WO1995008299A1 - Ensemble melangeur de liquides pour dialyse peritoneale - Google Patents

Ensemble melangeur de liquides pour dialyse peritoneale Download PDF

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Publication number
WO1995008299A1
WO1995008299A1 PCT/US1994/010738 US9410738W WO9508299A1 WO 1995008299 A1 WO1995008299 A1 WO 1995008299A1 US 9410738 W US9410738 W US 9410738W WO 9508299 A1 WO9508299 A1 WO 9508299A1
Authority
WO
WIPO (PCT)
Prior art keywords
mixing assembly
liquid mixing
breakaway
outlet tubes
assembly according
Prior art date
Application number
PCT/US1994/010738
Other languages
English (en)
Inventor
Menahem Kraus
Ellen Tobe
Naomi Gal
Eli Shemesh
Eitan Rogel
Original Assignee
Travenol Laboratories (Israel) Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Travenol Laboratories (Israel) Ltd. filed Critical Travenol Laboratories (Israel) Ltd.
Publication of WO1995008299A1 publication Critical patent/WO1995008299A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/221—Frangible or pierceable closures within tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1462—Containers with provisions for hanging, e.g. integral adaptations of the container
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A61J1/1487—Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2027—Separating means having frangible parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2034—Separating means having separation clips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/287—Dialysates therefor

