WO1994024993A1 - Compositions antisudorales - Google Patents

Compositions antisudorales Download PDF

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Publication number
WO1994024993A1
WO1994024993A1 PCT/EP1994/001225 EP9401225W WO9424993A1 WO 1994024993 A1 WO1994024993 A1 WO 1994024993A1 EP 9401225 W EP9401225 W EP 9401225W WO 9424993 A1 WO9424993 A1 WO 9424993A1
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WO
WIPO (PCT)
Prior art keywords
antiperspirant
composition according
antiperspirant composition
composition
weight
Prior art date
Application number
PCT/EP1994/001225
Other languages
English (en)
Inventor
John Francis Leng
David Terence Parrot
Jacqueline Diane Hewitt-Jones
Original Assignee
Unilever Plc
Unilever Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc, Unilever Nv filed Critical Unilever Plc
Priority to AU66798/94A priority Critical patent/AU6679894A/en
Publication of WO1994024993A1 publication Critical patent/WO1994024993A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0295—Liquid crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds

Definitions

  • the invention relates to antiperspirant compositions
  • suitable for topical application to the human skin in any product form.
  • These can be, for example, as liquid
  • compositions suitable for use in a roll-on dispenser solid compositions for use as a cosmetic stick together with a stick holder, a liquid composition suitable for dispensing from a propellant-driven aerosol container or a pump spray, or a cream suitable for dispensing from a suitable
  • antiperspirant market and the technical and patent literature in the field of antiperspirants are dominated by products based on metal salts, for example aluminium or zirconium salts such as aluminium chloride, aluminium chlorohydrate, zirconium hydroxychloride, to name but a few, which are intended to reduce or prevent perspiration at the skin surface, particularly on the underarm.
  • metal salts for example aluminium or zirconium salts such as aluminium chloride, aluminium chlorohydrate, zirconium hydroxychloride, to name but a few, which are intended to reduce or prevent perspiration at the skin surface, particularly on the underarm.
  • antiperspirant actives in fact exhibit a remarkably good performance as antiperspirant actives, are compatible with known antiperspirant type formulations, and may be included into compositions which have remarkably good sensory
  • compositions as described therein may be experienced by certain users, in that it has been found that occasionally after prolonged application of some of the products described therein a few users experienced a reddening of the skin in the axilla, known as erythema. It is amongst the objects of this invention to provide compositions which do not have this disadvantage of such previous compositions.
  • an antiperspirant composition suitable for topical application to the human skin comprising an antiperspirant active which comprises at least one amphiphilic material, the antiperspirant active being one which forms, upon contact with perspiration, a water-insoluble liquid crystal phase of greater than one-dimensional periodicity, in a cosmetic vehicle comprising a volatile silicone and
  • such an antiperspirant composition is highly preferred when the product form of the composition is a lotion for dispensing from a roll-on container, a solid for use as a stick, or a cream , but may also be preferred when the composition is a liquid composition suitable for
  • the antiperspirant composition is to be a sprayable
  • the sprayable solution may comprise up to 25% of a short chain
  • composition additionally comprises a propellant gas, and if for a pump spray
  • amphiphilic antiperspirant active in the composition is fully solubilised (i.e. the pump spray antiperspirant composition contains no suspended amphiphilic material antiperspirant active).
  • solution compositions may comprise a higher initial amount of short chain
  • a solution antiperspirant composition suitable for topical application to the human skin by spraying it onto the skin as a propellant driven aerosol, comprising an antiperspirant active which comprises at least one
  • the antiperspirant active being one which forms, upon contact with perspiration, a water-insoluble liquid crystal phase of greater than one-dimensional periodicity, in a liquid solution cosmetic vehicle comprising volatile silicone, a propellant gas, and containing less than 25% by weight of a short chain
  • amphiphilic antiperspirant active material in the composition is fully solubilized.
  • a solution antiperspirant suitable for topical application to the human skin by spraying it onto the skin from a pump spray, comprising an antiperspirant active which comprises at least one amphiphilic material, the
  • antiperspirant active being one which forms, upon contact with perspiration, a water-insoluble liquid crystal phase of greater than one-dimensional periodicity, in a liquid solution cosmetic vehicle comprising a volatile silicone, the amphiphilic antiperspirant active material being fully solubilized in the vehicle, the vehicle containing less than 25% by weight of a short chain monohydric alcohol.
  • compositions are novel over and above
