WO1995007630A1 - Composition saline - Google Patents

Composition saline Download PDF

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Publication number
WO1995007630A1
WO1995007630A1 PCT/EP1994/003072 EP9403072W WO9507630A1 WO 1995007630 A1 WO1995007630 A1 WO 1995007630A1 EP 9403072 W EP9403072 W EP 9403072W WO 9507630 A1 WO9507630 A1 WO 9507630A1
Authority
WO
WIPO (PCT)
Prior art keywords
salt
salt composition
blood pressure
potassium
lowering
Prior art date
Application number
PCT/EP1994/003072
Other languages
English (en)
Inventor
Justus Marie De Jong
Diederick Egbertus Grobbee
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of WO1995007630A1 publication Critical patent/WO1995007630A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/40—Table salts; Dietetic salt substitutes

Definitions

  • the invention relates to a salt composition containing 15-70 wt.% of NaCl, 5-85 wt.% of K/Mg double salts, and 0-65 wt.% of KC1 , with the molar ratio of potassium to magnesium being greater than or equal to 1.
  • Such a salt composition is known from non-prepublished Danish patent application No. 362/92.
  • a low-salt or salt-free diet is not rated as highly as a diet without any restrictions.
  • salt compositions serving as a substitute for common or table salt will (also) include a magnesium salt. Since magnesium salts and, to a lesser extent, potassium salts are considered to have a bitter taste, following a reduced NaCl diet with added K and Mg salts is appreciated even less.
  • magnesium- and potassium-containing salt compositions will contain, in addition to the salts, means for concealing the bitter (after)taste.
  • the salty taste which was less pronounced to begin with due to the reduced NaCl content, is weakened still further, affecting the appreciation of salt and the taste stimulus in general.
  • Controlled studies carried out on people have shown that the addition of magnesium is not expected to give any significant reducing effect. Since magnesium salts are highly hygroscopic, it has not proved possible so far to put together a table salt composition without including agents to counter such hygroscopicity.
  • the sodium-, potassium-, and magnesium-containing salt compositions currently available often have a bitter aftertaste and were found to be less suitable to be used in foodstuffs for a variety of reasons.
  • the invention relates to a salt composition containing 15-70% of NaCl, 5-85% of K/Mg double salts, and 0-65 wt.% of KC1 , with the molar ratio of potassium to magnesium being greater than or equal to 1, for lowering the systolic and the diastolic blood pressure in human beings.
  • this salt composition is very similar to that of common table salt, irrespective of the foodstuff with which it is ingested. Moreover, because of its specific composition and the absence of hygroscopic magnesium compounds, the salt turns out not to be hygroscopic, so there is no need to add hygroscopicity suppressing means.
  • the now found salt proved to be highly suitable as a substitute for common salt in everyday use, e.g., as a table salt. Also, tests have shown that such a salt is as suitable for use in the foodstuffs industry as common table salt, which is by no means the case for every salt composition serving as a substitute for sodium chloride table salt to effect a lowering of blood pressure.
  • the salt composition was also found to be highly suitable as a substitute for NaCl in a wide range of foodstuffs, including beverages, solid foods, and the like, again with the objective of lowering blood pressure.
  • the salts which, according to the invention, are suitable for lowering blood pressure have a sodium chloride content of at least 15 wt.%, preferably at least 21 wt.%, more particularly 25 wt.%, and most particularly at least 30 wt.%, and not more than 70 wt.%, preferably not more than 65 wt.%, more particularly 52 wt.%, and most particularly not more than 48 wt.%.
  • the percentages by weight are based on the overall quantity by weight of the salt composition.
