WO1994012115A1 - Gant medical de protection et composition antibacterienne/antisudorale destinee a reduire la croissance bacterienne lors de l'utilisation desdits gants - Google Patents

Gant medical de protection et composition antibacterienne/antisudorale destinee a reduire la croissance bacterienne lors de l'utilisation desdits gants Download PDF

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Publication number
WO1994012115A1
WO1994012115A1 PCT/US1993/011317 US9311317W WO9412115A1 WO 1994012115 A1 WO1994012115 A1 WO 1994012115A1 US 9311317 W US9311317 W US 9311317W WO 9412115 A1 WO9412115 A1 WO 9412115A1
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WO
WIPO (PCT)
Prior art keywords
hand
medical glove
agent
protective medical
accordance
Prior art date
Application number
PCT/US1993/011317
Other languages
English (en)
Inventor
Jonnie Buchanan
Harry C. Dees, Jr.
Original Assignee
Buchanan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Buchanan, Inc. filed Critical Buchanan, Inc.
Publication of WO1994012115A1 publication Critical patent/WO1994012115A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B42/00—Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/28—Zirconium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D19/00—Gloves
    • A41D19/0055—Plastic or rubber gloves
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D2400/00—Functions or special features of garments
    • A41D2400/32—Therapeutic use
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D2400/00—Functions or special features of garments
    • A41D2400/52—Disposable
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/30—Antimicrobial, e.g. antibacterial
    • A41D31/305—Antimicrobial, e.g. antibacterial using layered materials

Definitions

  • the present invention relates to a composition for reducing the incidence of bacterial growth on the hands of an individual wearing a pair of protective medical gloves.
  • the invention relates to a composition containing an antiperspirant agent in combination with an antibacterial agent selected to reduce the rate of bacterial growth within the protective medical glove.
  • the present invention further relates to a protective medical glove having an antiperspirant agent and an antibacterial agent disposed on its interior surface in order to reduce the rate of bacterial growth within the protective medical glove during wearing thereof.
  • the protective medical gloves are constructed of a non-porous material designed to provide a tight fit between the glove and the hand, thereby preventing the evaporation of perspiration secreted from the hand.
  • the resulting warm, moist environment within the glove promotes the growth of bacteria within the protective medical glove.
  • the presence of perspiration within the protective glove can also cause the glove to slip from its desired position on the hand, thereby interfering with the wearer's ability manually to manipulate objects. Slipping of the protective medical glove may result in the exposure of the wearer's skin to the very external agents which the glove is designed to exclude.
  • slippage of the protective medical glove may result in the introduction of perspiration and the human flora contained therein into the tissues of the patient being treated, thereby bringing about the development of infections or necrosis.
  • Bacterial growth within protective medical gloves is attributable in part to the common use of cornstarch on the interior surface of the glove in order to facilitate donning. It has been found that the cornstarch typically used as a donning agent contains bacteria which reproduce rapidly during the wearing of the protective medical glove. In addition, bacteria commonly found on human skin, or secreted in human perspiration, tend to reproduce at an accelerated rate during the wearing of protective medical gloves due to the entrapment of perspiration on the skin's surface. Prolonged exposure of the hand to these bacteria can produce skin irritation, allergic reactions, and even serious skin infections.
  • U.S. Patent No. 5,019,604 to Lemole discloses a gel composition to be applied to the hands prior to the donning of protective medical gloves.
  • the gel composition includes antimicrobial and antiviral agents selected to reduce the rate of bacterial growth on the skin during wearing of the protective medical glove.
  • U.S. Patent No. 5,003,638 to Miyake et al. and U.S. Patent No. 5,089,205 to Huang et al. show the application of an antimicrobial or an antiviral agent to a surface of the protective medical glove.
  • the present invention is directed to a composition comprising a combination of an antiperspirant agent and an antibacterial agent selected to reduce the rate of bacterial growth on a human hand during the wearing of a protective medical glove.
  • the composition can be applied to the hand in powder or lotion form or can be applied as a coating to the interior surface of a protective medical glove.
  • the present invention is directed to a method for reducing the rate of bacterial growth on a hand during the wearing of a protective medical glove, the method including the steps of applying an antibacterial agent in combination with an antiperspirant agent to the hand prior to donning the protective medical glove.
