WO1994028431A1 - Porte-echantillon pour resonance magnetique nucleaire - Google Patents

Porte-echantillon pour resonance magnetique nucleaire Download PDF

Info

Publication number
WO1994028431A1
WO1994028431A1 PCT/AU1994/000258 AU9400258W WO9428431A1 WO 1994028431 A1 WO1994028431 A1 WO 1994028431A1 AU 9400258 W AU9400258 W AU 9400258W WO 9428431 A1 WO9428431 A1 WO 9428431A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample holder
sample
resonator
elongate member
exterior
Prior art date
Application number
PCT/AU1994/000258
Other languages
English (en)
Inventor
James Field
Ross Thomas Mckenna
Stephen Edward Rose
Ian Malcolm Brereton
Wolfgang Roffmann
Stephen James Wilson
Stuart Crozier
David Michael Doddrell
Original Assignee
The University Of Queensland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of Queensland filed Critical The University Of Queensland
Priority to AU67888/94A priority Critical patent/AU6788894A/en
Priority to EP94916081A priority patent/EP0710363A1/fr
Publication of WO1994028431A1 publication Critical patent/WO1994028431A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/285—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR

Definitions

  • NMRSAMPLEHOLDER relates to an NMR (Nuclear Magnetic Resonance) probe and associated components which enable Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Imaging (MRI) to be performed on subjects such as living tissues and organs, as well as inanimate materials.
  • the invention is directed to a removable sample holder for use with the probe, means for precise positioning of the sample holder relative to the probe, and means for secure and accurate fixing of the sample relative to the holder.
  • RF radio frequency
  • NMR probes are currently constructed so that all of the RF electronics and sensing hardware are enclosed in the body of the probe. These probes have been designed primarily for microscopy on inanimate objects. Attempts have been made to employ such hardware to study living animals, namely laboratory mice. To date, when conducting magnetic resonance imaging of live laboratory rodents, the animal has been attached to a minimally contoured member and positioned appropriately in the resonator prior to the imaging procedure. The animal has been attached in an improvised manner, either by fixing of its incisor teeth by a rigid member or ligature, or the fixation of external auditory meatus by adjustable conical members, or both. There has been no provision on the probe for the application of anaesthetic compounds nor removal of waste products from the animal. Importantly, the probes do not have any animal control processes (such as temperature, respiration, ECG monitoring) built into them.
  • animal control processes such as temperature, respiration, ECG monitoring
  • the physical wellbeing of the animal is typically monitored electrocardiographically by separate means.
  • anaesthetic gases and vapours are administered to the animal by an added tube, this being an additional procedure for the technician, and requiring entities.
  • this facility is normally provided only on state of the art probes.
  • the probe Once the probe has been fixed in place however, it is not possible to change the position of the rodent or other sample. Typically, the probe is placed in a superconducting magnetic bore which precludes any physical alteration to the sample during the experimental procedure. It is an object of the present invention to provide a sample holder for an RF probe, which overcomes or ameliorates the abovedescribed disadvantages, or which at least provides the user with a useful choice.
  • the present invention provides a sample holder suitable for use with a RF probe having a tubular resonator, the sample holder comprising an elongate member removably insertible axially within the bore of the resonator and having means for fixing a sample relative thereto.
  • the axial position of the elongate member relative to the resonator can be varied by adjustment means on the resonator. In this manner, different regions of interest in the sample may be optimally placed relative to the resonator by the adjustment means.
  • the sample under examination can be changed without the necessity of removing the RF probe from its superconducting magnet. That is, a plurality of sample holders may be provided, each containing a respective sample. The sample under examination may be interchanged with another sample simply by interchanging the associated sample holders. Thus, the efficiency of multiple examinations is improved substantially.
  • the adjustment means comprises a knob on the exterior of the resonator base which has a pinion on its inner end. This pinion engages a rack fixed relative to the sample holder. Rotation of the knob causes the sample holder to move axially within the resonator.
  • the means for fixing the sample relative to the sample holder preferably comprises a pair of callipers adapted to grasp the inanimate sample therebetween.
  • the callipers For a live sample, such as a rodent, the callipers each have a conical element at their free end which locates in a respective ear opening in the rodent's hea .
  • the opening and closing of the callipers is suitably controlled by a manually operable knob on the exterior of the sample holder.
  • the sample holder preferably comprises a member for fixing the anterior of the cranium.