Definitions

  • the present invention relates to a liquid mixing assembly for mixing two or more liquids together.
  • the invention is particularly useful for mixing solutions for use in various types of perfusion and infusion treatments, especially in peritoneal dialysis, and the invention is therefore described below with respect to this application.
  • Solutions for use in perfusion and infusion treatments are conventionally stored in flexible, sterilizable plastic bags.
  • These bags generally include inlet and outlet ports, means for hanging the bag above the patient, and tubing, sometimes pre-attached to the bag, for conducting the solution in the bag to the patient.
  • Continuous Ambulatory Peritoneal Dialysis is a widely used method of treatment in which a sterile, osmotic solution is introduced, usually by gravity, into the peritoneal cavity, allowed to remain there for several hours, and then replaced by a fresh solution.
  • This type of dialysis can be carried out by the patient himself or herself outside of a medical environment. It is therefore important to provide dialysis equipment which is as user- friendly and mistake-proof as posi-_ble.
  • CAPD solutions generally use glucose as the osmotically active agent. Since glucose undergoes caramelization when autoclaved at a neutral or basic pH, CAPD solutions are usually manufactured at an acidic pH of approximately 5.1-5.5. This low pH, however, can cause problems for the patient such as abdominal pains and suppression of the immune system.
  • the two sterilized solutions are premixed in one container prior to being administered to the patient.
  • This can be done using two separate containers connected to each other, or using a two-compartment plastic bag such as is disclosed in U.S. 4,630,727 to Feriani, et al.
  • This method however is complex as it necessitates two separate operations - mixing and perfusing - in order to perform the dialysis.
  • An object of the present invention is to provide a liquid mixing assembly capable of containing two or more liquids in separate, isolated compartments, which can be easily and safely mixed in a single operation by an ambulatory patient for self-administered treatments.
  • a liquid mixing assembly for mixing at least two liquids, comprising: a container divided into at least two separate compartments in side-by-side relation, each for containing one of the liquids, the container including: a bottom wall having an outlet tube for each of the compartments; a common conduit joined to all the outlets; and a blocking device normally blocking liquid flow from each of the outlet tubes to any other outlet tube or to the common conduit, but manipulatable to permit liquid flow from all the outlet tubes simultaneously to the common conduit.
  • the container is a plastic bag formed with at least one longitudinal weld line to divide its interior into the at least two separate compartments; also, the common conduit is of a length such that the liquids introduced into one end are thoroughly mixed before emerging from the opposite end.
  • Such a mixing bag thus allows the user to simultaneously mix the contents of the compartments of the bag and self-administer the mixture in one step.
  • Multi-compartment bags for use with infusion solutions are well known in the literature. See for example US 4,458,811 to Wilkinson, US 4,997,083 to Loretti, et al, EP 0 132 632 to Abbott Laboratories, DE 3,238,649 to Theuer, and DE 3,830,630 to Fresenius AG.
  • the separate solutions are first mixed and only afterwards administered to the patient by opening the bag's outlet. As explained above, this adds additional manipulations to the dialysis treatment and introduces a safety problem in the event that the patient neglects to pre-mix the solutions.
  • the bag of the present invention By using the bag of the present invention, the number of manipulations required of the patient is no different from the number required during a standard CAPD treatment.
  • the bag is simple to use and needs no special equipment to operate so that it can be used outside a hospital or medical center environment. This is especially advantageous for patients requiring peritoneal dialysis who wish to continue as much as possible with a normal, routine lifestyle.
  • the bag itself will generally be made from a flexible, plastic material which can withstand autoclaving and is chemically inert.
  • Several embodiments of the invention are described below using various types of blocking devices normally blocking liquid flow but manipulatable to unblock liquid flow from all the outlets simultaneously to the common conduit.
  • One described blocking device is a pinch clamp applied to the juncture of the common conduit with all the outlet tubes.
  • Other described blocking devices comprise a breakaway cannula in each of the outlet tubes and located in side-by-side relation so that all the cannulas may be broken away simultaneously by one manipulation.
  • tubing leading from the bag to the patient must be of sufficient length so as to allow thorough mixing of the different solutions.
  • standard tubing having a length of one meter or more would be used with the bags of the invention, but shorter lengths can be used in particular applications, as can be easily determined by simple experimentation.
  • CAPD CAPD
  • the invention may be applied in other methods of treatment requiring a plurality of liquids which must be stored separately and mixed before use.
  • the invention is also not limited to two-compartment bags, but could be used with bags having three or more compartments.
  • Fig. 1 is a plan view illustrating one type of liquid mixing apparatus constructed in accordance with the present invention
  • Fig. 2 is a sectional view illustrating one form of blocking device, namely a breakaway cannula, which can be used;
  • Figs. 3 and 4 are plan views illustrating two types of liquid mixing apparatus constructed in accordance with the present invention including breakaway cannulas as the blocking device;
  • Fig. 5 is a front view illustrating one form of housing which may be used with the breakaway cannulas of Fig. 3;
  • Fig. 6 is a side elevational view of the housing of Fig. 5;
  • Fig. 7 is a front view illustrating another type of housing which may be used with the breakaway cannula arrangement of Fig. 3; and Fig. 8 is a side elevational view of the housing of Fig. 7.
  • the mixing bag 2 comprises two equal-volumed rectangular compartments 4a and 4b, positioned side by side in parallel to the longitudinal axis of the bag and separated by a longitudinal weld line 6. Each compartment has an outlet 10a, 10b located in its bottom wall adjacent to the longitudinal weld line 6.
  • the bag has a hole 12 centrally in its upper wall for hanging the bag above the patient.
  • the two outlets 10a, 10b are of equal diameter and length, and have outlet tubes 14a, 14b attached to their external ends.