  • FIGURE 1 is a graph showing the beneficial effects achieved by utilizing a compound containing an antiperspirant agent and an antibacterial agent in accordance with the present invention
  • FIGURE 2 is a plan view of a protective medical glove having an internal coating in accordance with the present invention.
  • FIGURE 3 is a cross-sectional view of the body of the protective medical glove of FIGURE 2.
  • the present invention comprises an antiperspirant agent in combination with an antibacterial agent, such composition being created for the purpose of inhibiting the growth of bacteria on the skin of a hand during the wearing of a protective medical glove.
  • Protective medical gloves are ordinarily constructed of a substantially liquid-impermeable material, including rubber materials such as latex and thermoplastic materials such as vinyl. Such liquid-impermeable materials tend to inhibit or prevent the evaporation of moisture from the hand during wearing of the protective medical glove.
  • the antiperspirant agent used in conjunction with the composition of the present invention is preferably of a type that does not irritate the skin.
  • Aluminum glycinate and aluminum chlorohydrate glycinate have been found to provide the desired perspiration-inhibiting characteristics without causing skin irritation.
  • other antiperspirant agents can be used in connection with the present invention.
  • aluminum-zirconium tetrachlorohydrex glycine sold by Dow Corning Corporation under the trademark "AZG-369" can be used as an antiperspirant agent in conjunction with the present invention.
  • alcloxa aluminum chloride, aluminum chlorohydrex, aluminum PCA, zirconium chlorohydrates, aluminum zirconium tetrachlorohydrates and aluminum chlorohydrates can be used as antiperspirant agents in conjunction with the composition of the present invention. It will be appreciated that any combination of the above-enumerated antiperspirant agents also can be employed in conjunction with the composition of the present invention.
  • the antiperspirant agent is present in the composition of the present invention in an amount sufficient to provide a reduction in the perspiration rate in the affected skin region without causing irritation to the skin. It will be appreciated that the amount and concentration of the antiperspirant agent required to produce the requisite reduction in the perspiration rate will vary dependent upon the basal perspiration rate of the individual wearing the protective medical glove. In addition, the amount of antiperspirant agent required will vary dependent upon the length of time that the protective medical glove is to be worn as well as the environmental conditions in which the glove will be worn. The requisite amount of antiperspirant agent will also vary based upon the particular antiperspirant composition used. Antiperspirant agent concentrations of 1% - 20% (by volume of the composition) have been found to provide optimal results in conjunction with the composition of the present invention.
  • an antiperspirant agent in the composition of the present invention will tend to reduce the rate of perspiration and thus reduce the amount of perspiration trapped between the hand and the protective medical glove.
  • FIGURE 1 the use of an antiperspirant agent has been shown to result in a marked reduction in the incidence of bacteria on the skin of the hand during periods of protective medical glove use.
  • the reduction in the rate of bacterial growth is attributable to the reduction in the presence of moisture on the skin surface, thereby providing a less hospitable environment for bacterial growth.
  • the reduction in the rate of bacterial growth depicted in FIGURE 1 is further attributable to the reduction in the presence of bacteria secreted with human perspiration.
  • perspiration contains various salts which can cause irritation to the skin.
  • the use of an antiperspirant agent in the composition of the present invention reduces bacterial growth and concurrently reduces the incidence of skin irritation.
  • composition of the present invention further includes an antibacterial agent.
  • the particular antibacterial agent used in conjunction with the present invention may vary dependent upon the chemical characteristics of the antiperspirant agent selected. However, it has been found that 5-chloro-2- (2,4- dichlorophenoxy)phenol 2,4,4', commonly known as Triclosan, provides the desired antibacterial characteristics when used in conjunction with the composition of the present invention.
  • antibacterial agents including ammonium iodide, chlorhexidine, chlorhexidine diacetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, hexamidine diisethionate, hexetidine, lauralkonium bromide, lauralkonium chloride, laurtrimonium chloride, laurylpyridinium chloride, orange peel extract, quaternium 73, benzalkonium chloride, bromochlorophene, 2-bromo-2-nitropropane-l,3-propandiol, captan, cetethyldimonium bromide, cetyl pyridinium chloride, chlorothymol, chloroxylenol, copper PCA, dichlorobenzyl alcohol, dilauryldimonium chloride, domiphen bromide, hexamidine diisethionate, lichen extract, myristalkonium chloride, phenoxyethanol, phenoxyethyl
  • any combination of the above- enumerated antibacterial agents also may be used in conjunction with the composition of the present invention.