  • the K/Mg double salt may be any double salt containing both potassium and magnesium.
  • the principal double salts in this case are carnallite and kainite, which are described in greater detail in non-prepublished Danish patent application No. 362/92.
  • the amount of K/Mg double salt will be at least 5 wt.%, preferably at least 11 wt.%, more particularly at least 16 wt.%, calculated on the overall quantity by weight of the composition.
  • the amount of double salt in the composition is less than 85 wt.%, more preferably still less than 50 wt.% or even less than 35 wt.%.
  • the amount of free potassium chloride present i.e., the additional amount of potassium chloride which is not part of a double salt, may be 0, but preference is given to its being at least 16 wt.%, more particularly still 26 wt.% or even 29 wt.%, but not more than 65 wt.%, preferably not more than 48 wt.%, more particularly still less than 38 wt.% or even less than 35 wt.%.
  • Highly suitable for lowering blood pressure is a salt composition according to the preamble of the first claim, with the salt composition containing at least 16 wt.% of potassium chloride.
  • the salt composition will further contain at least some trace elements, preferably in an amount of 0 to 2 wt.%, calculated on the overall amount of the salt composition. Although there is no firm data on this, the presence of the trace elements is also surmised to affect the lowering of the blood pressure in some way. Very suitable salts will therefore contain some amount of trace elements, preferably of 0 to 2 wt.%.
  • the product will generally contain a composition of at least the following components: chloride, sodium, magnesium, sulphate, calcium, potassium, boron, phosphate, selenium, tin, and zinc.
  • the intervention group was given Sagasalt® (composition: 43,1 wt.% of sodium chloride, 32,1 wt.% of potassium chloride, 20,4 wt.% of carnallite, 2,5 wt.% of kainite, 1,8 wt.% of trace elements) in cooked food and at the table, while the control group was given common salt (100% sodium chloride).
  • Sagasalt® composition: 43,1 wt.% of sodium chloride, 32,1 wt.% of potassium chloride, 20,4 wt.% of carnallite, 2,5 wt.% of kainite, 1,8 wt.% of trace elements
  • common salt 100% sodium chloride
  • foodstuffs contributing significantly to the daily salt intake were replaced by foodstuffs prepared with Sagasalt®, namely bread, new and matured cheese, five kinds of cold cuts, three kinds of tinned soup and powdered soup, and smoked sausage.
  • the control group was given the same foodstuffs prepared with
  • the blood pressure and the body weight of each of the testees were measured at the start of the trial and after 8, 16, and 24 weeks. Prior to having their blood pressure measured, the participants collected urine samples for two days for determination of the mineral excretion. Blood samples were taken at the start of the trial and on its conclusion to measure the mineral contents in the serum.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composition saline contenant 15 à 70 % de NaCl, 5 à 85 % de sels doubles de K/Mg, et 0 à 65 % en poids de KCl, le rapport molaire potassium/magnésium étant supérieur ou égal à 1. Il a été démontré que cette composition, lorsqu'elle est utilisée comme succédané du sel de table (NaCl), entraîne une réduction majeure surprenante de la tension artérielle systolique et diastolique chez l'humain. Une composition saline encore plus adaptée à un tel usage est obtenue lorsqu'une telle composition saline contient en outre au moins 16 % en poids de chlorure de potassium, ainsi que, de préférence, des oligo-éléments en une teneur comprise entre 0 et 2 % en poids. Un effet bénéfique notable est observé chez des personnes souffrant d'une forme bénigne à modérée d'hypertension.
PCT/EP1994/003072 1993-09-17 1994-09-14 Composition saline WO1995007630A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL9301611 1993-09-17
NL9301611 1993-09-17