  • composition 15 described in EP 92310294.1 described above as this composition is in the form of a suspension of lipid in the ethanol and silicone vehicle, suspended by Bentone 38. Such a suspension would also not be readily sprayable.
  • compositions according to the invention comprise less than 25 % by weight of a short chain monohydric alkanol in certain embodiments of the invention described above, and in all embodiments preferably less than 10 % of the monohydric alcohol, more preferably less than 5% by weight of a short chain monohydric alkanol, and most preferably is substantially free (ie. it contains less than 0,5% by weight) of short chain monohydric alkanols.
  • amphiphilic material may include a mixture of materials, at least one of which is amphiphilic.
  • the invention provides a method of preventing or reducing perspiration at the human skin surface, comprising applying thereto an antiperspirant composition comprising an antiperspirant active in a
  • cosmetic vehicle comprising volatile silicone and containing less than 10 % by weight of the composition of short chain monohydric alkanols, the active comprising at least one amphiphilic material, the antiperspirant active being one which forms, upon contact with perspiration, a water-insoluble liquid crystal phase of greater than one- dimensional periodicity.
  • a method of preventing or reducing perspiration at the human skin surface comprising applying thereto by spraying as a propellant driven aerosol a solution antiperspirant
  • composition comprising an antiperspirant active in a liquid solution cosmetic vehicle comprising volatile silicone and containing less than 25 % by weight of the composition of short chain monohydric alkanol and a propellant gas, the active comprising at least one amphiphilic material, the antiperspirant active being one which forms, upon contact with perspiration, a water-insoluble liquid crystal phase of greater than one-dimensional periodicity.
  • a method of preventing or reducing perspiration at the human skin surface comprising applying thereto by spraying from a pump spray a solution antiperspirant composition comprising an antiperspirant active in a liquid solution cosmetic vehicle comprising volatile silicone and containing less than 25% by weight of the composition of short chain
  • antiperspirant active being one which forms, upon contact with perspiration, a water-insoluble liquid crystal phase of greater than one dimensional periodicity, the amphiphilic antiperspirant active material being fully solubilized in the vehicle.
  • the antiperspirant composition is free or substantially free of antiperspirant levels of metal salts, especially those metal salts used in the prior art as antiperspirant or deodorant actives.
  • the invention provides the novel use as an antiperspirant active of an amphiphilic material in a cosmetic vehicle comprising volatile silicone and containing less than 10 % by weight of the composition of a short chain monohydric alkanol, which active forms, upon contact with perspiration, a water-insoluble liquid crystal phase of greater than one-dimensional periodicity, for the purpose of reducing irritation the amphiphilic material may cause to skin.
  • propellant driven aerosol as a solution antiperspirant active of an amphiphilic material in a liquid solution sprayable cosmetic vehicle comprising a propellant gas, volatile silicone and containing less than 25 % by weight of the composition of a short chain monohydric alkanol, which active forms, upon contact with perspiration, a water-insoluble liquid crystal phase of greater than one-dimensional periodicity, for the purpose of reducing
  • amphiphilic material in a liquid solution sprayable cosmetic vehicle comprising volatile silicone and containing less than 25% by weight of the composition of a short chain monohydric alcohol, which active in fully solubilized in the cosmetic vehicle and forms, upon contact with perspiration, a water-insoluble liquid crystal phase of greater than one-dimensional periodicity, for the purpose of reducing
  • compositions according to the invention may comprise a relatively high level of volatile silicones; this level may be from 50-90% by weight, more preferably 60-80% by weight.
  • Volatile silicones for use according to the invention are typically cyclomethicones and cyclic dimethyl siloxanes, and include Dow Corning fluids 249, 245, 344, 345, 1463, and 200
  • Figure 1 is a three component phase diagram illustrating various physical phases of glycerol monooleate/oleic
  • Figure 2 is another three component phase diagram, similar to that of Figure 1, but showing the various phases of mixtures of glycerol monolaurate/oleic acid/water;
  • liquid crystal structures that can be formed are cubic liquid crystal structures, which have a long-range periodicity in three dimensions, and hexagonal structures, which have a long-range periodicity in two dimensions.
  • amphiphilic substances an amphiphilic substance by definition having both hydrophilic and hydrophobic portions in its structure
  • amphiphilic substances an amphiphilic substance by definition having both hydrophilic and hydrophobic portions in its structure
  • mixtures of amphiphilic substances when used as
  • antiperspirant actives have an appropriate relative