  • This may suitably comprise a transverse bar which locates behind the upper incisor teeth of the rodent.
  • the axial position of the bar is adjustable to accommodate different sized animals. Again, the position of the bar is adjustable via a knob on the exterior of the sample holder.
  • the sample holder suitably includes means for delivering anaesthetic gas to the region of the animal's head.
  • such means comprises a delivery tube extending longitudinally along the holder. One end of the tube terminates adjacent the rodent's head, while the other end extends beyond the opposite end of the holder for connection to a gas supply.
  • FIG. 1 is a schematic exploded view of a sample holder for an NMR probe, principally adapted for laboratory animal studies;
  • Fig. 2 is a perspective view of the contoured element of the holder of Fig. 1, with rodent sample fixed thereon;
  • Fig. 3a is a perspective view (from one end) of the animal fixing means of the holder of Fig. 1.;
  • Fig. 3b is a perspective view (from the other end) of the animal fixing means
  • Fig. 4 is a perspective view of a modified form of the fixing means for inanimate objects
  • Fig. 5 is a perspective view illustrating the sample holder of Fig. 1 relative to its associated resonator
  • Fig. 6 is a schematic perspective view of the position adjustment means of the sample holder.
  • a sample holder 10 for an NMR probe comprises a contoured element 11 in which the animal or other sample is accommodated in use.
  • the animal/sample is precisely located and fixed in position relative to the contoured element 11 by a shroud member 12 (described in more detail later).
  • the contoured element 11 is connected to a spacer member 13 via an intermediate member 14.
  • a rack member 15 is connected to the other end of spacer member 13.
  • the rack member 15 forms part of a position adjustment mechanism, also described in more detail later.
  • the end of the sample holder 10 is capped by base member 16.
  • the various elements of the sample holder are keyed to prevent relative axial rotation between them.
  • the laboratory animal (a mouse) is placed on its back on the contoured element 11, and the cranium of the animal is fixed relative to the sample holder 10 by fixing means on shroud member 12.
  • the fixing means comprises a transverse bar 20 which is located behind the upper incisor teeth of the mouse, thereby fixing the cranium in the axial direction.
  • the bar 20 is mounted on a sliding element 21 which is threadedly connected to a threaded rod 22 which functions as a lead screw.
  • the threaded rod 22 is connected to a manually operable knob 23 on the exterior of the shroud 12.
  • the base of the mouse cranium is located transversely by a pair of callipers 24, 25 each of which has a respective conical element 26, 27 adjacent its end.
  • the callipers 24, 25 are pivotally connected to a crank 28 which, in turn, is able to be rotated by knob 29 on the exterior of the shroud 12. In this manner, the callipers 24, 25 can be open and closed by manual rotation of the knob 29.
  • the conical elements 26, 27 locate in the external auditory meatus of the mouse.
  • Anaesthetic gases are delivered to the head of the mouse by a tube 17 which extends from base 16, through spacer member 13 and along the reverse side of the contoured element 11 to be delivered to the mouth and nose of the animal held by shroud 12.
  • the mouse end of the tube 17 is suitably located in a channel 29 in the end face of the shroud 12, as shown in Figs. 3a and 3b.
  • the exhausting of waste vapours and gases is performed by a negative pressure applied via base 16 to the lumen of tubular spacer 13. Waste vapours and gases flow through the interstices of element 14 from all regions adjacent to the subject animal.
  • Fig. 4 illustrates a modified version of the shroud 12a suitable for locating an inanimate sample 30.
  • callipers 31, 32 have contoured lengthened arms to grasp the sample 30 in a secure grip.
  • the modified shroud 12a of Fig. 4 can also be used for fixing live samples.
  • the sample holder 10 is inserted into the probe resonator 40, as shown in Fig. 5. (The sample is omitted from Fig. 5 for clarity). Controls 42, 43 on the resonator 40 alter the resonant frequency and electrical impedance of the resonator. A further control knob 44 is used to provide axial adjustment of the sample holder 10 relative to resonator 40.
  • control knob 44 is mounted on a shaft which has a pinion 45 at its inner end.
  • the pinion 45 engages a toothed rack 46 on the rack member 15 when the sample is placed in the resonator 40.
  • the sample holder of this invention overcomes, or at least ameliorates, the difficulties of performing Magnetic Resonance Imaging and Spectroscopy on samples in a vertical bore magnet system.
  • the living sample is securely, but safely, held. During the imaging procedure, the position of the sample can be adjusted accurately without interfering with the imaging procedure.
  • the mechanism is non-invasive to the magnet and the image and spectra quality are not compromised.
  • the sample holder 10 forms an integrated system with the resonator 40, which is readily useable by the untrained operator. Moreover, the sample holder described above enables samples to be interchanged quickly and simply.

