2

The product was a mobile, free flowing "G" phase.

Example 2: The "in situ" Preparation of a Laurie Imidazoline derivative (CLHL) in 85/15 w/w water:propylene glycol reaction medium

In an appropriate vessel, 438g of lauric hydroxyethyl imidazoline was added to a reaction medium comprising an 391g water and 119g propylene glycol. 21g of 47% NaOH solution was added thereto. To the reaction medium was added, as a carboxymethylating agent, 80% monochloroacetic acid (280g) and subsequently, as a neutralising agent, 47% NaOH (180g) . The the reaction mixture was maintained at 70°C for 15 hours, and the pH of the reaction mixture was maintained by further addition of 47% NaOH Solution

The product was a clear, mobile amber coloured liquid with a total ssoolliiddss ccoonntteeint of 50% by weight, being an L phase at ambient temperature.

Finally, the pH of the reaction mixture was lowered to 10% aqueous solution pH 10.0 by the addition of 20g of C.HCI (36%) , over a period of 1 hour, giving a total reaction time of approximately 22 hours.

Analysis of Product

Total Active Matter 33.5%

(of which:

(Carboxymethylated amidoamine 32%)

(Noncarboxymethylated material 0.5%)

(Free fatty acid 1.0%)

33.5

Sodium chloride 9.3%

Sodium monochloroacetate <0.1%

Sodium glycollate 1.7%

Water (Karl-Fischer) 42.7%

Propylene glycol 7.1%

Total solids 50.2% Viscosity (25°C, Brookfield, spindle #3, speed 10) 4100cps pH (10% solution, 25°C) 10.3

Appearance clear, mobile, pale amber solution.

Phase (25°C) LI

The inclusion of propylene glycol (15:85 propylene glycol:water) in the initial charge yielded a product with a similar viscosity to a sample of a conventional carboxymethylated lauric hydroxy ethyl imidazoline derivative prepared in the absence of solvent, with the former having the advantage of a 39% w/w increase in solids content with an identical composition, on a "pro rata" basis.

Example 3: Preparation of amphoteric surfactants (I) in the absence of solvent

Samples of the lauric imidazoline derivative (I) prepared "in situ" according to the method of Example 2 in an aqueous reaction medium containing no water miscible organic solvent exhibited much higher viscosities at corresponding levels of solids than compositions produced in the presence of said solvent.

SOLIDS VISCOSITY (a 25°C (Brookfield)

Lauric imidazaline 36 + 2% solids (24.0-26.0% total actives) 5000 m.Pa.s

42 + 2% solids 36000 m.Pa.s

50% solids 3725 m.Pa.s

The composition containing 50% solids exhibits an hexagonal M phase structure at 25 C i.e. an immobile gel. Example 4: Concentration and subsequent re-dilution of compositions of Example 2

Samples of the lauric imidazoline derivative composition of Example 3 were concentrated to 70-80% w/w solids by evaporation of water, and subsequently re-diluted to 50% w/w solids by the addition of mixtures of propylene glycol:water or glycerol:water co-solvents of various ratios.

After dilution and mixing was complete the phase viscosity at 25°C, 37°C and 45°C and the phase at ambient temperature of the coirpositions were determined.

Viscosity Determined Using a Controlled Shear/Stress Rheometer

% Solids % Water % Propylene % Glycerol Teπp. Viscosity Glycol deg.c cps

50 45 5 - 25 13,120

50 42.5 7.5 - 25 3,942

50 40 10 - 25 1,080

50 45 - 5 25 18,420

50 42.5 - 7.5 25 26,010

42 58 - - 25 36,030

36 64 - - 25 2,452

50 45 5 - 37 4,912

50 40 10 - 37 916

50 45 - 5 37 16,560

50 42.5 - 7.5 37 13,690

42 58 - - 37 19,740

36 64 - - 37 2,351

50 45 5 - 45 2,198

50 40 10 - 45 623

50 45 - 5 45 6,727

50 42.5 - 7.5 45 6,150

42 58 - - 45 10,260

36 64 - - 45 1,812

Measuring system used by controlled shear/stress rheometer

42cm 2 cone & plate Shear rate 8.51 S~ All of the coirpositions were clear L- phase solutions at ambient temperature, and exhibited no gel formation or phase separation upon dilution of the concentrated samples. The results suggest that the inclusion of glycerol is beneficial in reducing the viscosity of saπples of the composition of Example 3, with the inclusion of propylene glycol being even more effective with regard to viscosity reduction.

Example 5 Preparation of Lauryl Amidopropyl Betaine (IAPB) in Propylene Glycol : Water 60:40 w/w Reaction Medium

IAPB was prepared in situ in a 60:40 w/w mixture of propylene glycol:water.