  • the antibacterial agent is present in the composition of the present invention in an amount sufficient to inhibit the growth of bacteria on the hand during wearing of a protective medical glove without causing skin irritation.
  • the amount and concentration of the antibacterial agent used in connection with the present invention will vary dependent upon the type of antibacterial agent used, the type of antiperspirant agent used in the composition of the present invention, the body chemistry of the person utilizing the compound of the present invention, the period of time during which the protective medical glove is to be worn, as well as the environmental conditions in which the glove is used.
  • FIGURE 1 shows the decrease in bacteria count realized through the application of an antibacterial agent to the hand prior to donning a protective medical glove.
  • FIGURE 1 also shows the decrease in bacteria count achieved through the use of the composition of the present invention which contains both an antiperspirant agent and an antimicrobial agent. It is to be appreciated that the antiperspirant and antibacterial agents work synergistically to reduce the rate of bacterial growth on the hand during wearing of the glove.
  • an antiperspirant agent in combination with an antibacterial agent in accordance with the present invention provides a greater reduction in the bacteria count on the hand during wearing of a protective medical glove than the reductions realized by using either the antiperspirant agent or the antibacterial agent by itself.
  • the composition of the present invention may include an antiviral agent.
  • the type of antiviral agent used can be varied dependent upon the particular circumstances in which the protective medical gloves are to be used. For example, if there is a risk of infection with the HIV virus, it is preferable that the antiviral agent be capable of killing the HIV virus in the event of an inadvertent piercing of the protective medical glove. It has been found that the antiviral agent nonoxynol-9 provides significant HIV virus killing capabilities.
  • the composition of the present invention may also incorporate a skin moisturizing agent.
  • a skin moisturizing agent in the composition of the present invention has been shown to reduce the occurrence of skin irritation often associated with the wearing of non-porous protective medical gloves.
  • skin moisturizing agents can be used in combination with the method of the present invention.
  • moisture sealants such as "GLYCOCER", the name given to Waitaki International Biosciences' family of glycoceramides, can be used in conjunction with the composition of the present invention.
  • Glycosphingolipids also can be used as skin moisturizing agents in conjunction with the composition of the present invention.
  • the composition of the present invention can also include an anti-irritant agent effective for relieving skin irritations such as dermatitis, eczema, itching, allergy, rash, or general inflammation.
  • Hydrocortisone 11, 17, 21-trihydroxypreg-4-ene-3, 20-dione
  • the concentration of the anti-irritant agent in the composition of the present invention will vary dependent upon the circumstances under which the protective medical glove is used as well as the particular needs of the person wearing the protective medical gloves. However, concentrations of the anti-irritant agent of 5% - 10% by volume of the composition of the present invention have been found to provide the desired characteristics.
  • composition of the present invention can be formulated with any known pharmaceutically acceptable carrier, such as lotions, creams, and powders whereby the composition can be applied either to the hands or to the interior surface of the protective medical glove.
  • the particular formulation to be used can vary based upon the particular desires and needs of the individual wearing the protective medical gloves.
  • the composition of the present invention is to be applied to the interior surface of a protective medical glove, it is preferable that the composition of the present invention be formulated in a powder form such that it can be combined with common talc and then applied to the interior surface of the protective medical glove.
  • Methods for the application of common talc to the interior surface of a protective medical glove are well-known in the art.
  • composition of the present invention can also be formulated in a spray form so that a coating may be sprayed on the hands or on the interior of a protective medical glove prior to the donning of the glove. It will be appreciated that a spray coating of the composition of the present invention on the interior surface of a protective medical glove will provide substantially the same results as applying the composition to the hands prior to donning of the glove.
  • the antiperspirant and antibacterial agents of the composition of the present invention can be incorporated into liposomes whereby they are delivered to the skin of the hand on a time-released basis.
  • liposomes can be formulated for application to the interior surface of the protective medical glove, or they can be formulated for application directly to the hand prior to donning of the glove.