Landscapes

  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Porte-échantillon (10) destiné à être utilisé avec une sonde de résonance mangétique nucléaire (RMN), comprenant un élément profilé (11) dans lequel on peut placer un petit animal ou un échantillon. L'échantillon est fixé longitudinalement et de manière à pouvoir tourner par rapport à l'élément profilé (11), par des dispositifs de fixation comprenant une barre transversale (20) et des mâchoires (24, 25), ces deux types d'éléments étant réglables depuis l'extérieur du porte-échantillon. Des gaz anesthésiques sont distribués par le tuyau (17) et les vapeurs résiduelles sont extraites par aspiration. La position axiale du porte-échantillon par rapport au résonateur de sonde associé est réglable au moyen d'un bouton (44) situé à l'extérieur du résonateur.
PCT/AU1994/000258 1993-05-21 1994-05-20 Porte-echantillon pour resonance magnetique nucleaire WO1994028431A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU67888/94A AU6788894A (en) 1993-05-21 1994-05-20 Nmr sample holder
EP94916081A EP0710363A1 (fr) 1993-05-21 1994-05-20 Porte-echantillon pour resonance magnetique nucleaire

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPL8949 1993-05-21
AUPL894993 1993-05-21

Publications (1)

Publication Number Publication Date
WO1994028431A1 true WO1994028431A1 (fr) 1994-12-08

Family

ID=3776913

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1994/000258 WO1994028431A1 (fr) 1993-05-21 1994-05-20 Porte-echantillon pour resonance magnetique nucleaire

Country Status (2)

Country Link
EP (1) EP0710363A1 (fr)
WO (1) WO1994028431A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814674A1 (de) * 1998-04-01 1999-10-07 Gsf Forschungszentrum Umwelt Anordnung zur Untersuchung von Objekten
WO2009015678A1 (fr) * 2007-08-01 2009-02-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Dispositif de maintien d'échantillon, en particulier pour maintenir un rongeur ou un fantôme de rm dans un dispositif de trm
EP2166367A1 (fr) 2008-09-23 2010-03-24 Bruker BioSpin AG Dispositif et procédé de positionnement d'un petit animal pour une mesure IRM
CN107907845A (zh) * 2017-12-15 2018-04-13 国家纳米科学中心 一种用于小动物核磁成像的测量装置
CN107957346A (zh) * 2017-10-17 2018-04-24 青海省青海湖肉业有限责任公司 动物胴体检疫扒钩杆及检疫取样方法
EP3351178A1 (fr) * 2017-01-20 2018-07-25 Delta Electronics, Inc. Dispositif d'imagerie par balayage et lit de transport d'animaux
CN108324404A (zh) * 2017-01-20 2018-07-27 台达电子工业股份有限公司 造影扫描装置及其动物载床

