Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
  • A01N59/14—Boron; Compounds thereof

Definitions

• the present invention relates to germicidal com ⁇ positions which can be used for a wide variety of ap ⁇ plications ranging from applications to foods, paper and fibers to domestic applications. Specifically, the present invention relates to germicidal compositions which can be used typically for the sterilization and disinfection of city water for purification, the sterilization and disinfection of general foods led by meat and fishery products, the antisepsis of wood, antisepsis in paper manufacturing processes, and the sterilization and disinfection of toilet, bath rooms and kitchen at home and which are excellent in sterilizing effects and storage stability.
• an inorganic peroxide such as sodium perborate, sodium percarbonate or sodium persul- fate generates both hydrogen peroxide and nascent oxygen when dissolved in water and owing to these hydrogen peroxide and nascent oxygen, the peroxide ex ⁇ hibits cleaning, bleaching, sterilizing and disinfect- ing effects.
• compositions have been developed in which an inorganic peroxide is mixed with, as an ac ⁇ tivator for the inorganic peroxide, an organic acid ester such as an acetate ester or a propionate ester (Japanese Patent Laid-Open Nos. 14886/1973, 25011/1977, 139500/1970 and 63504/1987) .
• organic acid ester such as an acetate ester or a propionate ester
• compositions however undergo such reactions in the presence of even a slightest amount of water so that when stored for a long time, they will give off an irritating organic acid odor.
• those containing an inorganic peroxide and an ester of a polyhydric alcohol and an organic acid in combination are relatively stable against water (Japa- nese Patent Laid-Open No. 25011/1977) . They are, on the other hand, accompanied by the drawback that due to their low solubility in water, an organic peracid is not produced sufficiently, hence oxygen is formed only at a low rate and their sterilizing power is low.
• compositions with an organic peracid incorporated therein as is are accompanied with the drawback that they have an irritating odor and are hence low- in commercial value. Further, those composed of an organic peracid alone will involve the drawback that they decompose when stored for a long time.
• an object of the present invention is to provide a germicidal composition which stably generates an organic peracid, has sustained sterilizing power and has excellent storage stability.
• the present invention provides a germicidal com ⁇ position comprising the following components (A) , (B) and (C) :
• the resulting germicidal composition according to the pres ⁇ ent invention has good storage stability, good water solubility and high and long-lasting sterilizing ef ⁇ fects so that it can be used for a wide variety of ap- plications ranging from applications to foods, paper and fibers to domestic applications.
• the component (A) that is, the in- organic peroxide used in the present invention
• examples of the component (A) include sodium percarbonate, sodium perborate, sodium peroxytripolyphosphate, sodium peroxypyrophosphate and sodium peroxysilicate. Among them, sodium percarbonate and sodium perborate are particularly preferred.
• the component (B) which is the incomplete ester of the polyhydric alcohol with the organic acid serves as an activator for the inorganic peroxide as the com ⁇ ponent (A) . It reacts with the component (A) to form an organic peracid.
• One of characteristic features of the present in ⁇ vention resides in the incorporation of the incomplete ester of the polyhydric alcohol with the organic acid as an activator for the inorganic peroxide.
• the com ⁇ position with this incomplete ester incorporated there- in has excellent water-solubility and dramatically im- proved sterilizing effects compared with conventional compositions containing the complete ester of a polyhydric alcohol with an organic acid.
• the term "in ⁇ complete ester” as used herein means an ester in which the degree of esterification of a polyhydric alcohol is less than 100%.
• the esterification degree can preferably be 5-95%, with 60-95% being particularly preferred.
• the esterification degree can be measured from the degree of absorption at 3500 cm -1 in an infrared absorption spectrum.
• Illustrative examples of the polyhydric alcohol can include glycerins such as glycerin, diglycerin, triglycerin and polyglycerin; alkali-modified sucroses such as sorbitol, glutitol, pentaerythritol, alkyl- polyglycosides and alkylfuranosides; alkylene-oxide ad- ducts of these glycerins and sucroses.
• Preferred exam ⁇ ples of the organic acid can include saturated or un- saturated C 1 _ 8 fatty acids.
• alkali earth metal salt as the component (C) can include alkali earth metal salts of inorganic acids and halides of alkali earth metal salts.
• Illustrative alkali earth metals can include calcium and magnesium
• illustrative inorganic acids can include sulfuric acid, nitric acid, phosphoric acid and carbonic acid
• illustrative halogens can include chlorine and bromine.
• Specific examples of the com ⁇ ponent (C) include magnesium sulfate, calcium sulfate, magnesium phosphate, calcium phosphate, magnesium nitrate, calcium nitrate, magnesium chloride, calcium chloride, basic magnesium carbonate and calcium car ⁇ bonate, and anhydrous salts thereof.
• the component (C) has stabilizing effects for the organic peracid to be formed through the reaction be ⁇ tween the component (A) and the component (B) , and the addition of the component (C) has improved the long- lasting ability of sterilizing effects.