  • the antiperspirant actives in the compositions according to the invention have a solubility in water (or sweat) of less than about 0.1% by weight (at 35°C), more preferably less than about 0.05% by weight.
  • these amphiphilic materials may pass through physical phases of one dimensional periodicity or less, such as a lamellar phase, or a simple liquid phase, in which they remain fairly fluid. These types of structures are thought not to be conducive to good antiperspirant activity, unless on subsequent contact with more perspiration they form a liquid crystal structure of greater than one dimensional periodicity.
  • amphiphilic compound (s) in compositions according to the invention may pass through further physical states, and form liquid crystal structures of greater than one dimensional periodicity. These have a sufficiently rigid structure to physically block the
  • Preferred amphiphilic materials in accordance with the invention are those which in the environment of a perspiring axilla form the most rigid liquid crystal structures (e.g. those with three-dimensional periodicity) so as to provide the most effective, physically strongest blocking of eccrine ducts.
  • the amphiphilic antiperspirant active used in the compositions is one which physically swells as it forms the liquid crystal structure on contact with perspiration, hence enhancing the pore-blocking effect.
  • the structure of the antiperspirant active in the compositions according to the invention can be any structure of the antiperspirant active in the compositions according to the invention.
  • compositions according to the invention comprise those which form the most physically rigid liquid crystal at an ambient axilla temperature, typically 30-40°C.
  • Compositions according to the invention are, in preferred embodiments, free or substantially free of antiperspirant or deodorant levels of metal salts.
  • antiperspirant metal salts these are typically aluminium and/or zirconium salts, often present in prior art antiperspirant
  • compositions at a concentration of around 10% by weight or more.
  • aluminium salts are known to have deodorant activity at a concentration of around 5% by weight or more.
  • antiperspirant metal salts a non-limiting list of antiperspirant metal salts is provided by the FDA in "Antiperspirant drug products for over the counter human use, a tentative final monograph", Fed. Register 47:36592 (1982).
  • a preferred category of amphiphilic materials which form effective antiperspirant compositions according to the invention comprises lipid substances, in particular lipids, which may for example be found to occur naturally in the human skin.
  • lipids which form effective antiperspirant compositions according to the invention are glyceryl monooleate, optionally as a mixture with oleic acid, and a mixture of glyceryl monolaurate and oleic acid.
  • a preferred combination of lipids is a mixture of glyceryl monolaurate and isostearyl alcohol.
  • antiperspirant active in the composition according to the invention comprises a mixture of glyceryl monolaurate and either oleic acid or isostearyl alcohol, preferably the ratio of glyceryl monolaurate to oleic acid or isostearyl alcohol is from 3:2 to 4:1.
  • preferred lipid materials which form effective antiperspirant actives in compositions according to the invention include glyceryl monolaurate in combination with either oleyl alcohol, or isostearyl alcohol. Mixtures of polyoxyethylene ethers are also suitable actives
  • antiperspirant actives in compositions according to the invention include surfactants, such as, for example, a mixture of sodium oleate with oleic acid or oleic alcohol, or potassium oleate with oleic acid or oleic alcohol.
  • amphiphilic substances which form effective antiperspirant actives for use in compositions according to the invention are emulsifiers, such as, for example, a mixture of lecithin and oleic acid or oleic alcohol.
  • a further category of antiperspirant actives for use in compositions according to the invention are polymer
  • amphiphilic complexes such as for example, a mixture of Merquat 100 (poly (dimethyl diallyl ammonium chloride)), and sodium dodecyl sulphate (SDS), in an equimolar mixture of Merquat 100 monomer: SDS.
  • SDS sodium dodecyl sulphate
  • antiperspirant actives for use in compositions according to the invention are block copolymer surfactants, for example sodium 10- ⁇ -butyl [poly
  • the antiperspirant active used in compositions according to the invention comprises a mixture containing more than one amphiphilic substance
  • the amphiphilic substances in the mixture it is preferable that, of the amphiphilic substances in the mixture, at least one of these substances has a more strongly hydrophobic portion (i.e. the substance has a relatively low HLB value), whilst at least one of the substances has a more strongly
  • hydrophilic portion i.e. the substance has a relatively high HLB value
  • compositions according to the invention may advantageously be delivered from a vehicle which comprises volatile silicone, and which contains in some embodiments described less than 25 % by weight, and in the others described less than 10 % of the composition of a short chain monohydric alcohol.
  • Antiperspirant compositions according to the invention which contain as their antiperspirant active amphiphilic