Publications (1)

Publication Number Publication Date
WO1995007630A1 true WO1995007630A1 (fr) 1995-03-23

Family

ID=19862892

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1994/003072 WO1995007630A1 (fr) 1993-09-17 1994-09-14 Composition saline

Country Status (1)

Country Link
WO (1) WO1995007630A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2989556A1 (fr) * 2012-04-24 2013-10-25 Midi & Salines Est Salins Substitut de sel
WO2013169619A1 (fr) * 2012-05-08 2013-11-14 General Mills, Inc. Procédé et système pour réguler des réactions de levée
WO2014087056A1 (fr) * 2012-12-07 2014-06-12 Materiaalikonsultointi Oy Matercon Procédé de fabrication d'un sel minéral et produit à base de sel minéral
US10251909B2 (en) 2007-02-09 2019-04-09 Board Of Regents, The University Of Texas System Potassium-magnesium citrate as a surrogate of the DASH diet in managing hypertension

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3008171A1 (de) * 1980-03-04 1981-09-10 Biolabor Walter Brachmann, 2800 Bremen Verfahren zur herstellung eines ernaehrungsphysiologisch wertvollen speisesalzes unter verwendung von meersalz
WO1985000958A1 (fr) * 1983-08-23 1985-03-14 Rood Robert P Succedane de sel a faible teneur en sodium
WO1986005954A1 (fr) * 1985-04-09 1986-10-23 Sunpol Consult Aps Preparation et methode de production de sels mineraux
AU584659B2 (en) * 1983-06-14 1989-06-01 Cederroth Nordic Aktiebolag Mineral salt mixture
WO1990000522A1 (fr) * 1988-07-15 1990-01-25 Ab Hanson & Möhring Produit salin et procede de preparation correspondant
GB2237720A (en) * 1989-11-08 1991-05-15 Patrick Hylton Heron Potassium-enriched dietary salt substitute
WO1993018668A1 (fr) * 1992-03-19 1993-09-30 Saga Food Ingredients A/S Produit salin et procede pour sa preparation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3008171A1 (de) * 1980-03-04 1981-09-10 Biolabor Walter Brachmann, 2800 Bremen Verfahren zur herstellung eines ernaehrungsphysiologisch wertvollen speisesalzes unter verwendung von meersalz
AU584659B2 (en) * 1983-06-14 1989-06-01 Cederroth Nordic Aktiebolag Mineral salt mixture
WO1985000958A1 (fr) * 1983-08-23 1985-03-14 Rood Robert P Succedane de sel a faible teneur en sodium
WO1986005954A1 (fr) * 1985-04-09 1986-10-23 Sunpol Consult Aps Preparation et methode de production de sels mineraux
WO1990000522A1 (fr) * 1988-07-15 1990-01-25 Ab Hanson & Möhring Produit salin et procede de preparation correspondant
GB2237720A (en) * 1989-11-08 1991-05-15 Patrick Hylton Heron Potassium-enriched dietary salt substitute
WO1993018668A1 (fr) * 1992-03-19 1993-09-30 Saga Food Ingredients A/S Produit salin et procede pour sa preparation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D.E.GROBBEE ET AL.: "Does sodium restriction lower blood pressure?", BRITISH MEDICAL JOURNAL, vol. 293, 5 July 1986 (1986-07-05), LONDON, pages 27 - 29 *
D.E.GROBBEE ET AL: "Restriction and potassium supplementation in Young people with mildly elevated blood pressure", JOURNAL OF HYPERTENSION, vol. 5, no. 1, 1987, pages 115 - 119 *
J.A.CUTLER ET AL.: "An overview of randomized trials of sodium reduction and blood pressure", SUPPELEMENT TO HYPERTENSION, vol. 17, no. 1, January 1991 (1991-01-01), BETHESDA,MD, pages 27 - 33 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10251909B2 (en) 2007-02-09 2019-04-09 Board Of Regents, The University Of Texas System Potassium-magnesium citrate as a surrogate of the DASH diet in managing hypertension
FR2989556A1 (fr) * 2012-04-24 2013-10-25 Midi & Salines Est Salins Substitut de sel
WO2013160599A1 (fr) * 2012-04-24 2013-10-31 Compagnie Des Salins Du Midi Et Des Salines De L'est Substitut de sel
CN104334036A (zh) * 2012-04-24 2015-02-04 南部盐场和东部盐场公司 盐的替代物
EP3348151A1 (fr) * 2012-04-24 2018-07-18 Compagnie Des Salins Du Midi Et Des Salines De L'Est Substitut de sel
CN110226735A (zh) * 2012-04-24 2019-09-13 南部盐场和东部盐场公司 盐的替代物
WO2013169619A1 (fr) * 2012-05-08 2013-11-14 General Mills, Inc. Procédé et système pour réguler des réactions de levée
US10694756B2 (en) 2012-05-08 2020-06-30 General Mills, Inc. Method and system for regulating leavening reactions
US11992019B2 (en) 2012-05-08 2024-05-28 General Mills, Inc. Method and system for regulating leavening reactions
WO2014087056A1 (fr) * 2012-12-07 2014-06-12 Materiaalikonsultointi Oy Matercon Procédé de fabrication d'un sel minéral et produit à base de sel minéral
CN104918503A (zh) * 2012-12-07 2015-09-16 智能盐有限公司 制造矿物盐和矿物盐产品的方法
US9554588B2 (en) 2012-12-07 2017-01-31 Smart Salt Inc. Method for making mineral salt and mineral salt product

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