  • the antiviral agent and the moisturizing agent of the composition of the present invention can be incorporated into the same pharmaceutically acceptable carrier, including a carrier containing liposomes for time-released delivery.
  • the non-greasy hand conditioner consisted of glyceryl stearate (3.6% by volume), PEG-40 stearate (2.0% by volume) , cetearyl alcohol (and) ceteareth-20 (promulgen D) (1.5% by volume), cetyl alcohol (1.0% by volume), cetyl c i 2, i s pareth-9-carboxylate (Velsan P8-16) (4.1% by volume), propylparaben (0.2% by volume), hydroxyethylcellulose (Natrosol HHR 250) (0.5% by volume) propylene glycol (3.1% by volume), methylparaben (0.1% by volume), and water (83.7% by volume) .
  • the resulting composition can be applied to the hands prior to the donning of a protective medical glove.
  • FIGURE 1 depicts the beneficial results of the application of a non-greasy hand conditioner prepared in accordance with Example 1.
  • the first bar set forth in FIGURE 1 reflects the mean colony forming unit (CFU) count found on a hand prior to the donning of a protective medical glove, the mean being determined over five (5) tests. Each count was achieved by rinsing the hand with 50 ml of trypticase soy broth. The rinsing solution was collected and filtered through a 0.22 micron filter. The filter was then incubated overnight on a 5% sheep's blood agar. The number of colony forming units was then determined using standard microbiological techniques. The mean CFU count for a hand prior to the donning of a protective medical glove was thus determined to be 31.2.
  • CFU colony forming unit
  • the second bar set forth in FIGURE 1 reflects the mean CFU count determined after a protective medical glove had been worn on a hand for a period of six (6) hours, the mean being determined over five tests. Again, each count was achieved by rinsing the hand with 50 ml of trypticase soy broth. The rinsing solution was collected and filtered through a 0.22 micron filter. The filter was then incubated overnight on sheep's blood agar. The number of colony forming units was then determined using standard microbiological techniques. The mean CFU count for a hand after wearing of a protective medical glove for a period of six (6) hours was thus determined to be 65.4.
  • the third bar set forth in FIGURE 1 reflects the mean CFU count determined after a protective medical glove had been worn on a hand for a period of six (6) hours, the mean being determined over five (5) tests.
  • approximately 5 ml of a non-greasy hand conditioner (as discussed above in Example 1) containing 1% by volume of Triclosan was applied to each hand.
  • each count was achieved by rinsing the hand with 50 ml of trypticase soy broth.
  • the rinsing solution was collected and filtered through a 0.22 micron filter. The filter was then incubated overnight on sheep's blood agar. The number of colony forming units was then determined using standard microbiological techniques.
  • the mean CFU count for a hand after wearing of a protective medical glove for a period of six (6) hours following the application of an antibacterial agent was thus determined to be 27.8.
  • the fourth bar set forth in FIGURE 1 reflects the mean CFU count determined after a protective medical glove had been worn on a hand for a period of six (6) hours, the mean being determined over five (5) tests.
  • 5 ml of a non-greasy hand conditioner (as discussed above in Example 1) containing 1% by weight of Dow Corning "AZG-368" was applied to each hand. Each count was achieved by rinsing the hand with 50 ml of trypticase soy broth.
  • the rinsing solution was collected and filtered through a 0.22 micron filter. The filter was then incubated overnight on sheep's blood agar. The number of colony forming units was then determined using standard microbiological techniques. The mean CFU count for a hand after wearing of a protective medical glove for a period of six (6) hours following the application of an antiperspirant agent was thus determined to be 25.8.
  • the fifth bar set forth in FIGURE 1 reflects the mean CFU count determined after a protective medical glove had been worn on a hand for a period of six (6) hours, the mean being determined over five (5) tests.
  • a non- greasy hand conditioner containing an antiperspirant agent and an antibacterial agent in accordance with Example 1 was applied to the hands. Each count was achieved by rinsing the hand with 50 ml of trypticase soy broth. The rinsing solution was collected and filtered through a 0.22 micron filter. The filter was then incubated overnight on sheep's blood agar. The number of colony forming units was then determined using standard microbiological techniques. The mean CFU count for a hand after wearing of a protective medical glove for a period of six (6) hours following the application of a bacteriostat was thus determined to be 2.8.