  • antiperspirant or deodorant levels of metal salts have several advantages over conventional, essentially metal- based antiperspirant compositions. First, it is possible for these materials, once applied, either to be washed away from the skin, or to be gradually metabolised by the skin, thereby to unblock the skin pore.
  • Antiperspirant actives used in compositions according to the invention may
  • glyceryl monooleate such as glyceryl monooleate
  • materials such as glyceryl monooleate are substantially cheaper than certain conventional antiperspirant astringents, such as activated aluminium chlorohydrate (AACH) .
  • AACH activated aluminium chlorohydrate
  • compositions according to the invention also have other advantages over conventional antiperspirant compositions.
  • certain antiperspirant actives which may be used in compositions according to the invention, such as glyceryl monolaurate, are known antimicrobial agents, thereby imparting an important additional property to the composition.
  • Compositions according to the invention may readily have a natural pH balance on the skin, and are thereby less likely to cause skin irritation. They also have a reduced tendency to cause permanent staining to clothing.
  • antiperspirant materials used in compositions according to the invention have been found to be compatible with conventional (e.g. aluminium) antiperspirant materials, and can thus be used in mixtures with aluminium- or zirconium-based antiperspirant materials to form antiperspirant compositions. It is preferred (but not mandatory) however, that such conventional metal salt actives are not used in combination with the antiperspirant active of the invention, as this may tend to negate some of the advantages to be had from the invention as compared with the prior art. Particularly advantageously, antiperspirant compositions according to the invention which comprise a volatile oils, and solubric acid, and sodiol, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbon
  • silicone and contain relatively low levels of a short chain monohydric alcohol may cause less irritation and erythema to the axillae of users of such compositions, in particular after relatively long term exposure (ie more than about two weeks) to such compositions.
  • the antiperspirant active used in compositions according to the invention may comprise from 5 to 95%, more preferably from about 5 to about 50%, even more preferably from about 5 to about 30%, by weight of the antiperspirant composition.
  • the antiperspirant composition according to the invention may comprise other ingredients, depending on the nature and form of the finished product. Such additional ingredients should not however interfere with the ability of the finished product.
  • antiperspirant active to form, in the residual composition on the skin, the required water-insoluble liquid crystal phase of greater than one-dimensional periodicity.
  • non-volatile silicones such polydimethylsiloxane, having a viscosity in excess of 5 mm 2 s -1 , for example from 50 to 100 mm 2 s -1 , such as DOW CORNING 200 Fluids (standard viscosities 50-1000 mm 2 s -1 );
  • deodorant compounds which can also act as antimicrobial agents, such as unsaturated fatty acids; or other antimicrobial agents e.g. Irgasan DP300, ex Ciba Geigy;
  • oils such as liquid paraffin oils
  • - thickeners such as clays, for example Bentone 38 (trade mark), silicas, for example Aerosil 200 (trade mark), and hydroxypropyl celluloses such Klucel (trade mark) and other cellulose derivatives conventionally used for thickening purposes;
  • - skin feel improvers such as talc and finely divided polyethylene, an example of which is Acumist B18;
  • - gelling agents such as stearyl alcohol or waxes, for
  • humectants such as polyols, for example glycerol
  • compositions according to the invention comprise at least 60% by weight of the composition of volatile silicones.
  • the ingredients other than the antiperspirant active can conveniently form the balance of the composition, and accordingly may form up to about 90% by weight of the total composition, preferably from 2 to about 30%, even more preferably from about 5 to about 30% by weight of the total composition.
  • composition according to the invention can take the form of liquid or solid products, each of which is suited to, or adapted for, topical application to human skin.
  • composition of the invention is a solid stick, usually contained in a suitable holder or dispenser to enable it to be applied to the area of the skin, particularly the underarm, where control of perspiration and deodorancy is required.
  • This lotion can typically be an emulsion, a suspension of solids in liquid, or a thickened solution.
  • liquid composition for dispensing via a finger-operated pump spray or a hand-operated squeeze spray to provide for delivery to the skin of a finely divided spray or aerosol, without the use of propellant gases to deliver it.
  • a composition according to the invention can take the form of liquid, optionally containing suspended particulate solids, which is suited to, or adapted for, topical application to human skin from an aerosol container.