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1196820A (en) * 1967-11-25 1970-07-01 Jeol Ltd Sample Holder for a Nuclear Magnetic Resonance Instrument.
DE3241178A1 (de) * 1982-11-08 1984-05-10 Siemens AG, 1000 Berlin und 8000 München Ultraschall-applikator
EP0314359A2 (fr) * 1987-10-30 1989-05-03 The Regents Of The University Of California Support de bobine à haute fréquence pour l'imagerie de l'articulation de mâchoires par résonance magnétique
EP0532966A1 (fr) * 1991-09-16 1993-03-24 Bruker Instruments, Inc. Sonde à RMN améliorée pour l'imagerie d'échantillons de dimensions modestes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275350A (en) * 1979-05-29 1981-06-23 Varian Associates, Inc. Sample spinning mechanism for NMR probes
DE3124435A1 (de) * 1981-06-22 1983-01-20 Siemens AG, 1000 Berlin und 8000 München Geraet zur erzeugung von bildern eines untersuchungsobjektes
US4979519A (en) * 1988-05-05 1990-12-25 Board Of Regents, University Of Texas System Head positioning system for accurate cranial alignment and dimension in magnetic resonance

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1196820A (en) * 1967-11-25 1970-07-01 Jeol Ltd Sample Holder for a Nuclear Magnetic Resonance Instrument.
DE3241178A1 (de) * 1982-11-08 1984-05-10 Siemens AG, 1000 Berlin und 8000 München Ultraschall-applikator
EP0314359A2 (fr) * 1987-10-30 1989-05-03 The Regents Of The University Of California Support de bobine à haute fréquence pour l'imagerie de l'articulation de mâchoires par résonance magnétique
EP0532966A1 (fr) * 1991-09-16 1993-03-24 Bruker Instruments, Inc. Sonde à RMN améliorée pour l'imagerie d'échantillons de dimensions modestes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DERWENT ABSTRACT; Accession No. 93-235998/30, class S01, S03, S05; & DE,A,4201440 (GUENTHER GMBH EBERHARD), 22 July 1993. *
See also references of EP0710363A4 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814674A1 (de) * 1998-04-01 1999-10-07 Gsf Forschungszentrum Umwelt Anordnung zur Untersuchung von Objekten
WO2009015678A1 (fr) * 2007-08-01 2009-02-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Dispositif de maintien d'échantillon, en particulier pour maintenir un rongeur ou un fantôme de rm dans un dispositif de trm
US8334698B2 (en) 2007-08-01 2012-12-18 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Sample holding device, in particular for holding a rodent or an MR phantom in an MRT device
EP2166367A1 (fr) 2008-09-23 2010-03-24 Bruker BioSpin AG Dispositif et procédé de positionnement d'un petit animal pour une mesure IRM
DE102008048414A1 (de) 2008-09-23 2010-04-15 Bruker Biospin Ag Vorrichtung und Verfahren zur Positionierung eines Kleintieres für eine MRI-Messung
US8482278B2 (en) 2008-09-23 2013-07-09 Bruker Biospin Ag Method of positioning and aligning with precision, a small animal in order to conduct and perform MRI measurements
JP2018114284A (ja) * 2017-01-20 2018-07-26 台達電子工業股▲ふん▼有限公司Ｄｅｌｔａ Ｅｌｅｃｔｒｏｎｉｃｓ，Ｉｎｃ． 造影スキャン装置及びその動物用寝台
EP3351178A1 (fr) * 2017-01-20 2018-07-25 Delta Electronics, Inc. Dispositif d'imagerie par balayage et lit de transport d'animaux
CN108324404A (zh) * 2017-01-20 2018-07-27 台达电子工业股份有限公司 造影扫描装置及其动物载床
CN108324404B (zh) * 2017-01-20 2020-01-03 台达电子工业股份有限公司 造影扫描装置及其动物载床
US10874368B2 (en) * 2017-01-20 2020-12-29 Delta Electronics, Inc. Scanning imaging device and animal carrying bed thereof
CN107957346A (zh) * 2017-10-17 2018-04-24 青海省青海湖肉业有限责任公司 动物胴体检疫扒钩杆及检疫取样方法
CN107957346B (zh) * 2017-10-17 2020-04-14 青海省青海湖肉业有限责任公司 动物胴体检疫扒钩杆及检疫取样方法
CN107907845A (zh) * 2017-12-15 2018-04-13 国家纳米科学中心 一种用于小动物核磁成像的测量装置

Also Published As

Publication number Publication date
EP0710363A4 (fr) 1996-02-22
EP0710363A1 (fr) 1996-05-08

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