Water (450.8g), propylene glycol (1149.9g), 80% w/w aqueous monochloroacetic acid (MCA) solution (540.7g; 4.58mol), 47% w/w aqueous NaOH solution (272.7g; 3.20mol), and lauryl amidopropyl dimethylamine based on 99% C fatty acid (1300.Og; 4.58mol) were mixed together and heated to 80°C. The pH of the reaction mixture was raised to 9.0 by further addition of 47% w/w aqueous NaOH solution (119.0g; 1.40mol). The mixture was then stirred and heated at 80°C for 4 hours whilst maintaining the pH in the range of 9.0 to 9.5 by dropwise addition of NaOH solution. A further quantity of 80% w/w aqueous MCA (5.8g; 0.05mol) was added to lower the free amidoamine content, and the mixture was heated for another 20 hours at 80°C and at a pH of 9.0 to 9.5. The pH was lowered by addition of 36% w/w hydrochloric acid and the product cooled to ambient temperature. The overall mole ratio lauryl amidopropyl dimethylamine: MCA was 1.00:1.01.

The reaction mixture had the appearance of a clear, highly mobile, pale yellow solution throughout the charging, reaction, and neutralization steps. Analysis of the final products was as follows : w/w

IAPB Active Matter 40.8%

Total Solids 48.1%

Sodium Chloride 7.3%

Sodium Monochloroacetate <80ppm

Free Amidoamine 0.2%

Free Fatty Acid 0.5%

Water 21.9%

Propylene Glycol 29.4%

Colour (Hazen) 70 pH (5% w/w solution at 25 °C) 5.8

Viscosity (Brookfield; 24 °C) 705 m.P.a.s.

Appearance at 25°C Clear, mobile, pale yellow solution

The product remained stable during storage over three months at 3°C, at the end of which the appearance remained unchanged with no precipitation having occurred.

Example 6: The Preparation of LAPB in

Dipropylene Glycol Monomethylether Water 60:40 w/w Reaction Medium

LAPB was prepared in situ in a 60:40 w/w mixture of dipropylene glycol monomethylether:water.

Water (86.4g), dipropylene glycol monomethylether (223.5g) 80% w/w aqueous MCA solution (107.6g;0.91 ol), 47% aqueous NaOH solution (77.5g;0.91mol) , and lauryl amidopropyl dimethylamine based on 99% C.. fatty acid (250.Og; 0.88mol) were mixed together and heated at 80°C. The mixture was stirred and heated at 80°C for 4 hours whilst maintaining the pH in the range 9.0 to 9.5 by dropwise addition of NaOH solution. A further quantity of 80% w/w aqueous MCA (2.1g; O.Olδmol) was added to lower the free amidoamine content, and the mixture was heated for another 16 hours at 80°C and at a pH of 9.0 to 9.5. The pH was lowered by addition of 36% w/w hydrochloric acid and the product cooled to ambient temperature. The overall mole ratio lauryl amidopropyl dimethylamine: MCA was 1.0:1.05.

The reaction mixture had the appearance of a mobile G-phase throughout the charging, reaction, and neutralization steps. Analysis of the final product was as follows :

Analysis w/w LAPB Active Matter 41.0%

Total Solids 49.3%

Sodium Chloride 7.3%

Sodium Glycollate 0.4%

Sodium Monochloroacetate <5ppm

Free Amidoamine 0.3%

Free Fatty Acid 0.3%

Water 23.4%

Dipropylene Glycol Monomethylether 27.3% pH (5% w/w solution at 25°C) 6.0 Viscosity (15°C; 4cm 2°cone & Plate; 3725mPa.s shear rate 8.51 s~ ) Appearance at 25°C mobile, pale yellow G phase solution Example 7 The Preparation of Lauric Imidazoline Derivative in Water:Propylene Glycol 80:20 w/w Reaction Medium

Carboxymethylated lauric hydroxyethyl imidazoline derivative was prepared in situ in an 20:80 w/w propylene glycol:water mixture.

Lauric hydroxyethyl imidazoline (im) having 99% C content (268.Og; 1.00 mol) was added to a reaction medium comprising water (126.Og) , propylene glycol (80.4g), and 47% w/w aqueous NaOH solution (12.8g; 0.15mol) .

To the reaction mixture was added 80% w/w aqueous MCA solution (141.8g; 1.20 mol in total) and 47% w/w aqueous NaOH solution (111.9g; 1.31 mol in total) . The mixture was then heated at 85°C for a further 15 hours whilst maintaining the pH by further addition of 47% w/w aqueous NaOH solution.

The reaction mixture was clear and highly mobile throughout the reaction, but became highly viscous on cooling, particularly below 55°C. A further quantity of solvent (164g) comprising 80:20 w/w water:propylene glycol was therefore added. The product was cooled to ambient temperature and the 10% solution pH adjusted to 10.0 by addition of 36% w/w hydrochloric acid.

Analysis w/w

Total Active 34.7%

Total Solids 48.6%

Ratio Active/Solids 71.4%

Noncarboxymethylated material 0.8%

Free Fatty Acid 1.4%

Sodium Chloride 7.3%

Sodium Monochloroacetate <500ppm

Water 41.4%

Propylene Glycol 10.0% pH (10% w/w solution at 25°C) 10.0

Viscosity (Brookfield at 25°C) l,40o m.Pa.s spindle #3, speed 10 rpm) )

Appearance at 25°C clear, rnobi solution

Example 8 The Preparation of Coconut Imidazoline Derivative in Water:Propylene Glycol 80:20 w/w Reaction Mixture

Carboxymethylated coconut hydroxyethyl imidazoline derivative was prepared in situ in an 20:80 w/w propylene glycol:water mixture.