  • the water-in-oil skin cream consisted of methyl glucose isostearate (grillocose IS) (2.0% by volume), octyl octanoate (4.1% by volume), cyclomethicone (4.1% by volume), jojoba oil (0.8% by volume), PEG-45/dodecyl glycol copolymer (1.0% by volume), deionized water (79.8% by volume), glycerin (3.1% by volume), propylene glycol (3.1% by volume), magnesium sulphate (0.7% by volume), panthenol (0.5% by volume), tocopheryl acetate (0.2% by volume), methyldibromo glutaronitrile (and) phenoxyethanol (0.2% by volume), and fragrance (0.4% by volume).
  • the resulting formulation can be used by applying it to the hands prior to donning a protective medical glove.
  • the resulting composition can be applied to the hands prior to the donning of a protective medical glove.
  • the rejuvenating cream consisted of PEG-150 stearate (2.0% by volume), glyceryl stearate (2.6% by volume), glyceryl laurate (2.0% by volume), octyl stearate (10.2% by volume), octyl palmitate (10.2% by volume), stearic acid (2.6% by volume), cetyl alcohol (2.0% by volume), tocopheryl nicotinate (0.1% by volume), 3- (4-methylbenzylidene) -camphor (2.6% by volume), aloe extract, oil-soluble (0.5% by volume), propylparaben (0.03% by volume), propylene glycol (2.0% by volume), methylparaben (0.2% by volume), DMDM hydantoin (0.3% by volume, triethanolamine, DEA-free (0.5% by volume), demineralized water (54.5% by volume), glycerine (pricerine 9081) (5.1% by volume), sodium lactate (and) sodium PCA (and
  • the protective hand cream consisted of steareth-2 (3.1% by volume), steareth- 21 (2.0% by volume), glyceryl stearate (3.1% by volume), stearic acid (2.0% by volume), caprylic/capric triglyceride (myritol 318) (3.1% by volume), parabens
  • the spray moisturizer consisted of deionized water (92.6% by volume), hyaluronic acid (and) echinacin (lipocare HA/EC) (2.0% by volume), glycereth-26 (liponic EG-l) (5.1% by volume), slippery elm extract, 5:1PG (0.1% by volume), matricaria extract, 5:1PG (0.1% by volume), althea extract, 5.1PG (0.1% by volume) .
  • the resulting formulation can be used by applying it to the hands prior to donning a protective medical glove, or the resulting formulation can be sprayed onto the interior surface of a protective medical glove to form a moist coating which will facilitate donning of the glove and will coat the surface of the hand and fingers.
  • the protective hand cream can consist of steareth-2 (3.1% by volume), steareth-21 (2.0% by volume), glyceryl stearate (3.1% by volume), stearic acid (2.0% by volume), caprylic/capric triglyceride (myritol 318) (3.1% by volume), parabens (0.15% by volume), water (74.9% by volume), cyclomethicone (Abil K4) (4.1% by volume), glycerin (5.1% by volume), perfluoropolymethylisopropyl ether (Fomblin Hc/H) (2.0% by volume), imidazolidinyl urea (0.3% by volume), and sodium dehydroacetate (0.1% by volume) .
  • the resulting formulation can be used by applying it to the hands prior to donning a protective medical glove.
  • the non-greasy hand conditioner can consist of glyceryl stearate (5.8% by volume), PEG-40 stearate (3.3% by volume) , cetearyl alcohol (and) ceteareth-20 (promulgen D) (2.5% by volume), cetyl alcohol (1.7% by volume), cetyl c i 2, i s pareth-9-carboxylate (Velsan P8-16) (6.7% by volume), propylparaben (0.3% by volume), hydroxyethylcellulo ⁇ e (Natrosol HHR 250) (0.8% by volume) propylene glycol (5.0% by volume), methylparaben (0.2% by volume), and water (73.7% by volume) .
  • the resulting composition can be applied to the hands prior to the donning of protective medical gloves.
  • the present invention further includes a method for reducing the rate of bacterial growth on a hand during the wearing of a protective medical glove.
  • the method includes the application of an antiperspirant agent and an antibacterial agent to the skin of the hand prior to the donning of the glove.
  • the particular antiperspirant agent and antibacterial agent used in conjunction with the method of the present invention are the same as discussed in detail above with respect to the composition of the present invention.