  • the opposite ends of the outlet tubes are joined to a common conduit 16.
  • An external pinch clamp shown schematically at 18, blocks or seals the two outlet tubes at their juncture with the common conduit 16, so that normally there is no contact between the liquids in the two compartments and no flow to the common conduit 16.
  • the function of the bag will be exemplified by a description of its use in peritoneal dialysis.
  • Equal volumes of an acidic glucose solution and a basic buffered solution are introduced into the respective compartments 4a, 4b through the outlets 10a, 10b.
  • the outlet tubes 14a, 14b, conduit 16 and clamp 18 are then connected to the outlets, thereby sealing each compartment.
  • the bag with its contents is sterilized in an autoclave in preparation for use.
  • the patient When the patient desires to perform a dialysis treatment, the patient simply hangs the bag by the hole 12 above the patient's body, connects the common conduit 16 to a receiving tube leading into the patient's peritoneal cavity, and releases the clamp 18.
  • the volumes of the compartments need not be equal, but can be adjusted to the needs of the treatment involved. For example, a small-volume concentrated basic solution can be used together with a large-volume dilute acidic solution. The dimensions of the compartments would then be designed accordingly.
  • the rate of flow out of the compartments can also be controlled by adjusting the relative diameters of the outlets.
  • the diameters of the outlets can be permanently fixed at a predetermined value, or they can be varied using an appropriate variable closure device. Then outlet conduit 16 is of a length such that the two liquids introduced into one end become thoroughly mixed together before reaching the opposite end.
  • FIG. 2 illustrates the construction of a breakaway cannula, generally designated 18, which may also be used as the blocking device; and Fig. 3 illustrates a further embodiment of the invention in which two such breakaway cannulas 18 are used as the blocking devices for sealing the outlets.
  • Each cannula 18, as shown in Fig. 2 is made of a rigid plastic comprising a short hollow sleeve 20 having an open end 21 and an outer diameter equal to the inner diameter of its respective tube.
  • the opposite end 23 of sleeve 20 is closed by a solid core 22 to define a breakaway handle integrally formed with the sleeve and of smaller diameter than it.
  • a narrowed, short hollow neck 24 joins sleeve 20 of each cannula 18 to its core 22.
  • an outlet tube_26a, 26b is applied to each of the two outlets 10a, 10b.
  • Each of the outlet tubes 26a, 26b includes one of the breakaway cannulas 18a, 18b described above with respect to Fig. 2, namely a hollow rigid sleeve 20a, 20b closed at one end by a breakaway solid core 22a, 22b, with the breakaway necks 24a, 24b of the two cannulas aligned with each other.
  • the opposite end of the two tubes 26a, 26b are joined to the outlet conduit 16 by a Y-shaped connector 28.
  • Fig. 4 illustrates an arrangement wherein a single dual-branched breakaway cannula 30 is used for conducting the liquid from the two compartments 4a, 4b, via outlets 10a, 10b and outlet tubes 32a, 32b leading to the common outlet tube 16.
  • the breakaway cannula 30 includes two hollow sleeves (each corresponding to sleeve 20, Fig. 2) normally sealed by a common solid core (corresponding to core 22, Fig. 2) which may be broken away to open the flow simultaneously from both tubes 10a, 10b to the common outlet conduit 16.
  • Figs. 5 and 6 illustrate one form of housing which may be used in the cannula arrangement of Fig. 3 to facilitate breaking away the two cannulas 18a, 18b simultaneously.
  • a housing generally designated 40, includes a front housing section 41 of rectangular configuration overlying the front side of the two outlet tubes 26a, 26b, and a rear housing section 42 of the same rectangular configuration overlying the rear side of the two outlet tubes.
  • the two housing sections may be secured together on opposite sides of the outlet tubes by hook- shaped clamping elements 43 formed on one section receivable within recesses formed in the other section.
  • the two housing sections 41, 42 are formed with rectangular cutouts 44 to permit viewing the portions of the outlet tubes 26a, 26b, and particularly the breakaway necks 24a, 24b, of the breakaway cannulas 18a, 18b received in the outlet tubes.
  • the two housing sections are formed with two grooves 45, 46, aligned with each other and with the breakaway necks of the cannulas.
  • the two cannulas 18a, 18b are received within their respective outlet tubes 26a, 26b, with the breakaway necks 24a, 24b aligned with each other.
  • the two housing sections 41 , 42 may then be applied to enclose the outlet tubes 26a, 26b with the housing grooves 45, 46 aligned with the breakaway jaws of the two cannulas.
  • the solid cores 22a, 22b of the two breakaway cannulas 18a, 18b would block the flow of liquid from one outlet tube 26a, to the other outlet tube 26b or to the common outlet conduit 16.
  • housing 40 When it is desired to mix the two liquids, housing 40 would be grasped and bent along the grooves 45, 46 to thereby break away the two cannulas at their breakaway necks 24a, 24b, to permit the liquids to pass from the two outlet tubes 26a, 26b to the common outlet conduit 16.
  • Figs. 7 and 8 illustrate another form of housing that may be used with the breakaway cannula construction of Fig. 3.
  • the housing generally designated 50, is constituted of one side section 51 partially closing one of the outlet tubes 26a, and a second side section 52 partially enclosing the other outlet tube 26b.
  • the two side sections 51 , 52 are attached together by fastener pins 53 projecting from one section and received with a friction fit in the other section.
  • Both housing sections 51 , 52 are formed with cutouts 54 extending completely across the respective housing section except for a thin web portion 55 at the side of the housing section.
  • the cutouts 54 are of a size to permit viewing the two cannulas 18a, 18b, and particularly their breakaway necks 24a, 24b between their rigid sleeves 20a, 20b and their solid cores 22a, 22b.
  • One outlet be 26a including one cannula 18 therein, is applied to one housing section 51 with the breakaway jaw 24a aligned with web 55 of that housing secton; and the other outlet tube 26b is applied to the other housing section 52 in a similar manner, with its breakaway jaw 24b aligned with web 55 of that housing section.
  • the two housing sections are then attached by pins 53.
  • the common conduit 16 is of a length, e.g., one meter or more, such that the two liquids introduced together into one end of the conduit will be thoroughly mixed before emerging from the opposite end of the conduit into the peritoneal cavity.