  • the aerosol container can then be used to dispense the composition as a spray to enable it to be applied to the area of the skin, particularly the underarm, where control of perspiration and deodorancy is required.
  • liquid compositions according to the invention for use in pump sprays or propellant driven aerosols may be solutions (i.e. do not contain any suspended particles).
  • composition according to the invention can also take the form of a cream, suited to, or adapted for, topical
  • compositions may be lotion, propellant driven aerosol, and solid stick forms. Use of the composition
  • the invention provides for the use of an antiperspirant composition in accordance with the invention in perspiration control, following topical application to the human skin.
  • a further preferred composition according to the invention is one which comprises a surfactant which strongly interacts with the skin, thereby causing improved adhesion of the antiperspirant active to the skin.
  • surfactants may include, for example, cationic surfactants, alpha-hydroxy acids, alkyl lactylates and other surfactants having head groups which have a relatively strong affinity for the skin surface.
  • such additives may be present in the composition at a concentration of from about 0.1 to 2% by weight of the total composition.
  • compositions were prepared, using standard techniques known in the art. For the formulations not containing Bentone, it was sufficient simply to mix together the components of the mixture, and make the composition to the appropriate amount with a solvent such as volatile silicone. However, for the formulations containing Bentone, it was necessary to shear the Bentone into an aliquot of the volatile silicone, at a high rate of shear (e.g. at
  • composition represents a formulation according to the invention with improved irritation properties.
  • composition (2) was tested on a panel, and produced a relatively high rate of physical reaction in the panel. (8 panellists from 20 demonstrated some form of physical reaction to the composition.)
  • Composition 2 Component %(w/w)
  • composition provides a satisfactory stick composition according to the invention:
  • composition 4 When tested, .this stick produced a zero rate of physical reaction in the test panel of 20 panellists.
  • Composition 6 The following represents a propellant aerosol formulation according to one aspect of the invention. Component %(w/w)
  • a feature of the compositions according to the invention is that it is possible to illustrate advantageous compositions according to the invention using phase diagrams.
  • a phase diagram is a diagram which can be used to display the physical structure of a multicomponent mixture at a given temperature and composition. Phase diagrams may be
  • phase diagrams for a three-component mixture, but phase diagrams for two, or four or more component mixtures may equally well be used to illustrate effective antiperspirant active compositions according to the invention.
  • the phase diagram used should take account of at least every non-volatile component of the antiperspirant composition, i.e. those components residual on the skin after the treatment.
  • Figure 1 shows an actual triangular phase diagram for a three-component mixture of water, oleic acid and glyceryl monooleate, at 25 degrees centigrade. Shown on this diagram are some of the physical phases that are formed at various compositions represented by this diagram. These phases may be, for example, a liquid phase 32, in which the mixture has the physical structure of a free-flowing liquid. Some compositions represented also have a lamellar phase form 33, in which they have the consistency of a more viscous liquid. It has been found that these two physical phases, which do not have greater than 1 dimensional periodicity (a lamellar phase has 1 dimensional periodicity, whilst a liquid phase has zero order periodicity) , do not form a very effective antiperspirant active.
  • a lamellar phase has 1 dimensional periodicity
  • a liquid phase has zero order periodicity
  • the composition applied is exposed to more water, and in terms of the phase diagram this effectively moves the composition originally applied in a straight line towards the left of the diagram, i.e.
  • the resultant composition will generally pass from the liquid 32 or lamellar 33 areas of the diagram, towards, for example, the hexagonal 35 or cubic 34 areas of the diagram.
  • a composition represented for example by the point 36 in Figure 1 the observed structure of the composition is in fact a dynamic equilibrium between the hexagonal structure of liquid crystal 35 and free water. However, most of this free water is located on the eccrine gland side of the crystal structure, and thus is retained in the gland. It is when the antiperspirant composition in equilibrium with water has a greater than 1 dimensional periodicity, i.e. when it has the hexagonal 35 or cubic 34 structure, that the composition forms an effective
  • compositions which lie below the dotted line 37 in figure 1 form effective antiperspirant active.
  • Figure 2 shows a similar triangular phase diagram for a three-component mixture comprising water, oleic acid and glyceryl monolaurate (GML), at 35 degrees centigrade.
  • GML glyceryl monolaurate
  • phase diagrams may provide a useful indication of which compositions involving an