• the components (A) to (C) can be mixed properly depending on its application purpose. In view of sterilizing effects, storage stability, economy and the like, it is preferred to mix 0.01-10 parts by weight of the component (B) and 0.01-90 parts by weight of the component (C) with 1 part by weight of the component (A) . Particularly preferred is to add the component (C) 0.01-100 times, particularly 0.1-20 times in weight relative to the component (B) .
• the germicidal composition of the present invention can contain various additives such as surfactants, in ⁇ organic or organic alkali metal salts, builders, flavorants, pigments, dyes, pH regulators and metallic chelating agents.
• surfactants can include nonionic, anionic and ampholytic ones.
• ples can include nonionic surfactants such as polyoxy- ethylene (hereinafter abbreviated as "POE") C 6 _ 22 alkyl ethers, POE C 4 _ 18 alkylphenol ethers, block or random polyoxypropylene-polyoxyethylene alkyl ethers, POE phenylphenol ether, POE styrenated phenol ether and POE tribenzylphenol ether; anionic surfactants such as lig- nin sulfonate salts, alkylbenzene sulfonate salts, alkyl sulfonate salts, POE alkyl sulfonate salts, POE alkylphenylether sulfonate salts, POE alkylphenylether- phosphate ester salts, POE phenylphenolether sulfonate salts, POE phenylphenolether phosphate ester salts, naphthalene sul, PO
• alkali metal salts in ⁇ clude alkali metal salts of organic acids and those of inorganic acids.
• Specific examples of the former ones can include alkali metal salts of carboxylic acids such as succinic acid, malonic acid, citric acid and gluconic acid, glutaric acid; and those of the latter on can include alkali metal salts of phosphoric acid compou such as tripolyphosphoric acid, hexametaphosphoric acid phosphoric acid, and alkali metal salts of mineral acids such as Na 2 S0 4 , K S0 4 and NaHS0 4 .
• the addition of such a salt makes it possible to provide improved storage stability and also to prevent the generation of an organic peracid odor.
• These salts may be used ei ⁇ ther singly or in combination.
• These alkali metal salt can be added preferably in an amount of 0.1-10 wt.%, with 0.5-5 wt.% being particularly preferred.
• pH regulator examples include organic acids such as citric acid, malonic acid, suc ⁇ cinic acid and gluconic acid. They may be used either singly or in combination. It is preferred to add such a regulator in such an amount as providing an aqueous solution of the composition of this invention with pH 5-10, for example in an amount of 0.5-5 wt.%.
• metal chelating agent examples include ethylenedia inetetraacetic acid, nitrilotriacetic acid, tripolyphosphoric acid and polyhydroxyacrylic acid, and salts thereof.
• the germicidal composition according to the pres ⁇ ent invention can be produced in a solid form such as powder, granules or tablets by a method known per se in the art. Upon use, it is diluted with water and is then applied. The concentration of the composition differs with the item, place or the like to be treated. In general, however, 25-1,000 ppm is desired in terms of ⁇ he concentration of the inorganic peroxide.
• the components (A) , (B) and (C) can be furnished in separate packages and upon use, they are diluted together with water and are then ap ⁇ plied together.
• each invention composition comprising the components (A) , (B) and (C) generates a corresponding organic peracid in a large amount and furthermore, the organic peracid remains at a high concentration for a long time.
• germicidal compositions were prepared by pro- portioning the components. They were hermetically stored at 40°C and 75% humidity for a month. Each com ⁇ position was then checked for any organic acid odor.
• the sterilizing power of the composition accord ⁇ ing to the present invention was studied against Escherichia Coli IFO 3796 by modifying the Tanaka's meth- od [Tokumitsu Tanaka, "Method for Measuring Sensitivity to Chemicals” edited by Susumu Mitsuhashi, Kodansha, Tokyo Japan (1980)].
• precultured cells about 10 8 cells/m£
• precultured cells about 10 8 cells/m£
• test tube containing 10 m_ of a solution of an invention germicidal composition which solution had been prepared 15 minutes ago by diluting the composition a predetermined number of times in distilled sterile water, and the solution was allowed to act on them at room temperature.
• the contents of the test tube were sampled out by a platinum loop and in ⁇ oculated to a 96-well Petri dish (product of Corning Glass Works.; 370 ⁇ l per well) whose wells each con- tained 300 ⁇ l of a postculture medium.
• the germicidal compositions according to the present invention have strong and long-lasting sterilizing effects and also excellent storage stability, so that they can be employed at a wide vari- ety of places ranging from various factories to home.

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• Life Sciences & Earth Sciences (AREA)
• Agronomy & Crop Science (AREA)
• Pest Control & Pesticides (AREA)
• Plant Pathology (AREA)
• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Dentistry (AREA)
• General Health & Medical Sciences (AREA)
• Wood Science & Technology (AREA)
• Zoology (AREA)
• Environmental Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Inorganic Chemistry (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)

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Cited By (26)

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• 1993
  • 1993-04-28 JP JP10295793A patent/JP3281445B2/ja not_active Expired - Fee Related
• 1994
  • 1994-04-26 TW TW83103723A patent/TW252907B/zh active
  • 1994-04-27 WO PCT/JP1994/000710 patent/WO1994024869A1/en not_active Ceased

Patent Citations (4)

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