Coconut hydroxyethyl imidazoline (CHI) based on hardened coconut fatty acid (278g; 1.00 mol) was added to a reaction medium comprising water (198.0g), propylene glycol (91.3g), and 47% w/w aqueous NaOH solution (12.8g; 0.15 mol) . To the reaction mixture was added 80% w/w aqueous MCA solution (141.8g: 1.20 mol in total) and 47% w/w aqueous NaOH solution (109.8g: 1.29 mol in total) . The mixture was heated at 85°C for a further 15 hours whilst maintaining the pH by further addition of 47% w/w aqueous NaOH solution.

The product was cooled to ambient temperature and the 10% solution pH adjusted to 8.8 by addition of 36% w/w hydrochloric acid, whereupon a precipitate of sodium chloride crystals formed. A further quantity of water (36g) was mixed with the product yielding a mobile, slightly turbid, amber solution free of solid precipitate.

Analysis w/w

Total Active 34.9%

Total Solids 53.4%

Noncarboxymetylated material 2.0%

Free Fatty Acid 1.4%

Sodium Chloride 9.9%

Sodium Monochloroacetate <500ppm

Water 36.6%

Propylene Glycol 10.0% pH (10% w/w solution at 25°C) 8.8

Viscosity (Brookfield at 25°C) 2,150 m.Pa.s spindle #3, speed 10 rpm))

Appearance at 25°C turbid, mobi solution

Claims

CEAIMSAn amphoteric surfactant coirposition, consisting essentially of at least 5% and not more than 45% by weight of water; at least 30% by weight of aπphoteric surfactant; and 5 to 45% of a water-miscible, non-surfactant organic solvent, wherein the concentration of surfactant in said coirposition corresponds to that at which the composition can exist, at least predominantly, in the "G" phase.An amphoteric surfactant coirposition, consisting essentially of at least 5% and not greater than 65% by weight of water; at least 25% by weight of amphoteric surfactant; 5% to 45% of a water miscible, non-surfactant organic solvent, wherein said composition is an "L " phase.A coirposition according to claim 1 consisting essentially of from 4 to 40% by weight water, 35 to 70% by weight of amphoteric surfactant and 5 to 45% by weight of said organic solvent.A coirposition according to claim 2 consisting essentially of 10% to 60% by weight, water, 30% to 70% by weight of amphoteric surfactant and 5 to 45% by weight of said solvent.A composition according to any foregoing claim wherein the amphoteric surfactant comprises a compound of the formula:-R [00NH(CH2) χ]y[0(CH2) χ]2 (CH2) nA*2 Wherein R is an alkyl, alkenyl, alkylamidoalkyl, alkenylamidoalkyl, alkyl polyoxyalkylene, alkenyl polyoxyalkylene or alkaryl group having in each case a C C straight or branched chain alkyl or alkenyl group or may be combined with R

1 . to form a cyclic group, x = 0 to 8, y = 0 or 1, z = 0 to 20, R is

H or a C -C₈ straight or branched chain alkyl, alkenyl or hydroxyalkyl group or may be combined with R or to form a cyclic group, is H or a ^cτ_^C6 straight °r branched chain alkyl, alkenyl or hydroxyl group, or may be absent or may be combined with R. to form a cyclic group, X is nitrogen or phosphorus, n is from 1 to 3, and A is C00~, SO ~ or PO H~.

A method for preparing a composition according to any foregoing claim by reacting a secondary or tertiary amine:-

R[CONH(CH₂)_χ]_y[0(CH₂)_χ]_z

*2

wherein R, R and R^ are as defined in claim 5, with a carboxymethylating agent in the presence of the appropriate proportions of the non-surfactant water-miscible solvent and water.

A method according to claim 6 which comprises adding a chloroacetate ester to a secondary or tertiary amine to produce an ester of formula:

R[C0NH(CH₂) _χ] [0(CH₂) _χ]

Wherein R, II, II are as hereinabove defined and R is a C to C alkyl group, wherein said quaternised amine is subsequently saponified with an aqueous base to produce a betaine.

8. A method according to either of claims 6 and 7 wherein said aπphoteric surfactants are prepared from alkylamido dimethyl amines, alkyldimethylamines or fatty acid hydroxy ethyl imidazolamines.

9. A method according to claim 8 wherein said imidazoline comprises a C -C alkyl group, and a C₂~C hydroxyalkyl group.

10. A method according to any of claims 6 to 9 wherein said solvent is propylene glycol, polyethylene glycol, dipropylene glycol monomethy1 ether and/or glycerol.

11. A method according to any of claims 6 to 10 wherein the ratio of water-soluble, non-surface active organic solvent:water in said reaction medium is from 1:10 to 10:1.