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Epidemiology (AREA)
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  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
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Abstract

L'invention concerne une composition antisudorale destinée à être appliquée localement sur l'épiderme humain. Ladite composition contient un agent actif antisudoral se composant d'au moins une matière amphiphile. Ledit agent actif antisudoral forme, en contact avec la transpiration, une phase de cristal liquide insoluble dans l'eau présentant une périodicité pluridimensionnelle dans un véhicule cosmétique contenant du silicone volatil et des faibles taux de monoalcool à chaîne courte.
PCT/EP1994/001225 1993-04-30 1994-04-19 Compositions antisudorales WO1994024993A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66798/94A AU6679894A (en) 1993-04-30 1994-04-19 Antiperspirant compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93303383.9 1993-04-30
EP93303383 1993-04-30

Publications (1)

Publication Number Publication Date
WO1994024993A1 true WO1994024993A1 (fr) 1994-11-10

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ID=8214396

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1994/001225 WO1994024993A1 (fr) 1993-04-30 1994-04-19 Compositions antisudorales

Country Status (3)

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AU (1) AU6679894A (fr)
WO (1) WO1994024993A1 (fr)
ZA (1) ZA942847B (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5855877A (en) * 1996-09-06 1999-01-05 Colgate-Palmolive Company Non-aqueous antiperspirant composition
DE10057767A1 (de) * 2000-11-22 2002-05-23 Beiersdorf Ag Deodorant- und Antitranspirantprodukte mit einem Gehalt an dispersen Flüssigkristallen, welche kubische Phasen darstellen
WO2002041850A1 (fr) 2000-11-22 2002-05-30 Beiersdorf Ag Produits pour soins capillaires a teneur en cristaux liquides presentant des phases cubiques
WO2004071476A1 (fr) * 2003-02-11 2004-08-26 Unilever Plc Compositions antitranspiration
WO2009063016A1 (fr) * 2007-11-16 2009-05-22 Unilever Plc Composition topique
US8263058B2 (en) 2004-04-21 2012-09-11 The Procter & Gamble Company Personal care compositions that deposit hydrophilic benefit agents
WO2016005198A1 (fr) * 2014-07-08 2016-01-14 Henkel Ag & Co. Kgaa Agents cosmétiques anti-transpirants avec des protéines spéciales provenant de sécrétions animales, de sécrétions d'insectes ou de sécrétions humaines, qui ne contiennent pas d'halogénures et/ou d'hydroxyhalogénures d'aluminium et/ou de zirconium
WO2016005243A1 (fr) * 2014-07-08 2016-01-14 Henkel Ag & Co. Kgaa Agents cosmétiques anti-transpirants avec des protéines spéciales provenant de légumineuses de l'espèce pisum et/ou phaseolus et/ou vigna et/ou macrotyloma ou provenant de crucifères de l'espèce brassica, qui ne contiennent pas d'halogénures et/ou d'hydroxyhalogénures d'aluminium et/ou de zirconium
WO2016005199A1 (fr) * 2014-07-08 2016-01-14 Henkel Ag & Co. Kgaa Produits cosmétiques anti-transpirants comprenant des protéines spéciales issues des légumineuses du genre glycine, lesquelles ne contiennent pas d'halogénures et/ou d'hydroxyhalogénures d'aluminium et/ou de zirconium
WO2016030048A1 (fr) * 2014-08-26 2016-03-03 Henkel Ag & Co. Kgaa Produits cosmétiques anti-transpirants contenant des protéines spéciales dérivées de malvacées du genre adansonia, exempts d'halogénures et/ou d'hydroxyhalogénures d'aluminium et/ou de zirconium
WO2019185419A1 (fr) 2018-03-28 2019-10-03 Unilever Plc Compositions anti-transpirantes non-aluminium
WO2020108882A1 (fr) 2018-11-30 2020-06-04 Unilever Plc Compositions anti-transpirantes sans aluminium
WO2020108885A1 (fr) 2018-11-30 2020-06-04 Unilever Plc Compositions antitranspirantes sans aluminium
WO2022258385A2 (fr) 2021-06-07 2022-12-15 Unilever Ip Holdings B.V. Compositions et méthodes de régulation de la production de sueur
WO2023117481A1 (fr) 2021-12-22 2023-06-29 Unilever Ip Holdings B.V. Compositions cosmétiques de gestion de la transpiration
WO2023117480A1 (fr) 2021-12-22 2023-06-29 Unilever Ip Holdings B.V. Compositions cosmétiques de gestion de la transpiration
WO2023117371A1 (fr) 2021-12-22 2023-06-29 Unilever Ip Holdings B.V. Compositions cosmétiques de gestion de la transpiration