  • the antiperspirant agent and the antibacterial agent can be applied simultaneously to the skin of the hand, i.e., in a single formulation as discussed in detail above, or they can be applied separately.
  • the antiperspirant agent and the antibacterial agent can be incorporated into any pharmaceutically acceptable carrier, as discussed above with respect to the composition of the present invention. Following the application of these agents to the skin, a protective medical glove is applied to the hand.
  • a protective medical glove 12 has an interior surface 14 and an exterior surface 16.
  • Protective medical gloves are commonly constructed of a thin plastic film as depicted in FIGURE 2.
  • Interior surface 14 is constructed to engage the hand of a person during wearing of protective medical glove 12.
  • a coating 18 is applied to interior surface 14 of protective medical glove 12.
  • Coating 18 comprises an antiperspirant agent and an antibacterial agent as discussed in detail above. It will be appreciated that coating 18 can be applied to interior surface 14 of protective medical glove 12 through a variety of known methods.
  • coating 18 can be applied to interior surface 14 in a powder form, as discussed above in Example 6, such that the antibacterial agent and the antiperspirant contained in coating 18 at least partially adhere to interior surface 14.
  • coating 18 can include a liquid carrier in which the antiperspirant and antibacterial agents are dissolved, as discussed above in Example 5. The liquid carrier is then sprayed onto interior surface 14 of protective medical glove 12 in order to create coating 18.

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Abstract

Composition destinée à inhiber la croissance bactérienne sur une main pendant le port d'un gant médical de protection sur ladite main. Ladite composition comporte un agent antisudoral et un agent antibactérien qui sont appliqués sur la main de l'utilisateur avant que ce dernier n'enfile le gant médical de protection, afin de réduire le degré de transpiration et de croissance bactérienne sur la peau de la main. Un gant médical de protection doté sur sa surface interne d'un agent antibactérien et d'un agent antisudoral est également décrit.
PCT/US1993/011317 1992-11-20 1993-11-22 Gant medical de protection et composition antibacterienne/antisudorale destinee a reduire la croissance bacterienne lors de l'utilisation desdits gants WO1994012115A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98417892A 1992-11-20 1992-11-20
US07/984,178 1992-11-20

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WO1994012115A1 true WO1994012115A1 (fr) 1994-06-09

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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996015666A1 (fr) * 1994-11-22 1996-05-30 The University Of Connecticut Composition biocide synergique contenant de la pyrithione et un additif
EP0771156A1 (fr) * 1994-07-15 1997-05-07 Laxmi S. Srivastava Gant a matiere colorant les mains
EP0776191A1 (fr) * 1995-06-13 1997-06-04 Zahra Mansouri Procede d'administration de materiaux dans la peau et compositions utilisees lors de ce procede
DE19905585A1 (de) * 1999-02-11 2000-08-17 Beiersdorf Ag Verwendung von quaternären Ammoniumverbindungen als Antitranspirantien
US6274154B1 (en) * 1999-04-07 2001-08-14 Belle L Chou Aloe Vera glove and manufacturing method
WO2001010567A3 (fr) * 1999-08-06 2001-09-27 Procter & Gamble Applicateur semi-ouvert utilisant un materiau en feuille activable de façon selective destine a distribuer et disperser une substance a la surface d'un objet cible