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • External Artificial Organs (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention se rapporte à un ensemble mélangeur de liquides (2), qui sert à mélanger au moins deux liquides et qui comprend à cet effet un récipient divisé en au moins deux compartiments séparés (4a, 4b) disposés côte à côte et contenant chacun l'un des liquides. Des orifices de sortie (10a, 10b) pour les compartiments sont ménagés dans la paroi inférieure du récipient et sont reliés à un conduit commun (16). Un dispositif obturateur (18) bloque en situation normale le liquide pour l'empêcher de s'écouler par les orifices de sortie (10a, 14a, 10b, 14b) jusqu'au conduit commun (16), mais on peut, afin d'obtenir le mélange voulu, manipuler ledit dispositif pour libérer le liquide et le laisser s'écouler par tous les orifices de sortie (10a, 10b, 14a, 14b) en même temps, jusque dans le conduit commun (16).
PCT/US1994/010738 1993-09-23 1994-09-21 Ensemble melangeur de liquides pour dialyse peritoneale WO1995008299A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL107,088 1993-09-23
IL10708893A IL107088A (en) 1993-09-23 1993-09-23 Multi-compartment bag

Publications (1)

Publication Number Publication Date
WO1995008299A1 true WO1995008299A1 (fr) 1995-03-30

Family

ID=11065297

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/010738 WO1995008299A1 (fr) 1993-09-23 1994-09-21 Ensemble melangeur de liquides pour dialyse peritoneale

Country Status (2)

Country Link
IL (1) IL107088A (fr)
WO (1) WO1995008299A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041902A1 (fr) * 1996-05-03 1997-11-13 Baxter International Inc. Sac jumele a double remplissage, emballage et procede pour former un emballage destine a l'administration d'une solution
WO2000057935A1 (fr) * 1999-03-30 2000-10-05 Gambro Lundia Ab Procede, appareil et composants de systemes de dialyse
US6132413A (en) * 1998-03-06 2000-10-17 Baxter International Inc. Breakable cannula assemblies and methods for manipulating them
EP0974331A3 (fr) * 1998-07-23 2000-11-02 Haemopharm Industry Ag Poche pour solutions d'hémofiltration
WO2001032237A1 (fr) * 1999-11-02 2001-05-10 Hospal Ag Procede et dispositif de preparation d'un liquide medical
WO2005028001A1 (fr) * 2003-09-23 2005-03-31 Gambro Lundia Ab Appareil, systeme et procedes associes a l'hemodialyse, a l'hemodiafiltration, a l'hemofiltration ou a la dialyse peritoneale
WO2007146794A2 (fr) * 2006-06-09 2007-12-21 Baxter International Inc. Système à double chambre et sécurité intégrée de dialyse/perfusion péritonéale
EP2186504A3 (fr) * 2008-11-13 2010-09-29 Duomedica GmbH Scellement d'originalité pour fermetures de liens tubulaires d'un récipient
US20140316332A1 (en) * 2011-06-24 2014-10-23 Richard Wai Cheong Lo Multi-container systems and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576603A (en) * 1984-06-18 1986-03-18 Gerald Moss Feeding device for enterally administering liquids into a human body
US5211643A (en) * 1989-05-26 1993-05-18 Fresenius Ag Sodium bicarbonate containing precipitate-free dialysis solutions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576603A (en) * 1984-06-18 1986-03-18 Gerald Moss Feeding device for enterally administering liquids into a human body
US5211643A (en) * 1989-05-26 1993-05-18 Fresenius Ag Sodium bicarbonate containing precipitate-free dialysis solutions