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1119960A (fr) * 1979-06-01 1982-03-16 Warner-Lambert Company Antisudorifique a sechage rapide
US4863721A (en) * 1987-05-22 1989-09-05 The Procter & Gamble Company Reduced stinging antiperspirant compositions
EP0373499A2 (fr) * 1988-12-16 1990-06-20 Colgate-Palmolive Company Antitranspirant et déodorant
EP0388111A1 (fr) * 1989-03-14 1990-09-19 The Procter & Gamble Company Sticks antiperspirants laissant peu de dépôt
EP0550960A1 (fr) * 1991-11-12 1993-07-14 Unilever Plc Matériaux et compositions antiperspirants

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1119960A (fr) * 1979-06-01 1982-03-16 Warner-Lambert Company Antisudorifique a sechage rapide
US4863721A (en) * 1987-05-22 1989-09-05 The Procter & Gamble Company Reduced stinging antiperspirant compositions
EP0373499A2 (fr) * 1988-12-16 1990-06-20 Colgate-Palmolive Company Antitranspirant et déodorant
EP0388111A1 (fr) * 1989-03-14 1990-09-19 The Procter & Gamble Company Sticks antiperspirants laissant peu de dépôt
EP0550960A1 (fr) * 1991-11-12 1993-07-14 Unilever Plc Matériaux et compositions antiperspirants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 8215, Derwent World Patents Index; AN 82-28730E *