JP2003064514A (ja) * 2001-08-23 2003-03-05 Shen Wei (Usa) Inc アロエ・ベラのグローブおよび製造方法
US6560782B2 (en) 2001-06-11 2003-05-13 Playtex Products, Inc. Antimicrobial glove and method of making same
US6579516B1 (en) 1995-06-13 2003-06-17 Zahra Mansouri Methods of delivering materials into the skin, and compositions used therein
US6630152B2 (en) * 1999-04-07 2003-10-07 Shen Wei (Usa), Inc. Aloe vera glove and manufacturing method
EP1360940A1 (fr) * 2002-05-02 2003-11-12 Belle L. Chou Article élastomère, flexible et anti-microbien, tel que un gant, et procédé de fabrication
EP1362581A2 (fr) 2002-05-17 2003-11-19 Xantech Pharmaceuticals, Inc. Compositions contenant une combinaison d'agent antiperspirant et antimicrobienne
WO2004060432A1 (fr) * 2002-12-23 2004-07-22 Kimberly-Clark Worldwide, Inc. Articles elastomeres comprenant un revetement benefique sur la surface en contact avec la peau
EP1581051A1 (fr) * 2002-12-17 2005-10-05 Ansell Healthcare Products LLC Gant traite a la camomille/ a l'aloe vera
EP1590009A1 (fr) * 2002-10-21 2005-11-02 Allegiance Corporation Composition de revetement pour surface en contact avec la peau d'articles elastomeriques et articles contenant ladite composition
WO2005105027A1 (fr) * 2004-04-27 2005-11-10 Beiersdorf Ag Formulation anti-transpiration aqueuse
WO2010046061A2 (fr) * 2008-10-21 2010-04-29 Cognis Ip Management Gmbh Préparations cosmétiques et/ou pharmaceutiques
CN1946371B (zh) * 2004-04-27 2011-01-26 拜尔斯道夫股份有限公司 含水止汗制剂
JP2016516856A (ja) * 2013-03-28 2016-06-09 ペーアーエルイクス プラスティクス ベーフェーＰＡＲＸ Ｐｌａｓｔｉｃｓ ＢＶ 抗菌性ポリマーおよびそれを製造する方法

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Cited By (45)

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Publication number Priority date Publication date Assignee Title
EP0771156A1 (fr) * 1994-07-15 1997-05-07 Laxmi S. Srivastava Gant a matiere colorant les mains
EP0771156A4 (fr) * 1994-07-15 1997-10-08 Laxmi S Srivastava Gant a matiere colorant les mains
CN1101131C (zh) * 1994-11-22 2003-02-12 康涅狄格州大学 含有羟基吡啶硫酮和添加剂的协同生物杀伤剂组合物
US5540920A (en) * 1994-11-22 1996-07-30 Olin Corporation Synergistic biocide composition containing pyrithione plus an additive
WO1996015666A1 (fr) * 1994-11-22 1996-05-30 The University Of Connecticut Composition biocide synergique contenant de la pyrithione et un additif
US5716628A (en) * 1994-11-22 1998-02-10 The University Of Connecticut Synergistic biocide composition containing pyrithione plus an additive
MY115993A (en) * 1994-11-22 2003-10-31 Univ Connecticut Synergistic biocide composition containing pyrithione plus an additive
US7771753B2 (en) 1995-06-13 2010-08-10 Laboratory Skin Care, Inc. Topical formulations comprising ceramic hydroxyapatite particles
EP0776191A1 (fr) * 1995-06-13 1997-06-04 Zahra Mansouri Procede d'administration de materiaux dans la peau et compositions utilisees lors de ce procede
US7655250B2 (en) 1995-06-13 2010-02-02 Laboratory Skin Care, Inc. Topical formulations comprising ceramic hydroxyapatite particles
EP0776191A4 (fr) * 1995-06-13 1999-01-20 Zahra Mansouri Procede d'administration de materiaux dans la peau et compositions utilisees lors de ce procede
US6579516B1 (en) 1995-06-13 2003-06-17 Zahra Mansouri Methods of delivering materials into the skin, and compositions used therein
DE19905585A1 (de) * 1999-02-11 2000-08-17 Beiersdorf Ag Verwendung von quaternären Ammoniumverbindungen als Antitranspirantien
EP1774863A3 (fr) * 1999-04-07 2007-04-25 Belle L. Chou Gant à l'aloe vera et son procédé de fabrication
US20120192336A1 (en) * 1999-04-07 2012-08-02 Shen Wei (Usa), Inc. Skin-Enhancing Glove and Method of Manufacture