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU719156B2 (en) * 1996-05-03 2000-05-04 Baxter International Inc. Dual-filled twin bag and a package for administering a solution
WO1997041902A1 (fr) * 1996-05-03 1997-11-13 Baxter International Inc. Sac jumele a double remplissage, emballage et procede pour former un emballage destine a l'administration d'une solution
US6508800B1 (en) 1996-05-03 2003-01-21 Baxter International Inc. Dual-filled twin bag, a package and a method for forming a package administering a solution
US6764482B2 (en) 1996-05-03 2004-07-20 Baxter International Inc. Dual-filled twin bag, a package and a method for forming a package for administering a solution
US6132413A (en) * 1998-03-06 2000-10-17 Baxter International Inc. Breakable cannula assemblies and methods for manipulating them
EP0974331A3 (fr) * 1998-07-23 2000-11-02 Haemopharm Industry Ag Poche pour solutions d'hémofiltration
AU767769B2 (en) * 1999-03-30 2003-11-20 Gambro Lundia Ab Method, apparatus and components of dialysis system
WO2000057935A1 (fr) * 1999-03-30 2000-10-05 Gambro Lundia Ab Procede, appareil et composants de systemes de dialyse
AU776403B2 (en) * 1999-11-02 2004-09-09 Baxter Healthcare Sa Method and device for preparing a medical fluid
JP2003512899A (ja) * 1999-11-02 2003-04-08 ホスパル・アクツィエンゲゼルシャフト 医用液体を調製する方法及び装置
WO2001032237A1 (fr) * 1999-11-02 2001-05-10 Hospal Ag Procede et dispositif de preparation d'un liquide medical
US6793827B1 (en) 1999-11-02 2004-09-21 Gambro Hospal Ag Method and device for preparing a medical fluid
US7067061B2 (en) 1999-11-02 2006-06-27 Gambro Hospal (Schweiz) Ag Method and a device for preparing a medical liquid
WO2005028001A1 (fr) * 2003-09-23 2005-03-31 Gambro Lundia Ab Appareil, systeme et procedes associes a l'hemodialyse, a l'hemodiafiltration, a l'hemofiltration ou a la dialyse peritoneale
WO2007146794A2 (fr) * 2006-06-09 2007-12-21 Baxter International Inc. Système à double chambre et sécurité intégrée de dialyse/perfusion péritonéale
WO2007146794A3 (fr) * 2006-06-09 2008-04-24 Baxter Int Système à double chambre et sécurité intégrée de dialyse/perfusion péritonéale
US8062269B2 (en) 2006-06-09 2011-11-22 Baxter International Inc. Fail safe dual chamber peritoneal dialysis/infusion system
EP2186504A3 (fr) * 2008-11-13 2010-09-29 Duomedica GmbH Scellement d'originalité pour fermetures de liens tubulaires d'un récipient
US20140316332A1 (en) * 2011-06-24 2014-10-23 Richard Wai Cheong Lo Multi-container systems and uses thereof
US10363353B2 (en) * 2011-06-24 2019-07-30 Richard Wai Cheong Lo Multi-container systems and uses thereof
US11253637B2 (en) 2011-06-24 2022-02-22 Richard Wai Cheong Lo Multi-container systems and uses thereof

Also Published As

Publication number Publication date
IL107088A0 (en) 1993-12-28
IL107088A (en) 1997-01-10

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