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5855877A (en) * 1996-09-06 1999-01-05 Colgate-Palmolive Company Non-aqueous antiperspirant composition
DE10057767A1 (de) * 2000-11-22 2002-05-23 Beiersdorf Ag Deodorant- und Antitranspirantprodukte mit einem Gehalt an dispersen Flüssigkristallen, welche kubische Phasen darstellen
WO2002041850A1 (fr) 2000-11-22 2002-05-30 Beiersdorf Ag Produits pour soins capillaires a teneur en cristaux liquides presentant des phases cubiques
WO2004071476A1 (fr) * 2003-02-11 2004-08-26 Unilever Plc Compositions antitranspiration
US7744857B2 (en) 2003-02-11 2010-06-29 Unilever Home & Personal Care Usa A Division Of Conopco, Inc. Antiperspirant compositions
US8263058B2 (en) 2004-04-21 2012-09-11 The Procter & Gamble Company Personal care compositions that deposit hydrophilic benefit agents
WO2009063016A1 (fr) * 2007-11-16 2009-05-22 Unilever Plc Composition topique
WO2016005243A1 (fr) * 2014-07-08 2016-01-14 Henkel Ag & Co. Kgaa Agents cosmétiques anti-transpirants avec des protéines spéciales provenant de légumineuses de l'espèce pisum et/ou phaseolus et/ou vigna et/ou macrotyloma ou provenant de crucifères de l'espèce brassica, qui ne contiennent pas d'halogénures et/ou d'hydroxyhalogénures d'aluminium et/ou de zirconium
WO2016005199A1 (fr) * 2014-07-08 2016-01-14 Henkel Ag & Co. Kgaa Produits cosmétiques anti-transpirants comprenant des protéines spéciales issues des légumineuses du genre glycine, lesquelles ne contiennent pas d'halogénures et/ou d'hydroxyhalogénures d'aluminium et/ou de zirconium
US10123958B2 (en) 2014-07-08 2018-11-13 Henkel Ag & Co. Kgaa Antiperspirant cosmetics comprising specific proteins from legumes of the genus Pisum and/or Phaseolus and/or Vigna and/or Macrotyloma or from cruciferous plants of the genus Brassica and including no aluminum and/or zirconium halides and/or hydroxy halides
WO2016005198A1 (fr) * 2014-07-08 2016-01-14 Henkel Ag & Co. Kgaa Agents cosmétiques anti-transpirants avec des protéines spéciales provenant de sécrétions animales, de sécrétions d'insectes ou de sécrétions humaines, qui ne contiennent pas d'halogénures et/ou d'hydroxyhalogénures d'aluminium et/ou de zirconium
WO2016030048A1 (fr) * 2014-08-26 2016-03-03 Henkel Ag & Co. Kgaa Produits cosmétiques anti-transpirants contenant des protéines spéciales dérivées de malvacées du genre adansonia, exempts d'halogénures et/ou d'hydroxyhalogénures d'aluminium et/ou de zirconium
CN111918634A (zh) * 2018-03-28 2020-11-10 荷兰联合利华有限公司 非铝止汗剂组合物
WO2019185419A1 (fr) 2018-03-28 2019-10-03 Unilever Plc Compositions anti-transpirantes non-aluminium
WO2019185314A1 (fr) * 2018-03-28 2019-10-03 Unilever Plc Compositions anti-transpirantes sans aluminium
CN111918634B (zh) * 2018-03-28 2023-11-03 联合利华知识产权控股有限公司 非铝止汗剂组合物
AU2019245805B2 (en) * 2018-03-28 2022-05-26 Unilever Global Ip Limited Non-aluminium antiperspirant compositions
AU2019245709B2 (en) * 2018-03-28 2021-07-08 Unilever Global Ip Limited Non-aluminium antiperspirant compositions
WO2020108882A1 (fr) 2018-11-30 2020-06-04 Unilever Plc Compositions anti-transpirantes sans aluminium
WO2020108886A1 (fr) 2018-11-30 2020-06-04 Unilever Plc Compositions antiperspirantes non-aluminium
CN113164347A (zh) * 2018-11-30 2021-07-23 联合利华知识产权控股有限公司 非铝止汗剂组合物
CN113164351A (zh) * 2018-11-30 2021-07-23 联合利华知识产权控股有限公司 非铝止汗剂组合物
WO2020108878A1 (fr) 2018-11-30 2020-06-04 Unilever Plc Compositions anti-transpirantes sans aluminium
AU2019389075B2 (en) * 2018-11-30 2023-05-11 Unilever Global Ip Limited Non-aluminium antiperspirant compositions
WO2020108885A1 (fr) 2018-11-30 2020-06-04 Unilever Plc Compositions antitranspirantes sans aluminium
WO2022258385A2 (fr) 2021-06-07 2022-12-15 Unilever Ip Holdings B.V. Compositions et méthodes de régulation de la production de sueur
WO2023117481A1 (fr) 2021-12-22 2023-06-29 Unilever Ip Holdings B.V. Compositions cosmétiques de gestion de la transpiration
WO2023117480A1 (fr) 2021-12-22 2023-06-29 Unilever Ip Holdings B.V. Compositions cosmétiques de gestion de la transpiration
WO2023117371A1 (fr) 2021-12-22 2023-06-29 Unilever Ip Holdings B.V. Compositions cosmétiques de gestion de la transpiration

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AU6679894A (en) 1994-11-21

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