US6630152B2 (en) * 1999-04-07 2003-10-07 Shen Wei (Usa), Inc. Aloe vera glove and manufacturing method
US6423328B2 (en) * 1999-04-07 2002-07-23 Shen Wei (Usa) Inc. Aloe vera glove and manufacturing method
US6274154B1 (en) * 1999-04-07 2001-08-14 Belle L Chou Aloe Vera glove and manufacturing method
US6953582B2 (en) 1999-04-07 2005-10-11 Sheh Wei (Usa), Inc. Skin-enhancing glove and method of manufacture
US6692756B2 (en) 1999-04-07 2004-02-17 Shen Wei (Usa), Inc. Aloe vera glove and manufacturing method
WO2001010567A3 (fr) * 1999-08-06 2001-09-27 Procter & Gamble Applicateur semi-ouvert utilisant un materiau en feuille activable de façon selective destine a distribuer et disperser une substance a la surface d'un objet cible
US6913758B2 (en) 2001-06-11 2005-07-05 Playtex Products, Inc. Antimicrobial glove and method of making same
US6560782B2 (en) 2001-06-11 2003-05-13 Playtex Products, Inc. Antimicrobial glove and method of making same
JP4656800B2 (ja) * 2001-08-23 2011-03-23 シェンウェイ （ユーエスエー），インコーポレイテッド アロエ・ベラのグローブおよび製造方法
JP2003064514A (ja) * 2001-08-23 2003-03-05 Shen Wei (Usa) Inc アロエ・ベラのグローブおよび製造方法
EP1360940A1 (fr) * 2002-05-02 2003-11-12 Belle L. Chou Article élastomère, flexible et anti-microbien, tel que un gant, et procédé de fabrication
EP1362581A3 (fr) * 2002-05-17 2004-11-17 Xantech Pharmaceuticals, Inc. Compositions contenant une combinaison d'agent antiperspirant et antimicrobienne
JP2003335704A (ja) * 2002-05-17 2003-11-28 Xantech Pharmaceuticals Inc 制汗剤と抗菌剤の複合組成物
EP1362581A2 (fr) 2002-05-17 2003-11-19 Xantech Pharmaceuticals, Inc. Compositions contenant une combinaison d'agent antiperspirant et antimicrobienne
US7201914B2 (en) 2002-05-17 2007-04-10 Xantech Pharmaceuticals, Inc. Combination antiperspirant and antimicrobial composition
EP1590009A1 (fr) * 2002-10-21 2005-11-02 Allegiance Corporation Composition de revetement pour surface en contact avec la peau d'articles elastomeriques et articles contenant ladite composition
US8835014B2 (en) 2002-10-22 2014-09-16 Allegiance Corporation Coating composition for skin-contacting surface of elastomeric articles and articles containing the same
EP1590009A4 (fr) * 2002-10-22 2010-11-03 Allegiance Corp Composition de revetement pour surface en contact avec la peau d'articles elastomeriques et articles contenant ladite composition
EP1581051A1 (fr) * 2002-12-17 2005-10-05 Ansell Healthcare Products LLC Gant traite a la camomille/ a l'aloe vera
US8282948B2 (en) 2002-12-17 2012-10-09 Ansell Healthcare Products, Inc. Camomile treated glove
EP1581051A4 (fr) * 2002-12-17 2007-08-08 Ansell Healthcare Prod Llc Gant traite a la camomille/ a l'aloe vera
WO2004060432A1 (fr) * 2002-12-23 2004-07-22 Kimberly-Clark Worldwide, Inc. Articles elastomeres comprenant un revetement benefique sur la surface en contact avec la peau
CN1946371B (zh) * 2004-04-27 2011-01-26 拜尔斯道夫股份有限公司 含水止汗制剂
WO2005105027A1 (fr) * 2004-04-27 2005-11-10 Beiersdorf Ag Formulation anti-transpiration aqueuse
US9072916B2 (en) 2004-04-27 2015-07-07 Beiersdorf Ag Aqueous anti-perspiration formulation
WO2010046061A3 (fr) * 2008-10-21 2011-10-13 Cognis Ip Management Gmbh Préparations cosmétiques et/ou pharmaceutiques
CN102292066A (zh) * 2008-10-21 2011-12-21 考格尼斯知识产权管理有限责任公司 化妆品和/或药物制剂
JP2012506393A (ja) * 2008-10-21 2012-03-15 コグニス・アイピー・マネージメント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 化粧品および／または医薬品調製物
WO2010046061A2 (fr) * 2008-10-21 2010-04-29 Cognis Ip Management Gmbh Préparations cosmétiques et/ou pharmaceutiques
JP2016516856A (ja) * 2013-03-28 2016-06-09 ペーアーエルイクス プラスティクス ベーフェーＰＡＲＸ Ｐｌａｓｔｉｃｓ ＢＶ 抗菌性ポリマーおよびそれを製造する方法

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